Detail Information

Basic Information:


  VIRBase ID:  

HHID00105222

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2494

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-424-5p:           TMPRSS2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-424-5p TMPRSS2
miRBase
Accession/Entrez ID		 MIMAT0001341 7113
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PRSS10

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-424-5p
rs1486362336 chrX:134546684    A/G
rs888095819 chrX:134546701    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMPRSS2
chr21:42853862(-) A-I      intronic
chr21:42853848(-) A-I      intronic
chr21:42853888(-) A-I      intronic
chr21:42853850(-) A-I      intronic
chr21:42853879(-) A-I      intronic
chr21:42857482(-) A-I      intronic
chr21:42857493(-) A-I      intronic
chr21:42857494(-) A-I      intronic
chr21:42857532(-) A-I      intronic
chr21:42861840(-) A-I      intronic
chr21:42863176(-) A-I      intronic
chr21:42863181(-) A-I      intronic
chr21:42864020(-) A-I      intronic
chr21:42857454(-) A-I      intronic
chr21:42852821(-) A-I      intronic
chr21:42852811(-) A-I      intronic
chr21:42868840(-) A-I      intronic
chr21:42864037(-) A-I      intronic
chr21:42852802(-) A-I      intronic
chr21:42852784(-) A-I      intronic
chr21:42852783(-) A-I      intronic
chr21:42852698(-) A-I      intronic
chr21:42868853(-) A-I      intronic
chr21:42853773(-) A-I      intronic
chr21:42853747(-) A-I      intronic
chr21:42852838(-) A-I      intronic
chr21:42868879(-) A-I      intronic
chr21:42853786(-) A-I      intronic
chr21:42853787(-) A-I      intronic
chr21:42853866(-) A-I      intronic
chr21:42853876(-) A-I      intronic
chr21:42853901(-) A-I      intronic
chr21:42853902(-) A-I      intronic
chr21:42853905(-) A-I      intronic
chr21:42853936(-) A-I      intronic
chr21:42857436(-) A-I      intronic
chr21:42852837(-) A-I      intronic
chr21:42852694(-) A-I      intronic
chr21:42857467(-) A-I      intronic
chr21:42857468(-) A-I      intronic
chr21:42857476(-) A-I      intronic
chr21:42859902(-) A-I      ncRNA
chr21:42859884(-) A-I      ncRNA
chr21:42859893(-) A-I      ncRNA
chr21:42868835(-) A-I      intronic
chr21:42859992(-) A-I      intronic
chr21:42855936(-) A-I      intronic
chr21:42868944(-) A-I      intronic
chr21:42868836(-) A-I      intronic
chr21:42852668(-) A-I      intronic
chr21:42859993(-) A-I      intronic
chr21:42869010(-) A-I      intronic
chr21:42863353(-) A-I      intronic
chr21:42868900(-) A-I      intronic
chr21:42868945(-) A-I      intronic
chr21:42852703(-) A-I      intronic
chr21:42860827(-) A-I      intronic
chr21:42859858(-) A-I      ncRNA
chr21:42859831(-) A-I      ncRNA
chr21:42859844(-) A-I      ncRNA
chr21:42858403(-) A-I      ncRNA
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TMPRSS2
chr21:42858403(-) A-I intron -    15342557
chr21:42858406(-) A-I intron -    15342557
chr21:42859670(-) A-I intron -    15342557
chr21:42859831(-) A-I intron -    15342557   //15258596
chr21:42859844(-) A-I intron -    15342557   //15258596
chr21:42859858(-) A-I intron -    15342557   //15258596
chr21:42859884(-) A-I intron -    15342557   //15258596
chr21:42859893(-) A-I intron -    15342557   //15258596
chr21:42859902(-) A-I intron -    15342557   //15258596
chr21:42868835(-) A-I intron -    15342557
chr21:42868836(-) A-I intron -    15342557
chr21:42868864(-) A-I intron -    15342557
chr21:42868900(-) A-I intron -    15342557
chr21:42868905(-) A-I intron -    15342557
chr21:42868944(-) A-I intron -    15342557
chr21:42868945(-) A-I intron -    15342557
chr21:42868950(-) A-I intron -    15342557
chr21:42869010(-) A-I intron -    15342557
chr21:42869014(-) A-I intron -    15342557
chr21:42869073(-) A-I intron -    15342557
chr21:42853823(-) A-I intron -    21960545
chr21:42853826(-) A-I intron -    21960545
chr21:42853866(-) A-I intron -    21960545
chr21:42855839(-) A-I intron -    21960545
chr21:42855936(-) A-I intron -    21960545
chr21:42855984(-) A-I intron -    21960545
chr21:42857419(-) A-I intron -    21960545
chr21:42857454(-) A-I intron -    21960545
chr21:42857468(-) A-I intron -    21960545
chr21:42857493(-) A-I intron -    21960545

