Detail Information

Basic Information:


  VIRBase ID:  

HHID00105088

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9612

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-26b-5p:           PLOD2:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-26b-5p PLOD2
miRBase
Accession/Entrez ID		 MIMAT0000083 5352
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BRKS2//LH2//TLH

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-26b-5p
rs1173404354 chr2:218402668    C/T
rs1381090830 chr2:218402673    T/C
rs1417663771 chr2:218402671    G/A
rs1417663771 chr2:218402671    G/C
rs1434330126 chr2:218402675    G/A
rs766205860 chr2:218402672    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PLOD2
chr3:145800533(-) A-I      intronic
chr3:145800547(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PLOD2
chr3:145787781-145787782(-) m6A 3'UTR       26404942
chr3:145787848-145787849(-) m6A 3'UTR       26404942
chr3:145787902-145787903(-) m6A 3'UTR       27773535
chr3:145787931-145787932(-) m6A 3'UTR       27773535
chr3:145787977-145787978(-) m6A 3'UTR       27773535
chr3:145788016-145788017(-) m6A 3'UTR       27773535
chr3:145788069-145788070(-) m6A 3'UTR//exon       27773535
chr3:145788106-145788107(-) m6A 3'UTR//exon       27773535
chr3:145788177-145788178(-) m6A 3'UTR//exon       27773535
chr3:145788276-145788277(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr3:145788306-145788307(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr3:145788359-145788360(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr3:145788370-145788371(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr3:145788390-145788391(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr3:145788449-145788450(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr3:145788538-145788539(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085
chr3:145788557-145788558(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085
chr3:145788578-145788579(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr3:145788835-145788836(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr3:145788862-145788863(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr3:145790353-145790354(-) m6A CDS//exon       22575960
chr3:145790380-145790381(-) m6A CDS//exon       22575960
chr3:145796991-145796992(-) m6A CDS//exon       22575960
chr3:145804508-145804509(-) m6A exon//intron       24981863
chr3:145804582-145804583(-) m6A CDS//exon       24981863
chr3:145838942-145838943(-) m6A 3'UTR//CDS       24981863//26404942
chr3:145841066-145841067(-) m6A CDS//intron       24981863//26404942
chr3:145878696-145878697(-) m6A 5'UTR//CDS//intron       22575960
chr3:145878858-145878859(-) m6A 5'UTR//intron       27773536//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-26b-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Renal cancer cells     21670082
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Colon adenocarcinoma cells     20864815
PLOD2
Cytosol HCC cell line (HepG2)|HeLa-S3 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Endoplasmic reticulum Human fibrosarcoma cells (HT1080)     25753659
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-26b-5p
Sensorad 99342 Drug sensitive
CID 9604911 9604911 Drug resistant
4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive
Edatrexate 6917908 Drug sensitive
NO Data IN this field 6711510 Drug sensitive
Neocuproine 65237 Drug sensitive
(2R,3R,4S,5R)-2-(6-Benzylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol 6477178 Drug sensitive
Ketone, methyl 2-pyridyl, 4,4-dimethyl-3-thiosemicarbazone 5843399 Drug sensitive
Antineoplastic-328785 54607693 Drug sensitive
Aspiculamycin hcl 54600418 Drug resistant
4-Cycloheptyl-N-(1-pyridin-2-ylethylideneamino)piperazine-1-carbothioamide 5351332 Drug sensitive
Hydroxy AT 125 5351254 Drug sensitive
Herbimycin 5311102 Drug sensitive
