Basic Information:

  VIRBase ID:  

HHID00105124

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9526

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-34a-5p:  MIMAT0000255          IMPDH2:  NM_000884     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-34a-5p	IMPDH2
miRBase Accession/Entrez ID	MIMAT0000255	3615
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	IMPD2//IMPDH-II

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-34a-5p	rs1230701086 chr1:9151742    G/T rs35301225 chr1:9151743    C/A rs35301225 chr1:9151743    C/T rs750826817 chr1:9151744    T/A rs768065817 chr1:9151739    C/T rs1407488784 chr1:9151753    G/A rs369892834 chr1:9151752    T/C rs756492579 chr1:9151754    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IMPDH2	chr3:49061985-49061986(-) Am CDS//exon       - chr3:49062071-49062072(-) m6A exon//intron       22575960 chr3:49062121-49062122(-) m6A CDS//exon       22575960 chr3:49062184-49062185(-) m6A CDS//exon       22575960 chr3:49062836-49062837(-) m6A exon//intron       24284625//24981863//22608085 chr3:49064212-49064213(-) m6A CDS//exon       26404942 chr3:49064243-49064244(-) m6A CDS//exon       26404942//22575960 chr3:49064250-49064251(-) Am CDS//exon       - chr3:49064253-49064254(-) Am CDS//exon       - chr3:49064265-49064266(-) m6A CDS//exon       26404942//22575960 chr3:49064361-49064362(-) m6A exon//intron       24981863//26404942//22575960 chr3:49064460-49064461(-) m6A CDS//exon       26404942//22575960 chr3:49065163-49065164(-) m6A CDS//exon       26404942//22575960 chr3:49065188-49065189(-) m6A CDS//exon       26404942//22575960 chr3:49065236-49065237(-) m6A CDS//exon       22575960 chr3:49065323-49065324(-) m6A CDS//exon       22575960 chr3:49065517-49065518(-) m6A exon//intron       24284625//24981863 chr3:49065553-49065554(-) m6A exon//intron       24284625//24981863 chr3:49065696-49065697(-) Am CDS//exon//intron       - chr3:49065900-49065901(-) m6A CDS//exon       - chr3:49065925-49065926(-) m6A CDS//exon       - chr3:49065963-49065964(-) m6A CDS//exon       - chr3:49066027-49066028(-) m6A exon//intron       - chr3:49066732-49066733(-) m6A CDS//exon       24284625//27773535//22575960 chr3:49066808-49066809(-) m6A 5'UTR//exon       24284625//27773535//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-34a-5p	Cytoplasm Neural progenitor cells     21363885 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Primary dendritic cells     21505438 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome B lymphoblastoid cells     - Extracellular vesicle Human mesenchymal stem cells     25669974 Microvesicle Seminal plasma     23539611 Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Myotube     27396686 Mitochondrion Skeletal muscle cells     27563705 Mitochondrion Human umbilical vein endothelial cells     30348904 Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	IMPDH2	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-34a-5p	Curcumin 969516 Drug resistant 3-Hydroxy-N-1-naphthyl-2-naphthamide 67241 Drug sensitive Tacacoside A2 6712615 Drug sensitive Cordycepin 6303 Drug resistant Thapsia villosa compd 5477211 Drug resistant 5-(6-Methoxybenzimidazol-1-yl)-3-[1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide 53338692 Drug resistant 5-Iodo-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 45029271 Drug resistant H-Cys(mmt)-OH 420454 Drug resistant 3-(3-Hydroxy-4-methoxybenzyl)-5,7-dihydroxychroman-4-one 404571 Drug resistant (2S)-2,6-Diamino-N-[4-(5-amino-6,8-difluoro-7-methyl-4-oxochromen-2-yl)-2-fluorophenyl]hexanamide;methanesulfonic acid 399587 Drug sensitive Antineoplastic-615804 355949 Drug resistant Pyrazoloacridine 339455 Drug resistant AT 116, benzylamine salt 282523 Drug resistant L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug resistant 5-(1H-1,3-Benzodiazol-1-yl)-3-[(2-bromophenyl)methoxy]thiophene-2-carboxamide 25263083 Drug resistant Antimycin A3 245869 Drug sensitive 1-[1-(Diethylamino)propan-2-ylamino]-4-nitrothioxanthen-9-one;chloride 24186469 Drug sensitive Nile Blue 2B 20520 Drug sensitive 1H-Indole-3-methanol, 1-[(4-chlorophenyl)methyl]- 11821732 Drug sensitive 2-(naphthalen-2-yl)-1-(3,4,5-trimethoxyphenyl)-1h-imidazole - Drug resistant 2,2'-thienyl selenophenyl-5',2-thiophene - Drug resistant 3-piperidinone, 3,5-bis[(3,4-dichlorophenyl)methylene]- - Drug resistant 6-Chloro-5-[2-(1H-imidazol-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one - Drug resistant benzofuro[3,2-b]benzopyran-11-one, 3-hydroxy- - Drug resistant l-cysteine, s-[(4-methylphenyl)diphenylmethyl]- (9ci) - Drug resistant Paracymene-ruthenium(II)-[N-(3-(1H-imidazol-1-yl)propyl)-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8 tetrahydronaphthalen-2-yl)vinyl)benzamide] dichloride - Drug resistant (-)-dactylolide - Drug resistant 2-amino-5-chloro-6-(2-thiazolyloxy)-benzimidazole - Drug resistant Basic Fuchsin - Drug resistant organosulfur compound - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-34a-5p	Palmitic acid 985 Drug interaction    RC00001744 Curcumin 969516 Drug interaction    RC00001775 Formaldehyde 712 Drug interaction    RC00001743 Oxaliplatine 6857599 Drug interaction    RC00001784 Gemcitabine 60750 Drug interaction    RC00001763 Cholesterol 5997 Drug interaction    RC00001754 Vincristine 5978 Drug interaction    RC00001753 Prednisolone 5755 Drug interaction    RC00001752 Mitomycin 5746 Drug interaction    RC00001751 Doxycycline 54671203 Drug interaction    RC00001786 Sunitinib 5329102 Drug interaction    RC00001783 Vorinostat 5311 Drug interaction    RC00001750 Eloxatine 5310940 Drug interaction    RC00001782 delta-Tocotrienol 5282350 Drug interaction    RC00001781 Genistein 5280961 Drug interaction    RC00001780 Quercetin 5280343 Drug interaction    RC00001779 Decitabine 451668 Drug interaction    RC00001774 Diethylstilbestrol 448537 Drug interaction    RC00001773 Trichostatin A 444732 Drug interaction    RC00001772 Cyclopamine 442972 Drug interaction    RC00001771 Vemurafenib 42611257 Drug interaction    RC00001785 Etoposide 36462 Drug interaction    RC00001762 Paclitaxel 36314 Drug interaction    RC00001761 5-Fluorouracil 3385 Drug interaction    RC00001749 Emodin 3220 Drug interaction    RC00001748 Doxorubicin 31703 Drug interaction    RC00001760 Daunorubicin 30323 Drug interaction    RC00001759 Lithium 3028194 Drug interaction    RC00001778 Lithium ion 28486 Drug interaction    RC00001758 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001747 Tamoxifen 2733526 Drug interaction    RC00001777 Verapamil 2520 Drug interaction    RC00001746 Hyaluronan 24759 Drug interaction    RC00001757 Camptothecin 24360 Drug interaction    RC00001756 Benzene 241 Drug interaction    RC00001742 Aspirin 2244 Drug interaction    RC00001745 Lenalidomide 216326 Drug interaction    RC00001770 Sorafenib 216239 Drug interaction    RC00001769 Erlotinib 176870 Drug interaction    RC00001768 Capsaicin 1548943 Drug interaction    RC00001776 Arsenic trioxide 14888 Drug interaction    RC00001755 Docetaxel 148124 Drug interaction    RC00001767 Leucovorin 135403648 Drug interaction    RC00001787 Gefitinib 123631 Drug interaction    RC00001766 Paclitaxel + Cyclopamine - Drug interaction    RC00001795 platinum-based doublet chemotherapy - Drug interaction    RC00001788 TRAIL therapy - Drug interaction    RC00001789 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001790 Anthranilamide-pyrazolo[1,5-a]pyrimidine - Drug interaction    RC00001791 CDF(analogues of curcumin) - Drug interaction    RC00001792 Glucocorticoid - Drug interaction    RC00001793 Nicotinamide + Etoposide - Drug interaction    RC00001794

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-34a-5p	Cisplatin 5702198       27056900 Cisplatin 5702198       28073349 Cisplatin 5702198       28281638 Carboplatin 426756       27056900 Carboplatin 426756       28073349 Etoposide 36462       27056900 Etoposide 36462       28073349 Etoposide 36462       28281638 Doxorubicin 31703       27056900 Doxorubicin 31703       28073349 Doxorubicin 31703       28281638 Methotrexate 126941       27056900 Methotrexate 126941       28281638

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-34a-5p
Interactor2: IMPDH2

Evidence Support:

Strong-Evidence	Luciferase assay//Northern blot//qPCR
Support Database	ViRBase

References:

PMID	33675361	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	H1299 cells//HCT116 cells	Interactor2 expression	Downregulation
Description	In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.