Basic Information:

  VIRBase ID:  

HHID00105154

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-124-3p:  MIMAT0000422          JAK2:  NR_169764     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-124-3p	JAK2
miRBase Accession/Entrez ID	MIMAT0000422	3717
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	JTK10

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-124-3p	rs1256263272 chr8:9903400    T/C rs1482188536 chr8:9903410    C/A rs753437646 chr8:9903401    G/T rs759045572 chr8:9903402    G/T rs764861083 chr8:9903408    A/G rs759034202 chr8:64379220    G/A rs1364752547 chr20:63178563    G/A rs749909250 chr20:63178569    G/A rs1287398108 chr20:63178559    C/G rs34059726 chr20:63178555    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	JAK2	chr9:5102325(+) A-I      intronic chr9:5025674(+) A-I      intronic chr9:5025678(+) A-I      intronic chr9:5064281(+) A-I      intronic chr9:5102353(+) A-I      intronic chr9:5102375(+) A-I      intronic chr9:5120073(+) A-I      intronic chr9:5102378(+) A-I      intronic chr9:5102381(+) A-I      intronic chr9:5102389(+) A-I      intronic chr9:5120051(+) A-I      intronic chr9:5120066(+) A-I      intronic chr9:5064291(+) A-I      intronic chr9:5120089(+) A-I      intronic chr9:5120098(+) A-I      intronic chr9:5025742(+) A-I      intronic chr9:5025663(+) A-I      intronic chr9:5025608(+) A-I      intronic chr9:5085751(+) A-I      intronic chr9:5085772(+) A-I      intronic chr9:5085787(+) A-I      intronic chr9:5085806(+) A-I      intronic chr9:5112688(+) A-I      intronic chr9:5112689(+) A-I      intronic chr9:5112702(+) A-I      intronic chr9:5102318(+) A-I      intronic chr9:5102317(+) A-I      intronic chr9:5102328(+) A-I      intronic chr9:5102336(+) A-I      intronic chr9:5102351(+) A-I      intronic chr9:5112730(+) A-I      intronic chr9:5102331(+) A-I      intronic chr9:5025672(+) A-I      intronic chr9:4996305(+) A-I      intronic chr9:4996359(+) A-I      intronic chr9:4996380(+) A-I      intronic chr9:5021767(+) A-I      intronic chr9:5025627(+) A-I      intronic chr9:5102383(+) A-I      intronic chr9:5005212(+) A-I      intronic chr9:4996298(+) A-I      intronic chr9:4997041(+) A-I      intronic chr9:5042150(+) A-I      intronic chr9:5021764(+) A-I      intronic chr9:5021758(+) A-I      intronic chr9:5005188(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	JAK2	chr9:4985095-4985096(+) m6A exon       24981863 chr9:5090814-5090815(+) m6A CDS       24981863 chr9:5090862-5090863(+) m6A CDS       24981863 chr9:5111064-5111065(+) m6A intron       - chr9:5111103-5111104(+) m6A intron       - chr9:5114531-5114532(+) m6A intron       - chr9:5114537-5114538(+) m6A intron       - chr9:5114567-5114568(+) m6A intron       - chr9:5114582-5114583(+) m6A intron       - chr9:5126813-5126814(+) m6A 3'UTR//exon       24981863 chr9:5126832-5126833(+) m6A 3'UTR//exon       24981863 chr9:5126861-5126862(+) m6A 3'UTR//exon       24981863//22608085 chr9:5126934-5126935(+) m6A 3'UTR//exon       24981863//22608085 chr9:5126981-5126982(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-124-3p	Exosome Plasma     23663360 Exosome Blood     - Microvesicle Cerebrospinal fluid     24797360 Microvesicle Blood|Fibroblasts|Urine     - Mitochondrion Cell line (HEK-293)     22984580
	JAK2	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-124-3p	N,N-Dimethyltryptamine 6089 Drug interaction    RC00002595 Estradiol 5757 Drug interaction    RC00002594 Vorinostat 5311 Drug interaction    RC00002593 Cocaine 446220 Drug interaction    RC00002602 Paroxetine 43815 Drug interaction    RC00002601 Methylphenidate 4158 Drug interaction    RC00002592 Methadone 4095 Drug interaction    RC00002591 Etoposide 36462 Drug interaction    RC00002600 Harmaline 3564 Drug interaction    RC00002603 Fluoxetine 3386 Drug interaction    RC00002590 Enoxacin 3229 Drug interaction    RC00002589 Doxorubicin 31703 Drug interaction    RC00002599 Desipramine 2995 Drug interaction    RC00002588 Camptothecin 24360 Drug interaction    RC00002598 Cobalt chloride (CoCl2) 24288 Drug interaction    RC00002597 N,N-Dimethyl-5-methoxytryptamine 1832 Drug interaction    RC00002587 Arsenic trioxide 14888 Drug interaction    RC00002596 IR - Drug interaction    RC00002604

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-124-3p	Doxorubicin 31703       30807260

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-124-3p
Interactor2: JAK2

Evidence Support:

Strong-Evidence	qRT-PCR//Western blot
Support Database	ViRBase

References:

PMID	33675361	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	H1299 cells	Interactor2 expression	Downregulation
Description	In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.