Detail Information

Basic Information:


  VIRBase ID:  

HHID00105210

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2455

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-330-3p:           ACE2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-330-3p ACE2
miRBase
Accession/Entrez ID		 MIMAT0000751 59272
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ACEH

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-330-3p
rs1269737658 chr19:45639021    G/A
rs1286441022 chr19:45639015    C/T
rs1328358019 chr19:45639018    G/A
rs1328358019 chr19:45639018    G/T
rs1440354112 chr19:45639023    G/A
rs771429781 chr19:45639013    T/C
rs779437713 chr19:45639020    C/G
rs796347371 chr19:45639017    G/A
rs986424633 chr19:45639024    T/C

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ACE2
chrX:15579319-15579320(-) m6A 3'UTR//exon       27773535
chrX:15579343-15579344(-) m6A 3'UTR//exon       27773535
chrX:15579366-15579367(-) m6A 3'UTR//exon       27773535
chrX:15579420-15579421(-) m6A 3'UTR//exon       27773535
chrX:15579431-15579432(-) m6A 3'UTR//intron       27773535
chrX:15579618-15579619(-) m6A 3'UTR//intron       27773535
chrX:15579631-15579632(-) m6A 3'UTR//intron       27773535
chrX:15579696-15579697(-) m6A 3'UTR//exon       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-330-3p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Serum     18589210
Exosome Primary dendritic cells     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Blood     -
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
ACE2
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-330-3p
2-(2,4-Difluorophenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3(2H)-dione 9905583 Drug sensitive
Kahalalide F 9898671 Drug resistant
5-Iodo-8-quinolinol 96111 Drug sensitive
Actinomycin X4357G methoxime 9573583 Drug sensitive
Cyclo[N-methyl-L-alanyl-beta-alanyl-(2R)-2-hydroxy-4-pentenoyl-L-prolyl-L-isoleucyl-N-methyl-L-valyl] 91746256 Drug sensitive
[(1R,2Z,4R,8R,9R,11R,12S)-1,12-Dihydroxy-2-(hydroxymethyl)-11-methyl-7-methylidene-6-oxo-5,14-dioxatricyclo[9.2.1.04,8]tetradec-2-en-9-yl] (Z)-2-methylbut-2-enoate 90475906 Drug sensitive
(3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug sensitive
4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive
L-2-Aminobutyric acid 80283 Drug sensitive
Allyl 2,4,6-tribromophenyl ether 76767 Drug sensitive
Indolo[2,1-b]quinazoline-6,12-dione 73549 Drug sensitive
4,7-Diphenyl-1,10-phenanthroline 72812 Drug sensitive
Redoxal 72571 Drug sensitive
Piperidinium pentamethylenedithiocarbamate 72508 Drug sensitive
Coptisine chloride 72321 Drug sensitive
Edatrexate 6917908 Drug sensitive
Phosphotrienin 6913994 Drug sensitive
1-(2-Pyridylazo)-2-naphthol 6825 Drug sensitive
Sulbentine 67686 Drug sensitive
3-Hydroxy-3'-nitro-2-naphthanilide 67277 Drug sensitive
Neocuproine 65237 Drug sensitive
Ixabepilone 6445540 Drug sensitive
Verrucarin A 6326658 Drug sensitive
Primaquine phosphate 6135 Drug sensitive
Tributyrin 6050 Drug sensitive
Triethylenemelamine 5799 Drug sensitive
7Z-Plakortide H 5472712 Drug sensitive
Artelasticin 5471311 Drug sensitive
