Basic Information:

  VIRBase ID:  

HHID00105176

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9526

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          MARK2:  NM_001163297     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	MARK2
miRBase Accession/Entrez ID	MIMAT0000458	2011
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	EMK-1//EMK1//PAR-1//Par-1b//Par1b

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MARK2	chr11:63628207(+) A-I      intronic chr11:63617134(+) A-I      intronic chr11:63617145(+) A-I      intronic chr11:63628164(+) A-I      intronic chr11:63628171(+) A-I      intronic chr11:63628179(+) A-I      intronic chr11:63628285(+) A-I      intronic chr11:63628255(+) A-I      intronic chr11:63627278(+) A-I      intronic chr11:63627243(+) A-I      intronic chr11:63627230(+) A-I      intronic chr11:63627199(+) A-I      intronic chr11:63627127(+) A-I      intronic chr11:63626099(+) A-I      intronic chr11:63625992(+) A-I      intronic chr11:63625943(+) A-I      intronic chr11:63625868(+) A-I      intronic chr11:63624670(+) A-I      intronic chr11:63627293(+) A-I      intronic chr11:63622849(+) A-I      intronic chr11:63622833(+) A-I      intronic chr11:63622832(+) A-I      intronic chr11:63622713(+) A-I      intronic chr11:63622123(+) A-I      intronic chr11:63622097(+) A-I      intronic chr11:63621941(+) A-I      intronic chr11:63621924(+) A-I      intronic chr11:63621722(+) A-I      intronic chr11:63621510(+) A-I      intronic chr11:63621462(+) A-I      intronic chr11:63621394(+) A-I      intronic chr11:63620721(+) A-I      intronic chr11:63620711(+) A-I      intronic chr11:63620706(+) A-I      intronic chr11:63618370(+) A-I      intronic chr11:63617180(+) A-I      intronic chr11:63611944(+) A-I      intronic chr11:63617098(+) A-I      intronic chr11:63617096(+) A-I      intronic chr11:63617075(+) A-I      intronic chr11:63617073(+) A-I      intronic chr11:63617047(+) A-I      intronic chr11:63616969(+) A-I      intronic chr11:63615921(+) A-I      intronic chr11:63615911(+) A-I      intronic chr11:63614550(+) A-I      intronic chr11:63614491(+) A-I      intronic chr11:63614488(+) A-I      intronic chr11:63613274(+) A-I      intronic chr11:63613234(+) A-I      intronic chr11:63609872(+) A-I      intronic chr11:63614462(+) A-I      intronic chr11:63609869(+) A-I      intronic chr11:63609788(+) A-I      intronic chr11:63651169(+) A-I      intronic chr11:63632400(+) A-I      intronic chr11:63644709(+) A-I      intronic chr11:63621625(+) A-I      intronic chr11:63646606(+) A-I      intronic chr11:63637793(+) A-I      intronic chr11:63653490(+) A-I      intronic chr11:63626049(+) A-I      intronic chr11:63611865(+) A-I      intronic chr11:63632140(+) A-I      intronic chr11:63627979(+) A-I      intronic chr11:63620615(+) A-I      intronic chr11:63616528(+) A-I      intronic chr11:63625408(+) A-I      intronic chr11:63628658(+) A-I      intronic chr11:63621789(+) A-I      intronic chr11:63614515(+) A-I      intronic chr11:63613469(+) A-I      intronic chr11:63622845(+) A-I      intronic chr11:63652888(+) A-I      intronic chr11:63629659(+) A-I      intronic chr11:63617069(+) A-I      intronic chr11:63624815(+) A-I      intronic chr11:63653738(+) A-I      intronic chr11:63646615(+) A-I      intronic chr11:63633703(+) A-I      intronic chr11:63616525(+) A-I      intronic chr11:63621811(+) A-I      intronic chr11:63625955(+) A-I      intronic chr11:63642735(+) A-I      intronic chr11:63644766(+) A-I      intronic chr11:63652432(+) A-I      intronic chr11:63615996(+) A-I      