Basic Information:

  VIRBase ID:  

HHID00105162

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9523

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-143-3p:  MIMAT0000435          BRD2:  NM_001291986     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-143-3p	BRD2
miRBase Accession/Entrez ID	MIMAT0000435	6046
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BRD2-IT1//D6S113E//FSH//FSRG1//NAT//O27.1.1//RING3//RNF3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-143-3p	rs1275333653 chr5:149428986    A/G rs746434694 chr5:149428990    C/T rs867385739 chr5:149428984    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	BRD2	chr6:32939233(+) A-I      intronic chr6:32939235(+) A-I      intronic chr6:32939236(+) A-I      intronic chr6:32939257(+) A-I      intronic chr6:32939275(+) A-I      intronic chr6:32939280(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	BRD2	chr6:32936438-32936439(+) m6A 5'UTR       24284625//24209618//25456834//24981863 chr6:32936466-32936467(+) m6A 5'UTR       24284625//24209618//25456834//24981863 chr6:32936501-32936502(+) m6A 5'UTR       24284625//25456834//24981863 chr6:32936738-32936739(+) Y 5'UTR       26075521 chr6:32936956-32936957(+) m6A 5'UTR//intron       24284625 chr6:32938566-32938567(+) m6A exon//intron       - chr6:32938737-32938738(+) m6A 5'UTR//exon//intron       25456834 chr6:32938758-32938759(+) m6A 5'UTR//exon//intron       25456834 chr6:32938765-32938766(+) m6A 5'UTR//exon//intron       25456834 chr6:32938923-32938924(+) m6A 5'UTR//intron       24284625 chr6:32939402-32939403(+) m6A 5'UTR//CDS//exon//intron       24284625//24209618 chr6:32939570-32939571(+) m6A 5'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22575960 chr6:32939667-32939668(+) m6A 5'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr6:32940136-32940137(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:32940254-32940255(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//22575960 chr6:32940298-32940299(+) m6A 5'UTR//intron       24284625//24209618//22575960 chr6:32940346-32940347(+) m6A 5'UTR//intron       24284625//24209618//24981863//22575960 chr6:32940378-32940379(+) Gm 5'UTR//intron       - chr6:32940388-32940389(+) m6A 5'UTR//intron       24284625//24209618//24981863//22575960 chr6:32940515-32940516(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:32940601-32940602(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:32940618-32940619(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:32940633-32940634(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:32941383-32941384(+) Cm intron       - chr6:32942313-32942314(+) m6A 5'UTR//CDS       24284625//22575960 chr6:32942484-32942485(+) m6A CDS       26404942 chr6:32943180-32943181(+) m6A 3'UTR//CDS       26404942 chr6:32943191-32943192(+) m6A 3'UTR//CDS       26404942 chr6:32943213-32943214(+) m6A 3'UTR//CDS       26404942 chr6:32943221-32943222(+) m6A 3'UTR//CDS       26404942 chr6:32943887-32943888(+) m6A 3'UTR//CDS       24981863//26404942//27773535 chr6:32943916-32943917(+) m6A 3'UTR//CDS       24981863//26404942//27773535 chr6:32944189-32944190(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr6:32944501-32944502(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//22575960//22608085 chr6:32944536-32944537(+) Am 3'UTR//CDS//exon       - chr6:32944556-32944557(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//22575960//22608085 chr6:32944565-32944566(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//22575960//22608085 chr6:32944634-32944635(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//22575960//22608085 chr6:32944696-32944697(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//22575960//22608085 chr6:32944771-32944772(+) m6A 3'UTR//exon//intron       26404942//22608085 chr6:32945257-32945258(+) Y 3'UTR//CDS//exon       26075521 chr6:32945571-32945572(+) m6A 3'UTR//CDS//exon       24284625//27773535 chr6:32945580-32945581(+) m6A 3'UTR//CDS//exon       24284625//27773535 chr6:32945735-32945736(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535 chr6:32945769-32945770(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535 chr6:32945778-32945779(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828 chr6:32945919-32945920(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828 chr6:32946141-32946142(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960 chr6:32946188-32946189(+) m6A exon//intron       24284625//25456834//24981863//22575960 chr6:32947495-32947496(+) m6A exon//intron       - chr6:32947548-32947549(+) m6A exon//intron       - chr6:32947626-32947627(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr6:32947720-32947721(+) m6A 