(E)-1-(1H-Benzimidazol-2-yl)-3-(4-nitrophenyl)prop-2-en-1-one 5469981 Drug sensitive
3-Deazauridine 54684286 Drug sensitive
9-alpha-Acetoxyparthenolide 54611286 Drug sensitive
p-Chloranilinum[bis(p-chloraniline)dioxalatoruthenate(III)] 54608061 Drug sensitive
Piritrexim isethionate 54368 Drug sensitive
Elsamicin 5384876 Drug sensitive
Acetylrolandrolide 5384465 Drug sensitive
(1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive
Crassin, acetate 5355441 Drug sensitive
Hemiasterlin 5352092 Drug sensitive
Dihydro-5-azacytidine 5351280 Drug sensitive
4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid 53388144 Drug sensitive
5-[2-(4-Hydroxy-2,6-dimethylphenyl)ethenyl]pyridine-3-carboxamide 53239975 Drug sensitive
Vorinostat 5311 Drug sensitive
Erioflorin acetate 5281443 Drug sensitive
Kekule 499328 Drug sensitive
Pyrimethamine 4993 Drug sensitive
2-Hydroxy-2-phenyl-3-(p-tolylsulfanyl)butanamide 495813 Drug sensitive
1-[2-(3-Chlorophenyl)-2-oxoethyl]-2-acetylbenzimidazole 46911792 Drug sensitive
(S)-(+)-Tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 46907787 Drug sensitive
Melphalan 460612 Drug sensitive
Ossirene 451379 Drug sensitive
Mycophenolic acid 446541 Drug sensitive
1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive
Hookerianamide I 44587245 Drug sensitive
Isopinnatal 44558939 Drug sensitive
Justicidin B 442882 Drug sensitive
Oxyacanthine 442333 Drug sensitive
Methyl 4-[4-(dimethylamino)-5-[4-hydroxy-6-methyl-5-(6-methyl-5-oxooxan-2-yl)oxyoxan-2-yl]oxy-6-methyloxan-2-yl]oxy-2-ethyl-2,5,7,12-tetrahydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate 438788 Drug sensitive
Physalolactone 433866 Drug sensitive
Benzofurazan, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide 42640 Drug sensitive
4-Quinazolinamine, 2-[2-(1-pyrrolidinylazo)phenyl]- 424332 Drug sensitive
5-(Chloromethyl)quinolin-8-ol 416881 Drug sensitive
3-Dipropylarsanylsulfanylpropane-1,2-diol 406477 Drug sensitive
(2S)-2,6-Diamino-N-[4-(5-amino-6,8-difluoro-7-methyl-4-oxochromen-2-yl)-2-fluorophenyl]hexanamide;methanesulfonic acid 399587 Drug sensitive
Artelastin 399488 Drug sensitive
3-Iodoacetamido-benzoic acid ethyl ester 398530 Drug sensitive
5'-Hydromethyl-2,5-bis-(2'selenyl)-N-methylpyrrol 394653 Drug sensitive
5'-Formyl-2,5-bis(2'-selenyl)-N-methylpyrrol 394652 Drug sensitive
Asimicinone 393461 Drug sensitive
15-Oxozoapatlin 391317 Drug sensitive
6H-Pyrido[2,3,4-kl]acridin-6-one, 4-methoxy- 391209 Drug sensitive
Leflunomide 3899 Drug sensitive
beta-Lapachone 3885 Drug sensitive
Lapachol 3884 Drug sensitive
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive
ARQ monoacetate 385441 Drug sensitive
Hexanoic acid, 6-[(7-methoxy-1-nitro-9-acridinyl)amino]- 384253 Drug sensitive
1-Azido-2-phenyl-3-phenalenone 381891 Drug sensitive
7-Chloro-6-(2-fluoroethylamino)quinoline-5,8-dione 379079 Drug sensitive
2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug sensitive
O-Benzylfluorescein benzyl ester 371436 Drug sensitive
1,2-Dimethyl-phenothiazone 369387 Drug sensitive
4-Nitro-6-(trifluoromethyl)-2,1,3-benzoselenadiazole 362897 Drug sensitive
