Detail Information

Basic Information:


  VIRBase ID:  

HHID00105199

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2455

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-376c-3p:           ACE2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-376c-3p ACE2
miRBase
Accession/Entrez ID		 MIMAT0000720 59272
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ACEH

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-376c-3p
rs1170994043 chr14:101039748    C/G
rs1281247354 chr14:101039747    C/T
rs1367036250 chr14:101039750    C/T
rs753510956 chr14:101039752    T/A
rs765987749 chr14:101039751    G/A
rs1411564209 chr14:101039738    G/C

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ACE2
chrX:15579319-15579320(-) m6A 3'UTR//exon       27773535
chrX:15579343-15579344(-) m6A 3'UTR//exon       27773535
chrX:15579366-15579367(-) m6A 3'UTR//exon       27773535
chrX:15579420-15579421(-) m6A 3'UTR//exon       27773535
chrX:15579431-15579432(-) m6A 3'UTR//intron       27773535
chrX:15579618-15579619(-) m6A 3'UTR//intron       27773535
chrX:15579631-15579632(-) m6A 3'UTR//intron       27773535
chrX:15579696-15579697(-) m6A 3'UTR//exon       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-376c-3p
Exosome Serum     18589210
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Follicular fluid     23666971
Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
ACE2
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-376c-3p
Succinimide, 3-chloro-N-(p-methoxyphenyl)- 99724 Drug resistant
Piperidine, 2-methyl-6-undecyl- 99090 Drug resistant
(7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione 98137101 Drug sensitive
3,3'-Dihydroxyhexestrol 97762 Drug resistant
8-Aminoadenosine 96851 Drug resistant
Tiotixene 941651 Drug resistant
Ambrosin 92119 Drug resistant
[(1R,2Z,4R,8R,9R,11R,12S)-1,12-Dihydroxy-2-(hydroxymethyl)-11-methyl-7-methylidene-6-oxo-5,14-dioxatricyclo[9.2.1.04,8]tetradec-2-en-9-yl] (Z)-2-methylbut-2-enoate 90475906 Drug resistant
(3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant
3-Piperidino-2-phenylpropiophenone 89341 Drug resistant
2,5-Dimethyl-1,4-benzoquinone 8718 Drug resistant
2-(Benzyloxy)-4-methoxybenzaldehyde 820527 Drug sensitive
1H-Pyrazolo[3,4-d]pyrimidin-4-amine 75420 Drug resistant
4beta-Hydroxywithanolide E 73621 Drug resistant
Berberine iodide 72350 Drug sensitive
Nobiletin 72344 Drug resistant
1,3,5-Triacryloylhexahydro-1,3,5-triazine 70397 Drug resistant
Edatrexate 6917908 Drug resistant
1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant
Silver mesylate 6712944 Drug resistant
Pyrazolo[1,5-b]pyridazine deriv. 97 6539439 Drug resistant
Crotonoside 65085 Drug resistant
Jatrophon 6325446 Drug resistant
Primaquine phosphate 6135 Drug resistant
3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1-methyl-1H-indole 60147979 Drug resistant
Mitomycin 5746 Drug sensitive
Cisplatin 5702198 Drug sensitive
Dezaguanine 55710 Drug resistant
2-Azaadenine 5480214 Drug resistant
[(2Z)-12-Hydroxy-2,11-dimethyl-7-methylidene-6-oxo-5,14-dioxatricyclo[9.2.1.04,8]tetradec-2-en-9-yl] (E)-2-methylbut-2-enoate 5477565 Drug resistant
5-Bromo-3-(2-oxo-2-phenylethylidene)-1,3-dihydroindol-2-one 5477132 Drug resistant
