Basic Information:

  VIRBase ID:  

HHID00105141

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2494

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-224-5p:  MIMAT0000281          TMPRSS2:  NM_001135099     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-224-5p	TMPRSS2
miRBase Accession/Entrez ID	MIMAT0000281	7113
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PRSS10

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-224-5p	rs1035248243 chrX:151958637    A/G rs1222660556 chrX:151958634    G/A rs1267133168 chrX:151958642    T/C rs1337133345 chrX:151958637    AC/A rs370848505 chrX:151958633    C/T rs752887123 chrX:151958640    ACT/A rs756560331 chrX:151958638    C/T rs757685917 chrX:151958628    C/G rs779547865 chrX:151958644    G/T rs781374253 chrX:151958630    A/G rs1261723009 chrX:151958645    T/G rs1323267730 chrX:151958649    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TMPRSS2	chr21:42853862(-) A-I      intronic chr21:42853848(-) A-I      intronic chr21:42853888(-) A-I      intronic chr21:42853850(-) A-I      intronic chr21:42853879(-) A-I      intronic chr21:42857482(-) A-I      intronic chr21:42857493(-) A-I      intronic chr21:42857494(-) A-I      intronic chr21:42857532(-) A-I      intronic chr21:42861840(-) A-I      intronic chr21:42863176(-) A-I      intronic chr21:42863181(-) A-I      intronic chr21:42864020(-) A-I      intronic chr21:42857454(-) A-I      intronic chr21:42852821(-) A-I      intronic chr21:42852811(-) A-I      intronic chr21:42868840(-) A-I      intronic chr21:42864037(-) A-I      intronic chr21:42852802(-) A-I      intronic chr21:42852784(-) A-I      intronic chr21:42852783(-) A-I      intronic chr21:42852698(-) A-I      intronic chr21:42868853(-) A-I      intronic chr21:42853773(-) A-I      intronic chr21:42853747(-) A-I      intronic chr21:42852838(-) A-I      intronic chr21:42868879(-) A-I      intronic chr21:42853786(-) A-I      intronic chr21:42853787(-) A-I      intronic chr21:42853866(-) A-I      intronic chr21:42853876(-) A-I      intronic chr21:42853901(-) A-I      intronic chr21:42853902(-) A-I      intronic chr21:42853905(-) A-I      intronic chr21:42853936(-) A-I      intronic chr21:42857436(-) A-I      intronic chr21:42852837(-) A-I      intronic chr21:42852694(-) A-I      intronic chr21:42857467(-) A-I      intronic chr21:42857468(-) A-I      intronic chr21:42857476(-) A-I      intronic chr21:42859902(-) A-I      ncRNA chr21:42859884(-) A-I      ncRNA chr21:42859893(-) A-I      ncRNA chr21:42868835(-) A-I      intronic chr21:42859992(-) A-I      intronic chr21:42855936(-) A-I      intronic chr21:42868944(-) A-I      intronic chr21:42868836(-) A-I      intronic chr21:42852668(-) A-I      intronic chr21:42859993(-) A-I      intronic chr21:42869010(-) A-I      intronic chr21:42863353(-) A-I      intronic chr21:42868900(-) A-I      intronic chr21:42868945(-) A-I      intronic chr21:42852703(-) A-I      intronic chr21:42860827(-) A-I      intronic chr21:42859858(-) A-I      ncRNA chr21:42859831(-) A-I      ncRNA chr21:42859844(-) A-I      ncRNA chr21:42858403(-) A-I      ncRNA

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TMPRSS2	chr21:42858403(-) A-I intron -    15342557 chr21:42858406(-) A-I intron -    15342557 chr21:42859670(-) A-I intron -    15342557 chr21:42859831(-) A-I intron -    15342557   //15258596 chr21:42859844(-) A-I intron -    15342557   //15258596 chr21:42859858(-) A-I intron -    15342557   //15258596 chr21:42859884(-) A-I intron -    15342557   //15258596 chr21:42859893(-) A-I intron -    15342557   //15258596 chr21:42859902(-) A-I intron -    15342557   //15258596 chr21:42868835(-) A-I intron -    15342557 chr21:42868836(-) A-I intron -    15342557 chr21:42868864(-) A-I intron -    15342557 chr21:42868900(-) A-I intron -    15342557 chr21:42868905(-) A-I intron -    15342557 chr21:42868944(-) A-I intron -    15342557 chr21:42868945(-) A-I intron -    15342557 chr21:42868950(-) A-I intron -    15342557 chr21:42869010(-) A-I intron -    15342557 chr21:42869014(-) A-I intron -    15342557 chr21:42869073(-) A-I intron -    15342557 chr21:42853823(-) A-I intron -    21960545 chr21:42853826(-) A-I intron -    21960545 chr21:42853866(-) A-I intron -    21960545 chr21:42855839(-) A-I intron -    21960545 chr21:42855936(-) A-I intron -    21960545 chr21:42855984(-) A-I intron -    21960545 chr21:42857419(-) A-I intron -    21960545 chr21:42857454(-) A-I intron -    21960545 chr21:42857468(-) A-I intron -    21960545 chr21:42857493(-) A-I intron -    21960545