4-N,N-Bis-2'-cyanoethylaminobenzylidene-4-fluoro aniline 359414 Drug sensitive
3-Deazaneplanocin hydrochloride 358176 Drug sensitive
Pdtpt 357140 Drug sensitive
5-(4-Azido-3-chlorophenyl)-6-ethylpyrimidine-2,4-diamine 353605 Drug sensitive
5-Fluorocytosine arabinoside 352938 Drug sensitive
Buellolide 337850 Drug sensitive
Trimetrexate glucuronic acid salt 336805 Drug sensitive
Predorine 333830 Drug sensitive
4-Ethyl-6-methoxy-7-(oxiran-2-ylmethoxy)quinazoline 333565 Drug sensitive
2,4-Quinazolinediamine, 6-[[4-(dimethylamino)phenyl]thio]- 328145 Drug sensitive
2,4-Diamino-5-(3-amino-4-chloro-5-nitrophenyl)-6-ethylpyrimidine 327404 Drug sensitive
6-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]-7H-purin-2-amine 3246652 Drug sensitive
2,2',3,3'-Tetrahydroxy-1,1'-binaphthyl 316673 Drug sensitive
2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug sensitive
N,N-Dibenzyldaunorubicin 3081598 Drug sensitive
Cytosine, 1beta-D-arabinofuranosyl-N(sup 4)-stearoyl- 304673 Drug sensitive
1,1-Dimethyl-5-(2-naphthalenyl)dithiobiuret 3004012 Drug sensitive
Dichloroallyl lawsone 277767 Drug sensitive
Deoxycamptothecin 266552 Drug sensitive
3,6-Dibromophenanthrene-9,10-dione 258450 Drug sensitive
Carmofur 2577 Drug sensitive
2'-Deoxy-5-(trifluoromethyl)uridine 253083 Drug sensitive
3-Amino-N-(4-benzylphenyl)-1H-indazole-1-carboxamide 25197651 Drug sensitive
2-(7-Aminotriazolo[4,5-d]pyrimidin-3-yl)-5-(hydroxymethyl)oxolane-3,4-diol 251928 Drug sensitive
Hookerianamide J 25016666 Drug sensitive
Hydrazine sulfate 24842 Drug sensitive
9H-Purine, 6-(o-chlorobenzylthio)-9-(2-chloroethyl)- 246231 Drug sensitive
Antimycin A3 245869 Drug sensitive
Metoprine 24466 Drug sensitive
Sarcoviolin 24202820 Drug sensitive
1-[1-(Diethylamino)propan-2-ylamino]-4-nitrothioxanthen-9-one;chloride 24186469 Drug sensitive
[4-[(4-Arsonophenyl)methyl]phenyl]arsonic acid 241158 Drug sensitive
9H-Purine, 2-amino-6-(o-chlorobenzylthio)-9-propyl- 239486 Drug sensitive
Sodium 2-(4-((7-chloro-2-quinoxalinyl)oxy)phenoxy)propionate 23675947 Drug sensitive
7-Fluoro-2-benzoyl-3-trifluoromethylquioxaline 1,4-dioxide 23635154 Drug sensitive
Helenalin 23205 Drug sensitive
Drostanolone propionate 224004 Drug sensitive
Pirarubicin hydrochloride 20846247 Drug sensitive
(1S,3R,7Z,9R,12S,13R,15R)-13-Hydroxy-3,7,12-trimethyl-13-prop-1-en-2-yl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 20835084 Drug sensitive
Actinomycin VII 20055431 Drug sensitive
Methyl 1,6,8,14a-tetrahydroxy-11-[(4-hydroxy-3,5-dimethoxy-6-methyloxan-2-yl)amino]-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-5,6-dihydrobenzo[a]tetracene-2-carboxylate 197261 Drug sensitive
8-Hydroxyquinoline 1923 Drug sensitive
5-Nitroso-8-hydroxyquinoline 19103 Drug sensitive
7,8-Dihydroxyflavone 1880 Drug sensitive
Sudan II 18386 Drug sensitive
8-Chloro-cyclicamp 17856967 Drug sensitive
Azaribine 16574 Drug sensitive
Chonemorphine 165208 Drug sensitive
Dihydrotriazine derivative 160202 Drug sensitive
Antineoplastic-633273 15954131 Drug sensitive
Ammonium tetrathiomolybdate 15251598 Drug sensitive
Aklavin 149755 Drug sensitive
Dibromsalan 14839 Drug sensitive