Caracemide 54747 Drug resistant
Z-alpha-Chlorochalcone 5470324 Drug resistant
(Z)-1-Iodo-2-phenyl-1-penten-3-one 5468684 Drug resistant
2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive
[(1H-Benzimidazole-2-yl)dithio]-9H-purine 54613148 Drug resistant
Incomptina B 54612584 Drug resistant
Varacin trifluoroacetate salt 54611558 Drug resistant
9-alpha-Acetoxyparthenolide 54611286 Drug resistant
Biantrazole 54607781 Drug sensitive
Bleomycin 5460769 Drug sensitive
Antineoplastic-651590 54604785 Drug resistant
Selendale 54601159 Drug sensitive
Stereoisomer of 672120 (MW=262) 5459262 Drug resistant
2-Methylolivacinium acetate 5458752 Drug sensitive
Methyl (1R,4R,7E,9S,10R,11S)-9-acetyloxy-10-(2,3-dimethyloxirane-2-carbonyl)oxy-4-methyl-12-methylidene-13-oxo-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-ene-8-carboxylate 5458601 Drug resistant
[2-[2-[(1R,2S)-2-[[6-Amino-2-[1-[(2S)-2,3-diamino-3-oxopropyl]-4-oxoazetidin-2-yl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[(2R,3S,4S)-3-hydroxy-5-[[(2S,3R)-3-hydroxy-1-[2-[4-[4-[2-(2-hydroxypropylamino)ethylcarbamoyl]-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]-1-oxobutan-2-yl]amino]-4-methyl-5-oxopentan-2-yl]amino]-1-(1H-imidazol-5-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl] carbamate 5458321 Drug sensitive
Heliangolide 5384466 Drug resistant
Acetylrolandrolide 5384465 Drug resistant
Melampodin B acetate 5359212 Drug resistant
Ovatifolin acetate 5358419 Drug resistant
Xestin A 5352066 Drug resistant
1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant
Cytochalasin B 5311281 Drug sensitive
Herbimycin 5311102 Drug resistant
Vorinostat 5311 Drug resistant
Streptonigrin 5298 Drug sensitive
Plumericin 5281545 Drug resistant
Pyrethrosin 5281496 Drug resistant
Eupachlorin 5281446 Drug resistant
Erioflorin acetate 5281443 Drug resistant
Lychnopholide 49767028 Drug resistant
Methoxycamptothecin 494089 Drug sensitive
6-Methoxy-7-(2lambda(5)-1,2-triazadienyl)-5,8-quinolinedione 494043 Drug resistant
6-Bromosangivamycin 470030 Drug resistant
Patulin 4696 Drug resistant
L-Cysteine analog 457392 Drug resistant
SMA-838 (HCl salt of NSC 188491) 45028430 Drug resistant
Formycin A 447199 Drug resistant
Justicidin B 442882 Drug resistant
Suavedol 442245 Drug resistant
Fastigilin B 442241 Drug resistant
Elephantin 442205 Drug resistant
Musennin 441933 Drug sensitive
Antibiotic X-14766A 434840 Drug sensitive
Oridonin (thiol adduct OF) 432952 Drug resistant
Bleomycin-BAPP 431594 Drug sensitive
Elliptinium acetate 42722 Drug sensitive
Carboplatin 426756 Drug sensitive
Bleomycin A5, sulfate 422920 Drug sensitive
Mitoxantrone 4212 Drug sensitive
S-(Diisopropylarsino)-3-mercapto-1,2-propanediol 406478 Drug resistant
Nanaomycin A 40586 Drug resistant
Menadione 4055 Drug resistant
Fagaronine chloride 40304 Drug sensitive
Loratadine 3957 Drug resistant
5,8-Quinolinedione, 2-methyl- 388305 Drug resistant
1H-Purine, 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)seleno]- 3879067 Drug resistant
Uracil, 3-methyl-6-(phenylhydrazino)- 385874 Drug resistant
S-N-(Phenethylthiocarbamoyl)-L-glutathione 3843668 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug resistant
