Basic Information:

  VIRBase ID:  

HHID00105170

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9512

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-146a-5p:  MIMAT0000449          TLR3:  NM_003265     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-146a-5p	TLR3
miRBase Accession/Entrez ID	MIMAT0000449	7098
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD283//IIAE2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-146a-5p	rs1395832667 chr5:160485390    G/A rs1400440934 chr5:160485389    G/T rs1423068484 chr5:160485386    C/A rs772652917 chr5:160485372    T/A rs780488034 chr5:160485387    A/G rs780488034 chr5:160485387    A/T rs997376292 chr5:160485388    T/A rs997376292 chr5:160485388    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TLR3	chr4:187001863(+) A-I      intronic chr4:187003336(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TLR3	chr4:186990367-186990368(+) m6A 5'UTR       24981863 chr4:186997778-186997779(+) m6A CDS       24981863 chr4:187003525-187003526(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003579-187003580(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003649-187003650(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003659-187003660(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003978-187003979(+) m6A CDS//exon       24981863 chr4:187004022-187004023(+) m6A CDS//exon       24284625//24981863 chr4:187004037-187004038(+) m6A CDS//exon       24284625//24981863 chr4:187004177-187004178(+) m6A CDS//exon       24209618//24981863 chr4:187004260-187004261(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004635-187004636(+) m6A CDS//exon       24981863 chr4:187004686-187004687(+) m6A CDS//exon       24981863 chr4:187004746-187004747(+) m6A CDS//exon       24981863 chr4:187004829-187004830(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004906-187004907(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004932-187004933(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004948-187004949(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187005082-187005083(+) m6A CDS//exon       24284625//24981863 chr4:187005090-187005091(+) m6A CDS//exon       24284625//24981863 chr4:187005095-187005096(+) m6A CDS//exon       24284625//24981863 chr4:187005155-187005156(+) m6A CDS//exon       24284625//24981863 chr4:187005181-187005182(+) m6A CDS//exon       24284625//25456834//24981863 chr4:187005214-187005215(+) m6A CDS//exon       25456834//24981863 chr4:187005236-187005237(+) m6A CDS//exon       25456834//24981863 chr4:187005310-187005311(+) m6A CDS//exon       24981863 chr4:187005888-187005889(+) m6A CDS//exon       24981863 chr4:187005893-187005894(+) m6A CDS//exon       24981863 chr4:187005944-187005945(+) m6A CDS//exon       24981863 chr4:187006013-187006014(+) m6A CDS//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-146a-5p	Endoplasmic reticulum membrane Cortical tissue     32451872 Exosome Plasma     19289371 Exosome Primary dendritic cells     21505438 Exosome Renal cancer cells     21670082 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Blood|B lymphoblastoid cells|Endothelial cells|Epithelial cells|Lymphoma tissue|Mast cells|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Hepatoma cells     23771658 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Osteosarcoma cell line (143B)     27396686 Mitochondrion Osteosarcoma cell line (143B)     27563705 Mitochondrion Human umbilical vein endothelial cells     30348904
