Detail Information

Basic Information:


  VIRBase ID:  

HHID00105174

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9630

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-154-5p:           CUL2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-154-5p CUL2
miRBase
Accession/Entrez ID		 MIMAT0000452 8453
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-154-5p
rs1339080441 chr14:101059785    C/T
rs375213313 chr14:101059778    C/G
rs375213313 chr14:101059778    C/T
rs41286570 chr14:101059790    G/A
rs41286570 chr14:101059790    G/C
rs575922548 chr14:101059779    G/A
rs770620613 chr14:101059789    C/T
rs772665345 chr14:101059769    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CUL2
chr10:35362701(-) A-I      intronic
chr10:35362700(-) A-I      intronic
chr10:35369603(-) A-I      intronic
chr10:35362708(-) A-I      intronic
chr10:35332453(-) A-I      intronic
chr10:35301087(-) A-I      intronic
chr10:35362697(-) A-I      intronic
chr10:35301079(-) A-I      intronic
chr10:35319561(-) A-I      intronic
chr10:35367466(-) A-I      intronic
chr10:35369545(-) A-I      intronic
chr10:35350809(-) A-I      intronic
chr10:35362704(-) A-I      intronic
chr10:35350792(-) A-I      intronic
chr10:35301078(-) A-I      intronic
chr10:35350800(-) A-I      intronic
chr10:35326688(-) A-I      intronic
chr10:35369885(-) A-I      intronic
chr10:35375482(-) A-I      intronic
chr10:35375479(-) A-I      intronic
chr10:35325881(-) A-I      intronic
chr10:35371138(-) A-I      intronic
chr10:35300169(-) A-I      intronic
chr10:35370979(-) A-I      intronic
chr10:35370965(-) A-I      intronic
chr10:35305675(-) A-I      intronic
chr10:35370964(-) A-I      intronic
chr10:35357935(-) A-I      intronic
chr10:35325884(-) A-I      intronic
chr10:35370738(-) A-I      intronic
chr10:35313058(-) A-I      intronic
chr10:35370683(-) A-I      intronic
chr10:35376115(-) A-I      intronic
chr10:35370662(-) A-I      intronic
chr10:35369907(-) A-I      intronic
chr10:35369656(-) A-I      intronic
chr10:35306558(-) A-I      intronic
chr10:35369633(-) A-I      intronic
chr10:35375376(-) A-I      intronic
chr10:35370699(-) A-I      intronic
chr10:35302151(-) A-I      intronic
chr10:35367352(-) A-I      intronic
chr10:35369611(-) A-I      intronic
chr10:35365858(-) A-I      intronic
chr10:35355266(-) A-I      intronic
chr10:35365733(-) A-I      intronic
chr10:35357863(-) A-I      intronic
chr10:35356461(-) A-I      intronic
chr10:35356066(-) A-I      intronic
chr10:35356029(-) A-I      intronic
chr10:35355500(-) A-I      intronic
chr10:35354710(-) A-I      intronic
chr10:35319567(-) A-I      intronic
chr10:35354704(-) A-I      intronic
chr10:35354687(-) A-I      intronic
chr10:35354425(-) A-I      intronic
chr10:35319721(-) A-I      intronic
chr10:35357864(-) A-I      intronic
chr10:35319738(-) A-I      intronic
chr10:35354359(-) A-I      intronic
chr10:35353717(-) A-I      intronic
chr10:35350808(-) A-I      intronic
chr10:35366194(-) A-I      intronic
chr10:35330702(-) A-I      intronic
chr10:35375040(-) A-I      intronic
chr10:35325822(-) A-I      intronic
chr10:35325864(-) A-I      intronic
chr10:35306456(-) A-I      intronic
chr10:35373067(-) A-I      intronic
chr10:35375341(-) A-I      intronic
chr10:35300446(-) A-I      intronic
chr10:35358222(-) A-I      intronic
chr10:35375380(-) A-I      intronic
chr10:35375180(-) A-I      intronic
chr10:35304102(-) A-I      intronic
chr10:35300483(-) A-I      intronic
chr10:35300470(-) A-I      intronic
chr10:35353679(-) A-I      intronic
chr10:35353750(-) A-I      intronic
chr10:35325851(-) A-I      intronic
chr10:35357934(-) A-I      intronic
chr10:35305688(-) A-I      intronic
chr10:35300540(-) A-I      intronic
chr10:35369583(-) A-I      intronic
chr10:35325895(-) A-I      intronic
chr10:35330478(-) A-I      intronic
chr10:35353721(-) A-I      intronic
chr10:35375599(-) A-I      intronic
chr10:35300103(-) A-I      intronic
chr10:35362661(-) A-I      intronic
chr10:35356028(-) A-I      intronic
chr10:35375190(-) A-I      intronic
chr10:35376101(-) A-I      intronic
chr10:35358455(-) A-I      intronic