1-Azido-2-formyl-benzo[ij]quinolizin-3-one 381901 Drug resistant
Carquniostatin B 380452 Drug resistant
2-Chloro-3-(1-(4-methyl)piperazino)naphthazarin 378627 Drug resistant
2-Bromo-8-methoxy-6-methyl-1,4-naphthoquinone 378440 Drug resistant
2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant
2-(2-(Dimethylamino)ethylamino)naphthazarin 376950 Drug resistant
5,8-Dihydroxy-2-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]naphthalene-1,4-dione 376948 Drug resistant
Antineoplastic-D648114 372647 Drug sensitive
Jasplakinolide epoxide C 372550 Drug resistant
2-N-Methyl-6-thiaellipticinum iodide 367888 Drug sensitive
Benzoxazole, 2-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]- 364608 Drug resistant
4-(1-Benzofuran-2-yl)-7-methoxychromen-2-one 364364 Drug sensitive
4-Nitro-6-(trifluoromethyl)-2,1,3-benzoselenadiazole 362897 Drug resistant
Discorhabdin C-nitrodienone . TFA 362394 Drug resistant
Discorhabdin C . TFA 362393 Drug resistant
2-Hydroxy discorhabdin D 362391 Drug resistant
4H-1-Benzothiopyran-4-one, 2-(methylsulfinyl)- 360259 Drug resistant
1,1-Dioxido-1,5-benzothiazepin-4-yl methyl ether 358940 Drug resistant
Thiosangivamycin 3580213 Drug resistant
Haloprogin 3561 Drug resistant
Imidazole, 1-(4-chlorophenyl)-4-(4-nitrophenyl)- 355940 Drug sensitive
p-Bromophenacyl benzoate 345792 Drug resistant
Rustaiyan A 324967 Drug resistant
Dmask 32465 Drug resistant
Ellipticine 3213 Drug sensitive
Benzofurazan, 4-[(3-methoxyphenyl)thio]-7-nitro-, 3-oxide 313591 Drug resistant
9-Methoxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazol-2-ium iodide 3086380 Drug sensitive
2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium acetate 3086131 Drug sensitive
4,6-Diamino-7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile 300567 Drug resistant
[(5Z)-1,7,7-Trimethyl-5-(nitromethylene)-6-oxo-norbornan-2-yl] acetate 3004516 Drug resistant
2,3-Bis(iodomethyl)-6-methoxyquinoxaline 286257 Drug resistant
1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea 26328 Drug sensitive
2-(7-Aminotriazolo[4,5-d]pyrimidin-3-yl)-5-(hydroxymethyl)oxolane-3,4-diol 251928 Drug resistant
1-(3-Diethylarsino-3-thio-2-methyl-1-oxopropyl)-L-proline 24203225 Drug resistant
Antibiotic U 29135 24196291 Drug resistant
Tartrolon b 23685389 Drug sensitive
Sodium 2-(4-((7-chloro-2-quinoxalinyl)oxy)phenoxy)propionate 23675947 Drug sensitive
N-Butyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 219760 Drug resistant
2-Bromo-4-methyl-1,3,5-trinitrobenzene 219376 Drug resistant
Amsacrine 2179 Drug sensitive
Vitamin E acetate 2117 Drug resistant
Pirarubicin hydrochloride 20846247 Drug sensitive
(1S,3R,7Z,9R,12S,13R,15R)-13-Hydroxy-3,7,12-trimethyl-13-prop-1-en-2-yl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 20835084 Drug resistant
(R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug resistant
P-Dioxane,5-bis[(benzoyloxymercuri)methyl]- 16683647 Drug resistant
Morsodren 16682942 Drug resistant
Sangivamycin monohydrate 16219974 Drug resistant
Jolkinolide B 161954 Drug resistant
Paucin 161538 Drug resistant
Miltirone 160142 Drug resistant
[(1R,2R,4R,6E,9R,10S)-2,7-Dimethyl-5,8,14-trioxo-10-prop-1-en-2-yl-15-oxatricyclo[11.2.1.02,4]hexadeca-6,13(16)-dien-9-yl] acetate 15384977 Drug resistant
