Detail Information

Basic Information:


  VIRBase ID:  

HHID00105155

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9630

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-125b-5p:           ANGPT2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-125b-5p ANGPT2
miRBase
Accession/Entrez ID		 MIMAT0000423 285
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AGPT2//ANG2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-125b-5p
rs1178860098 chr11:122099819    G/A
rs764155531 chr11:122099809    T/A
rs1325186129 chr21:16590264    C/A
rs1459840793 chr21:16590263    C/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ANGPT2
chr8:6381248(-) A-I      intronic
chr8:6381226(-) A-I      intronic
chr8:6381285(-) A-I      intronic
chr8:6364530(-) A-I      intronic
chr8:6364526(-) A-I      intronic
chr8:6381249(-) A-I      intronic
chr8:6381242(-) A-I      intronic
chr8:6371817(-) A-I      intronic
chr8:6381288(-) A-I      intronic
chr8:6371808(-) A-I      intronic
chr8:6364506(-) A-I      intronic
chr8:6381239(-) A-I      intronic
chr8:6364502(-) A-I      intronic
chr8:6379764(-) A-I      intronic
chr8:6364515(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ANGPT2
chr8:6360078-6360079(-) m6A 3'UTR       -
chr8:6360132-6360133(-) m6A 3'UTR       -
chr8:6360152-6360153(-) m6A 3'UTR       -
chr8:6360243-6360244(-) m6A 3'UTR       -
chr8:6360276-6360277(-) m6A 3'UTR       27773535
chr8:6360281-6360282(-) m6A 3'UTR       27773535
chr8:6360353-6360354(-) m6A 3'UTR       27773535
chr8:6360372-6360373(-) m6A 3'UTR       27773535
chr8:6360390-6360391(-) m6A 3'UTR       27773535
chr8:6360395-6360396(-) m6A 3'UTR       27773535
chr8:6360415-6360416(-) m6A 3'UTR       27773535
chr8:6360422-6360423(-) m6A 3'UTR       27773535
chr8:6360433-6360434(-) m6A 3'UTR       27773535
chr8:6360451-6360452(-) m6A 3'UTR       27773535
chr8:6360465-6360466(-) m6A 3'UTR       -
chr8:6360494-6360495(-) m6A 3'UTR       -
chr8:6360576-6360577(-) m6A 3'UTR       -
chr8:6360589-6360590(-) m6A 3'UTR       -
chr8:6360599-6360600(-) m6A 3'UTR       -
chr8:6360620-6360621(-) m6A 3'UTR       -
chr8:6420189-6420190(-) m6A CDS       -
chr8:6420201-6420202(-) m6A CDS       -
chr8:6420303-6420304(-) m6A CDS       -
chr8:6420375-6420376(-) m6A CDS       -
chr8:6420514-6420515(-) m6A 5'UTR       25456834
chr8:6420566-6420567(-) m6A 5'UTR       25456834
chr8:6420580-6420581(-) m6A 5'UTR       25456834
chr8:6420615-6420616(-) m6A 5'UTR       25456834
chr8:6420629-6420630(-) m6A 5'UTR       25456834
chr8:6420677-6420678(-) m6A 5'UTR       25456834
chr8:6420728-6420729(-) m6A 5'UTR       -
chr8:6420735-6420736(-) m6A 5'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-125b-5p
Apoptotic body Human umbilical vein endothelial cells     19996457
Cytoplasm Neural progenitor cells     21363885
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Primary dendritic cells     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human esophageal cancer cell line (EC9706)     25184951
Exosome Blood|Breast milk|Endothelial cells|Epithelial cells|Seminal fluid     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Hepatoma cells     23771658
Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Myotube     27396686
Mitochondrion Skeletal muscle cells     27563705
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Colon adenocarcinoma cells     20864815
ANGPT2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-125b-5p
Aspiculamycin hcl 54600418 Drug sensitive
Lovastatin 53232 Drug sensitive
Rhamnazin 5320945 Drug sensitive
(3R,5S)-Fluvastatin(1-) 37888681 Drug sensitive
Imidazole, 1-(4-chlorophenyl)-4-(4-nitrophenyl)- 355940 Drug sensitive