	TLR3	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-146a-5p	Bis-A-tda 97676 Drug resistant Tiotixene 941651 Drug sensitive Acridine Yellow G 8672 Drug resistant Clothixamide maleate 76972759 Drug sensitive 9-Methoxyellipticine 72512 Drug resistant Anaxirone 71218 Drug resistant Thiocoraline 70698112 Drug resistant Phosphotrienin 6913994 Drug sensitive Tacacoside A2 6712615 Drug sensitive Rufigallol 65737 Drug resistant Lanatoside C 656630 Drug resistant Pyrazolo[1,5-b]pyridazine deriv. 40 6539382 Drug resistant Crotonoside 65085 Drug resistant (2R,3R,4S,5R)-2-(6-Benzylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol 6477178 Drug resistant 1,3,8-Trihydroxy-6-methoxyanthracene-9,10-dione 636723 Drug sensitive Chalcone analog 6296717 Drug resistant Daunorubicin hydrochloride 62770 Drug resistant Gallium nitrate 61635 Drug sensitive Primaquine phosphate 6135 Drug sensitive N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-(1H-pyrrol-2-yl)thieno[3,2-d]pyrimidin-4-amine;hydrochloride 57401575 Drug resistant Teclothiazide potassium 56841138 Drug resistant (3beta)-3-((4-O-beta-D Glucopyranosyl-beta-D-xylopyranosyl)oxy)-14-hydroxy-19-oxocarda-4,20(22)-dienolide 56840951 Drug resistant Tetrocarcin A, sodium salt 54724658 Drug sensitive 21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt 54612678 Drug resistant Biantrazole 54607781 Drug resistant Herveline O 5459269 Drug sensitive Betuletol 5459196 Drug resistant Hemiasterlin 5352092 Drug resistant MX2 hydrochloride 5351347 Drug resistant 1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug sensitive Proscillaridin 5284613 Drug resistant 10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug resistant 9-beta-D-Xylofuranosyladenine 447916 Drug resistant Formycin A 447199 Drug resistant Neriifolin 441867 Drug resistant Calactin 441849 Drug resistant Digitoxigenin 4369270 Drug resistant Ditercalinium dimethanesulfonate dimethanesulfonate 435243 Drug resistant Benzofurazan, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide 42640 Drug resistant Mitoxantrone 4212 Drug resistant S-(Diisopropylarsino)-3-mercapto-1,2-propanediol 406478 Drug sensitive Menadione 4055 Drug sensitive 2-S-Dimethylarsino-2-thiobenzoic acid 404813 Drug sensitive Purpureagitosid 401298 Drug resistant 1,2 Benzo-8-(1-hydroxy-2-methylamino propane)-3-phenoxazone 400530 Drug sensitive Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug resistant Trapoxin B 395803 Drug sensitive 7,8-Dehydrocalotropin 390666 Drug resistant 3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one 387973 Drug resistant 1H-Purine, 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)seleno]- 3879067 Drug sensitive 3-(4-Fluorophenyl)-3-(4-acetoxy-2-methylphenyl)phthalide 383342 Drug resistant Carquniostatin B 380452 Drug sensitive 7-Chloro-6-(2-fluoroethylamino)quinoline-5,8-dione 379079 Drug sensitive 2-(3-Chloropropyloxy)naphthazarin 378771 Drug sensitive 2-(2-Chloroethoxy)naphthazarin 378770 Drug sensitive N-(8-Hydroxy-6-methyl-1,4-dioxo-1,4-dihydro-2-naphthalenyl)acetamide 377214 Drug sensitive 5,8-Dihydroxy-2-(4-(2-pyridinyl)-1-piperazinyl)naphthoquinone 376947 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant 2,3-Bis(dodecanoyloxy)propylarsonic acid 375754 Drug sensitive 1H-Benz[g]indol-5-ol, 2-phenyl 371327 Drug sensitive Sanguilutine pseudobase 371258 Drug resistant 3,8,13,18,23-Pentaazapentacosane 368998 Drug sensitive Diethoxybis(1,4-naphthochinone-2-olato)titanium(IV) 368297 Drug sensitive Diisopropoxybis(1,4-naphthochinone-2-olato)titanium(IV) 368058 Drug sensitive 2-N-Methyl-6-thiaellipticinum iodide 367888 Drug resistant Girolline 362388 Drug resistant 1,2,4,5-Tetrazine, 3,6-bis(1-azetidinyl)- 362170 Drug sensitive Antineoplastic-615804 355949 Drug resistant Imidazole, 1-(4-chlorophenyl)-4-(4-nitrophenyl)- 355940 Drug resistant 