Detail Information

Basic Information:


  VIRBase ID:  

HHID00105180

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9612

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-206:           GAK:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-206 GAK
miRBase
Accession/Entrez ID		 MIMAT0000462 2580
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DNAJ26//DNAJC26

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-206
rs1377769915 chr6:52144418    T/C
rs1444614734 chr6:52144412    G/C
rs529520481 chr6:52144422    G/T
rs761212265 chr6:52144417    G/T
rs764617948 chr6:52144414    A/C
rs767863130 chr6:52144401    T/A
rs767863130 chr6:52144401    T/C
rs775920179 chr6:52144406    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR GAK
chr4:849631(-) A-I      intronic
chr4:849879(-) A-I      intronic
chr4:849898(-) A-I      intronic
chr4:849921(-) A-I      intronic
chr4:850582(-) A-I      intronic
chr4:850658(-) A-I      intronic
chr4:884943(-) A-I      intronic
chr4:913768(-) A-I      intronic
chr4:913855(-) A-I      intronic
chr4:914329(-) A-I      intronic
chr4:914384(-) A-I      intronic
chr4:914460(-) A-I      intronic
chr4:914470(-) A-I      intronic
chr4:847789(-) A-I      intronic
chr4:916120(-) A-I      intronic
chr4:916135(-) A-I      intronic
chr4:916240(-) A-I      intronic
chr4:916241(-) A-I      intronic
chr4:917456(-) A-I      intronic
chr4:918844(-) A-I      intronic
chr4:922190(-) A-I      intronic
chr4:922257(-) A-I      intronic
chr4:914621(-) A-I      intronic
chr4:847790(-) A-I      intronic
chr4:848589(-) A-I      intronic
chr4:848590(-) A-I      intronic
chr4:848640(-) A-I      intronic
chr4:849599(-) A-I      intronic
chr4:849621(-) A-I      intronic
chr4:847697(-) A-I      intronic
chr4:849667(-) A-I      intronic
chr4:849705(-) A-I      intronic
chr4:916217(-) A-I      intronic
chr4:848711(-) A-I      intronic
chr4:850542(-) A-I      intronic
chr4:845124(-) A-I      intronic
chr4:848769(-) A-I      intronic
chr4:922118(-) A-I      intronic
chr4:850636(-) A-I      intronic
chr4:845053(-) A-I      intronic
chr4:849737(-) A-I      intronic
chr4:846525(-) A-I      intronic
chr4:902566(-) A-I      intronic
chr4:913704(-) A-I      intronic
chr4:902398(-) A-I      intronic
chr4:849494(-) A-I      intronic
chr4:891571(-) A-I      intronic
chr4:847762(-) A-I      intronic
chr4:849680(-) A-I      intronic
chr4:846897(-) A-I      intronic
chr4:847701(-) A-I      intronic
chr4:849539(-) A-I      intronic
chr4:913915(-) A-I      intronic
chr4:850588(-) A-I      intronic
chr4:846339(-) A-I      intronic
chr4:902246(-) A-I      intronic
chr4:914969(-) A-I      intronic
chr4:847675(-) A-I      intronic
chr4:849852(-) A-I      intronic
chr4:849491(-) A-I      intronic
chr4:848830(-) A-I      intronic
chr4:849860(-) A-I      intronic
chr4:910283(-) A-I      intronic
chr4:913865(-) A-I      intronic
chr4:879818(-) A-I      intronic
chr4:902779(-) A-I      intronic
chr4:848733(-) A-I      intronic
chr4:902329(-) A-I      intronic
chr4:850642(-) A-I      intronic
chr4:849840(-) A-I      intronic
chr4:849797(-) A-I      intronic
chr4:879660(-) A-I      intronic
chr4:848568(-) A-I      intronic
chr4:914987(-) A-I      intronic
chr4:915154(-) A-I      intronic
chr4:915155(-) A-I      intronic
chr4:849551(-) A-I      intronic
chr4:922127(-) A-I      intronic
chr4:847765(-) A-I      intronic
chr4:913984(-) A-I      intronic
chr4:850563(-) A-I      intronic
chr4:847768(-) A-I      intronic
chr4:844996(-) A-I      intronic
chr4:913948(-) A-I      intronic
chr4:902259(-) A-I      intronic
chr4:849560(-) A-I      intronic
