Basic Information:

  VIRBase ID:  

HHID00105227

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2494

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-200a-5p:  MIMAT0001620          BSG:  NM_198591     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-200a-5p	BSG
miRBase Accession/Entrez ID	MIMAT0001620	682
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	5F7//CD147//EMMPRIN//EMPRIN//HAb18G//OK//SLC7A11//TCSF

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-200a-5p	rs1177481571 chr1:1167894    G/A rs1334235197 chr1:1167895    C/T rs1344162946 chr1:1167899    A/G rs746444042 chr1:1167886    C/G rs746444042 chr1:1167886    C/T rs770481292 chr1:1167887    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	BSG	chr19:572192(+) A-I      intronic chr19:574162(+) A-I      intronic chr19:576506(+) A-I      intronic chr19:576564(+) A-I      intronic chr19:576595(+) A-I      intronic chr19:576598(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	BSG	chr19:583488(+) C-A intron -    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	BSG	chr19:571454-571455(+) m6A 5'UTR       24981863 chr19:571517-571518(+) m6A 5'UTR       24981863 chr19:572614-572615(+) m6A 5'UTR//exon//intron       24284625//25456834//24981863//26404942//22575960 chr19:575063-575064(+) m6A 5'UTR//exon//intron       24284625//25456834//24981863//26404942//22575960 chr19:575233-575234(+) m6A 5'UTR//intron       24284625 chr19:579526-579527(+) m6A 5'UTR//CDS//exon//intron       24284625//26404942//22575960 chr19:579735-579736(+) m6A exon//intron       24284625 chr19:579742-579743(+) m6A exon//intron       24284625 chr19:580383-580384(+) m6A 5'UTR//CDS//exon//intron       24284625//22575960 chr19:580570-580571(+) m6A exon//intron       24284625 chr19:580679-580680(+) m6A CDS//exon//intron       24284625//26404942 chr19:580758-580759(+) Am CDS//exon//intron       - chr19:580777-580778(+) m6A CDS//exon//intron       24284625//26404942//22575960 chr19:581387-581388(+) m6A CDS//exon//intron       24284625//26404942//22575960 chr19:581393-581394(+) m6A CDS//exon//intron       24284625//26404942//22575960 chr19:582566-582567(+) m6A 3'UTR//CDS//exon       24284625//26404942//22575960 chr19:582843-582844(+) m6A 3'UTR//exon       24284625//26404942 chr19:583238-583239(+) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//27773535//22575960 chr19:583345-583346(+) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//22575960 chr19:583363-583364(+) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//22575960 chr19:583371-583372(+) m6A 3'UTR//exon       24284625//25456834//27773535//22575960 chr19:583441-583442(+) m6A 3'UTR//exon       24284625//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-200a-5p	Exosome Peripheral blood     31746410 Exosome B cell line (Raji)|Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Colon tissue|Tongue tissue     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	BSG	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-200a-5p
Interactor2: BSG

Evidence Support:

Prediction-Evidence	microT//miRanda//miRMap//PicTar//PITA//Targetscan
Support Database	ViRBase

References:

PMID	33428154	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	To explore the regulatory relationship between the 5 key genes, 3 coronavirus-related genes (ACE2, TMPRSS2, BSG), and their target miRNA, we used 6 miRNA target prediction databases to predict the target miRNA of these genes.