Detail Information

Basic Information:


  VIRBase ID:  

HHID00105190

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9612

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-299-3p:           JAK1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-299-3p JAK1
miRBase
Accession/Entrez ID		 MIMAT0000687 3716
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AIIDE//JAK1A//JAK1B//JTK3

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-299-3p
rs571491748 chr14:101023841    T/C
rs761962815 chr14:101023847    A/C
rs772505828 chr14:101023849    C/T
rs773042381 chr14:101023848    C/A
rs773714729 chr14:101023850    G/A
rs773714729 chr14:101023850    G/T
rs768725045 chr14:101023835    G/T
rs769090357 chr14:101023829    ATGTATG/A
rs954825951 chr14:101023839    G/A
rs954825951 chr14:101023839    G/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR JAK1
chr1:65382439(-) A-I      intronic
chr1:65382457(-) A-I      intronic
chr1:65382476(-) A-I      intronic
chr1:65382275(-) A-I      intronic
chr1:65380495(-) A-I      intronic
chr1:65380366(-) A-I      intronic
chr1:65417546(-) A-I      intronic
chr1:65419595(-) A-I      intronic
chr1:65425889(-) A-I      intronic
chr1:65425692(-) A-I      intronic
chr1:65425688(-) A-I      intronic
chr1:65419481(-) A-I      intronic
chr1:65406164(-) A-I      intronic
chr1:65406160(-) A-I      intronic
chr1:65406148(-) A-I      intronic
chr1:65398013(-) A-I      intronic
chr1:65411609(-) A-I      intronic
chr1:65411677(-) A-I      intronic
chr1:65417506(-) A-I      intronic
chr1:65417536(-) A-I      intronic
chr1:65417537(-) A-I      intronic
chr1:65409716(-) A-I      intronic
chr1:65382522(-) A-I      intronic
chr1:65406223(-) A-I      intronic
chr1:65397930(-) A-I      intronic
chr1:65397913(-) A-I      intronic
chr1:65397893(-) A-I      intronic
chr1:65406203(-) A-I      intronic
chr1:65406193(-) A-I      intronic
chr1:65382518(-) A-I      intronic
chr1:65419630(-) A-I      intronic
chr1:65406188(-) A-I      intronic
chr1:65419631(-) A-I      intronic
chr1:65423259(-) A-I      intronic
chr1:65409741(-) A-I      intronic
chr1:65409866(-) A-I      intronic
chr1:65406739(-) A-I      intronic
chr1:65315058(-) A-I      intronic
chr1:65417596(-) A-I      intronic
chr1:65406804(-) A-I      intronic
chr1:65382426(-) A-I      intronic
chr1:65382473(-) A-I      intronic
chr1:65406725(-) A-I      intronic
chr1:65406735(-) A-I      intronic
chr1:65406097(-) A-I      intronic
chr1:65398060(-) A-I      intronic
chr1:65419467(-) A-I      intronic
chr1:65401230(-) A-I      intronic
chr1:65406613(-) A-I      intronic
chr1:65406128(-) A-I      intronic
chr1:65406588(-) A-I      intronic
chr1:65326387(-) A-I      intronic
chr1:65406242(-) A-I      intronic
chr1:65406110(-) A-I      intronic
chr1:65428741(-) A-I      intronic
chr1:65406631(-) A-I      intronic
chr1:65406127(-) A-I      intronic
chr1:65406096(-) A-I      intronic
chr1:65401202(-) A-I      intronic
chr1:65351414(-) A-I      intronic
chr1:65406682(-) A-I      intronic
chr1:65346554(-) A-I      intronic
chr1:65406685(-) A-I      intronic
chr1:65406676(-) A-I      intronic
chr1:65423505(-) A-I      intronic
chr1:65417728(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED JAK1
chr1:65346554(-) A-G intron -    22484847
chr1:65401230(-) A-G intron -    22484847
chr1:65406613(-) A-G intron -    22484847
chr1:65406631(-) A-G intron -    22484847
chr1:65406682(-) A-G intron -    22484847
chr1:65406685(-) A-G intron -    22484847
chr1:65406725(-) A-G intron -    22484847
chr1:65406735(-) A-G intron -    22484847
chr1:65411671(-) G-A intron -    22484847
chr1:65416064(-) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase JAK1
chr1:65299215-65299216(-) m6A 3'UTR       26404942
chr1:65299232-65299233(-) m6A 3'UTR       26404942
chr1:65299253-65299254(-) m6A 3'UTR       26404942
chr1:65299483-65299484(-) m6A 3'UTR       26404942//27773535
chr1:65299496-65299497(-) m6A 3'UTR       26404942//27773535
chr1:65299543-65299544(-) m6A 3'UTR       26404942//27773535
