Detail Information

Basic Information:


  VIRBase ID:  

HHID00105221

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2494

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-196b-5p:           TMPRSS2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-196b-5p TMPRSS2
miRBase
Accession/Entrez ID		 MIMAT0001080 7113
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PRSS10

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-196b-5p
rs1390795117 chr7:27169536    C/T
rs373198735 chr7:27169531    A/G
rs373198735 chr7:27169531    A/T
rs1321323373 chr7:27169547    C/T
rs555707988 chr7:27169546    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMPRSS2
chr21:42853862(-) A-I      intronic
chr21:42853848(-) A-I      intronic
chr21:42853888(-) A-I      intronic
chr21:42853850(-) A-I      intronic
chr21:42853879(-) A-I      intronic
chr21:42857482(-) A-I      intronic
chr21:42857493(-) A-I      intronic
chr21:42857494(-) A-I      intronic
chr21:42857532(-) A-I      intronic
chr21:42861840(-) A-I      intronic
chr21:42863176(-) A-I      intronic
chr21:42863181(-) A-I      intronic
chr21:42864020(-) A-I      intronic
chr21:42857454(-) A-I      intronic
chr21:42852821(-) A-I      intronic
chr21:42852811(-) A-I      intronic
chr21:42868840(-) A-I      intronic
chr21:42864037(-) A-I      intronic
chr21:42852802(-) A-I      intronic
chr21:42852784(-) A-I      intronic
chr21:42852783(-) A-I      intronic
chr21:42852698(-) A-I      intronic
chr21:42868853(-) A-I      intronic
chr21:42853773(-) A-I      intronic
chr21:42853747(-) A-I      intronic
chr21:42852838(-) A-I      intronic
chr21:42868879(-) A-I      intronic
chr21:42853786(-) A-I      intronic
chr21:42853787(-) A-I      intronic
chr21:42853866(-) A-I      intronic
chr21:42853876(-) A-I      intronic
chr21:42853901(-) A-I      intronic
chr21:42853902(-) A-I      intronic
chr21:42853905(-) A-I      intronic
chr21:42853936(-) A-I      intronic
chr21:42857436(-) A-I      intronic
chr21:42852837(-) A-I      intronic
chr21:42852694(-) A-I      intronic
chr21:42857467(-) A-I      intronic
chr21:42857468(-) A-I      intronic
chr21:42857476(-) A-I      intronic
chr21:42859902(-) A-I      ncRNA
chr21:42859884(-) A-I      ncRNA
chr21:42859893(-) A-I      ncRNA
chr21:42868835(-) A-I      intronic
chr21:42859992(-) A-I      intronic
chr21:42855936(-) A-I      intronic
chr21:42868944(-) A-I      intronic
chr21:42868836(-) A-I      intronic
chr21:42852668(-) A-I      intronic
chr21:42859993(-) A-I      intronic
chr21:42869010(-) A-I      intronic
chr21:42863353(-) A-I      intronic
chr21:42868900(-) A-I      intronic
chr21:42868945(-) A-I      intronic
chr21:42852703(-) A-I      intronic
chr21:42860827(-) A-I      intronic
chr21:42859858(-) A-I      ncRNA
chr21:42859831(-) A-I      ncRNA
chr21:42859844(-) A-I      ncRNA
chr21:42858403(-) A-I      ncRNA
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TMPRSS2
chr21:42858403(-) A-I intron -    15342557
chr21:42858406(-) A-I intron -    15342557
chr21:42859670(-) A-I intron -    15342557
chr21:42859831(-) A-I intron -    15342557   //15258596
chr21:42859844(-) A-I intron -    15342557   //15258596
chr21:42859858(-) A-I intron -    15342557   //15258596
chr21:42859884(-) A-I intron -    15342557   //15258596
chr21:42859893(-) A-I intron -    15342557   //15258596
chr21:42859902(-) A-I intron -    15342557   //15258596
chr21:42868835(-) A-I intron -    15342557
chr21:42868836(-) A-I intron -    15342557
chr21:42868864(-) A-I intron -    15342557
chr21:42868900(-) A-I intron -    15342557
chr21:42868905(-) A-I intron -    15342557
chr21:42868944(-) A-I intron -    15342557
chr21:42868945(-) A-I intron -    15342557
chr21:42868950(-) A-I intron -    15342557
chr21:42869010(-) A-I intron -    15342557
chr21:42869014(-) A-I intron -    15342557
chr21:42869073(-) A-I intron -    15342557
chr21:42853823(-) A-I intron -    21960545
chr21:42853826(-) A-I intron -    21960545
chr21:42853866(-) A-I intron -    21960545
chr21:42855839(-) A-I intron -    21960545
chr21:42855936(-) A-I intron -    21960545
chr21:42855984(-) A-I intron -    21960545
chr21:42857419(-) A-I intron -    21960545
chr21:42857454(-) A-I intron -    21960545
chr21:42857468(-) A-I intron -    21960545
chr21:42857493(-) A-I intron -    21960545

