Detail Information

Basic Information:


  VIRBase ID:  

HHID00105228

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9630

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-200a-5p:           BRD4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-200a-5p BRD4
miRBase
Accession/Entrez ID		 MIMAT0001620 23476
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CAP//HUNK1//HUNKI//MCAP

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-200a-5p
rs1177481571 chr1:1167894    G/A
rs1334235197 chr1:1167895    C/T
rs1344162946 chr1:1167899    A/G
rs746444042 chr1:1167886    C/G
rs746444042 chr1:1167886    C/T
rs770481292 chr1:1167887    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BRD4
chr19:15385865(-) A-I      intronic
chr19:15389924(-) A-I      intronic
chr19:15389889(-) A-I      intronic
chr19:15389884(-) A-I      intronic
chr19:15389870(-) A-I      intronic
chr19:15389868(-) A-I      intronic
chr19:15389856(-) A-I      intronic
chr19:15389853(-) A-I      intronic
chr19:15389845(-) A-I      intronic
chr19:15389829(-) A-I      intronic
chr19:15389788(-) A-I      intronic
chr19:15389749(-) A-I      intronic
chr19:15389731(-) A-I      intronic
chr19:15389715(-) A-I      intronic
chr19:15388870(-) A-I      intronic
chr19:15388860(-) A-I      intronic
chr19:15388753(-) A-I      intronic
chr19:15388515(-) A-I      intronic
chr19:15388489(-) A-I      intronic
chr19:15388421(-) A-I      intronic
chr19:15388367(-) A-I      intronic
chr19:15386758(-) A-I      intronic
chr19:15386755(-) A-I      intronic
chr19:15386748(-) A-I      intronic
chr19:15386729(-) A-I      intronic
chr19:15386620(-) A-I      intronic
chr19:15386600(-) A-I      intronic
chr19:15386561(-) A-I      intronic
chr19:15385902(-) A-I      intronic
chr19:15385897(-) A-I      intronic
chr19:15385883(-) A-I      intronic
chr19:15385852(-) A-I      intronic
chr19:15385849(-) A-I      intronic
chr19:15385848(-) A-I      intronic
chr19:15385759(-) A-I      intronic
chr19:15385755(-) A-I      intronic
chr19:15385746(-) A-I      intronic
chr19:15385742(-) A-I      intronic
chr19:15373490(-) A-I      intronic
chr19:15373458(-) A-I      intronic
chr19:15373451(-) A-I      intronic
chr19:15385737(-) A-I      intronic
chr19:15385830(-) A-I      intronic
chr19:15369613(-) A-I      intronic
chr19:15369205(-) A-I      intronic
chr19:15369227(-) A-I      intronic
chr19:15369232(-) A-I      intronic
chr19:15369233(-) A-I      intronic
chr19:15369259(-) A-I      intronic
chr19:15369426(-) A-I      intronic
chr19:15369429(-) A-I      intronic
chr19:15369504(-) A-I      intronic
chr19:15369532(-) A-I      intronic
chr19:15369572(-) A-I      intronic
chr19:15372501(-) A-I      intronic
chr19:15372626(-) A-I      intronic
chr19:15373333(-) A-I      intronic
chr19:15389340(-) A-I      intronic
chr19:15386652(-) A-I      intronic
chr19:15389791(-) A-I      intronic
chr19:15386792(-) A-I      intronic
chr19:15388514(-) A-I      intronic
chr19:15389813(-) A-I      intronic
chr19:15389901(-) A-I      intronic
chr19:15389846(-) A-I      intronic
chr19:15389680(-) A-I      intronic
chr19:15386655(-) A-I      intronic
chr19:15386761(-) A-I      intronic
chr19:15369439(-) A-I      intronic
chr19:15389859(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BRD4
chr19:15347667-15347668(-) m6A 3'UTR       27773535
chr19:15347739-15347740(-) m6A 3'UTR       27773535
chr19:15347781-15347782(-) m6A 3'UTR       27773535
chr19:15347898-15347899(-) m6A 3'UTR       27773535//27371828
chr19:15347910-15347911(-) m6A 3'UTR       27773535//27371828
chr19:15347933-15347934(-) m6A 3'UTR       27773535//27371828
chr19:15348104-15348105(-) m6A 3'UTR       24981863//27773535
chr19:15348132-15348133(-) m6A 3'UTR       24981863//27773535
chr19:15348173-15348174(-) m6A 3'UTR       24981863//27773535
chr19:15348178-15348179(-) m6A 3'UTR       24981863//27773535
chr19:15348222-15348223(-) m6A 3'UTR       27773535
chr19:15348269-15348270(-) m6A 3'UTR       27773535
chr19:15348656-15348657(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr19:15348845-15348846(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr19:15348918-15348919(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr19:15348995-15348996(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr19:15349147-15349148(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr19:15349608-15349609(-) m6A CDS       24284625//24209618//27371828//27773536
chr19:15350058-15350059(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//27773536
chr19:15350222-15350223(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//27773536
