Detail Information

Basic Information:


  VIRBase ID:  

HHID00105118

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2494

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-129-5p:           TLR7:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-129-5p TLR7
miRBase
Accession/Entrez ID		 MIMAT0000242 51284
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IMD74//TLR7-like

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-129-5p
rs1242359724 chr7:128207890    G/A
rs1263648656 chr7:128207889    G/A
rs1274463608 chr7:128207884    G/A
rs1279636719 chr7:128207895    G/C
rs1279636719 chr7:128207895    G/T
rs756117952 chr7:128207886    T/C
rs779889090 chr7:128207891    G/T
rs1229617898 chr11:43581416    G/A
rs1289973713 chr11:43581418    T/C
rs1320545184 chr11:43581421    G/A
rs765549410 chr11:43581422    G/T
rs1331459988 chr7:128207878    T/G
rs750308373 chr7:128207883    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TLR7
chrX:12894099(+) A-I      intronic
chrX:12892292(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TLR7
chrX:12895719-12895720(+) m6A exon//intron       -
chrX:12903645-12903646(+) m6A CDS       -
chrX:12903656-12903657(+) m6A CDS       -
chrX:12903695-12903696(+) m6A CDS       -
chrX:12903723-12903724(+) m6A CDS       -
chrX:12903760-12903761(+) m6A CDS       -
chrX:12903775-12903776(+) m6A CDS       -
chrX:12903784-12903785(+) m6A CDS       -
chrX:12903823-12903824(+) m6A CDS       -
chrX:12903832-12903833(+) m6A CDS       -
chrX:12903862-12903863(+) m6A CDS       -
chrX:12903887-12903888(+) m6A CDS       -
chrX:12903892-12903893(+) m6A CDS       -
chrX:12903952-12903953(+) m6A CDS       -
chrX:12903983-12903984(+) m6A CDS       -
chrX:12904001-12904002(+) m6A CDS       -
chrX:12904036-12904037(+) m6A CDS       -
chrX:12904136-12904137(+) m6A CDS       -
chrX:12904171-12904172(+) m6A CDS       -
chrX:12904231-12904232(+) m6A CDS       -
chrX:12904313-12904314(+) m6A CDS       -
chrX:12904561-12904562(+) m6A CDS       -
chrX:12904571-12904572(+) m6A CDS       -
chrX:12904580-12904581(+) m6A CDS       -
chrX:12904597-12904598(+) m6A CDS       -
chrX:12904682-12904683(+) m6A CDS       -
chrX:12904880-12904881(+) m6A CDS       -
chrX:12904892-12904893(+) m6A CDS       -
chrX:12904974-12904975(+) m6A CDS       -
chrX:12904994-12904995(+) m6A CDS       -
chrX:12905009-12905010(+) m6A CDS       -
chrX:12905062-12905063(+) m6A CDS       -
chrX:12905115-12905116(+) m6A CDS       -
chrX:12905220-12905221(+) m6A CDS       -
chrX:12905269-12905270(+) m6A CDS       -
chrX:12905327-12905328(+) m6A CDS       -
chrX:12905395-12905396(+) m6A CDS       -
chrX:12905407-12905408(+) m6A CDS       -
chrX:12905426-12905427(+) m6A CDS       -
chrX:12905469-12905470(+) m6A CDS       -
chrX:12905493-12905494(+) m6A CDS       -
chrX:12905593-12905594(+) m6A CDS       -
chrX:12905708-12905709(+) m6A CDS       -
chrX:12905725-12905726(+) m6A CDS       -
chrX:12905733-12905734(+) m6A CDS       -
chrX:12905740-12905741(+) m6A CDS       -
chrX:12905919-12905920(+) m6A CDS       -
chrX:12906289-12906290(+) m6A CDS       -
chrX:12906328-12906329(+) m6A CDS       -
chrX:12906371-12906372(+) m6A CDS       -
chrX:12906379-12906380(+) m6A CDS       -
chrX:12906392-12906393(+) m6A CDS       -
chrX:12906421-12906422(+) m6A CDS       -
chrX:12906451-12906452(+) m6A CDS       -
chrX:12906483-12906484(+) m6A CDS       -
chrX:12906502-12906503(+) m6A CDS       -
chrX:12906516-12906517(+) m6A CDS       -
chrX:12907879-12907880(+) m6A 3'UTR       -
chrX:12907958-12907959(+) m6A 3'UTR       -
chrX:12907971-12907972(+) m6A 3'UTR       -
chrX:12908075-12908076(+) m6A 3'UTR       -
chrX:12908089-12908090(+) m6A 3'UTR       -
chrX:12908119-12908120(+) m6A 3'UTR       -
chrX:12908141-12908142(+) m6A 3'UTR       -
chrX:12908153-12908154(+) m6A 3'UTR       -
chrX:12908159-12908160(+) m6A 3'UTR       -
chrX:12908218-12908219(+) m6A 3'UTR       -
chrX:12908283-12908284(+) m6A 3'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-129-5p
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Blood     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     -
TLR7
Exosome Blood     -
Nucleoplasm K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-129-5p
Iodine Green 9956454 Drug sensitive
Kahalalide F 9898671 Drug resistant
Midostaurin 9829523 Drug resistant
2,5-Dimethyl-1,4-benzoquinone 8718 Drug sensitive
Acid Green 27 80837 Drug sensitive
L-2-Aminobutyric acid 80283 Drug sensitive
Coptisine chloride 72321 Drug sensitive
Ixabepilone 6445540 Drug sensitive
Verrucarin A 6326658 Drug sensitive
Tributyrin 6050 Drug sensitive
3-Deazauridine 54684286 Drug sensitive
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Simvastatin 54454 Drug resistant
2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug sensitive
Centaureidin 5315773 Drug sensitive
Spiperone 5265 Drug resistant
Kekule 499328 Drug sensitive
Lychnopholide 49767028 Drug sensitive
(S)-(+)-Tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 46907787 Drug sensitive