2,3-Dimethylbenzo[g]quinoxaline-5,10-dione 353644 Drug sensitive Acronycine, 2-nitro 342903 Drug sensitive Bis(helenalinyl)glutarate 336831 Drug sensitive Predorine 333830 Drug resistant Phenyl gallate 333279 Drug resistant 3'-Chloro-2-hydroxy-2'-methyl-3-nitrobenzanilide 332278 Drug sensitive 12-Hydroxyindolo[2,1-b]quinazoline-6(12H)-one 324952 Drug sensitive Ellipticine 3213 Drug resistant 2,2',3,3'-Tetrahydroxy-1,1'-binaphthyl 316673 Drug resistant 9-Methoxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazol-2-ium iodide 3086380 Drug resistant 2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium acetate 3086131 Drug resistant Razoxane 30623 Drug resistant Cytosine, 1beta-D-arabinofuranosyl-N(sup 4)-stearoyl- 304673 Drug resistant Clomifene citrate 3033832 Drug sensitive Digoxin 2724385 Drug resistant N-[(4R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine 24205348 Drug sensitive Haterumalide NA methyl esters 24204452 Drug sensitive 1,2-Benzo-8-(L-alanyl)-3-phenoxazone nitrate salt 24202491 Drug sensitive Tetracenomycin C, amino-butyryl- 24200289 Drug resistant 1-[1-(Diethylamino)propan-2-ylamino]-4-nitrothioxanthen-9-one;chloride 24186469 Drug sensitive Mepacrine mustard dihydrochloride 24180972 Drug resistant 4-[[(8-Hydroxyquinolin-7-yl)-phenylmethyl]amino]benzoic acid 219564 Drug resistant Amsacrine 2179 Drug resistant Pirarubicin hydrochloride 20846247 Drug resistant 8-Hydroxyquinoline 1923 Drug resistant Chonemorphine 165208 Drug sensitive Jolkinolide B 161954 Drug sensitive Acrovestone 159969 Drug resistant Thevetin 159331 Drug resistant 3,6-Diamino-10-methylacridinium chloride hydrochloride 15558347 Drug resistant (6R,7R,9R,14As,15R)-7-cyano-4-hydroxy-2,11-dimethoxy-3,12,16-trimethyl-10,13-dioxo-9-((2-oxopropanamido)methyl)-6,7,9,10,13,14,14a,15-octahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinolin-1-yl 2-hydroxyacetate 154731670 Drug sensitive 5-Chloro-2[(E)-2-(4-nitrophenyl)vinyl]-1H-benzimidazole 15373173 Drug resistant (10S,13S,16S,19S)-16-Butan-2-yl-10,11,14-trimethyl-3-(oxiran-2-ylmethyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 152771884 Drug sensitive Sulfanilanilide, 4'-(9-acridinylamino)- 148802 Drug resistant [6-[(12R)-12-Acetyloxy-10-[(4S)-5-acetyloxy-4-(dimethylamino)-4,6-dimethyloxan-2-yl]-2-but-2-en-2-yl-11-hydroxy-12-methoxy-5-methyl-4,7-dioxonaphtho[7,6-h]chromen-8-yl]-4-(dimethylamino)-2-methyloxan-3-yl] acetate 146158821 Drug resistant (2R)-2-Hydroxy-3-[(6R)-11-hydroxy-2-[4-[(6R)-4-hydroxy-2-[1-hydroxy-3-[(6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5'-oxolane]-2'-yl]but-3-en-2-yl]-4-methyl-1,7-dioxaspiro[5.5]undec-4-en-8-yl]-2-methylpropanoic acid 146158002 Drug sensitive (5S,10S,13R,14S)-3-[3,4-Dihydroxy-6-methyl-5-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5,14-dihydroxy-13-methyl-17-(6-oxopyran-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde 146156945 Drug resistant Acid Alizarine Red B 135565636 Drug resistant C8, Carbonyl prodigiosine 135540857 Drug sensitive 12-Iminodaunorubicin hcl 135539784 Drug resistant 1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug resistant 4-[2-[4-(2-Methylprop-1-enyl)-2-oxoindol-3-yl]hydrazinyl]benzenesulfonamide 135409809 Drug resistant Discorhabdin B 135409044 Drug sensitive 8-Azaguanine 135403646 Drug sensitive 3-[(3R,5S,8S,9R,10R,13S,14R,17S)-3-[(2S,3S,4R,5R,6S)-3,5-Dihydroxy-4-methoxy-6-methyloxan-2-yl]oxy-14-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one 133561838 Drug resistant (2R,4R,6S,7S,12S)-6,7,16-Trihydroxy-18-methoxy-12-methyl-3,13-dioxatricyclo[13.4.0.02,4]nonadeca-1(15),9,16,18-tetraene-8,14-dione 131676399 Drug sensitive 