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMPRSS2
chr21:42836773-42836774(-) m6A 3'UTR       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-424-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Serum     18589210
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Serum     25349172
Exosome Endothelial cells     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
TMPRSS2
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-424-5p
18alpha,19Betah-Urs-20-ene-3beta,16beta-diol 9846222 Drug sensitive
Tiotixene 941651 Drug resistant
Venenatine 73061 Drug sensitive
10,11-Methylenedioxy-20S-camptothecin 72403 Drug sensitive
Fludarabine 657237 Drug sensitive
1,3,8-Trihydroxy-6-methoxyanthracene-9,10-dione 636723 Drug resistant
Irinotecan 60838 Drug sensitive
Topotecan 60700 Drug sensitive
(Z)-3-Iodo-1,2-diphenyl-2-propen-1-one 5468683 Drug resistant
Ferric-taxol 54612932 Drug resistant
Biantrazole 54607781 Drug sensitive
Betuletol 5459196 Drug sensitive
1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant
Improsulfan hydrochloride 5284401 Drug sensitive
Hopeaphenol 495605 Drug resistant
Melphalan 460612 Drug sensitive
Aclarubicin 451415 Drug sensitive
CID 44581723 44581723 Drug resistant
Isopinnatal 44558939 Drug sensitive
Neriifolin 441867 Drug sensitive
Calactin 441849 Drug sensitive
Digitoxigenin 4369270 Drug sensitive
Diaziquone 42616 Drug sensitive
Mitoxantrone 4212 Drug sensitive
S-(Dimethylarsino)-3-mercapto-1,2-propanediol 406475 Drug sensitive
Fagaronine chloride 40304 Drug sensitive
Sjg-136 393111 Drug sensitive
Cardenolide 2 388098 Drug sensitive
ARQ monoacetate 385441 Drug sensitive
(-)7,8-Dihydrocalanolide A 383107 Drug sensitive
1,2-Dimethyl-phenothiazone 369387 Drug sensitive
1,1-Dimethyl-5-(2-naphthalenyl)dithiobiuret 3004012 Drug sensitive
Tamoxifen 2733526 Drug resistant
Digoxin 2724385 Drug sensitive
Chelerythrine 2703 Drug resistant
1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea 26328 Drug sensitive
2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-[2-(methylamino)ethyl]-1H-imidazo[4,5-c]pyridine-7-carboxamide 25023715 Drug resistant
Camptothecin 24360 Drug sensitive
[(1R,2S,4R,6R,7R,10S,11R,14S,16S)-16-Hydroxy-7,11-dimethyl-6-(6-oxopyran-3-yl)-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecan-14-yl] acetate 23618199 Drug sensitive
Adenosine, 2-chloro- 235481 Drug sensitive
2-Chloro-3-phenoxy-1,4-naphthoquinone 219799 Drug resistant
Amsacrine 2179 Drug sensitive
Cladribine 20279 Drug sensitive
Thevetin 159331 Drug sensitive
Sulfanilanilide, 4'-(9-acridinylamino)- 148802 Drug sensitive
Oxanthrazole 135502299 Drug sensitive
Indotecan 11533060 Drug sensitive
Bialamicol 10304 Drug resistant
[(1R,3R,5R,8R,9S,10R,13R,14S,17R)-3-[(2R,3R,4R,5R,6S)-3,5-Dihydroxy-4-methoxy-6-methyloxan-2-yl]oxy-10,14-dihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-1-yl] acetate 101973931 Drug sensitive
1-octene, 3-(bromomethyl)-2,3,7-trichloro-7-methyl- - Drug resistant
anthraquinone, 1-hydroxy-4-[p-(2-hydroxyethyl)anilino]- - Drug resistant
benzene, 1-methoxy-4-(2-nitroethenyl)-, (e)- - Drug resistant
9-methoxy-5-hydroxycamptothecin - Drug resistant
antineoplastic-625577 - Drug resistant
bafilomycin deriv - Drug resistant
7h-5,6-dithioleno[4,3-d]uracil - Drug sensitive
9,10-anthracenedione, 1-[(oxiranylmethyl)amino]- - Drug sensitive
isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive
2-(n-d-glysoyl)aminobenzothiazole - Drug sensitive
Camptothecin Derivative - Drug sensitive
CI-921: amsacrine derivative - Drug sensitive
digitoxigenin glycoside - Drug sensitive
merophan - Drug sensitive
trimethyl(phenylthio)stannane - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-424-5p
10-Hydroxycamptothecin 97226 Drug interaction    RC00004933
Formaldehyde 712 Drug interaction    RC00004922
Gemcitabine 60750 Drug interaction    RC00004932
Vincristine 5978 Drug interaction    RC00004928
Estradiol 5757 Drug interaction    RC00004927
Eloxatine 5310940 Drug interaction    RC00004939
Imatinib 5291 Drug interaction    RC00004926
Cholecalciferol 5280795 Drug interaction    RC00004938
Decitabine 451668 Drug interaction    RC00004937
Etoposide 36462 Drug interaction    RC00004931
Paclitaxel 36314 Drug interaction    RC00004930
5-Fluorouracil 3385 Drug interaction    RC00004925
Doxorubicin 31703 Drug interaction    RC00004929
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00004924
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00004940
Bicalutamide 2375 Drug interaction    RC00004923
Docetaxel 148124 Drug interaction    RC00004936
Gefitinib 123631 Drug interaction    RC00004935
Ginsenoside Rh2 119307 Drug interaction    RC00004934
Chemotherapy - Drug interaction    RC00008864
Medpor - Drug interaction    RC00004942
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00004941

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-424-5p
Interactor2: TMPRSS2

Evidence Support:


Prediction-Evidence microT//miRanda//miRMap//PicTar//PITA//Targetscan
Support Database ViRBase

References:


PMID 33428154 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description To explore the regulatory relationship between the 5 key genes, 3 coronavirus-related genes (ACE2, TMPRSS2, BSG), and their target miRNA, we used 6 miRNA target prediction databases to predict the target miRNA of these genes.

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