1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive
2,6-Epoxy-2H-1-benzoxocin-5(6H)-one, 6,8-dimethyl- 434882 Drug sensitive
Di-n-octyl-secalonsaure A 430141 Drug sensitive
beta-Lapachone 3885 Drug sensitive
Lapachol 3884 Drug sensitive
2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Naphtho[2,3-f]quinoxaline-7,12-dione, 3-hydroxy-2-methyl- 371563 Drug resistant
Amchloramide 364434 Drug sensitive
2,7-Dicyanoxanthone 363841 Drug sensitive
1-Chloro-3-(3-chloropropylsulfonylsulfanyl)propane 355643 Drug sensitive
5-Fluorocytosine arabinoside 352938 Drug sensitive
Dichloroallyl lawsone 277767 Drug sensitive
2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-[2-(methylamino)ethyl]-1H-imidazo[4,5-c]pyridine-7-carboxamide 25023715 Drug resistant
2-(4-((Oxiran-2-yl)methoxy)styryl)-4,5-dihydrooxazole 24206038 Drug sensitive
Prumycin HCl 24197905 Drug resistant
Methyl 1,6,8,14a-tetrahydroxy-11-[(4-hydroxy-3,5-dimethoxy-6-methyloxan-2-yl)amino]-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-5,6-dihydrobenzo[a]tetracene-2-carboxylate 197261 Drug sensitive
Diphenyltin dichloride 14342 Drug sensitive
C8, Carbonyl prodigiosine 135540857 Drug sensitive
(2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug sensitive
15-Deacetylsergeolide 125729 Drug sensitive
(2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive
Unii-C616DV5Y11 117587576 Drug sensitive
N-(2-Aminophenyl)-4-{1-[(benzylamino)methyl]vinyl}benzamide 11588476 Drug sensitive
Acetylenedicarboxamide 10971 Drug sensitive
(1R,5S,7R,13R,20R)-11-Hydroxy-5,10,13,14,15-pentamethoxy-7,20-diphenyl-2,8,21-trioxapentacyclo[11.8.0.01,17.03,12.04,9]henicosa-3,9,11,14,17-pentaen-16-one 101664521 Drug sensitive
Chimaphilin 101211 Drug sensitive
[(1S,2S,4Z,8Z,12R,13S)-12-Hydroxy-4,8,12-trimethyl-16-methylidene-15-oxo-14-oxabicyclo[11.3.1]heptadeca-4,8-dien-2-yl] acetate 100921072 Drug sensitive
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
toxin .delta.53l - Drug resistant
tp4ek - Drug resistant
1,6,7,8-tetra-o-phenylcarbamoylcastnospermine - Drug sensitive
1,8-naphthyridin-4(1h)-one, 2-(3-chlorophenyl)-5-methyl- - Drug sensitive
3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6h)-one - Drug sensitive
4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug sensitive
4-[3-(3,4-dihydro-1H-isoquinolin-2-yl)prop-1-en-2-yl]-N-pyrazin-2-ylbenzamide - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive
7h-5,6-dithioleno[4,3-d]uracil - Drug sensitive
benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug sensitive
benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
phosphonium, (3-bromopropyl)triphenyl- bromide - Drug sensitive
propanedinitrile, [(3,5-dibromo-2-ethoxyphenyl)methylene]- - Drug sensitive
purine, 2,6,8-tris(hexylamino)- - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive
antibiotic a54556 - Drug sensitive
chlorambucil-spermidine - Drug sensitive
chlorobis(4-ethyltropolonato)bismuth(iii) - Drug sensitive
dolavaline - Drug sensitive
geldanamycin analog - Drug sensitive
hyperforinacetate - Drug sensitive
pancratium littorale - Drug sensitive
streptorubrin - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-129-5p
Vincristine 5978 Drug interaction    RC00001560
Prednisone 5865 Drug interaction    RC00001559
D-Glucose 5793 Drug interaction    RC00001558
Decitabine 451668 Drug interaction    RC00001567
Trichostatin A 444732 Drug interaction    RC00001566
Bortezomib 387447 Drug interaction    RC00001565
Etoposide 36462 Drug interaction    RC00001563
Paclitaxel 36314 Drug interaction    RC00001562
5-Fluorouracil 3385 Drug interaction    RC00001557
Doxorubicin 31703 Drug interaction    RC00001561
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001556
Docetaxel 148124 Drug interaction    RC00001564
Chemotherapy - Drug interaction    RC00008829
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-129-5p
Gemcitabine 60750       30117016
Cisplatin 5702198       28619508
Paclitaxel 36314       23627607
Paclitaxel 36314       27831649
Doxorubicin 31703       25344911
Doxorubicin 31703       27831649
Doxorubicin 31703       29802821
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       20162574
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       25344911
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       27831649
Trastuzumab -       29258115
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-129-5p
Irinotecan       60838

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-129-5p
Interactor2: TLR7

Evidence Support:


Prediction-Evidence microT//miRanda//miRMap//PicTar//PITA//Targetscan
Support Database ViRBase

References:


PMID 33428154 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description To explore the regulatory relationship between the 5 key genes, 3 coronavirus-related genes (ACE2, TMPRSS2, BSG), and their target miRNA, we used 6 miRNA target prediction databases to predict the target miRNA of these genes.

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