Basic Information:

  VIRBase ID:  

HHID00105161

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2455

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-141-3p:  MIMAT0000432          ACE2:  NM_021804     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-141-3p	ACE2
miRBase Accession/Entrez ID	MIMAT0000432	59272
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ACEH

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-141-3p	rs1555150375 chr12:6964163    T/A rs1555150376 chr12:6964164    C/A rs1555150377 chr12:6964165    T/G rs1555150378 chr12:6964168    TAA/T rs1555150374 chr12:6964158    C/A rs1555150374 chr12:6964158    C/T rs782556563 chr12:6964159    ACTGT/A

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ACE2	chrX:15579319-15579320(-) m6A 3'UTR//exon       27773535 chrX:15579343-15579344(-) m6A 3'UTR//exon       27773535 chrX:15579366-15579367(-) m6A 3'UTR//exon       27773535 chrX:15579420-15579421(-) m6A 3'UTR//exon       27773535 chrX:15579431-15579432(-) m6A 3'UTR//intron       27773535 chrX:15579618-15579619(-) m6A 3'UTR//intron       27773535 chrX:15579631-15579632(-) m6A 3'UTR//intron       27773535 chrX:15579696-15579697(-) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-141-3p	Cytoplasmic stress granule HeLa cells     28488892 Exosome Human milk     28688106 Exosome Pulmonary epithelial cell line (BEAS-2B)     31520698 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Colon tissue|Seminal fluid     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     - Nucleus Colon adenocarcinoma cells     20864815 P-body HeLa cells     28488892
	ACE2	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-141-3p	(7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione 98137101 Drug resistant Pingyangmycin 84046 Drug resistant 2-(Benzyloxy)-4-methoxybenzaldehyde 820527 Drug resistant 1H-Pyrazolo[3,4-d]pyrimidin-4-amine 75420 Drug sensitive 10,11-Methylenedioxy-20S-camptothecin 72403 Drug resistant 7-Hydroxystaurosporine 72271 Drug resistant Fludarabine 657237 Drug resistant Neocuproine 65237 Drug sensitive Mevastatin 64715 Drug resistant Irinotecan 60838 Drug resistant Topotecan 60700 Drug resistant 3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1-methyl-1H-indole 60147979 Drug sensitive Ketone, methyl 2-pyridyl, 4,4-dimethyl-3-thiosemicarbazone 5843399 Drug sensitive Cisplatin 5702198 Drug resistant (Z)-3-Iodo-1,2-diphenyl-2-propen-1-one 5468683 Drug sensitive Bleomycin 5460769 Drug resistant Cuspidatin C 5459164 Drug sensitive [2-[2-[(1R,2S)-2-[[6-Amino-2-[1-[(2S)-2,3-diamino-3-oxopropyl]-4-oxoazetidin-2-yl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[(2R,3S,4S)-3-hydroxy-5-[[(2S,3R)-3-hydroxy-1-[2-[4-[4-[2-(2-hydroxypropylamino)ethylcarbamoyl]-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]-1-oxobutan-2-yl]amino]-4-methyl-5-oxopentan-2-yl]amino]-1-(1H-imidazol-5-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl] carbamate 5458321 Drug resistant Simvastatin 54454 Drug resistant 4-Cycloheptyl-N-(1-pyridin-2-ylethylideneamino)piperazine-1-carbothioamide 5351332 Drug sensitive Hydroxy AT 125 5351254 Drug sensitive 3-[(4-Methoxyphenyl)thio]-2H-isoindole-1-carbaldehyde 53361730 Drug sensitive Lovastatin 53232 Drug resistant 8-Hydroxymanzamine A 5270765 Drug sensitive Staurosporine, 98% 49831000 Drug resistant Ditercalinium dimethanesulfonate dimethanesulfonate 435243 Drug sensitive Bleomycin-BAPP 431594 Drug resistant Diaziquone 42616 Drug resistant Bleomycin A5, sulfate 422920 Drug resistant cis-Diamminemalonatoplatinum(II) 422683 Drug resistant Aminopyrimidine-F 406276 Drug sensitive Fagaronine chloride 40304 Drug resistant 1-(4'-Phthalimidopropyl-carbonyl)-5-fluorouracil 388985 Drug sensitive Stereoisomer of NSC 674066-O 384359 Drug sensitive Antineoplastic-645804 371505 Drug sensitive 4-N,N-Bis-2'-cyanoethylaminobenzylidene-4-fluoro aniline 359414 Drug sensitive Thiosangivamycin 3580213 Drug sensitive Free base of NSC 610966 355990 Drug sensitive Ellipticine 3213 Drug sensitive Phomazarin 318385 Drug resistant 1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea 26328 Drug resistant Camptothecin 24360 Drug resistant 3-Bromo-4-(2-(4-methoxyphenyl)ethynyl)furan-2(5H)-one 24204187 Drug sensitive 1-(2-(Dimethylamino)ethyl)-3-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)urea 23634407 Drug sensitive Jolkinolide B 161954 Drug resistant N-(3-(1-Aziridinyl)propyl)-1,4-butanediamine 160394 Drug resistant 