Detail Information

Basic Information:


  VIRBase ID:  

HHID00105137

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2483

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-214-3p:           TMPRSS2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-214-3p TMPRSS2
miRBase
Accession/Entrez ID		 MIMAT0000271 7113
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PRSS10

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-214-3p
rs1484050967 chr1:172138816    A/G
rs1484050967 chr1:172138816    A/T
rs760725207 chr1:172138828    T/C
rs766486759 chr1:172138829    G/A
rs767404661 chr1:172138817    C/T
rs750386761 chr1:172138827    G/A
rs754055278 chr1:172138831    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMPRSS2
chr21:42853862(-) A-I      intronic
chr21:42853848(-) A-I      intronic
chr21:42853888(-) A-I      intronic
chr21:42853850(-) A-I      intronic
chr21:42853879(-) A-I      intronic
chr21:42857482(-) A-I      intronic
chr21:42857493(-) A-I      intronic
chr21:42857494(-) A-I      intronic
chr21:42857532(-) A-I      intronic
chr21:42861840(-) A-I      intronic
chr21:42863176(-) A-I      intronic
chr21:42863181(-) A-I      intronic
chr21:42864020(-) A-I      intronic
chr21:42857454(-) A-I      intronic
chr21:42852821(-) A-I      intronic
chr21:42852811(-) A-I      intronic
chr21:42868840(-) A-I      intronic
chr21:42864037(-) A-I      intronic
chr21:42852802(-) A-I      intronic
chr21:42852784(-) A-I      intronic
chr21:42852783(-) A-I      intronic
chr21:42852698(-) A-I      intronic
chr21:42868853(-) A-I      intronic
chr21:42853773(-) A-I      intronic
chr21:42853747(-) A-I      intronic
chr21:42852838(-) A-I      intronic
chr21:42868879(-) A-I      intronic
chr21:42853786(-) A-I      intronic
chr21:42853787(-) A-I      intronic
chr21:42853866(-) A-I      intronic
chr21:42853876(-) A-I      intronic
chr21:42853901(-) A-I      intronic
chr21:42853902(-) A-I      intronic
chr21:42853905(-) A-I      intronic
chr21:42853936(-) A-I      intronic
chr21:42857436(-) A-I      intronic
chr21:42852837(-) A-I      intronic
chr21:42852694(-) A-I      intronic
chr21:42857467(-) A-I      intronic
chr21:42857468(-) A-I      intronic
chr21:42857476(-) A-I      intronic
chr21:42859902(-) A-I      ncRNA
chr21:42859884(-) A-I      ncRNA
chr21:42859893(-) A-I      ncRNA
chr21:42868835(-) A-I      intronic
chr21:42859992(-) A-I      intronic
chr21:42855936(-) A-I      intronic
chr21:42868944(-) A-I      intronic
chr21:42868836(-) A-I      intronic
chr21:42852668(-) A-I      intronic
chr21:42859993(-) A-I      intronic
chr21:42869010(-) A-I      intronic
chr21:42863353(-) A-I      intronic
chr21:42868900(-) A-I      intronic
chr21:42868945(-) A-I      intronic
chr21:42852703(-) A-I      intronic
chr21:42860827(-) A-I      intronic
chr21:42859858(-) A-I      ncRNA
chr21:42859831(-) A-I      ncRNA
chr21:42859844(-) A-I      ncRNA
chr21:42858403(-) A-I      ncRNA
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TMPRSS2
chr21:42858403(-) A-I intron -    15342557
chr21:42858406(-) A-I intron -    15342557
chr21:42859670(-) A-I intron -    15342557
chr21:42859831(-) A-I intron -    15342557   //15258596
chr21:42859844(-) A-I intron -    15342557   //15258596
chr21:42859858(-) A-I intron -    15342557   //15258596
chr21:42859884(-) A-I intron -    15342557   //15258596
chr21:42859893(-) A-I intron -    15342557   //15258596
chr21:42859902(-) A-I intron -    15342557   //15258596
chr21:42868835(-) A-I intron -    15342557
chr21:42868836(-) A-I intron -    15342557
chr21:42868864(-) A-I intron -    15342557
chr21:42868900(-) A-I intron -    15342557
chr21:42868905(-) A-I intron -    15342557
chr21:42868944(-) A-I intron -    15342557
chr21:42868945(-) A-I intron -    15342557
chr21:42868950(-) A-I intron -    15342557
chr21:42869010(-) A-I intron -    15342557
chr21:42869014(-) A-I intron -    15342557
chr21:42869073(-) A-I intron -    15342557
chr21:42853823(-) A-I intron -    21960545
chr21:42853826(-) A-I intron -    21960545
chr21:42853866(-) A-I intron -    21960545
chr21:42855839(-) A-I intron -    21960545
chr21:42855936(-) A-I intron -    21960545
chr21:42855984(-) A-I intron -    21960545
chr21:42857419(-) A-I intron -    21960545
chr21:42857454(-) A-I intron -    21960545
chr21:42857468(-) A-I intron -    21960545
chr21:42857493(-) A-I intron -    21960545

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMPRSS2
chr21:42836773-42836774(-) m6A 3'UTR       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-214-3p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome Primary ovarian tumor cells|Serum     18589210
Exosome Plasma     19289371
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Follicular fluid     23666971
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Nasopharyngeal carcinoma cells     20498841
TMPRSS2
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-214-3p
Gemcitabine 60750 Drug interaction    RC00002087
Vincristine 5978 Drug interaction    RC00002082
Prednisone 5865 Drug interaction    RC00002081
Sunitinib 5329102 Drug interaction    RC00002093
Eloxatine 5310940 Drug interaction    RC00002092
Imatinib 5291 Drug interaction    RC00002080
Decitabine 451668 Drug interaction    RC00002091
Trichostatin A 444732 Drug interaction    RC00002090
Naringin 442428 Drug interaction    RC00002089
Desflurane 42113 Drug interaction    RC00002086
Isoflurane 3763 Drug interaction    RC00002079
Paclitaxel 36314 Drug interaction    RC00002085
Doxorubicin 31703 Drug interaction    RC00002084
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002078
Verapamil 2520 Drug interaction    RC00002077
Arsenic trioxide 14888 Drug interaction    RC00002083
Gefitinib 123631 Drug interaction    RC00002088
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00002094
Bio-Oss - Drug interaction    RC00002095
DNA methyltransferases (DNMTs) + 5-azacytidine (5-AzaC) - Drug interaction    RC00002096
Glucocorticoid - Drug interaction    RC00002097
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-214-3p
Cisplatin 5702198       29036598

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-214-3p
Interactor2: TMPRSS2

Evidence Support:


Prediction-Evidence miRanda//miRBase//miRDB//miRWalk//Targetscan
Support Database ViRBase

References:


[1]PMID 32992681 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Table 2 shows a list of novel potential candidate miRNAs against TMPRSS2 gene which were not studied previously.
[2]PMID 33359190 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Albeit, list of putative miRNAs (11 miRNAs) retrieved as result from all the three prediction tools is represented in Fig. 2f.

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