Gardenin A 261859 Drug sensitive
43-Dioxypectenotoxin 131751434 Drug sensitive
Uridine, 2'-deoxy-2'-methylene- 11075548 Drug sensitive
1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion - Drug sensitive
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug sensitive
atorvastatin calcium (usan) - Drug sensitive
crotoxin cd - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-125b-5p
Azacitidine 9444 Drug interaction    RC00002615
Oxaliplatine 6857599 Drug interaction    RC00002640
Capecitabine 60953 Drug interaction    RC00002625
Gemcitabine 60750 Drug interaction    RC00002624
Vincristine 5978 Drug interaction    RC00002614
Prednisolone 5755 Drug interaction    RC00002613
Dexamethasone 5743 Drug interaction    RC00002612
Temozolomide 5394 Drug interaction    RC00002611
Eloxatine 5310940 Drug interaction    RC00002639
Morphine 5288826 Drug interaction    RC00002638
Sirolimus 5284616 Drug interaction    RC00002637
Goserelinacetate 47725 Drug interaction    RC00002623
Decitabine 451668 Drug interaction    RC00002635
Cocaine 446220 Drug interaction    RC00002634
Cyclopamine 442972 Drug interaction    RC00002633
Vemurafenib 42611257 Drug interaction    RC00002641
Bortezomib 387447 Drug interaction    RC00002632
Etoposide 36462 Drug interaction    RC00002622
Paclitaxel 36314 Drug interaction    RC00002621
5-Fluorouracil 3385 Drug interaction    RC00002610
Enoxacin 3229 Drug interaction    RC00002609
Emodin 3220 Drug interaction    RC00002608
Doxorubicin 31703 Drug interaction    RC00002620
Daunorubicin 30323 Drug interaction    RC00002619
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002607
Tamoxifen 2733526 Drug interaction    RC00002636
Camptothecin 24360 Drug interaction    RC00002618
Bicalutamide 2375 Drug interaction    RC00002606
Benzo[a]pyrene 2336 Drug interaction    RC00002605
Arsenic trioxide 14888 Drug interaction    RC00002617
Docetaxel 148124 Drug interaction    RC00002631
Leucovorin 135403648 Drug interaction    RC00002642
Gefitinib 123631 Drug interaction    RC00002630
Ginsenoside Rh2 119307 Drug interaction    RC00002629
Methamphetamine 10836 Drug interaction    RC00002616
Mafosfamide 104746 Drug interaction    RC00002628
Asparaginase Escherichia coli - Drug interaction    RC00002643
Rituximab - Drug interaction    RC00002644
TRAIL therapy - Drug interaction    RC00002645
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00002646
1alpha,25-Dihydroxyvitamin D3 + 5-Aza + trichostatin A(TSA) - Drug interaction    RC00002647
Aidi injection - Drug interaction    RC00002648
Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00002649
Iron-sulfates and Aluminum-sulfates - Drug interaction    RC00002650
Marine fungal metabolite 1386A - Drug interaction    RC00002651
Mistletoe lectin-I - Drug interaction    RC00002652
Chemotherapy - Drug interaction    RC00008842
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-125b-5p
Prednisone 5865       30211623
Cisplatin 5702198       26676926
Cisplatin 5702198       28256505
Bortezomib 387447       23527180
Doxorubicin 31703       30211623
Cyclophosphamide 2907       30211623
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       30211623
Rituximab -       30211623

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-125b-5p
Interactor2: ANGPT2

Evidence Support:


Strong-Evidence Luciferase reporter assay//RT-qPCR//Western blot
Prediction-Evidence miRanda//Targetscan
Support Database ViRBase

References:


PMID 33675361 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line VETC-2 cells//Hepa1-6 cells Interactor2 expression Downregulation
Description In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.

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