chr10:35301082(-) A-I      intronic
chr10:35377975(-) A-I      intronic
chr10:35357895(-) A-I      intronic
chr10:35376189(-) A-I      intronic
chr10:35369655(-) A-I      intronic
chr10:35374122(-) A-I      intronic
chr10:35307103(-) A-I      intronic
chr10:35311829(-) A-I      intronic
chr10:35327039(-) A-I      intronic
chr10:35330573(-) A-I      intronic
chr10:35319562(-) A-I      intronic
chr10:35377981(-) A-I      intronic
chr10:35325826(-) A-I      intronic
chr10:35369524(-) A-I      intronic
chr10:35356482(-) A-I      intronic
chr10:35375174(-) A-I      intronic
chr10:35369664(-) A-I      intronic
chr10:35357925(-) A-I      intronic
chr10:35362725(-) A-I      intronic
chr10:35366501(-) A-I      intronic
chr10:35366580(-) A-I      intronic
chr10:35356513(-) A-I      intronic
chr10:35330729(-) A-I      intronic
chr10:35358070(-) A-I      intronic
chr10:35358387(-) A-I      intronic
chr10:35369602(-) A-I      intronic
chr10:35309925(-) A-I      intronic
chr10:35371151(-) A-I      intronic
chr10:35376144(-) A-I      intronic
chr10:35365761(-) A-I      intronic
chr10:35362785(-) A-I      intronic
chr10:35300097(-) A-I      intronic
chr10:35375318(-) A-I      intronic
chr10:35365868(-) A-I      intronic
chr10:35375207(-) A-I      intronic
chr10:35301119(-) A-I      intronic
chr10:35355499(-) A-I      intronic
chr10:35358067(-) A-I      intronic
chr10:35330737(-) A-I      intronic
chr10:35362605(-) A-I      intronic
chr10:35367515(-) A-I      intronic
chr10:35355268(-) A-I      intronic
chr10:35301074(-) A-I      intronic
chr10:35367388(-) A-I      intronic
chr10:35369950(-) A-I      intronic
chr10:35301120(-) A-I      intronic
chr10:35375602(-) A-I      intronic
chr10:35375326(-) A-I      intronic
chr10:35319739(-) A-I      intronic
chr10:35300422(-) A-I      intronic
chr10:35355350(-) A-I      intronic
chr10:35363517(-) A-I      intronic
chr10:35375168(-) A-I      intronic
chr10:35357298(-) A-I      intronic
chr10:35369931(-) A-I      intronic
chr10:35356026(-) A-I      intronic
chr10:35371007(-) A-I      intronic
chr10:35353743(-) A-I      intronic
chr10:35300411(-) A-I      intronic
chr10:35353697(-) A-I      intronic
chr10:35376118(-) A-I      intronic
chr10:35369939(-) A-I      intronic
chr10:35375181(-) A-I      intronic
chr10:35367361(-) A-I      intronic
chr10:35358463(-) A-I      intronic
chr10:35300538(-) A-I      intronic
chr10:35374996(-) A-I      intronic
chr10:35347697(-) A-I      intronic
chr10:35300087(-) A-I      intronic
chr10:35297903(-) A-I      3'UTR
chr10:35370655(-) A-I      intronic
chr10:35366525(-) A-I      intronic
chr10:35344629(-) A-I      intronic
chr10:35358393(-) A-I      intronic
chr10:35300018(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CUL2
chr10:35297958(-) T-C exon 3'UTR    22484847
chr10:35353697(-) A-G intron -    22484847
chr10:35355350(-) A-G intron -    22484847
chr10:35375376(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CUL2
chr10:35297524-35297525(-) m6A 3'UTR       27773535
chr10:35297560-35297561(-) m6A 3'UTR       27773535
chr10:35297626-35297627(-) m6A 3'UTR       27773535
chr10:35298830-35298831(-) m6A 3'UTR       27773535//22608085
chr10:35298888-35298889(-) m6A 3'UTR       27773535//22608085
chr10:35298903-35298904(-) m6A 3'UTR       27773535//22608085
chr10:35299028-35299029(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr10:35299162-35299163(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr10:35299296-35299297(-) m6A 3'UTR//CDS       27773535
chr10:35300857-35300858(-) m6A 3'UTR//CDS//intron       24981863//27773535
chr10:35300879-35300880(-) m6A 3'UTR//CDS//intron       24981863//27773535
chr10:35302636-35302637(-) m6A 3'UTR//CDS       24981863//27773535
chr10:35302670-35302671(-) m6A 3'UTR//CDS       24981863//27773535
chr10:35302687-35302688(-) m6A 3'UTR//CDS       24981863//27773535
chr10:35343382-35343383(-) m6A 3'UTR//CDS       24981863
chr10:35343419-35343420(-) m6A 3'UTR//CDS       24981863
chr10:35379521-35379522(-) m6A 5'UTR       25456834//24981863
chr10:35379527-35379528(-) m1A 5'UTR       26863196