8-Azahypoxanthine 135410720 Drug resistant 8-Azaguanine 135403646 Drug resistant Methyl (1S,10R,11S,12S)-11-acetyloxy-12-ethyl-4-[(13R,15R,17R)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 133126830 Drug sensitive Saintopin 131350 Drug resistant Dabequine 124332 Drug sensitive Pepleo 122804 Drug resistant 1-Phenyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazole 11162021 Drug resistant Uridine, 2'-deoxy-2'-methylene- 11075548 Drug resistant Clomesone 100651 Drug resistant 1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion - Drug resistant 1-[bis(4,4'-aminophenyl)methylidenyl]-[3]ferrocenophane - Drug resistant 1h-1,2,4-triazole, 3-(4-diazo-4h-imidazol-5-yl)- - Drug resistant 1-naphthalenecarboxamide, n,n'-1,8-(octanediyl)bis- - Drug resistant 5-hydroxy-7-amino(1,2,3)thiadiazole[5,4-d]pyrimidine - Drug resistant benzo[1,2-b:4,5-b']dithiophene-4,8-diol, diacetate - Drug resistant benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug resistant benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug resistant phosphinic acid, bis(1-aziridinyl)-, 2-naphthyl ester - Drug resistant piceatannol, 4,3',5'-trimethyl,1s0 - Drug resistant (-)-furodysinin - Drug resistant 2-(n-d-glysoyl)aminobenzothiazole - Drug resistant Aminocamptothecin - Drug resistant Annamycin Liposomal - Drug resistant Camptothecin Derivative - Drug resistant Chlorozotocin - Drug resistant CI-921: amsacrine derivative - Drug resistant crotoxin cd - Drug resistant orlistat (usan) - Drug resistant potassium[trichloro(isopropylamine)platinum] - Drug resistant protein toxin a 23 - mw approx. 6700 - Drug resistant protein toxin c 10 - mw approx. 6700 - Drug resistant 1,8-naphthyridin-4(1h)-one, 2-(4-fluorophenyl)-5-methyl- - Drug sensitive anthracen-9-one, 10-[(2-methoxyphenyl)methylene]- - Drug sensitive benzene, 1-methoxy-4-(2-nitroethenyl)-, (e)- - Drug sensitive ellipticine, 6-(3-aminopropyl)-9-methoxy-, dihydrochloride - Drug sensitive uridine, 5-fluoro-, 2',3',5'-triacetate - Drug sensitive antineoplastic-625577 - Drug sensitive antineoplastic-641297 - Drug sensitive arylmethylene-f - Drug sensitive dichlorobisoxinatotitanium(iv) - Drug sensitive hyperforinacetate - Drug sensitive streptorubrin - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-141-3p	N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide 9826528 Drug interaction    RC00002816 10-Hydroxycamptothecin 97226 Drug interaction    RC00002807 Hydrogen peroxide 784 Drug interaction    RC00002789 Oxaliplatine 6857599 Drug interaction    RC00002815 Ibandronic Acid 60852 Drug interaction    RC00002806 Gemcitabine 60750 Drug interaction    RC00002805 Progesterone 5994 Drug interaction    RC00002800 Vincristine 5978 Drug interaction    RC00002799 D-Glucose 5793 Drug interaction    RC00002798 Prednisolone 5755 Drug interaction    RC00002797 Sunitinib 5329102 Drug interaction    RC00002814 Eloxatine 5310940 Drug interaction    RC00002813 Docosahexaenoic acid 445580 Drug interaction    RC00002811 Resveratrol 445154 Drug interaction    RC00002810 Paclitaxel 36314 Drug interaction    RC00002804 5-Fluorouracil 3385 Drug interaction    RC00002796 Emodin 3220 Drug interaction    RC00002795 Doxorubicin 31703 Drug interaction    RC00002803 Daunorubicin 30323 Drug interaction    RC00002802 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002794 Tamoxifen 2733526 Drug interaction    RC00002812 Celecoxib 2662 Drug interaction    RC00002793 Verapamil 2520 Drug interaction    RC00002792 Bicalutamide 2375 Drug interaction    RC00002791 Benzo[a]pyrene 2336 Drug interaction    RC00002790 Erlotinib 176870 Drug interaction    RC00002809 Docetaxel 148124 Drug interaction    RC00002808 Epoxomicin 11226684 Drug interaction    RC00002817 Androstanolone 10635 Drug interaction    RC00002801 Asparaginase Escherichia coli - Drug interaction    RC00002818 Denosumab - Drug interaction    RC00002819

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-141-3p	Oxaliplatin 9887053       27644195 5-Fluorouracil 3385       27644195 Platinum 23939       25872328 Trastuzumab -       31087707

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-141-3p
Interactor2: ACE2

Evidence Support:

Prediction-Evidence	miRanda//miRBase//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	32992681	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	Table 1 shows a list of novel potential candidate miRNAs against ACE2 gene that were not studied previously.