Basic Information:

  VIRBase ID:  

HHID00105226

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2455

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-429:  MIMAT0001536          ACE2:  NM_021804     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-429	ACE2
miRBase Accession/Entrez ID	MIMAT0001536	59272
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ACEH

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-429	rs1172721875 chr1:1169069    A/ATT rs1192108086 chr1:1169073    C/T rs1198199636 chr1:1169063    T/C rs1408760888 chr1:1169072    ACCGTC/A rs1419384721 chr1:1169071    A/G rs368678282 chr1:1169075    G/A rs375039921 chr1:1169068    T/C rs749938763 chr1:1169074    C/A rs749938763 chr1:1169074    C/T rs751333131 chr1:1169067    G/A rs751333131 chr1:1169067    G/T rs1484992551 chr1:1169061    T/C rs370935426 chr1:1169058    T/C rs777220333 chr1:1169060    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ACE2	chrX:15579319-15579320(-) m6A 3'UTR//exon       27773535 chrX:15579343-15579344(-) m6A 3'UTR//exon       27773535 chrX:15579366-15579367(-) m6A 3'UTR//exon       27773535 chrX:15579420-15579421(-) m6A 3'UTR//exon       27773535 chrX:15579431-15579432(-) m6A 3'UTR//intron       27773535 chrX:15579618-15579619(-) m6A 3'UTR//intron       27773535 chrX:15579631-15579632(-) m6A 3'UTR//intron       27773535 chrX:15579696-15579697(-) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-429	Exosome Serum     18589210 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Colon tissue|Seminal fluid|Tongue tissue     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	ACE2	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-429	Kahalalide F 9898671 Drug sensitive S-Decyl p-toluenethiosulfonate 97461 Drug resistant Actinomycin X4357G methoxime 9573583 Drug resistant [[4-(3-Aminophenyl)-2-pyridyl]methyleneamino]thiourea 9556427 Drug resistant Acridine Yellow G 8672 Drug sensitive 1H-Pyrazolo[3,4-d]pyrimidin-4-amine 75420 Drug sensitive 10,11-Methylenedioxy-20S-camptothecin 72403 Drug resistant Coptisine chloride 72321 Drug resistant 4H-Furo(3,2-g)(1)benzopyran-4,7,9-trione 68083 Drug resistant NO Data IN this field 6711510 Drug resistant 4'-Chloro-3-hydroxy-2'-methyl-2-naphthanilide 66718 Drug resistant Fludarabine 657237 Drug resistant Irinotecan 60838 Drug resistant Topotecan 60700 Drug resistant 3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1-methyl-1H-indole 60147979 Drug sensitive Triethylenemelamine 5799 Drug resistant Cisplatin 5702198 Drug resistant Tetrocarcin A, sodium salt 54724658 Drug resistant 2-trans-n-Buten-1-yl-estradiol 5468334 Drug resistant (8R,9S,13S,14S,17S)-13-Methyl-2-[(E)-prop-1-enyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol 5468270 Drug resistant Antineoplastic-643001 5466797 Drug resistant Selendale 54601159 Drug resistant Aspiculamycin hcl 54600418 Drug resistant Simvastatin 54454 Drug resistant 2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug resistant Xestin A 5352066 Drug sensitive Lovastatin 53232 Drug resistant Centaureidin 5315773 Drug resistant Streptonigrin 5298 Drug resistant Improsulfan hydrochloride 5284401 Drug resistant Methoxycamptothecin 494089 Drug resistant Glaucarubinone 441796 Drug resistant Ditercalinium dimethanesulfonate dimethanesulfonate 435243 Drug sensitive Carboplatin 426756 Drug resistant Diaziquone 42616 Drug resistant cis-Diamminemalonatoplatinum(II) 422683 Drug resistant Mitoxantrone 4212 Drug resistant Fagaronine chloride 40304 Drug resistant 1,2 Benzo-8-(1-hydroxy-2-methylamino propane)-3-phenoxazone 400530 Drug resistant Sjg-136 393111 Drug resistant Benzo[1,2-b:5,4-b']dithiophene-4,8-dione, 2-acetyl- 388028 Drug resistant 3-(4-Fluorophenyl)-3-(4-acetoxy-2-methylphenyl)phthalide 383342 Drug sensitive 2-Ethenyl estradiol 381026 Drug resistant 2-Acetyl-1,2-dihydroellipticine 376328 Drug sensitive Antineoplastic-656904 376224 Drug resistant Antineoplastic-655905 375758 Drug resistant 1,2-Dimethyl-phenothiazone 369387 Drug resistant Diethoxybis(1,4-naphthochinone-2-olato)titanium(IV) 368297 Drug resistant Diselenide, bis(4-methylphenyl) 365239 Drug resistant Miltefosine 3599 Drug sensitive 2,3-Dimethylbenzo[g]quinoxaline-5,10-dione 353644 Drug resistant 5-Fluorocytosine arabinoside 352938 Drug resistant 2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium acetate 3086131 Drug resistant Chlorambucil 2708 Drug resistant 1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea 26328 Drug resistant Estramustine 259331 Drug resistant Camptothecin 24360 Drug resistant Sodium 2-(4-((7-chloro-2-quinoxalinyl)oxy)phenoxy)propionate 23675947 Drug resistant Scillirosidin, glycoside 222160 Drug resistant 5-Nitroso-8-hydroxyquinoline 19103 Drug resistant {4-[5-(4-Fluoro-phenyl)-3-(1-methyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-phenyl-amine 17892742 Drug sensitive Gold;(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium 138402869 Drug resistant C8, Carbonyl prodigiosine 135540857 Drug resistant Oxanthrazole 135502299 Drug resistant 1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug resistant 8-Azahypoxanthine 135410720 Drug resistant 8-Azaguanine 135403646 Drug resistant Saintopin 131350 Drug resistant (2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug resistant 3-Bromo-4-(3,3-dimethyl-but-1-ynyl)-2(5H)-furanone 11413833 Drug sensitive 2,2'-Bioxirane 11254 Drug resistant Clomesone 100651 Drug resistant 1h-1,2,4-triazole, 3-(4-diazo-4h-imidazol-5-yl)- - Drug resistant 7h-5,6-dithioleno[4,3-d]uracil - Drug resistant benzo[1,2-b:4,5-b']dithiophene-4,8-diol, diacetate - Drug resistant benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug resistant benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug resistant bersaldegenin 1,3,5-orthoacetate - Drug resistant mercury, tetrakis(acetato)(2,3,4,5-thiophenetetrayl)tetra- - Drug resistant naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug resistant naphtho[2,3-d]oxazole-4,9-dione, 2-(1,1-dimethylethyl)- - Drug resistant phosphinic acid, bis(1-aziridinyl)-, 2-naphthyl ester - Drug resistant piceatannol, 4,3',5'-trimethyl,1s0 - Drug resistant propanedinitrile, [(3,5-dibromo-2-ethoxyphenyl)methylene]- - Drug resistant roridin a, 8-hydroxy-9b,10b-epoxy- - Drug resistant tris(1,3-diphenylpropane-1,3-dionata)gallium(iii) - Drug resistant 2-(n-d-glysoyl)aminobenzothiazole - Drug resistant 3-farnesylthiopropionamide - Drug resistant active compound from cephalodiscus gilchristi - Drug resistant atorvastatin calcium (usan) - Drug resistant Camptothecin Derivative - Drug resistant chalmydocin - Drug resistant Chlorozotocin - Drug resistant CI-921: amsacrine derivative - Drug resistant crotoxin cd - Drug resistant Indenoisoquinoline derivative - Drug resistant orlistat (usan) - Drug resistant potassium arsenite - Drug resistant potassium[trichloro(isopropylamine)platinum] - Drug resistant protein toxin a 23 - mw approx. 6700 - Drug resistant protein toxin c 10 - mw approx. 6700 - Drug resistant trimethyl(phenylthio)stannane - Drug resistant 1-octene, 3-(bromomethyl)-2,3,7-trichloro-7-methyl- - Drug sensitive ERB-38 Immunotoxin - Drug sensitive tgf.alpha.-pe40 - Drug sensitive tp4ek - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-429	N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide 9826528 Drug interaction    RC00005025 10-Hydroxycamptothecin 97226 Drug interaction    RC00005018 Hydrogen peroxide 784 Drug interaction    RC00005007 Gemcitabine 60750 Drug interaction    RC00005017 Vincristine 5978 Drug interaction    RC00005013 D-Glucose 5793 Drug interaction    RC00005012 Eloxatine 5310940 Drug interaction    RC00005024 Goserelinacetate 47725 Drug interaction    RC00005016 Ferulic acid 445858 Drug interaction    RC00005022 Etoposide 36462 Drug interaction    RC00005015 5-Fluorouracil 3385 Drug interaction    RC00005011 Doxorubicin 31703 Drug interaction    RC00005014 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005010 Tamoxifen 2733526 Drug interaction    RC00005023 Verapamil 2520 Drug interaction    RC00005009 Bicalutamide 2375 Drug interaction    RC00005008 Erlotinib 176870 Drug interaction    RC00005021 Docetaxel 148124 Drug interaction    RC00005020 Flavylium 145858 Drug interaction    RC00005019 Chemotherapy - Drug interaction    RC00008865

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-429	Panobinostat       6918837 Nilotinib       644241 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide       24180719 Sorafenib       216239 Dovitinib       135398510 Crizotinib       11626560 Nvp-aew541       11476171

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-429
Interactor2: ACE2

Evidence Support:

Prediction-Evidence	miRanda//miRBase//miRWalk//Targetscan
Support Database	ViRBase

References:

[1]PMID	32992681	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	Table 1 shows a list of novel potential candidate miRNAs against ACE2 gene that were not studied previously.

[2]PMID	32814446	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	Considering the significance of ACE2 and TMPRSS2 in SARS-CoV-2 infection, we also performed a TargetScan (http://www.targetscan.org/vert_72/) search for the miRNAs that could target these two receptors, and the analysis revealed a list of miRNAs such as, hsa-miRNA 200b-3p, hsa-miRNA 200c-3p and miRNA 429 for ACE2, and hsa-let 7c-5p, hsa-miRNA 98-5p, hsa-let 7f-5p, hsa-let 7a-5p, hsa-let 7g-5p, hsa-let 7b-5p, hsa-miRNA 4458, hsa-let 7e-5p, hsa-let 7i-5p, hsa-let 7d-5p, and hsa-miRNA 4500 for TMPRSS2.