Sulfanilanilide, 4'-(9-acridinylamino)- 148802 Drug sensitive
[(1R,5R)-16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl] acetate 146159135 Drug sensitive
1,3-Diamino-5-methylphenazinium chloride 14132 Drug sensitive
(1S,4S,5S,9R,11S,14S,15R,19R)-5,15-Dihydroxy-21,22-dithia-3,13-diazahexacyclo[9.9.2.01,13.03,11.04,9.014,19]docosa-6,16-diene-2,8,12,18-tetrone 139589132 Drug resistant
(1S,3R,5R,9R,10R)-5-Ethenyl-2,3,9,10-tetrahydroxy-5,11,11-trimethyl-16-oxatetracyclo[7.5.2.01,10.02,7]hexadec-6-en-8-one 139587002 Drug resistant
Methyl ester prodigiosene 136040158 Drug resistant
Oxanthrazole 135502299 Drug sensitive
5-[(E)-[Amino(methyl)amino]azo]-1H-imidazole-4-carboxamide 135493930 Drug resistant
Cysteine, S-[(4-aminocarbonyl-1H-imidazol-5-yl)azo]- 135493928 Drug resistant
7H-1,2,3-Triazolo(4,5-d)pyrimidin-7-one, 3,4-dihydro-3-beta-D-ribofuranosyl-(9CI) 135492361 Drug resistant
1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug sensitive
Formycin b 135449281 Drug resistant
Salicylidene salicylhydrazide 135445765 Drug resistant
L-Alanosine 135413540 Drug sensitive
Allopurinol 135401907 Drug resistant
Inosine dialdehyde 135400916 Drug resistant
43-Dioxypectenotoxin 131751434 Drug sensitive
(2R,4R,6S,7S,12S)-6,7,16-Trihydroxy-18-methoxy-12-methyl-3,13-dioxatricyclo[13.4.0.02,4]nonadeca-1(15),9,16,18-tetraene-8,14-dione 131676399 Drug resistant
1,4-Bis((2-aminoethyl)amino)-5,8-dihydroxy-9,10-anthraquinone 125982 Drug sensitive
Litmomycin 12310334 Drug resistant
Pepleo 122804 Drug sensitive
2-Chloro-3-(phenylsulfonyl)propanenitrile 121458 Drug resistant
(1S,3R,7Z,9R,12S,13R,15S)-13-Butan-2-yl-13-hydroxy-3,7,12-trimethyl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 11972510 Drug resistant
6-(Hydroxymethyl)-1,4-anthracenedione 11402158 Drug resistant
Pararosaniline hydrochloride 11292 Drug sensitive
Uridine, 2'-deoxy-2'-methylene- 11075548 Drug sensitive
2,9-Dimethylellipticinium acetate 10472068 Drug sensitive
9-Chloro-2-methylellipticinium acetate, hydrate 10383530 Drug sensitive
Bialamicol 10304 Drug resistant
15,16-Dihydrocuracin A 101683509 Drug resistant
2-N-Methyl-6-oxaellipticinium acetate 10018975 Drug sensitive
1,4-anthracenedione, 5-hydroxy- - Drug resistant
1-[5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]-5-phenyl-1H-tetrazole - Drug resistant
1h-pyrazole-1-ethanol, 4,4'-azoxybis(3,5-dimethyl- - Drug resistant
2-(n,n-diethyl)acetyl-1,2-dihydroellipticine - Drug resistant
2-(p-nitrophenoxy)carbonyl-1,2-dihydroellipticine - Drug resistant
2,2',5,5'-tetrahydroxy-4,4'-dimethylbiphenyl - Drug resistant
2,3,4-tri-o-acetyl-1-s-dimethylarsino-1-thio- a -d-xylose - Drug resistant
2,6-bis(4-morpholinylmethyl)cyclohexanone,dihydrochloride - Drug resistant
2-bromo-5,8-dihydroxy-3-methyl-1,4-naphthoquinone - Drug resistant
4(1h)-quinazolinone, 2-(2-chlorophenyl)-2,3-dihydro- - Drug resistant
4-piperidinone, 1-methyl-2,6-bis[(2-nitrophenyl)methylene]- - Drug resistant
6-(4-hydroxy-2-methylphenyl)-2-(4-(methylsulfonyl)phenyl)-4,5-dihydropyridazin-3(2H)-one - Drug resistant
benzene, 1-methoxy-4-(2-nitroethenyl)-, (e)- - Drug resistant
benzofurazan, 5-nitro-6-(1-piperidinyl)-, 1-oxide - Drug resistant
