Detail Information

Basic Information:


  VIRBase ID:  

HHID00105117

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9612

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-129-5p:           VCP:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-129-5p VCP
miRBase
Accession/Entrez ID
MIMAT0000242 7415
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CDC48//FTDALS6//p97//TERA

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-129-5p
rs1242359724 chr7:128207890    G/A
rs1263648656 chr7:128207889    G/A
rs1274463608 chr7:128207884    G/A
rs1279636719 chr7:128207895    G/C
rs1279636719 chr7:128207895    G/T
rs756117952 chr7:128207886    T/C
rs779889090 chr7:128207891    G/T
rs1229617898 chr11:43581416    G/A
rs1289973713 chr11:43581418    T/C
rs1320545184 chr11:43581421    G/A
rs765549410 chr11:43581422    G/T
rs1331459988 chr7:128207878    T/G
rs750308373 chr7:128207883    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR VCP
chr9:35058515(-) A-I      intronic
chr9:35066380(-) A-I      intronic
chr9:35066350(-) A-I      intronic
chr9:35066165(-) A-I      intronic
chr9:35064453(-) A-I      intronic
chr9:35065113(-) A-I      intronic
chr9:35066015(-) A-I      intronic
chr9:35058516(-) A-I      intronic
chr9:35066348(-) A-I      intronic
chr9:35064509(-) A-I      intronic
chr9:35066040(-) A-I      intronic
chr9:35066036(-) A-I      intronic
chr9:35066076(-) A-I      intronic
chr9:35066183(-) A-I      intronic
chr9:35066184(-) A-I      intronic
chr9:35066210(-) A-I      intronic
chr9:35066499(-) A-I      intronic
chr9:35066503(-) A-I      intronic
chr9:35065138(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase VCP
chr9:35056078-35056079(-) m6A 3'UTR       27773535
chr9:35056149-35056150(-) m6A 3'UTR       24284625//27773535
chr9:35056255-35056256(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22575960//22608085
chr9:35056373-35056374(-) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085
chr9:35056518-35056519(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr9:35056583-35056584(-) m6A 3'UTR       24284625//24981863//27773535
chr9:35056609-35056610(-) m6A 3'UTR       24284625//24981863//27773535
chr9:35056631-35056632(-) m6A 3'UTR       24284625//27773535
chr9:35056805-35056806(-) m6A 3'UTR       26404942//27773535//22575960
chr9:35056822-35056823(-) m6A 3'UTR       27773535//22575960
chr9:35056937-35056938(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr9:35056966-35056967(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr9:35056992-35056993(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr9:35057033-35057034(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr9:35057074-35057075(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr9:35057138-35057139(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960
chr9:35057204-35057205(-) m6A CDS//exon       24209618//26404942//27773535//22575960
chr9:35057406-35057407(-) m6A CDS//exon       27773535//22575960
chr9:35057605-35057606(-) m6A exon//intron       24981863//27773535
chr9:35057613-35057614(-) m6A exon//intron       24981863//27773535
chr9:35057819-35057820(-) m6A exon//intron       24981863//26404942
chr9:35059077-35059078(-) m6A CDS//exon       24981863//26404942//22575960
chr9:35059208-35059209(-) m6A CDS//exon       26404942//22575960
chr9:35059842-35059843(-) m6A exon//intron       22575960
chr9:35060846-35060847(-) m6A CDS//exon       26404942//27773535
chr9:35060880-35060881(-) m6A CDS//exon       26404942//27773535
chr9:35061042-35061043(-) m6A CDS//exon       26404942//27773535//22575960
chr9:35061064-35061065(-) m6A CDS//exon       26404942//22575960
chr9:35061163-35061164(-) m6A CDS//exon       26404942
chr9:35061576-35061577(-) m6A CDS//exon       26404942
chr9:35061583-35061584(-) m6A CDS//exon       26404942
chr9:35061607-35061608(-) m6A CDS//exon       26404942
chr9:35062033-35062034(-) m6A CDS//exon       24981863//26404942
chr9:35062134-35062135(-) m6A CDS//exon       24981863//26404942//22575960
chr9:35062151-35062152(-) m6A exon//intron       24981863//26404942//22575960
chr9:35063031-35063032(-) m6A CDS//exon       26404942
chr9:35063040-35063041(-) m6A CDS//exon       26404942
chr9:35063050-35063051(-) m6A CDS//exon       26404942
chr9:35064183-35064184(-) m6A CDS//exon       26404942
chr9:35064195-35064196(-) m6A CDS//exon       26404942//22575960
chr9:35065287-35065288(-) m6A CDS//exon       26404942
chr9:35068272-35068273(-) m6A 5'UTR//CDS//exon       26404942

