Detail Information

Basic Information:


  VIRBase ID:  

HHID00105131

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2499

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-182-5p:           TMPRSS2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-182-5p TMPRSS2
miRBase
Accession/Entrez ID		 MIMAT0000259 7113
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PRSS10

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-182-5p
rs1164249188 chr7:129770446    CA/C
rs1232455061 chr7:129770449    T/G
rs1303310695 chr7:129770447    A/C
rs1331665171 chr7:129770448    G/A
rs750597507 chr7:129770453    A/G
rs760187044 chr7:129770452    G/A
rs765932794 chr7:129770462    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMPRSS2
chr21:42853862(-) A-I      intronic
chr21:42853848(-) A-I      intronic
chr21:42853888(-) A-I      intronic
chr21:42853850(-) A-I      intronic
chr21:42853879(-) A-I      intronic
chr21:42857482(-) A-I      intronic
chr21:42857493(-) A-I      intronic
chr21:42857494(-) A-I      intronic
chr21:42857532(-) A-I      intronic
chr21:42861840(-) A-I      intronic
chr21:42863176(-) A-I      intronic
chr21:42863181(-) A-I      intronic
chr21:42864020(-) A-I      intronic
chr21:42857454(-) A-I      intronic
chr21:42852821(-) A-I      intronic
chr21:42852811(-) A-I      intronic
chr21:42868840(-) A-I      intronic
chr21:42864037(-) A-I      intronic
chr21:42852802(-) A-I      intronic
chr21:42852784(-) A-I      intronic
chr21:42852783(-) A-I      intronic
chr21:42852698(-) A-I      intronic
chr21:42868853(-) A-I      intronic
chr21:42853773(-) A-I      intronic
chr21:42853747(-) A-I      intronic
chr21:42852838(-) A-I      intronic
chr21:42868879(-) A-I      intronic
chr21:42853786(-) A-I      intronic
chr21:42853787(-) A-I      intronic
chr21:42853866(-) A-I      intronic
chr21:42853876(-) A-I      intronic
chr21:42853901(-) A-I      intronic
chr21:42853902(-) A-I      intronic
chr21:42853905(-) A-I      intronic
chr21:42853936(-) A-I      intronic
chr21:42857436(-) A-I      intronic
chr21:42852837(-) A-I      intronic
chr21:42852694(-) A-I      intronic
chr21:42857467(-) A-I      intronic
chr21:42857468(-) A-I      intronic
chr21:42857476(-) A-I      intronic
chr21:42859902(-) A-I      ncRNA
chr21:42859884(-) A-I      ncRNA
chr21:42859893(-) A-I      ncRNA
chr21:42868835(-) A-I      intronic
chr21:42859992(-) A-I      intronic
chr21:42855936(-) A-I      intronic
chr21:42868944(-) A-I      intronic
chr21:42868836(-) A-I      intronic
chr21:42852668(-) A-I      intronic
chr21:42859993(-) A-I      intronic
chr21:42869010(-) A-I      intronic
chr21:42863353(-) A-I      intronic
chr21:42868900(-) A-I      intronic
chr21:42868945(-) A-I      intronic
chr21:42852703(-) A-I      intronic
chr21:42860827(-) A-I      intronic
chr21:42859858(-) A-I      ncRNA
chr21:42859831(-) A-I      ncRNA
chr21:42859844(-) A-I      ncRNA
chr21:42858403(-) A-I      ncRNA
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TMPRSS2
chr21:42858403(-) A-I intron -    15342557
chr21:42858406(-) A-I intron -    15342557
chr21:42859670(-) A-I intron -    15342557
chr21:42859831(-) A-I intron -    15342557   //15258596
chr21:42859844(-) A-I intron -    15342557   //15258596
chr21:42859858(-) A-I intron -    15342557   //15258596
chr21:42859884(-) A-I intron -    15342557   //15258596
chr21:42859893(-) A-I intron -    15342557   //15258596
chr21:42859902(-) A-I intron -    15342557   //15258596
chr21:42868835(-) A-I intron -    15342557
chr21:42868836(-) A-I intron -    15342557
chr21:42868864(-) A-I intron -    15342557
chr21:42868900(-) A-I intron -    15342557
chr21:42868905(-) A-I intron -    15342557
chr21:42868944(-) A-I intron -    15342557
chr21:42868945(-) A-I intron -    15342557
chr21:42868950(-) A-I intron -    15342557
chr21:42869010(-) A-I intron -    15342557
chr21:42869014(-) A-I intron -    15342557
chr21:42869073(-) A-I intron -    15342557
chr21:42853823(-) A-I intron -    21960545
chr21:42853826(-) A-I intron -    21960545
chr21:42853866(-) A-I intron -    21960545
chr21:42855839(-) A-I intron -    21960545
chr21:42855936(-) A-I intron -    21960545
chr21:42855984(-) A-I intron -    21960545
chr21:42857419(-) A-I intron -    21960545
chr21:42857454(-) A-I intron -    21960545
chr21:42857468(-) A-I intron -    21960545
chr21:42857493(-) A-I intron -    21960545

