Detail Information

Basic Information:


  VIRBase ID:  

HHID00105218

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9751

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-346:           BTK:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-346 BTK
miRBase
Accession/Entrez ID		 MIMAT0000773 695
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AGMX1//AT//ATK//BPK//IGHD3//IMD1//PSCTK1//XLA

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-346
rs1026858249 chr10:86264760    C/G
rs1026858249 chr10:86264760    C/T
rs1239349293 chr10:86264759    G/A
rs1310080313 chr10:86264769    A/G
rs1384729115 chr10:86264750    G/T
rs750124654 chr10:86264761    G/A
rs1329800845 chr10:86264764    C/G
rs1440341525 chr10:86264768    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BTK
chrX:100606122(-) A-I      intronic
chrX:100639590(-) A-I      intronic
chrX:100639503(-) A-I      intronic
chrX:100639502(-) A-I      intronic
chrX:100639501(-) A-I      intronic
chrX:100639498(-) A-I      intronic
chrX:100635932(-) A-I      intronic
chrX:100635840(-) A-I      intronic
chrX:100627924(-) A-I      intronic
chrX:100627923(-) A-I      intronic
chrX:100619822(-) A-I      intronic
chrX:100618656(-) A-I      intronic
chrX:100607961(-) A-I      intronic
chrX:100607932(-) A-I      intronic
chrX:100607039(-) A-I      intronic
chrX:100606147(-) A-I      intronic
chrX:100606163(-) A-I      intronic
chrX:100606188(-) A-I      intronic
chrX:100607029(-) A-I      intronic
chrX:100606895(-) A-I      intronic
chrX:100606263(-) A-I      intronic
chrX:100606227(-) A-I      intronic
chrX:100605501(-) A-I      intronic
chrX:100606473(-) A-I      intronic
chrX:100619868(-) A-I      intronic
chrX:100619835(-) A-I      intronic
chrX:100627574(-) A-I      intronic
chrX:100606121(-) A-I      intronic
chrX:100605540(-) A-I      intronic
chrX:100606108(-) A-I      intronic
chrX:100605708(-) A-I      intronic
chrX:100605599(-) A-I      intronic
chrX:100605658(-) A-I      intronic
chrX:100607721(-) A-I      intronic
chrX:100605579(-) A-I      intronic
chrX:100605572(-) A-I      intronic
chrX:100606187(-) A-I      intronic
chrX:100605707(-) A-I      intronic
chrX:100607945(-) A-I      intronic
chrX:100605608(-) A-I      intronic
chrX:100627989(-) A-I      intronic
chrX:100635911(-) A-I      intronic
chrX:100605638(-) A-I      intronic
chrX:100606228(-) A-I      intronic
chrX:100610022(-) A-I      intronic
chrX:100607978(-) A-I      intronic
chrX:100606112(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED BTK
chrX:100606121(-) A-G intron -    22484847
chrX:100606187(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BTK
chrX:100604521-100604522(-) m6A 3'UTR       28052920
chrX:100604643-100604644(-) m6A 3'UTR       28052920
chrX:100610722-100610723(-) m6A exon//intron       -
chrX:100610740-100610741(-) m6A exon//intron       -
chrX:100610749-100610750(-) m6A exon//intron       -
chrX:100611011-100611012(-) m6A exon//intron       -
chrX:100611033-100611034(-) m6A exon//intron       -
chrX:100611043-100611044(-) m6A CDS//exon//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-346
Exosome Serum     18589210
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293)     22984580
BTK
Chromatin K562 cells     -
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-346
Gemcitabine 60750 Drug interaction    RC00004544
D-Glucose 5793 Drug interaction    RC00004542
Risperidone 5073 Drug interaction    RC00004541
Diethylstilbestrol 448537 Drug interaction    RC00004545
Paclitaxel 36314 Drug interaction    RC00004543
5-Fluorouracil 3385 Drug interaction    RC00004540
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00004546
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-346
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-346
Interactor2: BTK

Evidence Support:


Strong-Evidence Luciferase reporter assay//qRT-PCR//Western blot
Weak-Evidence MiRNA microarray
Support Database ViRBase

References:


PMID 33675361 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line HEK293 cells//THP-1 cells Interactor2 expression Downregulation
Description In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.

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