intronic chr11:63621607(+) A-I      intronic chr11:63622753(+) A-I      intronic chr11:63626814(+) A-I      intronic chr11:63629577(+) A-I      intronic chr11:63609818(+) A-I      intronic chr11:63622959(+) A-I      intronic chr11:63617035(+) A-I      intronic chr11:63653977(+) A-I      intronic chr11:63653961(+) A-I      intronic chr11:63653928(+) A-I      intronic chr11:63653818(+) A-I      intronic chr11:63653783(+) A-I      intronic chr11:63653781(+) A-I      intronic chr11:63646598(+) A-I      intronic chr11:63625334(+) A-I      intronic chr11:63653638(+) A-I      intronic chr11:63653629(+) A-I      intronic chr11:63652764(+) A-I      intronic chr11:63652625(+) A-I      intronic chr11:63652519(+) A-I      intronic chr11:63652517(+) A-I      intronic chr11:63651342(+) A-I      intronic chr11:63651287(+) A-I      intronic chr11:63651183(+) A-I      intronic chr11:63651156(+) A-I      intronic chr11:63648683(+) A-I      intronic chr11:63648504(+) A-I      intronic chr11:63646691(+) A-I      intronic chr11:63646599(+) A-I      intronic chr11:63633659(+) A-I      intronic chr11:63646552(+) A-I      intronic chr11:63646527(+) A-I      intronic chr11:63645971(+) A-I      intronic chr11:63645091(+) A-I      intronic chr11:63645086(+) A-I      intronic chr11:63645050(+) A-I      intronic chr11:63629275(+) A-I      intronic chr11:63635666(+) A-I      intronic chr11:63633756(+) A-I      intronic chr11:63620791(+) A-I      intronic chr11:63633752(+) A-I      intronic chr11:63633713(+) A-I      intronic chr11:63632221(+) A-I      intronic chr11:63632049(+) A-I      intronic chr11:63629496(+) A-I      intronic chr11:63629564(+) A-I      intronic chr11:63629551(+) A-I      intronic chr11:63629525(+) A-I      intronic chr11:63629500(+) A-I      intronic chr11:63628745(+) A-I      intronic chr11:63626922(+) A-I      intronic chr11:63628636(+) A-I      intronic chr11:63621445(+) A-I      intronic chr11:63611177(+) A-I      intronic chr11:63622854(+) A-I      intronic chr11:63611196(+) A-I      intronic chr11:63653052(+) A-I      intronic chr11:63628183(+) A-I      intronic chr11:63645121(+) A-I      intronic chr11:63622029(+) A-I      intronic chr11:63618814(+) A-I      intronic chr11:63627364(+) A-I      intronic chr11:63648617(+) A-I      intronic chr11:63647169(+) A-I      intronic chr11:63615937(+) A-I      intronic chr11:63621813(+) A-I      intronic chr11:63632501(+) A-I      intronic chr11:63609789(+) A-I      intronic chr11:63617046(+) A-I      intronic chr11:63652846(+) A-I      intronic chr11:63621909(+) A-I      intronic chr11:63629475(+) A-I      intronic chr11:63620797(+) A-I      intronic chr11:63628176(+) A-I      intronic chr11:63634599(+) A-I      intronic chr11:63625432(+) A-I      intronic chr11:63618824(+) A-I      intronic chr11:63644763(+) A-I      intronic chr11:63648622(+) A-I      intronic chr11:63646626(+) A-I      intronic chr11:63632131(+) A-I      intronic chr11:63628665(+) A-I      intronic chr11:63622875(+) A-I      intronic chr11:63614510(+) A-I      intronic chr11:63652742(+) A-I      intronic chr11:63622196(+) A-I      intronic chr11:63632503(+) A-I      intronic chr11:63613384(+) A-I      intronic chr11:63629444(+) A-I      intronic chr11:63653997(+) A-I      intronic chr11:63645122(+) A-I      intronic chr11:63628069(+) A-I      intronic chr11:63633662(+) A-I      intronic chr11:63628223(+) A-I      intronic chr11:63615932(+) A-I      intronic chr11:63618326(+) A-I      intronic chr11:63627056(+) A-I      intronic chr11:63624778(+) A-I      intronic chr11:63625326(+) A-I      intronic