Detail Information

Basic Information:


  VIRBase ID:  

HHID00105208

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2455

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-381-3p:           ACE2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-381-3p ACE2
miRBase
Accession/Entrez ID
MIMAT0000736 59272
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ACEH

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-381-3p
rs1017172007 chr14:101045977    G/C
rs763142743 chr14:101045988    G/A
rs775776541 chr14:101045968    T/A
rs776581200 chr14:101045987    TGTGA/T
rs1242677465 chr14:101045969    A/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ACE2
chrX:15579319-15579320(-) m6A 3'UTR//exon       27773535
chrX:15579343-15579344(-) m6A 3'UTR//exon       27773535
chrX:15579366-15579367(-) m6A 3'UTR//exon       27773535
chrX:15579420-15579421(-) m6A 3'UTR//exon       27773535
chrX:15579431-15579432(-) m6A 3'UTR//intron       27773535
chrX:15579618-15579619(-) m6A 3'UTR//intron       27773535
chrX:15579631-15579632(-) m6A 3'UTR//intron       27773535
chrX:15579696-15579697(-) m6A 3'UTR//exon       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-381-3p
Exosome Serum     18589210
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Blood|Endothelial cells     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     -
ACE2
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID
Function
ncDR hsa-miR-381-3p
8-Aminoadenosine 96851 Drug resistant
Ambrosin 92119 Drug resistant
(3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant
1H-Pyrazolo[3,4-d]pyrimidin-4-amine 75420 Drug resistant
4beta-Hydroxywithanolide E 73621 Drug resistant
Berberine iodide 72350 Drug sensitive
1,3,5-Triacryloylhexahydro-1,3,5-triazine 70397 Drug resistant
1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant
Silver mesylate 6712944 Drug resistant
Pyrazolo[1,5-b]pyridazine deriv. 97 6539439 Drug resistant
Crotonoside 65085 Drug resistant
Jatrophon 6325446 Drug resistant
2-Azaadenine 5480214 Drug resistant
5-Bromo-3-(2-oxo-2-phenylethylidene)-1,3-dihydroindol-2-one 5477132 Drug resistant
2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive
[(1H-Benzimidazole-2-yl)dithio]-9H-purine 54613148 Drug resistant
Biantrazole 54607781 Drug sensitive
Selendale 54601159 Drug sensitive
Stereoisomer of 672120 (MW=262) 5459262 Drug resistant
2-Methylolivacinium acetate 5458752 Drug sensitive
Ovatifolin acetate 5358419 Drug resistant
Xestin A 5352066 Drug resistant
1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant
Vorinostat 5311 Drug resistant
Eupachlorin 5281446 Drug resistant
6-Bromosangivamycin 470030 Drug resistant
Patulin 4696 Drug resistant
Justicidin B 442882 Drug resistant
Suavedol 442245 Drug resistant
Musennin 441933 Drug sensitive
Isobrucein A 441802 Drug sensitive
Antibiotic X-14766A 434840 Drug sensitive
Di-n-octyl-secalonsaure A 430141 Drug sensitive
Elliptinium acetate 42722 Drug sensitive
Carboplatin 426756 Drug sensitive
Mitoxantrone 4212 Drug sensitive
5,8-Quinolinedione, 2-methyl- 388305 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug resistant
1-Azido-2-formyl-benzo[ij]quinolizin-3-one 381901 Drug resistant
Carquniostatin B 380452 Drug resistant
2-Chloro-3-(1-(4-methyl)piperazino)naphthazarin 378627 Drug resistant
2-(2-(Dimethylamino)ethylamino)naphthazarin 376950 Drug resistant
Antineoplastic-D648114 372647 Drug sensitive
2-N-Methyl-6-thiaellipticinum iodide 367888 Drug sensitive
2-Hydroxy discorhabdin D 362391 Drug resistant
1,1-Dioxido-1,5-benzothiazepin-4-yl methyl ether 358940 Drug resistant
Thiosangivamycin 3580213 Drug resistant
Haloprogin 3561 Drug resistant
Imidazole, 1-(4-chlorophenyl)-4-(4-nitrophenyl)- 355940 Drug sensitive
p-Bromophenacyl benzoate 345792 Drug resistant
Maxima isoflavone D 343081 Drug sensitive
Ellipticine 3213 Drug sensitive
9-Methoxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazol-2-ium iodide 3086380 Drug sensitive
2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium acetate 3086131 Drug sensitive
4,6-Diamino-7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile 300567 Drug resistant
[(5Z)-1,7,7-Trimethyl-5-(nitromethylene)-6-oxo-norbornan-2-yl] acetate 3004516 Drug resistant
