Detail Information

Basic Information:


  VIRBase ID:  

HHID00105187

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9630

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-200a-3p:           BRD4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-200a-3p BRD4
miRBase
Accession/Entrez ID		 MIMAT0000682 23476
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CAP//HUNK1//HUNKI//MCAP

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-200a-3p
rs1011167625 chr1:1167924    T/C
rs1219797994 chr1:1167926    T/A
rs376377337 chr1:1167932    C/A
rs376377337 chr1:1167932    C/T
rs746361624 chr1:1167930    A/G
rs1301032989 chr1:1167923    G/T
rs1377467792 chr1:1167920    A/G
rs749623182 chr1:1167920    ACTGT/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BRD4
chr19:15385865(-) A-I      intronic
chr19:15389924(-) A-I      intronic
chr19:15389889(-) A-I      intronic
chr19:15389884(-) A-I      intronic
chr19:15389870(-) A-I      intronic
chr19:15389868(-) A-I      intronic
chr19:15389856(-) A-I      intronic
chr19:15389853(-) A-I      intronic
chr19:15389845(-) A-I      intronic
chr19:15389829(-) A-I      intronic
chr19:15389788(-) A-I      intronic
chr19:15389749(-) A-I      intronic
chr19:15389731(-) A-I      intronic
chr19:15389715(-) A-I      intronic
chr19:15388870(-) A-I      intronic
chr19:15388860(-) A-I      intronic
chr19:15388753(-) A-I      intronic
chr19:15388515(-) A-I      intronic
chr19:15388489(-) A-I      intronic
chr19:15388421(-) A-I      intronic
chr19:15388367(-) A-I      intronic
chr19:15386758(-) A-I      intronic
chr19:15386755(-) A-I      intronic
chr19:15386748(-) A-I      intronic
chr19:15386729(-) A-I      intronic
chr19:15386620(-) A-I      intronic
chr19:15386600(-) A-I      intronic
chr19:15386561(-) A-I      intronic
chr19:15385902(-) A-I      intronic
chr19:15385897(-) A-I      intronic
chr19:15385883(-) A-I      intronic
chr19:15385852(-) A-I      intronic
chr19:15385849(-) A-I      intronic
chr19:15385848(-) A-I      intronic
chr19:15385759(-) A-I      intronic
chr19:15385755(-) A-I      intronic
chr19:15385746(-) A-I      intronic
chr19:15385742(-) A-I      intronic
chr19:15373490(-) A-I      intronic
chr19:15373458(-) A-I      intronic
chr19:15373451(-) A-I      intronic
chr19:15385737(-) A-I      intronic
chr19:15385830(-) A-I      intronic
chr19:15369613(-) A-I      intronic
chr19:15369205(-) A-I      intronic
chr19:15369227(-) A-I      intronic
chr19:15369232(-) A-I      intronic
chr19:15369233(-) A-I      intronic
chr19:15369259(-) A-I      intronic
chr19:15369426(-) A-I      intronic
chr19:15369429(-) A-I      intronic
chr19:15369504(-) A-I      intronic
chr19:15369532(-) A-I      intronic
chr19:15369572(-) A-I      intronic
chr19:15372501(-) A-I      intronic
chr19:15372626(-) A-I      intronic
chr19:15373333(-) A-I      intronic
chr19:15389340(-) A-I      intronic
chr19:15386652(-) A-I      intronic
chr19:15389791(-) A-I      intronic
chr19:15386792(-) A-I      intronic
chr19:15388514(-) A-I      intronic
chr19:15389813(-) A-I      intronic
chr19:15389901(-) A-I      intronic
chr19:15389846(-) A-I      intronic
chr19:15389680(-) A-I      intronic
chr19:15386655(-) A-I      intronic
chr19:15386761(-) A-I      intronic
chr19:15369439(-) A-I      intronic
chr19:15389859(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BRD4
chr19:15347667-15347668(-) m6A 3'UTR       27773535
chr19:15347739-15347740(-) m6A 3'UTR       27773535
chr19:15347781-15347782(-) m6A 3'UTR       27773535
chr19:15347898-15347899(-) m6A 3'UTR       27773535//27371828
chr19:15347910-15347911(-) m6A 3'UTR       27773535//27371828
chr19:15347933-15347934(-) m6A 3'UTR       27773535//27371828
chr19:15348104-15348105(-) m6A 3'UTR       24981863//27773535
chr19:15348132-15348133(-) m6A 3'UTR       24981863//27773535
chr19:15348173-15348174(-) m6A 3'UTR       24981863//27773535
chr19:15348178-15348179(-) m6A 3'UTR       24981863//27773535
chr19:15348222-15348223(-) m6A 3'UTR       27773535
chr19:15348269-15348270(-) m6A 3'UTR       27773535