Amphethinile 146332 Drug sensitive
Methyl (3'R)-3,4',9',10-tetrahydroxy-3'-[(2S,4R,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-7'-methoxy-5',8',9-trioxospiro[3,4-dihydropyrano[4,3-g]chromene-2,2'-3H-benzo[f][1]benzofuran]-7-carboxylate 137326876 Drug sensitive
2,4-Dihydroxybenzaldehyde 2-pyridylhydrazone 135509512 Drug sensitive
Emofolin sodium 135475347 Drug sensitive
2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug sensitive
8-Azahypoxanthine 135410720 Drug sensitive
3-Nitro-benzoic acid (2-hydroxy-benzylidene)-hydrazide 135408681 Drug sensitive
2-Chloro-3-(2-butoxyethoxy)naphthazarin 135406263 Drug sensitive
Mercury, (4-aminophenyl)(6-thioguanosinato-N7,S6)- 135403617 Drug sensitive
Raltitrexed 135400182 Drug sensitive
{1-[(3-Chlorophenyl)methyl]-1H-indol-3-yl}methanol 13288729 Drug sensitive
Actinomycin D, 93% 131954673 Drug sensitive
Methotrexate 126941 Drug sensitive
2,4-Pyrimidinediamine, 5-(3-azido-4-chlorophenyl)-6-ethyl- 125330 Drug sensitive
Triptolid 118701083 Drug sensitive
1H-Indole-3-methanol, 1-[(4-chlorophenyl)methyl]- 11821732 Drug sensitive
p-Toluquinone 11122 Drug sensitive
9-Chloro-2-methylellipticinium acetate, hydrate 10383530 Drug resistant
Fusariotoxin T-2 102515111 Drug sensitive
Withajardin C 102469053 Drug sensitive
(7S,9S)-7-[[(3As,4S,7aS)-1-[[(3aS,4S,7aS)-4-methyl-6-[[(1S,3S)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-2,4-dihydro-1H-tetracen-1-yl]oxy]-2,3a,4,6,7,7a-hexahydropyrano[4,3-d][1,3]oxazol-1-yl]methyl]-4-methyl-2,3a,4,6,7,7a-hexahydropyrano[4,3-d][1,3]oxazol-6-yl]oxy]-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione 101713728 Drug sensitive
(1S,2R,4R,6S,11R,12S,15R,18S,19R,20R,21S,23R,26R)-15-Hydroxy-11,18,21-trimethyl-5,17,24,28,29-pentaoxanonacyclo[17.9.1.11,20.02,12.04,6.06,11.015,19.018,23.021,26]triacont-8-ene-10,16,25,30-tetrone 101528280 Drug sensitive
(3S,6S)-1,4-Dimethyl-3,6-bis[(2R)-3,3,3-trichloro-2-methylpropyl]piperazine-2,5-dione 101425118 Drug sensitive
Erigerol 101318126 Drug sensitive
Tocladesine 100299 Drug sensitive
(z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive
1,8-naphthyridin-4(1h)-one, 2-(4-fluorophenyl)-5-methyl- - Drug sensitive
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug sensitive
1h-1,4,7-triazonine-1,4-diacetic acid, octahydro- - Drug sensitive
1h-benzimidazole, 5,5'-dithiobis[2-(trifluoromethyl)- (9ci) - Drug sensitive
2-(p-nitrophenoxy)carbonyl-1,2-dihydroellipticine - Drug sensitive
2-bromo-5,8-dihydroxy-3-methyl-1,4-naphthoquinone - Drug sensitive
3,3?-(1h-pyrrole-2,5-diyl)bis(5-chloro-1-methyl-1h-indole) - Drug sensitive
3',4',5'-trimethoxy-3-hydroxy flavone - Drug sensitive
4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug sensitive
4'-deoxy-13',17-dinitro-3',4'-epoxy-vincaleukoblastine - Drug sensitive
4-piperidinone, 3,5-bis[(4-fluorophenyl)methylene]-, (e,e)- - Drug sensitive
4-quinazolone, 7-amino-3-(4-methoxyphenyl)-, hydrate - Drug sensitive
5,8-quinolinedione, 6-amino-7-bromo- - Drug sensitive
5.alpha.,25d-spirostan-3.beta.-ol glycoside - Drug sensitive
6-(4-hydroxy-2-methylphenyl)-2-(4-(methylsulfonyl)phenyl)-4,5-dihydropyridazin-3(2H)-one - Drug sensitive