chr4:902353(-) A-I      intronic
chr4:915090(-) A-I      intronic
chr4:902739(-) A-I      intronic
chr4:850571(-) A-I      intronic
chr4:848721(-) A-I      intronic
chr4:913974(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED GAK
chr4:850563(-) A-I intron -    21960545   //22327324
chr4:850642(-) A-I intron -    21960545
chr4:845139(-) G-A intron -    22484847
chr4:846366(-) A-G intron -    22484847
chr4:849491(-) A-G intron -    22484847
chr4:849494(-) A-G intron -    22484847
chr4:849551(-) A-G intron -    22484847
chr4:849560(-) A-G intron -    22484847
chr4:849680(-) A-G intron -    22484847
chr4:850642(-) A-G intron -    22484847
chr4:857916(-) C-T intron -    22484847
chr4:889847(-) G-A intron -    22484847
chr4:896403(-) G-T intron -    22484847
chr4:896404(-) G-T intron -    22484847
chr4:902329(-) A-G intron -    22484847
chr4:902353(-) A-G intron -    22484847
chr4:902490(-) A-G intron -    22484847
chr4:902739(-) A-G intron -    22484847
chr4:902756(-) A-G intron -    22484847
chr4:902779(-) A-G intron -    22484847
chr4:902801(-) A-G intron -    22484847
chr4:902930(-) A-G intron -    22484847
chr4:913907(-) A-G intron -    22484847
chr4:913915(-) A-G intron -    22484847
chr4:915168(-) A-G intron -    22484847
chr4:916217(-) A-G intron -    22484847
chr4:922127(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase GAK
chr4:843247-843248(-) m6A 3'UTR//exon       24284625
chr4:843383-843384(-) m6A 3'UTR//exon       24284625//27773536
chr4:843404-843405(-) m6A 3'UTR//exon       24284625//27773536
chr4:843485-843486(-) m6A 3'UTR//CDS//exon       24284625
chr4:843824-843825(-) m6A 3'UTR//CDS//exon       24284625//25456834//27773535//27371828//27773536//22608085
chr4:843848-843849(-) m6A 3'UTR//CDS//exon       24284625//25456834//27773535//27371828//27773536//22608085
chr4:844187-844188(-) m6A exon//intron       -
chr4:844274-844275(-) m6A exon//intron       -
chr4:844530-844531(-) m6A exon//intron       27371828
chr4:844566-844567(-) m6A exon//intron       27371828
chr4:844572-844573(-) m6A exon//intron       27371828
chr4:844739-844740(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828//27773536
chr4:844745-844746(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828//27773536
chr4:844757-844758(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828//27773536
chr4:844782-844783(-) m6A CDS//exon       24284625//24981863//27773535//27371828//27773536
chr4:844899-844900(-) m6A exon//intron       24284625//27773535//27773536
chr4:844911-844912(-) m6A exon//intron       24284625//27773535//27773536
chr4:845590-845591(-) m6A CDS//exon       27773536
chr4:845600-845601(-) Y CDS//exon       26075521
chr4:845684-845685(-) m6A CDS//exon       27773536
chr4:845799-845800(-) m6A exon//intron       27773536
chr4:845819-845820(-) m6A exon//intron       27773536
chr4:846933-846934(-) m6A exon//intron       24284625
chr4:847089-847090(-) m6A exon//intron       24284625
chr4:847147-847148(-) m6A exon//intron       24284625
chr4:847170-847171(-) m6A exon//intron       24284625
chr4:847196-847197(-) m6A exon//intron       24284625//27371828
chr4:847224-847225(-) m6A exon//intron       24284625//27371828
chr4:847387-847388(-) m6A exon//intron       24284625//27371828//27773536
chr4:847463-847464(-) m6A exon//intron       24284625//27371828
chr4:847520-847521(-) m6A exon//intron       24284625//27371828
chr4:847565-847566(-) m6A exon//intron       24284625//27371828
chr4:847575-847576(-) m6A exon//intron       24284625//27371828
chr4:853434-853435(-) m6A CDS//exon//intron       27773536
chr4:853440-853441(-) m6A CDS//exon//intron       27773536