chr11:63628720(+) A-I      intronic chr11:63613460(+) A-I      intronic chr11:63628797(+) A-I      intronic chr11:63628704(+) A-I      intronic chr11:63627065(+) A-I      intronic chr11:63652510(+) A-I      intronic chr11:63633599(+) A-I      intronic chr11:63628010(+) A-I      intronic chr11:63617026(+) A-I      intronic chr11:63622092(+) A-I      intronic chr11:63629457(+) A-I      intronic chr11:63629617(+) A-I      intronic chr11:63628245(+) A-I      intronic chr11:63617059(+) A-I      intronic chr11:63646700(+) A-I      intronic chr11:63631289(+) A-I      intronic chr11:63621425(+) A-I      intronic chr11:63626910(+) A-I      intronic chr11:63628173(+) A-I      intronic chr11:63617185(+) A-I      intronic chr11:63622938(+) A-I      intronic chr11:63616307(+) A-I      intronic chr11:63622186(+) A-I      intronic chr11:63614028(+) A-I      intronic chr11:63617104(+) A-I      intronic chr11:63611726(+) A-I      intronic chr11:63631076(+) A-I      intronic chr11:63646102(+) A-I      intronic chr11:63627363(+) A-I      intronic chr11:63644928(+) A-I      intronic chr11:63611762(+) A-I      intronic chr11:63632227(+) A-I      intronic chr11:63621579(+) A-I      intronic chr11:63653643(+) A-I      intronic chr11:63629294(+) A-I      intronic chr11:63611852(+) A-I      intronic chr11:63649314(+) A-I      intronic chr11:63620710(+) A-I      intronic chr11:63609878(+) A-I      intronic chr11:63625919(+) A-I      intronic chr11:63634628(+) A-I      intronic chr11:63622790(+) A-I      intronic chr11:63621395(+) A-I      intronic chr11:63628788(+) A-I      intronic chr11:63622035(+) A-I      intronic chr11:63633774(+) A-I      intronic chr11:63624423(+) A-I      intronic chr11:63653481(+) A-I      intronic chr11:63627173(+) A-I      intronic chr11:63625768(+) A-I      intronic chr11:63646048(+) A-I      intronic chr11:63613734(+) A-I      intronic chr11:63635682(+) A-I      intronic chr11:63633749(+) A-I      intronic chr11:63613275(+) A-I      intronic chr11:63629580(+) A-I      intronic chr11:63621376(+) A-I      intronic chr11:63652753(+) A-I      intronic chr11:63652528(+) A-I      intronic chr11:63611277(+) A-I      intronic chr11:63628864(+) A-I      intronic chr11:63653728(+) A-I      intronic chr11:63622187(+) A-I      intronic chr11:63628661(+) A-I      intronic chr11:63621801(+) A-I      intronic chr11:63611714(+) A-I      intronic chr11:63615994(+) A-I      intronic chr11:63631506(+) A-I      intronic chr11:63621703(+) A-I      intronic chr11:63649331(+) A-I      intronic chr11:63627754(+) A-I      intronic chr11:63621484(+) A-I      intronic chr11:63651174(+) A-I      intronic chr11:63622846(+) A-I      intronic chr11:63613967(+) A-I      intronic chr11:63653131(+) A-I      intronic chr11:63625576(+) A-I      intronic chr11:63653793(+) A-I      intronic chr11:63611307(+) A-I      intronic chr11:63614084(+) A-I      intronic chr11:63625965(+) A-I      intronic chr11:63624784(+) A-I      intronic chr11:63652943(+) A-I      intronic chr11:63616508(+) A-I      intronic chr11:63652890(+) A-I      intronic chr11:63652523(+) A-I      intronic chr11:63627367(+) A-I      intronic chr11:63622073(+) A-I      intronic chr11:63625756(+) A-I      intronic chr11:63616500(+) A-I      intronic chr11:63628209(+) A-I      intronic chr11:63653660(+) A-I      intronic chr11:63625926(+) A-I      intronic chr11:63629571(+) A-I      intronic chr11:63617072(+) A-I      intronic chr11:63653293(+) A-I      intronic chr11:63617078(+) A-I      intronic chr11:63633704(+) A-I      intronic chr11:63609828(+) A-I      intronic