chr19:15350235-15350236(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//27773536
chr19:15350245-15350246(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//27773536
chr19:15350723-15350724(-) m6A CDS       24284625//24209618//24981863//27773535
chr19:15353724-15353725(-) m6A CDS       24284625//24209618//24981863//28052920//27773535
chr19:15354190-15354191(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828
chr19:15357396-15357397(-) m6A exon//intron       27773535
chr19:15357421-15357422(-) m6A exon//intron       27773535
chr19:15357956-15357957(-) m6A 3'UTR//intron       27773535
chr19:15358177-15358178(-) m6A 3'UTR//intron       24284625//24981863//22608085
chr19:15358190-15358191(-) m6A 3'UTR//intron       24284625//24981863//22608085
chr19:15358224-15358225(-) m6A 3'UTR//intron       24284625//24981863//22608085
chr19:15358241-15358242(-) m6A 3'UTR//intron       24981863//22608085
chr19:15358300-15358301(-) m6A 3'UTR//intron       24284625
chr19:15358439-15358440(-) m6A 3'UTR//intron       24284625//24981863
chr19:15358491-15358492(-) m6A 3'UTR//intron       24284625//24981863
chr19:15359615-15359616(-) Cm 3'UTR//intron       -
chr19:15366182-15366183(-) m6A CDS       27773535//22575960
chr19:15366292-15366293(-) m6A CDS       24981863//27773535//22575960
chr19:15366340-15366341(-) m6A CDS       24981863//27773535//22575960
chr19:15366924-15366925(-) m6A CDS       24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr19:15367000-15367001(-) m6A CDS//exon       25456834//24981863//27773535//27371828//27773536//22608085
chr19:15367024-15367025(-) m6A CDS//exon       25456834//24981863//27773535//27371828//27773536//22608085
chr19:15367841-15367842(-) m6A CDS//exon       27773535//22575960
chr19:15374353-15374354(-) m6A CDS//exon       27773535
chr19:15374962-15374963(-) m6A exon//intron       27773535
chr19:15375186-15375187(-) m6A exon//intron       24284625//27773535
chr19:15375230-15375231(-) m6A CDS       24284625//27773535
chr19:15375439-15375440(-) m6A CDS       24284625//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960
chr19:15375483-15375484(-) m6A CDS       24284625//25456834//24981863//28052920//26404942//27773535//27371828//27773536
chr19:15375548-15375549(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//27371828
chr19:15376307-15376308(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960
chr19:15376321-15376322(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960
chr19:15376385-15376386(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828
chr19:15376391-15376392(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828
chr19:15376420-15376421(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828
chr19:15376443-15376444(-) m6A 3'UTR//CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828
chr19:15376451-15376452(-) m6A 3'UTR//CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828
chr19:15378229-15378230(-) m6A 3'UTR//CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828
chr19:15378280-15378281(-) m6A 3'UTR//CDS       24981863//26404942//27773535//27371828
chr19:15379813-15379814(-) m6A CDS//exon       27773535
chr19:15383632-15383633(-) m6A CDS//exon       24284625//26404942//27773535
chr19:15383682-15383683(-) m6A CDS//exon       24284625//24981863//28052920//26404942//27773535
chr19:15383693-15383694(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828
chr19:15383732-15383733(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828
chr19:15383762-15383763(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828
chr19:15383843-15383844(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828
chr19:15383850-15383851(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828
chr19:15386491-15386492(-) m6A 5'UTR//intron       24209618//24981863//27773535//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-200a-5p
Exosome Peripheral blood     31746410
Exosome B cell line (Raji)|Jurkat-derived T cell line (J77cl20)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Colon tissue|Tongue tissue     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
BRD4
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-200a-5p
Interactor2: BRD4

Evidence Support:


Strong-Evidence Luciferase reporter assay//RT-PCR//Western blot
Prediction-Evidence miRanda//Targetscan
Support Database ViRBase

References:


PMID 33675361 Target region 3'UTR
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line LNCaP cells//C4-2B cells Interactor2 expression Upregulation
Description In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.

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