Detail Information

Basic Information:


  VIRBase ID:  

HHID00105094

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2494

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29a-3p:           ACE2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-29a-3p ACE2
miRBase
Accession/Entrez ID		 MIMAT0000086 59272
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ACEH

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-29a-3p
rs1554489270 chr7:130876753    G/A

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ACE2
chrX:15579319-15579320(-) m6A 3'UTR//exon       27773535
chrX:15579343-15579344(-) m6A 3'UTR//exon       27773535
chrX:15579366-15579367(-) m6A 3'UTR//exon       27773535
chrX:15579420-15579421(-) m6A 3'UTR//exon       27773535
chrX:15579431-15579432(-) m6A 3'UTR//intron       27773535
chrX:15579618-15579619(-) m6A 3'UTR//intron       27773535
chrX:15579631-15579632(-) m6A 3'UTR//intron       27773535
chrX:15579696-15579697(-) m6A 3'UTR//exon       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-29a-3p
Cytoplasm Hepatic carcinoma cells (Huh-7)     29253196
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Lung cancer cell lines (A549|SK-MES)     22753494
Exosome Human milk     28688106
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Microvesicle Plasma     19951903
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Hepatoma cells     23771658
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
ACE2
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-29a-3p
Isoflavone 72304 Drug interaction    RC00000864
Oxaliplatine 6857599 Drug interaction    RC00000873
Bisphenol A 6623 Drug interaction    RC00000857
Fludarabine 657237 Drug interaction    RC00000869
Cytarabine 6253 Drug interaction    RC00000856
Gemcitabine 60750 Drug interaction    RC00000863
Testosterone 6013 Drug interaction    RC00000855
D-Glucose 5793 Drug interaction    RC00000854
Sunitinib 5329102 Drug interaction    RC00000872
Eloxatine 5310940 Drug interaction    RC00000871
Imatinib 5291 Drug interaction    RC00000853
Calcitriol 5280453 Drug interaction    RC00000870
Decitabine 451668 Drug interaction    RC00000868
Trichostatin A 444732 Drug interaction    RC00000867
Etoposide 36462 Drug interaction    RC00000862
Paclitaxel 36314 Drug interaction    RC00000861
5-Fluorouracil 3385 Drug interaction    RC00000852
Doxorubicin 31703 Drug interaction    RC00000860
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000851
Arsenic(III)oxide,arsenic trioxide,arsenous acid anhydride,arsenous acid,arsenic sesquioxide,white arsenic 261004 Drug interaction    RC00000866
Verapamil 2520 Drug interaction    RC00000850
Arsenic trioxide 14888 Drug interaction    RC00000859
Docetaxel 148124 Drug interaction    RC00000865
Leucovorin 135403648 Drug interaction    RC00000874
Androstanolone 10635 Drug interaction    RC00000858
Natalizumab - Drug interaction    RC00000875
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00000876
Glucocorticoid - Drug interaction    RC00000877
Marine fungal metabolite 1386A - Drug interaction    RC00000878
Testosterone + 1,25-Dihydroxyvitamin D3 - Drug interaction    RC00000879
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-29a-3p
Cisplatin 5702198       26676926
Imatinib mesylate 123596       28533480

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-29a-3p
Interactor2: ACE2

Evidence Support:


Prediction-Evidence microT//miRanda//miRMap//PicTar//PITA//Targetscan
Support Database ViRBase

References:


PMID 33428154 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description To explore the regulatory relationship between the 5 key genes, 3 coronavirus-related genes (ACE2, TMPRSS2, BSG), and their target miRNA, we used 6 miRNA target prediction databases to predict the target miRNA of these genes.

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