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-129-5p
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Blood     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     -
VCP
Chromatin K562 cells     -
Cytosol K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID
Function
ncDR hsa-miR-129-5p
Iodine Green 9956454 Drug sensitive
Kahalalide F 9898671 Drug resistant
Midostaurin 9829523 Drug resistant
2,5-Dimethyl-1,4-benzoquinone 8718 Drug sensitive
Acid Green 27 80837 Drug sensitive
L-2-Aminobutyric acid 80283 Drug sensitive
Coptisine chloride 72321 Drug sensitive
Ixabepilone 6445540 Drug sensitive
Verrucarin A 6326658 Drug sensitive
Tributyrin 6050 Drug sensitive
3-Deazauridine 54684286 Drug sensitive
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Simvastatin 54454 Drug resistant
2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug sensitive
Centaureidin 5315773 Drug sensitive
Spiperone 5265 Drug resistant
Kekule 499328 Drug sensitive
Lychnopholide 49767028 Drug sensitive
(S)-(+)-Tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 46907787 Drug sensitive
1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive
2,6-Epoxy-2H-1-benzoxocin-5(6H)-one, 6,8-dimethyl- 434882 Drug sensitive
Di-n-octyl-secalonsaure A 430141 Drug sensitive
beta-Lapachone 3885 Drug sensitive
Lapachol 3884 Drug sensitive
2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Naphtho[2,3-f]quinoxaline-7,12-dione, 3-hydroxy-2-methyl- 371563 Drug resistant
Amchloramide 364434 Drug sensitive
2,7-Dicyanoxanthone 363841 Drug sensitive
1-Chloro-3-(3-chloropropylsulfonylsulfanyl)propane 355643 Drug sensitive
5-Fluorocytosine arabinoside 352938 Drug sensitive
Dichloroallyl lawsone 277767 Drug sensitive
2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-[2-(methylamino)ethyl]-1H-imidazo[4,5-c]pyridine-7-carboxamide 25023715 Drug resistant
2-(4-((Oxiran-2-yl)methoxy)styryl)-4,5-dihydrooxazole 24206038 Drug sensitive
Prumycin HCl 24197905 Drug resistant
Methyl 1,6,8,14a-tetrahydroxy-11-[(4-hydroxy-3,5-dimethoxy-6-methyloxan-2-yl)amino]-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-5,6-dihydrobenzo[a]tetracene-2-carboxylate 197261 Drug sensitive
Diphenyltin dichloride 14342 Drug sensitive
C8, Carbonyl prodigiosine 135540857 Drug sensitive
(2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug sensitive
15-Deacetylsergeolide 125729 Drug sensitive
(2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive
Unii-C616DV5Y11 117587576 Drug sensitive
N-(2-Aminophenyl)-4-{1-[(benzylamino)methyl]vinyl}benzamide 11588476 Drug sensitive
Acetylenedicarboxamide 10971 Drug sensitive
(1R,5S,7R,13R,20R)-11-Hydroxy-5,10,13,14,15-pentamethoxy-7,20-diphenyl-2,8,21-trioxapentacyclo[11.8.0.01,17.03,12.04,9]henicosa-3,9,11,14,17-pentaen-16-one 101664521 Drug sensitive
Chimaphilin 101211 Drug sensitive
[(1S,2S,4Z,8Z,12R,13S)-12-Hydroxy-4,8,12-trimethyl-16-methylidene-15-oxo-14-oxabicyclo[11.3.1]heptadeca-4,8-dien-2-yl] acetate 100921072 Drug sensitive
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
toxin .delta.53l - Drug resistant
tp4ek - Drug resistant
1,6,7,8-tetra-o-phenylcarbamoylcastnospermine - Drug sensitive
1,8-naphthyridin-4(1h)-one, 2-(3-chlorophenyl)-5-methyl- - Drug sensitive
3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6h)-one - Drug sensitive
4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug sensitive
4-[3-(3,4-dihydro-1H-isoquinolin-2-yl)prop-1-en-2-yl]-N-pyrazin-2-ylbenzamide - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive
7h-5,6-dithioleno[4,3-d]uracil - Drug sensitive
benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug sensitive
benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
phosphonium, (3-bromopropyl)triphenyl- bromide - Drug sensitive
propanedinitrile, [(3,5-dibromo-2-ethoxyphenyl)methylene]- - Drug sensitive
purine, 2,6,8-tris(hexylamino)- - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive
antibiotic a54556 - Drug sensitive
chlorambucil-spermidine - Drug sensitive
chlorobis(4-ethyltropolonato)bismuth(iii) - Drug sensitive
dolavaline - Drug sensitive
geldanamycin analog - Drug sensitive
hyperforinacetate - Drug sensitive
pancratium littorale - Drug sensitive
streptorubrin - Drug sensitive
Resource Symbol Drug Name PubChem
ID
Function Link  
RNAInter hsa-miR-129-5p
Vincristine 5978 Drug interaction    RC00001560
Prednisone 5865 Drug interaction    RC00001559
D-Glucose 5793 Drug interaction    RC00001558
Decitabine 451668 Drug interaction    RC00001567
Trichostatin A 444732 Drug interaction    RC00001566
Bortezomib 387447 Drug interaction    RC00001565
Etoposide 36462 Drug interaction    RC00001563
Paclitaxel 36314 Drug interaction    RC00001562
5-Fluorouracil 3385 Drug interaction    RC00001557
Doxorubicin 31703 Drug interaction    RC00001561
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001556
Docetaxel 148124 Drug interaction    RC00001564
Chemotherapy - Drug interaction    RC00008829
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-129-5p
Gemcitabine 60750       30117016
Cisplatin 5702198       28619508
Paclitaxel 36314       23627607
Paclitaxel 36314       27831649
Doxorubicin 31703       25344911
Doxorubicin 31703       27831649
Doxorubicin 31703       29802821
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       20162574
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       25344911
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       27831649
Trastuzumab -       29258115
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-129-5p
Irinotecan       60838

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-129-5p
Interactor2: VCP

Evidence Support:


Strong-Evidence Luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 33675361 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line HepG2cells//SK-HEP1 cells Interactor2 expression Downregulation
Description In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.

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