chr4:853453-853454(-) m6A CDS//exon//intron       27773536
chr4:858948-858949(-) m6A CDS//exon       24284625//27773536
chr4:858954-858955(-) m6A CDS//exon       24284625//27773536
chr4:858980-858981(-) m6A CDS//exon       24284625//27371828//27773536
chr4:860231-860232(-) m6A CDS//exon       24284625//24981863//28052920//27773535//27371828//27773536
chr4:860817-860818(-) m6A CDS//exon//intron       24284625//27371828//27773536
chr4:861016-861017(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22608085
chr4:861036-861037(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22608085
chr4:861089-861090(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr4:861150-861151(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr4:861202-861203(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr4:862334-862335(-) m6A CDS//exon//intron       24284625//24209618//25456834//27773535//27371828//27773536//22575960//22608085
chr4:862391-862392(-) m6A CDS//exon//intron       27773535//27371828//27773536//22608085
chr4:862399-862400(-) m6A CDS//exon//intron       27773535//27371828//27773536//22608085
chr4:864515-864516(-) m6A CDS//exon//intron       27371828
chr4:864554-864555(-) m6A CDS//exon//intron       -
chr4:864575-864576(-) m6A CDS//exon//intron       -
chr4:864608-864609(-) m6A CDS//exon//intron       -
chr4:864635-864636(-) m6A CDS//exon//intron       27773535
chr4:870992-870993(-) m6A CDS//intron       -
chr4:876485-876486(-) Tm CDS//intron       -
chr4:880309-880310(-) m6A exon//intron       27773535
chr4:880410-880411(-) m6A exon//intron       24981863
chr4:880415-880416(-) m6A exon//intron       24981863
chr4:880463-880464(-) m6A exon//intron       25456834//24981863
chr4:880480-880481(-) m6A exon//intron       25456834//24981863
chr4:887186-887187(-) m6A CDS//exon//intron       27773536
chr4:887258-887259(-) m6A 3'UTR//CDS//exon//intron       24284625
chr4:888432-888433(-) m6A exon//intron       27773535//27371828
chr4:890290-890291(-) m6A 3'UTR//CDS//intron       27773535
chr4:890306-890307(-) m6A 3'UTR//CDS//intron       27773535
chr4:907480-907481(-) m6A exon//intron       -
chr4:925873-925874(-) m6A CDS//exon       24284625//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-206
Exosome Primary ovarian tumor cells|Serum     18589210
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
GAK
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-206
Cholesterol 5997 Drug interaction    RC00003325
Vorinostat 5311 Drug interaction    RC00003324
Eloxatine 5310940 Drug interaction    RC00003331
Paroxetine 43815 Drug interaction    RC00003329
Paclitaxel 36314 Drug interaction    RC00003328
5-Fluorouracil 3385 Drug interaction    RC00003323
Doxorubicin 31703 Drug interaction    RC00003327
Bromocriptine 31101 Drug interaction    RC00003326
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003322
Verapamil 2520 Drug interaction    RC00003321
Sorafenib 216239 Drug interaction    RC00003330
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-206
Irinotecan       60838
Topotecan       60700
Paclitaxel       36314
Sorafenib       216239
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-206
Interactor2: GAK

Evidence Support:


Strong-Evidence Luciferase reporter assay//RT-qPCR//Western blot
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 33675361 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line 786-O cells//HK-2 cells//OS-RC-2 cells Interactor2 expression Downregulation
Description In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.

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