3'UTR//CDS//exon       24209618//24981863//26404942//22575960 chr6:32947801-32947802(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535 chr6:32947830-32947831(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535 chr6:32947892-32947893(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr6:32947946-32947947(+) m6A exon//intron       24981863//27773535 chr6:32948043-32948044(+) m6A exon//intron       24981863 chr6:32948051-32948052(+) m6A exon//intron       24981863 chr6:32948141-32948142(+) m6A 3'UTR//CDS//exon       24981863 chr6:32948152-32948153(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr6:32948206-32948207(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr6:32948369-32948370(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr6:32948469-32948470(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942 chr6:32948484-32948485(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:32948531-32948532(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:32948536-32948537(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:32948544-32948545(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:32948654-32948655(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:32948672-32948673(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:32948678-32948679(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:32948683-32948684(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:32948725-32948726(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-143-3p	Cytoplasm Luminal cells|Stromal cells     29073169 Exosome Human cervical cancer cell line (HeLa)     25760330 Exosome EBV- and KSHV-negative Burkitt lymphoma cell line (Bjab)|EBV-infected lymphoblastoid cell line (LCL)|KSHV-infected lymphoma cell lines (BCBL-1|TY-1)     27611973 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Serum     25349172 Exosome Cerebrospinal fluid     25420022 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Endothelial cells|Lymphoma tissue|Mast cells|Saliva     - Extracellular vesicle Human umbilical vein endothelial cells     22327366 Extracellular vesicle HEK-293T cells     22849433 Microvesicle Plasma     23077538 Microvesicle Blood|Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Nucleus Stromal cells     29073169
	BRD2	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-143-3p	Hyaluronidase 91820602 Drug interaction    RC00002874 Oxaliplatine 6857599 Drug interaction    RC00002872 Irinotecan 60838 Drug interaction    RC00002859 Gemcitabine 60750 Drug interaction    RC00002858 Estradiol 5757 Drug interaction    RC00002852 Temozolomide 5394 Drug interaction    RC00002851 Eloxatine 5310940 Drug interaction    RC00002871 Imatinib 5291 Drug interaction    RC00002850 Genistein 5280961 Drug interaction    RC00002870 Dinoprostone 5280360 Drug interaction    RC00002869 Quercetin 5280343 Drug interaction    RC00002868 Sodium butyrate 5222465 Drug interaction    RC00002867 Propofol 4943 Drug interaction    RC00002849 2-{[2-Ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one 46843772 Drug interaction    RC00002873 Decitabine 451668 Drug interaction    RC00002866 Docosahexaenoic acid 445580 Drug interaction    RC00002865 Trichostatin A 444732 Drug interaction    RC00002864 Ribavirin 37542 Drug interaction    RC00002857 Paclitaxel 36314 Drug interaction    RC00002856 5-Fluorouracil 3385 Drug interaction    RC00002848 Enoxacin 3229 Drug interaction    RC00002847 Doxorubicin 31703 Drug interaction    RC00002855 Ursodeoxycholic acid 31401 Drug interaction    RC00002854 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002846 Verapamil 2520 Drug interaction    RC00002845 Lenalidomide 216326 Drug interaction    RC00002863 Arsenic trioxide 14888 Drug interaction    RC00002853 Docetaxel 148124 Drug interaction    RC00002862 Geneticin 123865 Drug interaction    RC00002861 Gefitinib 123631 Drug interaction    RC00002860 Peginterferon alfa-2b - Drug interaction    RC00002875 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00002876 Estrogen - Drug interaction    RC00002877 Medpor - Drug interaction    RC00002878 Chemotherapy - Drug interaction    RC00008845

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-143-3p	Paclitaxel 36314       30275853

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-143-3p
Interactor2: BRD2

Evidence Support:

Strong-Evidence	qRT-PCR//Western blot
Weak-Evidence	MiRNA sequencing
Prediction-Evidence	microRNA.org//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	33675361	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	AGS cells//MKN28 cells//MKN45 cells//SNU-1 cells	Interactor2 expression	None
Description	In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.