chr19:15348656-15348657(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr19:15348845-15348846(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr19:15348918-15348919(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr19:15348995-15348996(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr19:15349147-15349148(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr19:15349608-15349609(-) m6A CDS       24284625//24209618//27371828//27773536
chr19:15350058-15350059(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//27773536
chr19:15350222-15350223(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//27773536
chr19:15350235-15350236(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//27773536
chr19:15350245-15350246(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//27773536
chr19:15350723-15350724(-) m6A CDS       24284625//24209618//24981863//27773535
chr19:15353724-15353725(-) m6A CDS       24284625//24209618//24981863//28052920//27773535
chr19:15354190-15354191(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828
chr19:15357396-15357397(-) m6A exon//intron       27773535
chr19:15357421-15357422(-) m6A exon//intron       27773535
chr19:15357956-15357957(-) m6A 3'UTR//intron       27773535
chr19:15358177-15358178(-) m6A 3'UTR//intron       24284625//24981863//22608085
chr19:15358190-15358191(-) m6A 3'UTR//intron       24284625//24981863//22608085
chr19:15358224-15358225(-) m6A 3'UTR//intron       24284625//24981863//22608085
chr19:15358241-15358242(-) m6A 3'UTR//intron       24981863//22608085
chr19:15358300-15358301(-) m6A 3'UTR//intron       24284625
chr19:15358439-15358440(-) m6A 3'UTR//intron       24284625//24981863
chr19:15358491-15358492(-) m6A 3'UTR//intron       24284625//24981863
chr19:15359615-15359616(-) Cm 3'UTR//intron       -
chr19:15366182-15366183(-) m6A CDS       27773535//22575960
chr19:15366292-15366293(-) m6A CDS       24981863//27773535//22575960
chr19:15366340-15366341(-) m6A CDS       24981863//27773535//22575960
chr19:15366924-15366925(-) m6A CDS       24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr19:15367000-15367001(-) m6A CDS//exon       25456834//24981863//27773535//27371828//27773536//22608085
chr19:15367024-15367025(-) m6A CDS//exon       25456834//24981863//27773535//27371828//27773536//22608085
chr19:15367841-15367842(-) m6A CDS//exon       27773535//22575960
chr19:15374353-15374354(-) m6A CDS//exon       27773535
chr19:15374962-15374963(-) m6A exon//intron       27773535
chr19:15375186-15375187(-) m6A exon//intron       24284625//27773535
chr19:15375230-15375231(-) m6A CDS       24284625//27773535
chr19:15375439-15375440(-) m6A CDS       24284625//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960
chr19:15375483-15375484(-) m6A CDS       24284625//25456834//24981863//28052920//26404942//27773535//27371828//27773536
chr19:15375548-15375549(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//27371828
chr19:15376307-15376308(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960
chr19:15376321-15376322(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960
chr19:15376385-15376386(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828
chr19:15376391-15376392(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828
chr19:15376420-15376421(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828
chr19:15376443-15376444(-) m6A 3'UTR//CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828
chr19:15376451-15376452(-) m6A 3'UTR//CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828
chr19:15378229-15378230(-) m6A 3'UTR//CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828
chr19:15378280-15378281(-) m6A 3'UTR//CDS       24981863//26404942//27773535//27371828
chr19:15379813-15379814(-) m6A CDS//exon       27773535
chr19:15383632-15383633(-) m6A CDS//exon       24284625//26404942//27773535
chr19:15383682-15383683(-) m6A CDS//exon       24284625//24981863//28052920//26404942//27773535
chr19:15383693-15383694(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828
chr19:15383732-15383733(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828
chr19:15383762-15383763(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828