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMPRSS2
chr21:42836773-42836774(-) m6A 3'UTR       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-196b-5p
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus HeLa cells     23940654
TMPRSS2
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-196b-5p
Tetrangulol 99188 Drug resistant
Midostaurin 9829523 Drug sensitive
N~4~-(3-Methyl-1h-Indazol-6-Yl)-N~2~-(3,4,5-Trimethoxyphenyl)pyrimidine-2,4-Diamine 9822610 Drug sensitive
S-Decyl p-toluenethiosulfonate 97461 Drug resistant
Actinomycin X4357G methoxime 9573583 Drug resistant
1,9-Pyrazoloanthrone 8515 Drug sensitive
2,4,6-Tris(2-pyridyl)-s-triazine 77258 Drug resistant
2-Amino-3H-phenoxazin-3-one 72725 Drug resistant
7-Hydroxystaurosporine 72271 Drug sensitive
NO Data IN this field 6711510 Drug resistant
Verrucarin A, 3'-(acetyloxy)-7'-deoxo-2'-deoxy-4'-hydroxy-7'-(1-hydroxyethyl)- 5933240 Drug resistant
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug resistant
Antibiotic 1907-VIII 5477807 Drug resistant
8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug resistant
1-[(3-Oxohex-1-enyl)thio]hex-1-en-3-one 5473096 Drug sensitive
Dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498558 Drug resistant
Pipamperone 4830 Drug resistant
4-[1-(4-Aminomethyl-phenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamine 44397453 Drug sensitive
Glaucarubinone 441796 Drug resistant
Antibiotic X-14766A 434840 Drug resistant
Homocoralyne sulfopropionate 40154 Drug resistant
2-(5-Amino-1-methyl-4,7-dioxoindol-3-yl)-4-methylthiazole 392620 Drug resistant
Sanguilutine pseudobase 371258 Drug resistant
Girolline 362388 Drug sensitive
Miltefosine 3599 Drug sensitive
2,3-Dimethylbenzo[g]quinoxaline-5,10-dione 353644 Drug resistant
2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium acetate 3086131 Drug resistant
Janus Red 3081985 Drug resistant
Dasatinib 3062316 Drug sensitive
Phenanthrene-9,10-diimine 2981 Drug resistant
2,4,6-Trichloro-5-heptylpyrimidine 260791 Drug resistant
1,2-Benzo-8-(L-alanyl)-3-phenoxazone nitrate salt 24202491 Drug resistant
2,2-Diethyl-6-(hydroxymethyl)-4,6,7,7a-tetrahydro-3aH-[1,3,2]dioxastannolo[4,5-c]pyran-4,7-diol 16683462 Drug resistant
O-Desmethylbouvardin 160296 Drug resistant
Bis(triethylphosphine)gold(I) chloride 149280 Drug resistant
1,3-Diamino-5-methylphenazinium chloride 14132 Drug resistant
N-[(1S,4R,7S,11R,14S,17R,20S,24R,27S)-2,4,12,15,17,25-Hexamethyl-27-methylsulfanyl-3,6,10,13,16,19,23,26-octaoxo-11,24-di(propan-2-yl)-20-(quinoxaline-2-carbonylamino)-9,22-dioxa-28-thia-2,5,12,15,18,25-hexazabicyclo[12.12.3]nonacosan-7-yl]quinoxaline-2-carboxamide 138402870 Drug resistant
Gold;(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium 138402869 Drug resistant
Dtxsid30327893 138402823 Drug resistant
Methyl (7E,9Z,11S,12R,13S,14R,15R,17R,18S,19S,20E)-2,16-diacetyloxy-11,12,14,18,19,31-hexahydroxy-3,7,11,13,17,19,21,27-octamethyl-6,28-dioxo-23,25-dioxa-5-azatetracyclo[20.7.1.14,29.026,30]hentriaconta-1,3,7,9,20,22(30),26,29(31)-octaene-15-carboxylate 138319233 Drug resistant
Oxanthrazole 135502299 Drug resistant
Inosine dialdehyde 135400916 Drug resistant
Halomon 132430 Drug sensitive
15-Deacetylsergeolide 125729 Drug resistant
Berberine chloride 12456 Drug resistant
Unii-C616DV5Y11 117587576 Drug resistant
3-Bromo-4-(3,3-dimethyl-but-1-ynyl)-2(5H)-furanone 11413833 Drug sensitive
