Detail Information

Basic Information:


  VIRBase ID:  

HHID00105158

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2455

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-3p:           ACE2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-3p ACE2
miRBase
Accession/Entrez ID		 MIMAT0000425 59272
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ACEH

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-3p
rs1160508308 chr11:57641272    A/T
rs1333199149 chr11:57641261    G/A

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ACE2
chrX:15579319-15579320(-) m6A 3'UTR//exon       27773535
chrX:15579343-15579344(-) m6A 3'UTR//exon       27773535
chrX:15579366-15579367(-) m6A 3'UTR//exon       27773535
chrX:15579420-15579421(-) m6A 3'UTR//exon       27773535
chrX:15579431-15579432(-) m6A 3'UTR//intron       27773535
chrX:15579618-15579619(-) m6A 3'UTR//intron       27773535
chrX:15579631-15579632(-) m6A 3'UTR//intron       27773535
chrX:15579696-15579697(-) m6A 3'UTR//exon       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-3p
Cytoplasm Neural progenitor cells     21363885
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Serum     29143228
Exosome Primary dendritic cells     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Blood|Endothelial cells     -
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Hepatoma cells     23771658
Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Colon adenocarcinoma cells     20864815
ACE2
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-130a-3p
Gardenin B 96539 Drug resistant
Tiotixene 941651 Drug resistant
4-(1,3-Benzoxazol-2-yl)aniline 88733 Drug resistant
7-Hydroxystaurosporine 72271 Drug resistant
Sulbentine 67686 Drug resistant
Methylestradiol 66413 Drug resistant
Vicenistatin 6438888 Drug resistant
Thiopyrimidine-CH3 5473238 Drug resistant
(Z)-3-Iodo-1,2-diphenyl-2-propen-1-one 5468683 Drug resistant
p-Chloranilinum[bis(p-chloraniline)dioxalatoruthenate(III)] 54608061 Drug resistant
Heliangolide 5384466 Drug resistant
(1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug resistant
Ovatifolin acetate 5358419 Drug resistant
Chaetochromin 53277 Drug resistant
1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug resistant
[(1R,2S,3S,5R,6R,8S,10E,12R,13S,15R,16S,17R,18S)-18-Benzyl-6-hydroxy-6,8,15,16-tetramethyl-7,20-dioxo-4,14-dioxa-19-azapentacyclo[10.8.0.01,17.03,5.013,15]icos-10-en-2-yl] acetate 44559501 Drug resistant
Oxyacanthine 442333 Drug resistant
15-Oxozoapatlin 391317 Drug resistant
1-(4'-Phthalimidopropyl-carbonyl)-5-fluorouracil 388985 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug resistant
(4-Methoxyphenyl)-(3,4,5-trimethoxyphenyl)methanol 368140 Drug resistant
Miltefosine 3599 Drug resistant
4-[3-[2-Chloro-4-(4,6-diamino-2,2-dimethyl-1,3,5-triazin-1-yl)phenyl]propanoylamino]benzenesulfonyl fluoride;ethanesulfonic acid 276171 Drug resistant
[(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug resistant
7-Fluoro-2-benzoyl-3-trifluoromethylquioxaline 1,4-dioxide 23635154 Drug resistant
Drostanolone propionate 224004 Drug resistant
4-Chloro-5-(pyridin-2-ylthio)-3H-1,2-dithiole-3-thione 16766538 Drug resistant
4-Chloro-5-phenoxy-3H-1,2-dithiole-3-thione 16766044 Drug resistant
Edelfosine 1392 Drug resistant
Triphenyltin chloride 12540 Drug resistant
2,4-Pyrimidinediamine, 5-(3-azido-4-chlorophenyl)-6-ethyl- 125330 Drug resistant
Octadecylphosphocholine 125219 Drug resistant
Melampodinin 11953936 Drug resistant
(E)-3-(3,5-dimethoxyphenyl)-1-(4-(quinazolin-4-ylamino)phenyl)prop-2-en-1-one - Drug resistant
(z) 2',3,4,5-tetramethoxystilbene - Drug resistant
1,2,3-thiadiazole, 5-[(4-chlorophenyl)sulfonyl]-4-phenyl- - Drug resistant
1h-1,4,7-triazonine-1,4,7-triacetic acid, octahydro- - Drug resistant
2,5-di-(2-thienyl)-pyrrole - Drug resistant
4-piperidinone, 3,5-bis[(4-fluorophenyl)methylene]-, (e,e)- - Drug resistant
5,6-dimethyl-9-oxo-9h-xanthene-4-acetic acid, sodium salt - Drug resistant
7-n,n-dimethylamino brefeldin a hydrochloride - Drug resistant
anthracen-9-one, 10-[(2-methoxyphenyl)methylene]- - Drug resistant
nsc 708781 incorporated in micelles, 0.55% (w/w) of drug - Drug resistant
bavachyaone - Drug resistant
n-acetyl-4-s-cystaminyl phenol - Drug resistant
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-3p
Formaldehyde 712 Drug interaction    RC00002679
Gemcitabine 60750 Drug interaction    RC00002686
Progesterone 5994 Drug interaction    RC00002683
Eloxatine 5310940 Drug interaction    RC00002692
Imatinib 5291 Drug interaction    RC00002682
Decitabine 451668 Drug interaction    RC00002690
Paclitaxel 36314 Drug interaction    RC00002685
5-Fluorouracil 3385 Drug interaction    RC00002681
Doxorubicin 31703 Drug interaction    RC00002684
Dasatinib 3062316 Drug interaction    RC00002691
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002680
Benzene 241 Drug interaction    RC00002678
Sorafenib 216239 Drug interaction    RC00002689
Docetaxel 148124 Drug interaction    RC00002688
Gefitinib 123631 Drug interaction    RC00002687
TRAIL therapy - Drug interaction    RC00002693
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-3p
Gemcitabine 60750       28560603
Cisplatin 5702198       25356050
Cisplatin 5702198       29020498
Cisplatin 5702198       30510209
5-Fluorouracil 3385       30510209
Doxorubicin 31703       24788655

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-3p
Interactor2: ACE2

Evidence Support:


Prediction-Evidence miRanda//miRBase//miRWalk//Targetscan
Support Database ViRBase

References:


PMID 32992681 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Table 1 shows a list of novel potential candidate miRNAs against ACE2 gene that were not studied previously.

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