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMPRSS2	chr21:42836773-42836774(-) m6A 3'UTR       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-224-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma|Serum     24683445 Exosome Breast milk|Endothelial cells|Tongue tissue     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	TMPRSS2	Exosome Blood     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-224-5p	4-Thiazolidinone, 3-(1-phenylethyl)-2-thioxo- 99773 Drug resistant Tetrangulol 99188 Drug resistant S-Decyl p-toluenethiosulfonate 97461 Drug resistant Ambrosin 92119 Drug resistant Jacaranone 73307 Drug resistant Fascaplysine 73292 Drug resistant Resorufin 69462 Drug resistant 4H-Furo(3,2-g)(1)benzopyran-4,7,9-trione 68083 Drug resistant Baccharinoid B4 6711263 Drug resistant Palisol 6393559 Drug resistant Jatrophon 6325446 Drug resistant Methylene blue 6099 Drug resistant Verrucarin A, 3'-(acetyloxy)-7'-deoxo-2'-deoxy-4'-hydroxy-7'-(1-hydroxyethyl)- 5933240 Drug resistant Cisplatin 5702198 Drug resistant Adenosine, 2-bromo-2'-deoxy- 55914 Drug resistant [3-Acetyloxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenyl] acetate 5473049 Drug resistant 2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug resistant Alvocidib 5287969 Drug resistant Patulin 4696 Drug resistant 1-[2-(3-Chlorophenyl)-2-oxoethyl]-2-acetylbenzimidazole 46911792 Drug resistant Menadione 4055 Drug resistant trans-Bis(acetato)amminepyridineplatinum(II) 405450 Drug resistant 3-(3-Hydroxy-4-methoxybenzyl)-5,7-dihydroxychroman-4-one 404571 Drug resistant Antineoplastic-690271 391308 Drug resistant Antineoplastic-690270 391307 Drug resistant Kuanoniamine A 390989 Drug resistant Isopropyl 4-(2-(4-bromo-2,5-dihydroxyphenyl)ethyl)benzoate 389288 Drug resistant 2-(p-Toluene sulfonyl)-L-glutamic acid phenyl hydrazide 388355 Drug resistant 2-Ethenyl estradiol 381026 Drug resistant 19-Hydroxy-8-O-methyltetrangulol 379539 Drug resistant N-(8-Hydroxy-6-methyl-1,4-dioxo-1,4-dihydro-2-naphthalenyl)acetamide 377214 Drug resistant 5,8-Dihydroxy-2-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]naphthalene-1,4-dione 376948 Drug resistant 5,8-Dihydroxy-2-(4-(2-pyridinyl)-1-piperazinyl)naphthoquinone 376947 Drug resistant 1H-Benz[g]indol-5-ol, 2-phenyl 371327 Drug resistant 1,2-Dimethyl-phenothiazone 369387 Drug resistant Idebenone 3686 Drug resistant Diisopropoxybis(1,4-naphthochinone-2-olato)titanium(IV) 368058 Drug resistant Tris(tropolonato)samarium(III) 366262 Drug resistant 1,1-Dioxido-1,5-benzothiazepin-4-yl methyl ether 358940 Drug resistant 1-Piperidinesulfonamide, N-(7-amino-2-naphthalenyl)- 333624 Drug resistant Zonarol 332671 Drug resistant 12-Hydroxyindolo[2,1-b]quinazoline-6(12H)-one 324952 Drug resistant Phenanthrene-9,10-diimine 2981 Drug resistant D-Arabinose, 5-O-trityl-tribenzoate 265952 Drug resistant 2'-Deoxy-5-(trifluoromethyl)uridine 253083 Drug resistant Cytembena 23665583 Drug resistant Methyl 1,6,8,14a-tetrahydroxy-11-[(4-hydroxy-3,5-dimethoxy-6-methyloxan-2-yl)amino]-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-5,6-dihydrobenzo[a]tetracene-2-carboxylate 197261 Drug resistant Trihexyltetradecylphosphonium hexafluorophosphate 16212610 Drug resistant Jolkinolide B 161954 Drug resistant [(1R,2R,4R,6E,9R,10S)-2,7-Dimethyl-5,8,14-trioxo-10-prop-1-en-2-yl-15-oxatricyclo[11.2.1.02,4]hexadeca-6,13(16)-dien-9-yl] acetate 15384977 Drug resistant 5-Hydroxypicolinaldehyde thiosemicarbazone 135453292 