Detail Information

Basic Information:


  VIRBase ID:  

HHID00105142

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9644

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-200b-3p:           LOX:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-200b-3p LOX
miRBase
Accession/Entrez ID		 MIMAT0000318 4015
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AAT10

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-200b-3p
rs1294480310 chr1:1167169    C/G
rs1390035156 chr1:1167179    T/A
rs373699831 chr1:1167174    A/G
rs370128336 chr1:1167167    G/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase LOX
chr5:121399323-121399324(-) m6A 3'UTR       27773535
chr5:121399903-121399904(-) m6A 3'UTR       27773535
chr5:121399917-121399918(-) m6A 3'UTR       27773535
chr5:121399970-121399971(-) m6A 3'UTR       27773535
chr5:121400002-121400003(-) m6A 3'UTR       27773535
chr5:121400012-121400013(-) m6A 3'UTR       27773535
chr5:121400022-121400023(-) m6A 3'UTR       27773535
chr5:121400071-121400072(-) m6A 3'UTR       27773535
chr5:121400099-121400100(-) m6A 3'UTR       27773535
chr5:121401960-121401961(-) m6A 3'UTR//exon       27773535
chr5:121401990-121401991(-) m6A 3'UTR//exon       27773535
chr5:121402039-121402040(-) m6A 3'UTR//exon       27773535
chr5:121402050-121402051(-) m6A 3'UTR//exon       27773535
chr5:121402069-121402070(-) m6A 3'UTR//exon       27773535
chr5:121402075-121402076(-) m6A 3'UTR//exon       27773535
chr5:121402305-121402306(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr5:121402328-121402329(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr5:121402335-121402336(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr5:121402373-121402374(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr5:121402423-121402424(-) m6A 3'UTR//exon       24981863//22608085
chr5:121411156-121411157(-) m6A 3'UTR//CDS//exon       27773535
chr5:121411164-121411165(-) m6A 3'UTR//CDS//exon       27773535
chr5:121412599-121412600(-) m6A CDS//exon//intron       27773535
chr5:121412771-121412772(-) m6A exon//intron       22608085
chr5:121412894-121412895(-) m6A exon//intron       25456834//24981863//22608085
chr5:121413098-121413099(-) m6A CDS       24284625//24981863//22608085
chr5:121413244-121413245(-) m6A CDS       24284625//24981863//22575960
chr5:121413249-121413250(-) m6A CDS       24284625//24981863//22575960
chr5:121413468-121413469(-) m6A CDS       27773536
chr5:121413531-121413532(-) m6A CDS       27773536
chr5:121413808-121413809(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//27773536//22608085
chr5:121413901-121413902(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//27773536//22575960//22608085
chr5:121413932-121413933(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//27773536//22608085
chr5:121413951-121413952(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773536//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-200b-3p
Cytoplasm Colon cancer cells     20864815
Exosome Urine     26576778
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Colon tissue|Seminal fluid|Tongue tissue     -
Microvesicle Seminal plasma     23539611
Microvesicle Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Nucleolus Breast adenocarcinoma cells (MCF-7)     24918059
LOX
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Endoplasmic reticulum Human fibrosarcoma cells (HT1080)     25753659
Exosome Blood     -
Nucleus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-200b-3p
Gardenin B 96539 Drug sensitive
[[4-(3-Aminophenyl)-2-pyridyl]methyleneamino]thiourea 9556427 Drug resistant
1,9-Pyrazoloanthrone 8515 Drug sensitive
2-(Benzyloxy)-4-methoxybenzaldehyde 820527 Drug resistant