chr11:63645067(+) A-I      intronic chr11:63613807(+) A-I      intronic chr11:63628730(+) A-I      intronic chr11:63652936(+) A-I      intronic chr11:63609952(+) A-I      intronic chr11:63613733(+) A-I      intronic chr11:63611769(+) A-I      intronic chr11:63611280(+) A-I      intronic chr11:63617102(+) A-I      intronic chr11:63629594(+) A-I      intronic chr11:63632138(+) A-I      intronic chr11:63635743(+) A-I      intronic chr11:63624675(+) A-I      intronic chr11:63613727(+) A-I      intronic chr11:63644511(+) A-I      intronic chr11:63616597(+) A-I      intronic chr11:63622882(+) A-I      intronic chr11:63653870(+) A-I      intronic chr11:63611195(+) A-I      intronic chr11:63624768(+) A-I      intronic chr11:63620616(+) A-I      intronic chr11:63654118(+) A-I      intronic chr11:63621619(+) A-I      intronic chr11:63617208(+) A-I      intronic chr11:63616996(+) A-I      intronic chr11:63651083(+) A-I      intronic chr11:63613295(+) A-I      intronic chr11:63622213(+) A-I      intronic chr11:63609753(+) A-I      intronic chr11:63631825(+) A-I      intronic chr11:63654057(+) A-I      intronic chr11:63654070(+) A-I      intronic chr11:63617170(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MARK2	chr11:63617102(+) A-G intron -    22484847 chr11:63646598(+) A-G intron -    22484847 chr11:63660402(+) C-T intron -    22484847 chr11:63660412(+) C-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MARK2	chr11:63606993-63606994(+) m6A 5'UTR//CDS       24284625//22575960 chr11:63607021-63607022(+) m6A 5'UTR//CDS       24284625//22575960 chr11:63617461-63617462(+) m6A 5'UTR//intron       24284625 chr11:63668298-63668299(+) m6A CDS       24981863 chr11:63668336-63668337(+) m6A CDS       24981863 chr11:63668347-63668348(+) m6A CDS       24981863 chr11:63668470-63668471(+) m6A CDS       24284625//24981863 chr11:63669695-63669696(+) m6A CDS       24284625 chr11:63670116-63670117(+) m6A CDS       24284625//24981863 chr11:63670156-63670157(+) m6A CDS       24284625//24981863 chr11:63670233-63670234(+) m6A CDS//exon       24284625//24981863 chr11:63670626-63670627(+) m6A CDS//exon//intron       24284625 chr11:63670637-63670638(+) m6A exon//intron       24284625 chr11:63675743-63675744(+) m6A CDS//intron       24284625 chr11:63675757-63675758(+) m6A CDS//intron       24284625 chr11:63676442-63676443(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr11:63676503-63676504(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:63676572-63676573(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:63676603-63676604(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:63676671-63676672(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:63676788-63676789(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960 chr11:63677103-63677104(+) m6A 3'UTR       24209618//25456834//24981863 chr11:63677112-63677113(+) m6A 3'UTR       24209618//25456834//24981863 chr11:63677155-63677156(+) m6A 3'UTR       24209618//25456834//24981863 chr11:63677250-63677251(+) m6A 3'UTR       24209618//25456834//24981863 chr11:63677898-63677899(+) m6A 3'UTR       24209618 chr11:63678273-63678274(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	MARK2	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: MARK2

Evidence Support:

Strong-Evidence	Luciferase reporter assay//qRT-PCR//Western blot
Support Database	ViRBase

References:

PMID	33675361	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	MCF-7 cells//293T cells//MDA-MB-231 cells	Interactor2 expression	Downregulation
Description	In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.