chr19:15383843-15383844(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828
chr19:15383850-15383851(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828
chr19:15386491-15386492(-) m6A 5'UTR//intron       24209618//24981863//27773535//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-200a-3p
Exosome Human milk     28688106
Exosome Pulmonary epithelial cell line (BEAS-2B)     31520698
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Ascites fluid|Pleural effusion     21601258
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Colon tissue|Seminal fluid|Tongue tissue     -
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Nucleus Colon adenocarcinoma cells     20864815
BRD4
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-200a-3p
Gardenin B 96539 Drug sensitive
2-(Benzyloxy)-4-methoxybenzaldehyde 820527 Drug resistant
1H-Pyrazolo[3,4-d]pyrimidin-4-amine 75420 Drug sensitive
10,11-Methylenedioxy-20S-camptothecin 72403 Drug resistant
Coptisine chloride 72321 Drug resistant
4H-Furo(3,2-g)(1)benzopyran-4,7,9-trione 68083 Drug resistant
4'-Chloro-3-hydroxy-2'-methyl-2-naphthanilide 66718 Drug resistant
Fludarabine 657237 Drug resistant
Mevastatin 64715 Drug resistant
Mastoparan 6324633 Drug resistant
Irinotecan 60838 Drug resistant
Gemcitabine 60750 Drug resistant
Topotecan 60700 Drug resistant
3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1-methyl-1H-indole 60147979 Drug sensitive
Cisplatin 5702198 Drug resistant
Thiopyrimidine-CH3 5473238 Drug sensitive
(Z)-3-Iodo-1,2-diphenyl-2-propen-1-one 5468683 Drug sensitive
2-trans-n-Buten-1-yl-estradiol 5468334 Drug resistant
(8R,9S,13S,14S,17S)-13-Methyl-2-[(E)-prop-1-enyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol 5468270 Drug resistant
Selendale 54601159 Drug resistant
Aspiculamycin hcl 54600418 Drug resistant
Simvastatin 54454 Drug resistant
2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug resistant
Xestin A 5352066 Drug sensitive
3-[(4-Methoxyphenyl)thio]-2H-isoindole-1-carbaldehyde 53361730 Drug sensitive
Lovastatin 53232 Drug resistant
Centaureidin 5315773 Drug resistant
8-Hydroxymanzamine A 5270765 Drug sensitive
Methoxycamptothecin 494089 Drug resistant
SMA-838 (HCl salt of NSC 188491) 45028430 Drug sensitive
Ditercalinium dimethanesulfonate dimethanesulfonate 435243 Drug sensitive
Carboplatin 426756 Drug resistant
Diaziquone 42616 Drug resistant
cis-Diamminemalonatoplatinum(II) 422683 Drug resistant
Mitoxantrone 4212 Drug resistant
Menadione 4055 Drug resistant
Fagaronine chloride 40304 Drug resistant
1,2 Benzo-8-(1-hydroxy-2-methylamino propane)-3-phenoxazone 400530 Drug resistant
3,3-Bis[4-(4-aminoiphenoxy)phenyl]diamantane 399961 Drug sensitive
1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug sensitive
1-(4'-Phthalimidopropyl-carbonyl)-5-fluorouracil 388985 Drug sensitive
Benzo[1,2-b:5,4-b']dithiophene-4,8-dione, 2-acetyl- 388028 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug sensitive
2-Ethenyl estradiol 381026 Drug resistant
Antineoplastic-655905 375758 Drug resistant
1,2-Dimethyl-phenothiazone 369387 Drug resistant
Diselenide, bis(4-methylphenyl) 365239 Drug resistant
Miltefosine 3599 Drug sensitive
4-N,N-Bis-2'-cyanoethylaminobenzylidene-4-fluoro aniline 359414 Drug sensitive
2-Benzoylaminobenzamide, N-thiazol-2-yl- 355710 Drug sensitive
5-Fluorocytosine arabinoside 352938 Drug resistant
Nordracorubin 341882 Drug sensitive
Phomazarin 318385 Drug resistant
Tamoxifen 2733526 Drug sensitive
Chlorambucil 2708 Drug resistant
Chelerythrine 2703 Drug sensitive
1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea 26328 Drug resistant
Estramustine 259331 Drug resistant
Fluorene, 9-bromo-2,4,7-trichloro- 248608 Drug resistant
Camptothecin 24360 Drug resistant
Scillirosidin, glycoside 222160 Drug resistant
5-Nitroso-8-hydroxyquinoline 19103 Drug resistant
{4-[5-(4-Fluoro-phenyl)-3-(1-methyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-phenyl-amine 17892742 Drug sensitive
8-Chloroadenosine 147569 Drug sensitive
4-Oxo-4-[[(13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]oxy]butanoic acid 146160078 Drug sensitive