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 2-methyl- - Drug sensitive
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 2-phenyl- - Drug sensitive
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 5-methoxy- - Drug sensitive
b676297k277 3',4'-deoxypsorospermin 3',4'-chlorohydrin - Drug sensitive
breast chalone, glycoprotein fraction - Drug sensitive
cis-2-hydroxymethyl-4-(5'-bromocytosin-1'-yl)-1,3-dioxolane - Drug sensitive
cis-2-hydroxymethyl-4-(isocytosin-1'-yl)-1,3-dioxolane - Drug sensitive
ethanone, 1-(2-pyrimidinyl)-, (2-benzoxazolyl)hydrazone - Drug sensitive
indole-2,3-dione, 3-(4,4-dimethyl-3-thiosemicarbazone) - Drug sensitive
isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive
mercury, tetrakis(acetato)(2,3,4,5-thiophenetetrayl)tetra- - Drug sensitive
n,n'-bis(oxydiethylene)thiocarbamoylsulfenamide - Drug sensitive
phenol, 4,4'-(5,5'-biisoxazole-3,3'-diyl)bis- - Drug sensitive
phosphonium, (3-bromopropyl)triphenyl- bromide - Drug sensitive
piceatannol, 4,3',5'-trimethyl,1s0 - Drug sensitive
propan-1-one, 2,3-dichloro-1,3-bis(4-methylphenyl)- - Drug sensitive
pyrimidine, 2,4,5-trichloro-6-propyl- - Drug sensitive
tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug sensitive
thiourea, n-(1-ethylpropyl)-n'-[(2-thienyl)thioxomethyl]- - Drug sensitive
(Z)-3-((2-(4-(trifluoromethyl)phenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug sensitive
4'-chloro-3-nitro-o-salicylotoluidide - Drug sensitive
7-propanoyltaxol - Drug sensitive
active compound from cephalodiscus gilchristi - Drug sensitive
Aminopterin Derivative - Drug sensitive
antineoplastic-641296 - Drug sensitive
bengamide g - Drug sensitive
Camptothecin Derivative - Drug sensitive
Copper(II) complex with quin as a ligand - Drug sensitive
his 47-methyl ct - Drug sensitive
hyperforinacetate - Drug sensitive
Indenoisoquinoline derivative - Drug sensitive
insulin-methotrexate conjugate - Drug sensitive
Methotrexate Derivative - Drug sensitive
methyl 3-farnesylthioacetate - Drug sensitive
organosulfur compound - Drug sensitive
Pyrithione Zinc - Drug sensitive
staurosporin analog kt 5944 - Drug sensitive
Tetraplatin - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-330-3p
Formaldehyde 712 Drug interaction    RC00004295
Gemcitabine 60750 Drug interaction    RC00004301
Docosahexaenoic acid 445580 Drug interaction    RC00004302
Etoposide 36462 Drug interaction    RC00004300
Paclitaxel 36314 Drug interaction    RC00004299
5-Fluorouracil 3385 Drug interaction    RC00004297
Doxorubicin 31703 Drug interaction    RC00004298
Tamoxifen 2733526 Drug interaction    RC00004303
Verapamil 2520 Drug interaction    RC00004296

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-330-3p
Interactor2: ACE2

Evidence Support:


Prediction-Evidence miRanda//miRBase//miRWalk//Targetscan
Support Database ViRBase

References:


PMID 32992681 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Table 1 shows a list of novel potential candidate miRNAs against ACE2 gene that were not studied previously.

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