1,4-Bis((2-aminoethyl)amino)-5,8-dihydroxy-9,10-anthraquinone 125982 Drug resistant Pecilocerin A 118701034 Drug resistant Acetylenedicarboxamide 10971 Drug sensitive 2,9-Dimethylellipticinium acetate 10472068 Drug resistant 9-Chloro-2-methylellipticinium acetate, hydrate 10383530 Drug resistant Bialamicol 10304 Drug sensitive Binimetinib 10288191 Drug sensitive Withajardin C 102469053 Drug sensitive Cepharanthine 10206 Drug sensitive [(1R,2R,4R,6R,7S,9S,10Z,12R)-10-(Hydroxymethyl)-4-methyl-15-methylidene-14-oxo-5,8,13-trioxatetracyclo[10.3.0.04,6.07,9]pentadec-10-en-2-yl] (Z)-2-(acetyloxymethyl)but-2-enoate 101277368 Drug sensitive Selumetinib 10127622 Drug sensitive Cinnoline, 4-nitro-, 1-oxide 100397 Drug resistant (Z)-5-chloro-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug resistant 1,4-bis(n-cysteinyldiethylamino)-5,8-dihydroxy anthraquinon - Drug resistant 1,6,7,8-tetra-o-phenylcarbamoylcastnospermine - Drug resistant 1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant 3-piperidinone, 3,5-bis[(3,4-dichlorophenyl)methylene]- - Drug resistant 5.alpha.,25d-spirostan-3.beta.-ol glycoside - Drug resistant 6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione - Drug resistant aceanthryleno[1,2-b]quinoxaline, 12-nitro- - Drug resistant cholestan-5.alpha.-ol-3,6-dione - Drug resistant ellipticine, 6-(3-aminopropyl)-, dihydrochloride - Drug resistant ellipticine, 6-(3-aminopropyl)-9-methoxy-, dihydrochloride - Drug resistant isoflavone, 5,7-dihydroxy-4'-nitro- - Drug resistant n,n'-bis(3-methoxy-9-acridinyl)-1,8-octanediamine - Drug resistant n,n'-di-9-acridinyl-1,6-hexanediamine - Drug resistant 2-(n-d-glysoyl)aminobenzothiazole - Drug resistant 2-methylellpticinium - Drug resistant Anthrapyrazole derivative - Drug resistant antineoplastic-641297 - Drug resistant antineoplastic-d655481 - Drug resistant Camptothecin Derivative - Drug resistant digitoxigenin glycoside - Drug resistant ERB-38 Immunotoxin - Drug resistant euchrysine - Drug resistant geldanamycin dimethylglycinate - Drug resistant il4(38-37)-pe38kdel - Drug resistant Indenoisoquinoline derivative - Drug resistant organosulfur compound - Drug resistant pneumocandin b(sub 0) - Drug resistant pneumocandin c(sub 0) - Drug resistant stereoisomer of nsc 675784-h - Drug resistant strophanthin - Drug resistant toxin .delta.53l - Drug resistant tp4ek - Drug resistant viridomycin - Drug resistant (1R,2E,6R,10E,11aS,13S,14aR)-1,13-dihydroxy-6-(2-methoxyethyl)-6,7,8,9,12,13,14,14a-octahydro-1H-cyclopenta[f][1]oxacyclotridecin-4(11aH)-one - Drug sensitive (1R,6S,11aS,13S,14aR)-1,13-dihydroxy-6-vinyl-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one - Drug sensitive 1,3-butadiene, 1,1,2,4,4-pentachloro-3-nitro- - Drug sensitive 2,3,4-tri-o-acetyl-1-s-dimethylarsino-1-thio- a -d-xylose - Drug sensitive 2-chloro-3-amino-5,8-dihydoxy-1,4-naphthoquinone - Drug sensitive 5,6-dimethyl-9-oxo-9h-xanthene-4-acetic acid, sodium salt - Drug sensitive benzo[1,2-b:4,5-b']dithiophene-4,8-diol, diacetate - Drug sensitive benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug sensitive benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug sensitive benzo[b]naphtho[2,3-d]furan-6,11-dione, 4-chloro-3-hydroxy - Drug sensitive dimethylarsinothious acid, 2,4-pyrimidinediyl ester - Drug sensitive mercury, tetrakis(acetato)(2,3,4,5-thiophenetetrayl)tetra- - Drug sensitive naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive naphthalene-1,2-dione, 1,2-dihydro-4-[(3-pyridinyl)amino]- - Drug sensitive naphthalene-1,2-dione, 4-[(4-bromophenyl)amino]-, 1-oxime - Drug sensitive naphtho[2,3-b]furan-4,9-dione, 2-bromo- - Drug sensitive