Pararosaniline hydrochloride 11292 Drug resistant
Chimaphilin 101211 Drug resistant
1,1'-biphenyl, 4,4'bis(thiomethyl)- - Drug resistant
1,2-benzo-8-(d,l-alanyl)-3-phenoxazone nitrate salt - Drug resistant
2-chloro-3-amino-5,8-dihydoxy-1,4-naphthoquinone - Drug resistant
7h-5,6-dithioleno[4,3-d]uracil - Drug resistant
benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug resistant
benzo[1,2-b:5,4-b']dithiophene-4,8-dione, 2,5-diacetyl- - Drug resistant
benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug resistant
naphtho[1,2-b]quinolizinium, 10,13-dimethyl- chloride - Drug resistant
naphtho[2,3-d]oxazole-4,9-dione, 2-(1,1-dimethylethyl)- - Drug resistant
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug resistant
thiazolo[3,2-f]phenanthridinium, 3-phenyl- perchlorate - Drug resistant
1-o-octadecyl-2-methoxy-glycero-3-phosphocarnitine - Drug resistant
2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug resistant
2-(4-methylthio-benzylidene)-2-(2-pyridyl)acetonitrile - Drug resistant
5-hydroxyamino camptothecin - Drug resistant
b705009k098 - Drug resistant
Basic Fuchsin - Drug resistant
chalmydocin - Drug resistant
pancratium littorale - Drug resistant
tetra(isobutenyl)antimony bromide - Drug resistant
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug sensitive
1-octene, 3-(bromomethyl)-2,3,7-trichloro-7-methyl- - Drug sensitive
6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione - Drug sensitive
antineoplastic-d655481 - Drug sensitive
toxin .delta.53l - Drug sensitive
tp4ek-k6 - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-196b-5p
10-Hydroxycamptothecin 97226 Drug interaction    RC00004863
Thymidine-5'-phosphate 9700 Drug interaction    RC00004858
Capecitabine 60953 Drug interaction    RC00004862
Gemcitabine 60750 Drug interaction    RC00004861
Prednisolone 5755 Drug interaction    RC00004857
Sunitinib 5329102 Drug interaction    RC00004872
Eloxatine 5310940 Drug interaction    RC00004871
Ferulic acid 445858 Drug interaction    RC00004870
Naringin 442428 Drug interaction    RC00004869
Puromycin 439530 Drug interaction    RC00004868
Etoposide 36462 Drug interaction    RC00004860
5-Fluorouracil 3385 Drug interaction    RC00004856
Doxorubicin 31703 Drug interaction    RC00004859
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00004855
Verapamil 2520 Drug interaction    RC00004854
Lenalidomide 216326 Drug interaction    RC00004867
Docetaxel 148124 Drug interaction    RC00004866
Ginsenoside Rh2 119307 Drug interaction    RC00004865
Proanthocyanidin 108065 Drug interaction    RC00004864
platinum-based doublet chemotherapy - Drug interaction    RC00004873
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00004874
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-196b-5p
5-Fluorouracil 3385       25356050
5-Fluorouracil 3385       28591704

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-196b-5p
Interactor2: TMPRSS2

Evidence Support:


Prediction-Evidence microT//miRanda//miRMap//PicTar//PITA//Targetscan
Support Database ViRBase

References:


PMID 33428154 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description To explore the regulatory relationship between the 5 key genes, 3 coronavirus-related genes (ACE2, TMPRSS2, BSG), and their target miRNA, we used 6 miRNA target prediction databases to predict the target miRNA of these genes.

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