cyclohexanone, 2,6-bis(piperidinomethyl)- - Drug resistant
cyclopentanone, 2,5-bis[(trimethylamino)methyl]-, iodide - Drug resistant
ethanone, 1-(2-pyrimidinyl)-, (2-benzoxazolyl)hydrazone - Drug resistant
ethyl, methoxy, prodigisine - Drug resistant
furan-2(3h)-one, 5-(4-methylphenyl)-3,3-diphenyl- - Drug resistant
geldanamycin, n,n'-dimethyl - Drug resistant
inosine, 6-thio-, 2',3',5'-tripentanoate - Drug resistant
n,n'-bis(oxydiethylene)thiocarbamoylsulfenamide - Drug resistant
pyrimidine, 2,4,5-trichloro-6-propyl- - Drug resistant
thymine, 1,3-bis[1,2-bis(ethoxycarbonyl)ethenyl]- - Drug resistant
2'-o-(all trans)-retinoyl-erythromicine a - Drug resistant
bafilomycin antibiotic - Drug resistant
bis(2-nitrophenyl)sulfilimine - Drug resistant
geldanamycin analog - Drug resistant
granatomycin a - Drug resistant
hymenialdisine - Drug resistant
kaurane deriv - Drug resistant
methyl (e)-4-methyl-6-(5-bromo-2-hydroxyphenyl)-4-hexenoate - Drug resistant
n-acetyl-4-s-cystaminyl phenol - Drug resistant
o-linoleoyl-2-butoxy-1-desoamine - Drug resistant
o-linoleoyl-6-d-glucose - Drug resistant
recombinant protein 1815 (plate 31 h4) - Drug resistant
somatostatin analog in diacetic form mw=1067.2 - Drug resistant
xenorhabdin 1 - Drug resistant
1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion - Drug sensitive
1,4-bis(n-cysteinyldiethylamino)-5,8-dihydroxy anthraquinon - Drug sensitive
1-naphthalenecarboxamide, n,n'-1,8-(octanediyl)bis- - Drug sensitive
N-(benzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine-5-carboxamide - Drug sensitive
naphtho[1,2-b]quinolizinium, 9-methyl-, bromide - Drug sensitive
phosphinic acid, bis(1-aziridinyl)-, 2-naphthyl ester - Drug sensitive
pyrazino[1,2-a]benzimidazole, 1,3-diphenyl- - Drug sensitive
2-(n-d-glysoyl)aminobenzothiazole - Drug sensitive
2-methylellpticinium - Drug sensitive
3-peg fudr (peg floxuridine) - Drug sensitive
active compound from cephalodiscus gilchristi - Drug sensitive
Annamycin Liposomal - Drug sensitive
Anthrapyrazole derivative - Drug sensitive
Basic Fuchsin - Drug sensitive
Camptothecin Derivative - Drug sensitive
chrysarobin - Drug sensitive
CI-921: amsacrine derivative - Drug sensitive
Cyanomorpholinodoxorubicin - Drug sensitive
from cephalodiscus gilchristi - Drug sensitive
protein: pahiv4 - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-376c-3p
Bisphenol A 6623 Drug interaction    RC00004114
5-Fluorouracil 3385 Drug interaction    RC00004113
Doxorubicin 31703 Drug interaction    RC00004115
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00004112
Verapamil 2520 Drug interaction    RC00004111
Bicalutamide 2375 Drug interaction    RC00004110
5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) - Drug interaction    RC00004116
Medpor - Drug interaction    RC00004117

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-376c-3p
Interactor2: ACE2

Evidence Support:


Prediction-Evidence miRanda//miRBase//miRWalk//Targetscan
Support Database ViRBase

References:


PMID 32992681 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Table 1 shows a list of novel potential candidate miRNAs against ACE2 gene that were not studied previously.

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