naphtho[2,3-d]oxazole-4,9-dione, 2-(1,1-dimethylethyl)- - Drug sensitive pyrimidine, 2,4,5-trichloro-6-propyl- - Drug sensitive 5-hydroxyamino camptothecin - Drug sensitive 6-nitro-1-indazolecarboxy-4'-chloro-2'-anisidide - Drug sensitive b705009k098 - Drug sensitive bafilomycin antibiotic - Drug sensitive chalmydocin - Drug sensitive chlorambucil-spermidine - Drug sensitive crambescidin 800 trihydrochloride - Drug sensitive crotoxin cd - Drug sensitive hymenialdisine - Drug sensitive xenorhabdin 1 - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-146a-5p	Hyaluronidase 91820602 Drug interaction    RC00003156 Nicotine 89594 Drug interaction    RC00003137 Oxaliplatine 6857599 Drug interaction    RC00003153 Bisphenol A 6623 Drug interaction    RC00003128 Plerixafor 65015 Drug interaction    RC00003136 Cytarabine 6253 Drug interaction    RC00003127 Capecitabine 60953 Drug interaction    RC00003135 Gemcitabine 60750 Drug interaction    RC00003134 Vincristine 5978 Drug interaction    RC00003126 Prednisone 5865 Drug interaction    RC00003125 Estradiol 5757 Drug interaction    RC00003124 Prednisolone 5755 Drug interaction    RC00003123 Mitomycin 5746 Drug interaction    RC00003122 Bleomycin a2 5360373 Drug interaction    RC00003152 Imatinib 5291 Drug interaction    RC00003121 Morphine 5288826 Drug interaction    RC00003151 Cholecalciferol 5280795 Drug interaction    RC00003150 Calcitriol 5280453 Drug interaction    RC00003149 Dinoprostone 5280360 Drug interaction    RC00003148 Praziquantel 4891 Drug interaction    RC00003119 Trichostatin A 444732 Drug interaction    RC00003146 Cyclopamine 442972 Drug interaction    RC00003145 Carboplatinum 38904 Drug interaction    RC00003133 Bortezomib 387447 Drug interaction    RC00003144 Etoposide 36462 Drug interaction    RC00003132 Paclitaxel 36314 Drug interaction    RC00003131 5-Fluorouracil 3385 Drug interaction    RC00003118 Enoxacin 3229 Drug interaction    RC00003117 Doxorubicin 31703 Drug interaction    RC00003130 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003116 Tamoxifen 2733526 Drug interaction    RC00003147 Verapamil 2520 Drug interaction    RC00003115 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00003155 Benzo[a]pyrene 2336 Drug interaction    RC00003114 Sorafenib 216239 Drug interaction    RC00003143 Acetaminophen 1983 Drug interaction    RC00003113 Erlotinib 176870 Drug interaction    RC00003142 Arsenic trioxide 14888 Drug interaction    RC00003129 Docetaxel 148124 Drug interaction    RC00003141 Leucovorin 135403648 Drug interaction    RC00003157 Sildenafil 135398744 Drug interaction    RC00003120 Gefitinib 123631 Drug interaction    RC00003140 Imatinib mesylate 123596 Drug interaction    RC00003139 4alpha-Phorbol 12-myristate 13-acetate 122634 Drug interaction    RC00003138 Afatinib 10184653 Drug interaction    RC00003154 Interferon-alpha - Drug interaction    RC00003158 Tenecteplase - Drug interaction    RC00003159 CDF(analogues of curcumin) - Drug interaction    RC00003160 Glucocorticoid - Drug interaction    RC00003161

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-146a-5p	Cisplatin 5702198       28560455 Cisplatin 5702198       28678319 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124 Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-146a-5p
Interactor2: TLR3

Evidence Support:

Strong-Evidence	RT-qPCR//Western blot
Weak-Evidence	MiRNA microarray
Prediction-Evidence	RNAHybrid//Targetscan
Support Database	ViRBase

References:

PMID	33675361	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	HeLa cells	Interactor2 expression	Downregulation
Description	In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.