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-154-5p
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
CUL2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)|K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-154-5p
8-Aminoadenosine 96851 Drug resistant
1H-Pyrazolo[3,4-d]pyrimidin-4-amine 75420 Drug resistant
Berberine iodide 72350 Drug sensitive
1,3,5-Triacryloylhexahydro-1,3,5-triazine 70397 Drug resistant
1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant
Silver mesylate 6712944 Drug resistant
Pyrazolo[1,5-b]pyridazine deriv. 97 6539439 Drug resistant
Crotonoside 65085 Drug resistant
3-[[4-[[2-(Methoxycarbonylamino)-3H-benzimidazol-5-yl]oxy]phenyl]carbamoylamino]benzoic acid;hydrochloride 57399799 Drug sensitive
2-Azaadenine 5480214 Drug resistant
Antibiotic 1907-VIII 5477807 Drug sensitive
2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive
[(1H-Benzimidazole-2-yl)dithio]-9H-purine 54613148 Drug resistant
Varacin trifluoroacetate salt 54611558 Drug resistant
2-Methylolivacinium acetate 5458752 Drug sensitive
Xestin A 5352066 Drug resistant
Berberal 5351462 Drug sensitive
5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive
Vorinostat 5311 Drug resistant
6-Bromosangivamycin 470030 Drug resistant
Justicidin B 442882 Drug resistant
Suavedol 442245 Drug resistant
Musennin 441933 Drug sensitive
Isobrucein A 441802 Drug sensitive
Antibiotic X-14766A 434840 Drug sensitive
Elliptinium acetate 42722 Drug sensitive
2-N-Methyl-6-thiaellipticinum iodide 367888 Drug sensitive
2-Hydroxy discorhabdin D 362391 Drug resistant
1,1-Dioxido-1,5-benzothiazepin-4-yl methyl ether 358940 Drug resistant
Haloprogin 3561 Drug resistant
Maxima isoflavone D 343081 Drug sensitive
Ellipticine 3213 Drug sensitive
8-Trichloromethyldihydroberberine 320713 Drug sensitive
2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium acetate 3086131 Drug sensitive
4,6-Diamino-7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile 300567 Drug resistant
Sarcoviolin 24202820 Drug sensitive
Sodium 2-(4-((7-chloro-2-quinoxalinyl)oxy)phenoxy)propionate 23675947 Drug sensitive
Kinetin riboside 20345 Drug resistant
(R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug resistant
Paucin 161538 Drug resistant
[(1R,2R,4R,6E,9R,10S)-2,7-Dimethyl-5,8,14-trioxo-10-prop-1-en-2-yl-15-oxatricyclo[11.2.1.02,4]hexadeca-6,13(16)-dien-9-yl] acetate 15384977 Drug resistant
(1S,3R,5R,9R,10R)-5-Ethenyl-2,3,9,10-tetrahydroxy-5,11,11-trimethyl-16-oxatetracyclo[7.5.2.01,10.02,7]hexadec-6-en-8-one 139587002 Drug resistant
Methyl ester prodigiosene 136040158 Drug resistant
Acid Alizarine Red B 135565636 Drug sensitive
Oxanthrazole 135502299 Drug sensitive
Formycin b 135449281 Drug resistant
Salicylidene salicylhydrazide 135445765 Drug resistant
43-Dioxypectenotoxin 131751434 Drug sensitive
(2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug sensitive
Berberine chloride 12456 Drug sensitive
Litmomycin 12310334 Drug resistant
3-Bromo-4-(3,3-dimethyl-but-1-ynyl)-2(5H)-furanone 11413833 Drug resistant
2-N-Methyl-6-oxaellipticinium acetate 10018975 Drug sensitive
1,6:2,3-dianhydro-4-o-benzyl-.beta.-d-mannopyranose - Drug resistant
ethyl, methoxy, prodigisine - Drug resistant
inosine, 6-thio-, 2',3',5'-tripentanoate - Drug resistant
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
granatomycin a - Drug resistant
o-linoleoyl-2-butoxy-1-desoamine - Drug resistant
naphtho[1,2-b]quinolizinium, 9-methyl-, bromide - Drug sensitive
phosphinic acid, bis(1-aziridinyl)-, 2-naphthyl ester - Drug sensitive
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive
2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive
2-methylellpticinium - Drug sensitive
protein: pahiv4 - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-154-5p
Gemcitabine 60750 Drug interaction    RC00003199
Doxorubicin 31703 Drug interaction    RC00003198
Verapamil 2520 Drug interaction    RC00003197
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003200

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-154-5p
Interactor2: CUL2

Evidence Support:


Strong-Evidence Dual luciferase reporter assay//RT-qPCR//Western blot
Prediction-Evidence miRBase//Targetscan
Support Database ViRBase

References:


PMID 33675361 Target region 3'UTR
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line 293T cells//SiHa cells Interactor2 expression Upregulation
Description In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.

Starting a new search, please wait ...