chr1:65299671-65299672(-) m6A 3'UTR       24284625//26404942//27773535
chr1:65299677-65299678(-) m6A 3'UTR       24284625//26404942//27773535
chr1:65299758-65299759(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr1:65299795-65299796(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr1:65300062-65300063(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr1:65300122-65300123(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr1:65300278-65300279(-) m6A CDS       26404942
chr1:65300291-65300292(-) m6A CDS       26404942
chr1:65303629-65303630(-) m6A CDS       26404942
chr1:65305320-65305321(-) m6A CDS//exon       26404942
chr1:65305335-65305336(-) m6A CDS//exon       26404942
chr1:65305431-65305432(-) m6A CDS//exon       26404942
chr1:65306979-65306980(-) m6A CDS       26404942
chr1:65306996-65306997(-) m6A CDS       26404942
chr1:65307156-65307157(-) m6A CDS//exon       26404942//27773535
chr1:65307201-65307202(-) m6A CDS//exon       26404942//27773535
chr1:65309762-65309763(-) m6A CDS//exon       26404942//27773535
chr1:65313239-65313240(-) m6A CDS//exon       26404942
chr1:65313282-65313283(-) m6A CDS//exon       26404942//27773535
chr1:65313312-65313313(-) m6A CDS//exon       26404942//27773535
chr1:65313330-65313331(-) m6A CDS//exon       26404942//27773535
chr1:65321277-65321278(-) m6A CDS       22575960
chr1:65321301-65321302(-) m6A CDS       22575960
chr1:65321349-65321350(-) m6A CDS       22575960
chr1:65330554-65330555(-) m6A CDS       24981863
chr1:65330575-65330576(-) m6A CDS       24981863
chr1:65330598-65330599(-) m6A CDS       24981863//27371828
chr1:65330610-65330611(-) m6A CDS       24981863//27371828
chr1:65330625-65330626(-) m6A CDS       24981863//26404942//27371828
chr1:65332554-65332555(-) m6A CDS       24981863//26404942//27371828
chr1:65332676-65332677(-) m6A CDS       24981863//26404942//27371828//22608085
chr1:65332701-65332702(-) m6A CDS       24981863//26404942//27371828//22608085
chr1:65332712-65332713(-) m6A CDS       24981863//26404942//27371828//22608085
chr1:65332775-65332776(-) m6A CDS       26404942//22608085
chr1:65332840-65332841(-) m6A CDS       26404942
chr1:65332848-65332849(-) m6A CDS       26404942
chr1:65332868-65332869(-) m6A CDS       26404942
chr1:65334999-65335000(-) m6A CDS       26404942
chr1:65335010-65335011(-) m6A CDS       26404942
chr1:65335094-65335095(-) m6A CDS       26404942
chr1:65335108-65335109(-) m6A CDS       26404942
chr1:65335116-65335117(-) m6A CDS       26404942
chr1:65339180-65339181(-) m6A CDS       27773535
chr1:65341688-65341689(-) m6A exon//intron       27773535
chr1:65349033-65349034(-) m6A CDS       26404942
chr1:65349081-65349082(-) m6A CDS       26404942
chr1:65349091-65349092(-) m6A CDS       26404942
chr1:65349138-65349139(-) m6A CDS       26404942
chr1:65432181-65432182(-) m6A 5'UTR       24981863//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-299-3p
Exosome Serum     18589210
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Endothelial cells     -
Microvesicle Blood|Fibroblasts|Mesenchymal stem cells     -
JAK1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-299-3p
10-Hydroxycamptothecin 97226 Drug interaction    RC00003927
Gemcitabine 60750 Drug interaction    RC00003926
Vorinostat 5311 Drug interaction    RC00003924
Doxorubicin 31703 Drug interaction    RC00003925
Verapamil 2520 Drug interaction    RC00003923
Gefitinib 123631 Drug interaction    RC00003928
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003929
Chemotherapy - Drug interaction    RC00008854
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-299-3p
Doxorubicin 31703       26617714

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-299-3p
Interactor2: JAK1

Evidence Support:


Strong-Evidence Luciferase reporter assay//qPCR//Western blot
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 33675361 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line PH5CH8 cells Interactor2 expression Downregulation
Description In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.

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