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMPRSS2
chr21:42836773-42836774(-) m6A 3'UTR       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-182-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Pooled sera     27278097
Exosome Bronchoalveolar lavage fluid|Pooled sera     27278097
Exosome Human milk     28688106
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Renal cancer cells     21670082
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Serum     24797360
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Colon adenocarcinoma cells     20864815
TMPRSS2
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-182-5p
Sensorad 99342 Drug sensitive
N-(6-Phenyl-1H-indazol-3-yl)cyclopropanecarboxamide 6539593 Drug sensitive
Ixabepilone 6445540 Drug sensitive
(1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
Tiazofurin 457954 Drug sensitive
Antineoplastic-645804 371505 Drug sensitive
(4-Methoxyphenyl)-(3,4,5-trimethoxyphenyl)methanol 368140 Drug sensitive
Predorine 333830 Drug sensitive
4-Benzoyl-3H-benzo[f]quinoline-3-carbonitrile 262649 Drug sensitive
Nile Blue 2B 20520 Drug sensitive
5-Chloro-2[(E)-2-(4-nitrophenyl)vinyl]-1H-benzimidazole 15373173 Drug sensitive
(Z)-5-chloro-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive
benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-182-5p
Hyaluronidase 91820602 Drug interaction    RC00001904
Formaldehyde 712 Drug interaction    RC00001887
Ethanol 702 Drug interaction    RC00001886
Atorvastatin 60823 Drug interaction    RC00001897
D-Glucose 5793 Drug interaction    RC00001894
Temozolomide 5394 Drug interaction    RC00001893
Vorinostat 5311 Drug interaction    RC00001892
Eloxatine 5310940 Drug interaction    RC00001902
Decitabine 451668 Drug interaction    RC00001900
Trichostatin A 444732 Drug interaction    RC00001899
Paclitaxel 36314 Drug interaction    RC00001896
5-Fluorouracil 3385 Drug interaction    RC00001891
Fentanyl 3345 Drug interaction    RC00001890
Doxorubicin 31703 Drug interaction    RC00001895
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001889
Tamoxifen 2733526 Drug interaction    RC00001901
Verapamil 2520 Drug interaction    RC00001888
Olaparib 23725625 Drug interaction    RC00001903
Aldesleukin - Drug interaction    RC00001905
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001906
5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) - Drug interaction    RC00001907
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001908
Marine fungal metabolite 1386A - Drug interaction    RC00001909
Chemotherapy - Drug interaction    RC00008834
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-182-5p
Tamoxifen 2733526       31153828
Veliparib 11960529       31063487
Serdemetan 11609586       31063487

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-182-5p
Interactor2: TMPRSS2

Evidence Support:


Prediction-Evidence microT//miRanda//miRBase//miRMap//miRWalk//PicTar//PITA//Targetscan
Support Database ViRBase

References:


[1]PMID 33428154 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description To explore the regulatory relationship between the 5 key genes, 3 coronavirus-related genes (ACE2, TMPRSS2, BSG), and their target miRNA, we used 6 miRNA target prediction databases to predict the target miRNA of these genes.
[2]PMID 32992681 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Table 2 shows a list of novel potential candidate miRNAs against TMPRSS2 gene which were not studied previously.

Starting a new search, please wait ...