Edelfosine 1392 Drug sensitive
Gold;(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium 138402869 Drug resistant
Oxanthrazole 135502299 Drug resistant
8-Azahypoxanthine 135410720 Drug resistant
8-Azaguanine 135403646 Drug resistant
Triphenyltin chloride 12540 Drug sensitive
Dabequine 124332 Drug sensitive
2,2'-Bioxirane 11254 Drug resistant
Clomesone 100651 Drug resistant
N,N-Bis(2-chloroethyl)-p-toluidine 100400 Drug resistant
1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion - Drug resistant
1h-1,2,4-triazole, 3-(4-diazo-4h-imidazol-5-yl)- - Drug resistant
benzo[1,2-b:4,5-b']dithiophene-4,8-diol, diacetate - Drug resistant
benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug resistant
benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug resistant
bersaldegenin 1,3,5-orthoacetate - Drug resistant
mercury, tetrakis(acetato)(2,3,4,5-thiophenetetrayl)tetra- - Drug resistant
naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug resistant
naphtho[2,3-d]oxazole-4,9-dione, 2-(1,1-dimethylethyl)- - Drug resistant
phosphinic acid, bis(1-aziridinyl)-, 2-naphthyl ester - Drug resistant
piceatannol, 4,3',5'-trimethyl,1s0 - Drug resistant
tris(1,3-diphenylpropane-1,3-dionata)gallium(iii) - Drug resistant
2-(n-d-glysoyl)aminobenzothiazole - Drug resistant
3-farnesylthiopropionamide - Drug resistant
Camptothecin Derivative - Drug resistant
Chlorozotocin - Drug resistant
CI-921: amsacrine derivative - Drug resistant
crotoxin cd - Drug resistant
potassium arsenite - Drug resistant
potassium[trichloro(isopropylamine)platinum] - Drug resistant
protein toxin a 23 - mw approx. 6700 - Drug resistant
protein toxin c 10 - mw approx. 6700 - Drug resistant
trimethyl(phenylthio)stannane - Drug resistant
(E)-3-(3,5-dimethoxyphenyl)-1-(4-(quinazolin-4-ylamino)phenyl)prop-2-en-1-one - Drug sensitive
uridine, 5-fluoro-, 2',3',5'-triacetate - Drug sensitive
Artemisinin Dimer - Drug sensitive
pyrazoline derivative - Drug sensitive
secafascaplysin - Drug sensitive
streptorubrin - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-200a-3p
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide 9826528 Drug interaction    RC00003889
10-Hydroxycamptothecin 97226 Drug interaction    RC00003881
Curcumin 969516 Drug interaction    RC00003886
Hydrogen peroxide 784 Drug interaction    RC00003868
Gemcitabine 60750 Drug interaction    RC00003880
Vincristine 5978 Drug interaction    RC00003876
Estradiol 5757 Drug interaction    RC00003875
RETINOIC ACID, 13-cis- 5538 Drug interaction    RC00003885
Eloxatine 5310940 Drug interaction    RC00003888
Goserelinacetate 47725 Drug interaction    RC00003879
Paclitaxel 36314 Drug interaction    RC00003878
5-Fluorouracil 3385 Drug interaction    RC00003874
Doxorubicin 31703 Drug interaction    RC00003877
Cyclophosphamide 2907 Drug interaction    RC00003873
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003872
Tamoxifen 2733526 Drug interaction    RC00003887
Verapamil 2520 Drug interaction    RC00003871
Bicalutamide 2375 Drug interaction    RC00003870
Benzo[a]pyrene 2336 Drug interaction    RC00003869
Erlotinib 176870 Drug interaction    RC00003884
Docetaxel 148124 Drug interaction    RC00003883
Gefitinib 123631 Drug interaction    RC00003882
Epoxomicin 11226684 Drug interaction    RC00003890
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003891
Chemotherapy - Drug interaction    RC00008851
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-200a-3p
Cisplatin 5702198       25356050
5-Fluorouracil 3385       28496200

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-200a-3p
Interactor2: BRD4

Evidence Support:


Strong-Evidence Luciferase reporter assay//RT-PCR//Western blot
Prediction-Evidence miRanda//Targetscan
Support Database ViRBase

References:


PMID 33675361 Target region 3'UTR
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line LNCaP cells//C4-2B cells Interactor2 expression Upregulation
Description In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.

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