Basic Information:

  VIRBase ID:  

HHID00105165

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9490

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-152-3p:  MIMAT0000438          TMEM97:  NM_014573     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-152-3p	TMEM97
miRBase Accession/Entrez ID	MIMAT0000438	27346
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MAC30//sigma2R

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-152-3p	rs1176563615 chr17:48037194    A/ACTGCTCCAGAGCC rs1284277905 chr17:48037185    C/T rs751476235 chr17:48037178    GT/G rs770658530 chr17:48037186    A/G rs770658530 chr17:48037186    A/T rs1222212566 chr17:48037187    T/A rs1222212566 chr17:48037187    T/C rs1350404796 chr17:48037190    A/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TMEM97	chr17:26654244(+) A-I      3'UTR chr17:26654249(+) A-I      3'UTR chr17:26650903(+) A-I      intronic chr17:26650566(+) A-I      intronic chr17:26650806(+) A-I      intronic chr17:26654225(+) A-I      3'UTR chr17:26654121(+) A-I      3'UTR chr17:26654072(+) A-I      3'UTR chr17:26650558(+) A-I      intronic chr17:26654271(+) A-I      3'UTR chr17:26654232(+) A-I      3'UTR chr17:26654117(+) A-I      3'UTR chr17:26654113(+) A-I      3'UTR chr17:26654008(+) A-I      3'UTR chr17:26650987(+) A-I      intronic chr17:26650705(+) A-I      intronic chr17:26650965(+) A-I      intronic chr17:26654127(+) A-I      3'UTR chr17:26654137(+) A-I      3'UTR chr17:26654231(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TMEM97	chr17:26654232(+) A-I intron -    21960545 chr17:26654113(+) A-G intron -    22484847 chr17:26654121(+) A-G intron -    22484847 chr17:26654137(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMEM97	chr17:26652535-26652536(+) m6A 5'UTR//CDS//intron       24284625 chr17:26652568-26652569(+) m6A 5'UTR//CDS//intron       24284625 chr17:26652829-26652830(+) m6A 3'UTR//intron       24284625//24209618//22608085 chr17:26653579-26653580(+) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr17:26653680-26653681(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr17:26653686-26653687(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr17:26653693-26653694(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr17:26653824-26653825(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr17:26653887-26653888(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr17:26653899-26653900(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr17:26653924-26653925(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr17:26653963-26653964(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr17:26653973-26653974(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr17:26654009-26654010(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr17:26654123-26654124(+) m6A 3'UTR       24209618//24981863 chr17:26654183-26654184(+) m6A 3'UTR       24209618 chr17:26654280-26654281(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr17:26654299-26654300(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr17:26654328-26654329(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr17:26654436-26654437(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr17:26654441-26654442(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr17:26654448-26654449(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr17:26654459-26654460(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr17:26654520-26654521(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr17:26655132-26655133(+) m6A 3'UTR       27773535 chr17:26655361-26655362(+) m6A 3'UTR       27773535 chr17:26655428-26655429(+) m6A 3'UTR       27773535 chr17:26655508-26655509(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr17:26655522-26655523(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-152-3p	Cytoplasm Neural progenitor cells     21363885 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Ovarian follicular fluid     22116803 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	TMEM97	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-152-3p	Morpholine-N-dithiocarbamate 72675 Drug resistant Temsirolimus 6918289 Drug sensitive 3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1-methyl-1H-indole 60147979 Drug resistant Dysorone E 5459221 Drug resistant 5-[6-[(1-Methylpiperidin-4-yl)methoxy]benzimidazol-1-yl]-3-[1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide 53338689 Drug resistant N'-(3-Pyridin-2-ylisoquinolin-1-yl)pyridine-2-carboximidamide 463108 Drug resistant Aminopyrimidine-F 406276 Drug sensitive Triacetyl crambescidin 800 hydrochloride 400721 Drug resistant Stereoisomer of NSC 674066-O 384359 Drug resistant 2-N-Methyl-6-thiaellipticinum iodide 367888 Drug sensitive 2-Hydroxy discorhabdin D 362391 Drug resistant Ellipticine 3213 Drug sensitive Salinomycin 3085092 Drug sensitive Stannane, trimethyl[(4-morpholinylthioxomethyl)thio]- 300936 Drug resistant Chelerythrine 2703 Drug resistant Noformicin 251919 Drug sensitive 9H-Purine, 6-(benzylthio)-9-(2-chloroethyl)- 246230 Drug resistant 7-Fluoro-2-benzoyl-3-trifluoromethylquioxaline 1,4-dioxide 23635154 Drug resistant (1S,3R,7Z,9R,12S,13R,15R)-13-Hydroxy-3,7,12-trimethyl-13-prop-1-en-2-yl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 20835084 Drug resistant Sangivamycin monohydrate 16219974 Drug resistant Edelfosine 1392 Drug resistant Roseophilin, HCl salt 135499311 Drug resistant Triphenyltin chloride 12540 Drug resistant Dabequine 124332 Drug resistant Benzyl trisulfide 122842 Drug resistant 2,9-Dimethylellipticinium acetate 10472068 Drug sensitive 2h-naphtho[1,2-b]pyran-2-one, 9-hydroxy-4-phenyl- - Drug resistant 4-morpholinecarbodithioic acid, antimony complex - Drug resistant 4-quinazolone, 7-amino-3-(4-methoxyphenyl)-, hydrate - Drug resistant inosine, 6-thio-, 2',3',5'-tripentanoate - Drug resistant sulfide, 2,4-dinitrophenyl 2-nitro-p-tolyl - Drug resistant 7-pentanoyltaxol - Drug resistant bisarylpurine - Drug resistant streptorubrin - Drug resistant naphtho[1,2-b]quinolizinium, 9-methyl-, bromide - Drug sensitive phosphinic acid, bis(1-aziridinyl)-, 2-naphthyl ester - Drug sensitive (-)-furodysinin - Drug sensitive .alpha.-sarcin - Drug sensitive 2'-deoxy-2'-difluoromethylene-adenosine - Drug sensitive Camptothecin Derivative - Drug sensitive crotoxin cd - Drug sensitive geldanamycin dimethylglycinate - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-152-3p	Hyaluronidase 91820602 Drug interaction    RC00002947 Formaldehyde 712 Drug interaction    RC00002936 Ethanol 702 Drug interaction    RC00002935 Gemcitabine 60750 Drug interaction    RC00002942 Decitabine 451668 Drug interaction    RC00002945 Diethylstilbestrol 448537 Drug interaction    RC00002944 5-Fluorouracil 3385 Drug interaction    RC00002940 Enoxacin 3229 Drug interaction    RC00002939 Doxorubicin 31703 Drug interaction    RC00002941 Lithium 3028194 Drug interaction    RC00002946 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002938 Bicalutamide 2375 Drug interaction    RC00002937 Docetaxel 148124 Drug interaction    RC00002943 Medpor - Drug interaction    RC00002948 Chemotherapy - Drug interaction    RC00008847

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-152-3p
Interactor2: TMEM97

Evidence Support:

Strong-Evidence	Luciferase assay//PCR
Weak-Evidence	MiRNA microarray//Sanger sequencing
Support Database	ViRBase

References:

PMID	33675361	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	HEK293Ta cells//LNCaP cells	Interactor2 expression	Downregulation
Description	In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.