Drug resistant Dibutyltin dichloride 12688 Drug resistant (1S,3R,7Z,9R,12S,13R,15S)-13-Butan-2-yl-13-hydroxy-3,7,12-trimethyl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 11972510 Drug resistant 6-[4-(1-Cyclohexenyl)-1,3-butadiyn-1-yl]-2(2H)-pyranone 10263039 Drug resistant Ethyl 2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)acetate 100323 Drug resistant 1h-naphth[2,3-d]imidazole-4,9-dione, 1-ethyl-2-methyl- - Drug resistant 3,5-bis(4-hydroxy-3-methoxystyryl)-N-(4-fluorophenyl)-1H-pyrazole-1-carboxamide - Drug resistant 4(3h)-quinazolinone, 2,2'-thiobis[3-amino- - Drug resistant 4,5,7-trihydroxy-2-anthraquinonecarboxaldehyde - Drug resistant 9-cis-retinol,palmitic acid ester - Drug resistant benzene, 1-methoxy-4-(2-nitroethenyl)-, (e)- - Drug resistant benzo[1,2-b:4,5-b']dithiophene-4,8-diol, diacetate - Drug resistant benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug resistant N-(3-(1H-imidazol-1-yl)propyl)-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8 tetrahydronaphthalen-2-yl)vinyl)benzamide - Drug resistant naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug resistant naphtho[2,3-d]-1,3-dioxepin-6,11-dione, 4-methyl- - Drug resistant naphtho[2,3-d]oxazole-4,9-dione, 2-(1,1-dimethylethyl)- - Drug resistant sp-adenosine-3',5'-cyclic phosphorothioate - Drug resistant 2-(1-(2-fluorophenylsulfonyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide - Drug resistant 2-(1-(4-chlorophenylsulfonyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide - Drug resistant antineoplastic-d665827 - Drug resistant bisacetylacetone ethylenediimine tin - Drug resistant Camptothecin Derivative - Drug resistant chlorambucil-spermidine - Drug resistant potassium[trichloro(isopropylamine)platinum] - Drug resistant rh(iii)-amodiaquine - Drug resistant somatostatin analog in diacetic form mw=1067.2 - Drug resistant protein: pahiv4 - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-224-5p	10-Hydroxycamptothecin 97226 Drug interaction    RC00002268 Formaldehyde 712 Drug interaction    RC00002259 Atorvastatin 60823 Drug interaction    RC00002267 Gemcitabine 60750 Drug interaction    RC00002266 Vincristine 5978 Drug interaction    RC00002263 Prednisone 5865 Drug interaction    RC00002262 Eloxatine 5310940 Drug interaction    RC00002274 Paclitaxel 36314 Drug interaction    RC00002265 5-Fluorouracil 3385 Drug interaction    RC00002261 Doxorubicin 31703 Drug interaction    RC00002264 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002260 Sorafenib 216239 Drug interaction    RC00002273 Erlotinib 176870 Drug interaction    RC00002272 Methotrexate 126941 Drug interaction    RC00002271 Gefitinib 123631 Drug interaction    RC00002270 Ginsenoside Rh2 119307 Drug interaction    RC00002269 FdUMP[10] - Drug interaction    RC00002275 Rituximab - Drug interaction    RC00002276

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-224-5p	Cisplatin 5702198       25017423 Cisplatin 5702198       26676926

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-224-5p
Interactor2: TMPRSS2

Evidence Support:

Prediction-Evidence	microT//miRanda//miRMap//PicTar//PITA//Targetscan
Support Database	ViRBase

References:

PMID	33428154	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	To explore the regulatory relationship between the 5 key genes, 3 coronavirus-related genes (ACE2, TMPRSS2, BSG), and their target miRNA, we used 6 miRNA target prediction databases to predict the target miRNA of these genes.