1-(3-Diethylarsino-3-thio-2-methyl-1-oxopropyl)-L-proline 24203225 Drug resistant
Sarcoviolin 24202820 Drug sensitive
Tartrolon b 23685389 Drug sensitive
Sodium 2-(4-((7-chloro-2-quinoxalinyl)oxy)phenoxy)propionate 23675947 Drug sensitive
Kinetin riboside 20345 Drug resistant
(R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug resistant
Sangivamycin monohydrate 16219974 Drug resistant
Paucin 161538 Drug resistant
[(1R,2R,4R,6E,9R,10S)-2,7-Dimethyl-5,8,14-trioxo-10-prop-1-en-2-yl-15-oxatricyclo[11.2.1.02,4]hexadeca-6,13(16)-dien-9-yl] acetate 15384977 Drug resistant
(1S,3R,5R,9R,10R)-5-Ethenyl-2,3,9,10-tetrahydroxy-5,11,11-trimethyl-16-oxatetracyclo[7.5.2.01,10.02,7]hexadec-6-en-8-one 139587002 Drug resistant
Methyl ester prodigiosene 136040158 Drug resistant
Oxanthrazole 135502299 Drug sensitive
Formycin b 135449281 Drug resistant
Salicylidene salicylhydrazide 135445765 Drug resistant
Allopurinol 135401907 Drug resistant
43-Dioxypectenotoxin 131751434 Drug sensitive
(2R,4R,6S,7S,12S)-6,7,16-Trihydroxy-18-methoxy-12-methyl-3,13-dioxatricyclo[13.4.0.02,4]nonadeca-1(15),9,16,18-tetraene-8,14-dione 131676399 Drug resistant
1,4-Bis((2-aminoethyl)amino)-5,8-dihydroxy-9,10-anthraquinone 125982 Drug sensitive
Litmomycin 12310334 Drug resistant
Pararosaniline hydrochloride 11292 Drug sensitive
2,9-Dimethylellipticinium acetate 10472068 Drug sensitive
15,16-Dihydrocuracin A 101683509 Drug resistant
2-N-Methyl-6-oxaellipticinium acetate 10018975 Drug sensitive
1h-pyrazole-1-ethanol, 4,4'-azoxybis(3,5-dimethyl- - Drug resistant
2-(p-nitrophenoxy)carbonyl-1,2-dihydroellipticine - Drug resistant
2,6-bis(4-morpholinylmethyl)cyclohexanone,dihydrochloride - Drug resistant
2-bromo-5,8-dihydroxy-3-methyl-1,4-naphthoquinone - Drug resistant
4-piperidinone, 1-methyl-2,6-bis[(2-nitrophenyl)methylene]- - Drug resistant
ethyl, methoxy, prodigisine - Drug resistant
furan-2(3h)-one, 5-(4-methylphenyl)-3,3-diphenyl- - Drug resistant
inosine, 6-thio-, 2',3',5'-tripentanoate - Drug resistant
2'-o-(all trans)-retinoyl-erythromicine a - Drug resistant
bafilomycin antibiotic - Drug resistant
bis(2-nitrophenyl)sulfilimine - Drug resistant
geldanamycin analog - Drug resistant
granatomycin a - Drug resistant
o-linoleoyl-2-butoxy-1-desoamine - Drug resistant
o-linoleoyl-6-d-glucose - Drug resistant
xenorhabdin 1 - Drug resistant
1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion - Drug sensitive
1,4-bis(n-cysteinyldiethylamino)-5,8-dihydroxy anthraquinon - Drug sensitive
5.alpha.,25d-spirostan-3.beta.-ol glycoside - Drug sensitive
naphtho[1,2-b]quinolizinium, 9-methyl-, bromide - Drug sensitive
phosphinic acid, bis(1-aziridinyl)-, 2-naphthyl ester - Drug sensitive
2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive
2-(n-d-glysoyl)aminobenzothiazole - Drug sensitive
2-methylellpticinium - Drug sensitive
active compound from cephalodiscus gilchristi - Drug sensitive
Annamycin Liposomal - Drug sensitive
Camptothecin Derivative - Drug sensitive
chrysarobin - Drug sensitive
CI-921: amsacrine derivative - Drug sensitive
protein: pahiv4 - Drug sensitive
Resource Symbol Drug Name PubChem
ID
Function Link  
RNAInter hsa-miR-381-3p
D-Glucose 5793 Drug interaction    RC00004255
Temozolomide 5394 Drug interaction    RC00004254
Vorinostat 5311 Drug interaction    RC00004253
5-Fluorouracil 3385 Drug interaction    RC00004252
Doxorubicin 31703 Drug interaction    RC00004256
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00004257
Bicalutamide 2375 Drug interaction    RC00004251
Docetaxel 148124 Drug interaction    RC00004258
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00004259
Chemotherapy - Drug interaction    RC00008859
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-381-3p

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-381-3p
Interactor2: ACE2

Evidence Support:


Prediction-Evidence miRanda//miRBase//miRWalk//Targetscan
Support Database ViRBase

References:


PMID 32992681 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Table 1 shows a list of novel potential candidate miRNAs against ACE2 gene that were not studied previously.

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