1H-Pyrazolo[3,4-d]pyrimidin-4-amine 75420 Drug sensitive
10,11-Methylenedioxy-20S-camptothecin 72403 Drug resistant
Coptisine chloride 72321 Drug resistant
4H-Furo(3,2-g)(1)benzopyran-4,7,9-trione 68083 Drug resistant
Fludarabine 657237 Drug resistant
Mastoparan 6324633 Drug resistant
Irinotecan 60838 Drug resistant
Gemcitabine 60750 Drug resistant
Topotecan 60700 Drug resistant
3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1-methyl-1H-indole 60147979 Drug sensitive
Cisplatin 5702198 Drug resistant
Thiopyrimidine-CH3 5473238 Drug sensitive
(Z)-3-Iodo-1,2-diphenyl-2-propen-1-one 5468683 Drug sensitive
2-trans-n-Buten-1-yl-estradiol 5468334 Drug resistant
(8R,9S,13S,14S,17S)-13-Methyl-2-[(E)-prop-1-enyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol 5468270 Drug resistant
Selendale 54601159 Drug resistant
Aspiculamycin hcl 54600418 Drug resistant
Simvastatin 54454 Drug resistant
2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug resistant
Xestin A 5352066 Drug sensitive
3-[(4-Methoxyphenyl)thio]-2H-isoindole-1-carbaldehyde 53361730 Drug sensitive
Lovastatin 53232 Drug resistant
Centaureidin 5315773 Drug resistant
Streptonigrin 5298 Drug resistant
Methoxycamptothecin 494089 Drug resistant
Melphalan 460612 Drug resistant
SMA-838 (HCl salt of NSC 188491) 45028430 Drug sensitive
Glaucarubinone 441796 Drug resistant
Ditercalinium dimethanesulfonate dimethanesulfonate 435243 Drug sensitive
Carboplatin 426756 Drug resistant
Diaziquone 42616 Drug resistant
cis-Diamminemalonatoplatinum(II) 422683 Drug resistant
Mitoxantrone 4212 Drug resistant
Menadione 4055 Drug resistant
Fagaronine chloride 40304 Drug resistant
1,2 Benzo-8-(1-hydroxy-2-methylamino propane)-3-phenoxazone 400530 Drug resistant
1-(4'-Phthalimidopropyl-carbonyl)-5-fluorouracil 388985 Drug sensitive
Benzo[1,2-b:5,4-b']dithiophene-4,8-dione, 2-acetyl- 388028 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug sensitive
2-Ethenyl estradiol 381026 Drug resistant
Antineoplastic-655905 375758 Drug resistant
1,2-Dimethyl-phenothiazone 369387 Drug resistant
Diselenide, bis(4-methylphenyl) 365239 Drug resistant
Miltefosine 3599 Drug sensitive
2-Benzoylaminobenzamide, N-thiazol-2-yl- 355710 Drug sensitive
5-Fluorocytosine arabinoside 352938 Drug resistant
Nordracorubin 341882 Drug sensitive
Phomazarin 318385 Drug resistant
2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium acetate 3086131 Drug resistant
Daunorubicin 30323 Drug resistant
Tamoxifen 2733526 Drug sensitive
Chlorambucil 2708 Drug resistant
1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea 26328 Drug resistant
Estramustine 259331 Drug resistant
Fluorene, 9-bromo-2,4,7-trichloro- 248608 Drug resistant
Camptothecin 24360 Drug resistant
5-Nitroso-8-hydroxyquinoline 19103 Drug resistant
{4-[5-(4-Fluoro-phenyl)-3-(1-methyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-phenyl-amine 17892742 Drug sensitive
Edelfosine 1392 Drug sensitive
Gold;(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium 138402869 Drug resistant
Oxanthrazole 135502299 Drug resistant
8-Azahypoxanthine 135410720 Drug resistant
8-Azaguanine 135403646 Drug resistant
Saintopin 131350 Drug resistant
(2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug resistant
Triphenyltin chloride 12540 Drug sensitive
Dabequine 124332 Drug sensitive
3-Bromo-4-(3,3-dimethyl-but-1-ynyl)-2(5H)-furanone 11413833 Drug sensitive
2,2'-Bioxirane 11254 Drug resistant
Clomesone 100651 Drug resistant
N,N-Bis(2-chloroethyl)-p-toluidine 100400 Drug resistant
1h-1,2,4-triazole, 3-(4-diazo-4h-imidazol-5-yl)- - Drug resistant
7h-5,6-dithioleno[4,3-d]uracil - Drug resistant
benzo[1,2-b:4,5-b']dithiophene-4,8-diol, diacetate - Drug resistant
benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug resistant
benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug resistant
bersaldegenin 1,3,5-orthoacetate - Drug resistant
mercury, tetrakis(acetato)(2,3,4,5-thiophenetetrayl)tetra- - Drug resistant
naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug resistant
naphtho[2,3-d]oxazole-4,9-dione, 2-(1,1-dimethylethyl)- - Drug resistant
phosphinic acid, bis(1-aziridinyl)-, 2-naphthyl ester - Drug resistant
piceatannol, 4,3',5'-trimethyl,1s0 - Drug resistant
tris(1,3-diphenylpropane-1,3-dionata)gallium(iii) - Drug resistant
2-(n-d-glysoyl)aminobenzothiazole - Drug resistant
3-farnesylthiopropionamide - Drug resistant
Camptothecin Derivative - Drug resistant
Chlorozotocin - Drug resistant
CI-921: amsacrine derivative - Drug resistant
crotoxin cd - Drug resistant
Indenoisoquinoline derivative - Drug resistant
potassium arsenite - Drug resistant
protein toxin a 23 - mw approx. 6700 - Drug resistant
protein toxin c 10 - mw approx. 6700 - Drug resistant
trimethyl(phenylthio)stannane - Drug resistant
(E)-3-(3,5-dimethoxyphenyl)-1-(4-(quinazolin-4-ylamino)phenyl)prop-2-en-1-one - Drug sensitive
uridine, 5-fluoro-, 2',3',5'-triacetate - Drug sensitive
Artemisinin Dimer - Drug sensitive
secafascaplysin - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-200b-3p
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide 9826528 Drug interaction    RC00002311
10-Hydroxycamptothecin 97226 Drug interaction    RC00002300
Curcumin 969516 Drug interaction    RC00002307
Hydrogen peroxide 784 Drug interaction    RC00002283
Gemcitabine 60750 Drug interaction    RC00002299
Phenylephrine 6041 Drug interaction    RC00002294
Vincristine 5978 Drug interaction    RC00002293
D-Glucose 5793 Drug interaction    RC00002292
Estradiol 5757 Drug interaction    RC00002291
Vorinostat 5311 Drug interaction    RC00002290
Eloxatine 5310940 Drug interaction    RC00002310
Genistein 5280961 Drug interaction    RC00002309
Goserelinacetate 47725 Drug interaction    RC00002298
Tretinoin 444795 Drug interaction    RC00002306
Metformin 4091 Drug interaction    RC00002289
Etoposide 36462 Drug interaction    RC00002297
Paclitaxel 36314 Drug interaction    RC00002296
Flutamide 3397 Drug interaction    RC00002288
5-Fluorouracil 3385 Drug interaction    RC00002287
Doxorubicin 31703 Drug interaction    RC00002295
Cyclophosphamide 2907 Drug interaction    RC00002286
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002285
Tamoxifen 2733526 Drug interaction    RC00002308
Methyltrienolone 261000 Drug interaction    RC00002305
Bicalutamide 2375 Drug interaction    RC00002284
Erlotinib 176870 Drug interaction    RC00002304
Docetaxel 148124 Drug interaction    RC00002303
Celastrol 122724 Drug interaction    RC00002302
Epoxomicin 11226684 Drug interaction    RC00002312
Fulvestrant 104741 Drug interaction    RC00002301
Anthranilamide-pyrazolo[1,5-a]pyrimidine - Drug interaction    RC00002313
CDF(analogues of curcumin) - Drug interaction    RC00002314
CDF(analogues of curcumin) + gemcitabine - Drug interaction    RC00002315
Chemotherapy - Drug interaction    RC00008838
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-200b-3p
Cisplatin 5702198       25356050

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-200b-3p
Interactor2: LOX

Evidence Support:


Strong-Evidence Luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence miRanda//miRBase//PicTar//PITA//Targetscan
Support Database ViRBase

References:


PMID 33675361 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line MCF-7 cells Interactor2 expression Downregulation
Description In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.

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