6-Bromosangivamycin 470030 Drug sensitive
N'-(3-Pyridin-2-ylisoquinolin-1-yl)pyridine-2-carboximidamide 463108 Drug sensitive
4-[1-(4-Aminomethyl-phenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamine 44397453 Drug resistant
Trichopolyn 431962 Drug sensitive
Rogiolol 402519 Drug sensitive
2-Diphenylphosphanylethyl(dipyridin-2-yl)phosphane 400499 Drug sensitive
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive
2-(5-Amino-1-methyl-4,7-dioxoindol-3-yl)-4-methylthiazole 392620 Drug sensitive
1H-Purine, 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)seleno]- 3879067 Drug resistant
4-Phenacyloxychromen-2-one 386272 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug sensitive
N-Hydroxy-N-methylpropanethioamide 371713 Drug sensitive
Sanguilutine pseudobase 371258 Drug sensitive
3-Nitro-5-formylisoxazole 362479 Drug sensitive
Thiosangivamycin 3580213 Drug sensitive
Nicomol 34081 Drug sensitive
Stannane, trimethyl[(4-morpholinylthioxomethyl)thio]- 300936 Drug sensitive
4,6-Diamino-7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile 300567 Drug sensitive
2-Hydroxy-4-((2,4,6-triamino-5-pyrimidinyl)diazenyl)phenylarsonic acid 272658 Drug sensitive
Ancitabine hydrochloride 25050 Drug sensitive
[(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug sensitive
Antibiotic U 29135 24196291 Drug sensitive
7-Fluoro-2-benzoyl-3-trifluoromethylquioxaline 1,4-dioxide 23635154 Drug sensitive
8-Hydroxyquinoline 1923 Drug sensitive
Antineoplastic-633273 15954131 Drug sensitive
Methyl (7E,9Z,11S,12R,13S,14R,15R,17R,18S,19S,20E)-2,16-diacetyloxy-11,12,14,18,19,31-hexahydroxy-3,7,11,13,17,19,21,27-octamethyl-6,28-dioxo-23,25-dioxa-5-azatetracyclo[20.7.1.14,29.026,30]hentriaconta-1,3,7,9,20,22(30),26,29(31)-octaene-15-carboxylate 138319233 Drug sensitive
Inosine dialdehyde 135400916 Drug sensitive
Methyl (1S,10R,11S,12S)-11-acetyloxy-12-ethyl-4-[(13R,15R,17R)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 133126830 Drug sensitive
43-Dioxypectenotoxin 131751434 Drug resistant
Litmomycin 12310334 Drug sensitive
Capri Blue 102162 Drug sensitive
15,16-Dihydrocuracin A 101683509 Drug sensitive
(3S,6S)-1,4-Dimethyl-3,6-bis[(2R)-3,3,3-trichloro-2-methylpropyl]piperazine-2,5-dione 101425118 Drug sensitive
4',8-Dinitroflavone 10041189 Drug resistant
(1R,6S,11aS,13S,14aR)-1,13-dihydroxy-6-vinyl-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one - Drug resistant
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug resistant
(-)-furodysinin - Drug resistant
(Z)-5-chloro-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive
21h,23h-porphine, pyridinium deriv., silver complex - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
antineoplastic-625543 - Drug sensitive
antineoplastic-625577 - Drug sensitive
antineoplastic-641296 - Drug sensitive
antineoplastic-641297 - Drug sensitive
antineoplastic-654379 - Drug sensitive
ERB-38 Immunotoxin - Drug sensitive
leucinostatine d - Drug sensitive
n-acetyl-4-s-cystaminyl phenol - Drug sensitive
streptorubrin - Drug sensitive
viridomycin - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-26b-5p
Formaldehyde 712 Drug interaction    RC00000786
Oxaliplatine 6857599 Drug interaction    RC00000799
Bisphenol A 6623 Drug interaction    RC00000792
Vincristine 5978 Drug interaction    RC00000791
Mitomycin 5746 Drug interaction    RC00000790
Eloxatine 5310940 Drug interaction    RC00000798
Morphine 5288826 Drug interaction    RC00000797
Carboplatinum 38904 Drug interaction    RC00000795
Etoposide 36462 Drug interaction    RC00000794
5-Fluorouracil 3385 Drug interaction    RC00000789
Doxorubicin 31703 Drug interaction    RC00000793
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000788
Celecoxib 2662 Drug interaction    RC00000787
Docetaxel 148124 Drug interaction    RC00000796
Leucovorin 135403648 Drug interaction    RC00000800
Trastuzumab - Drug interaction    RC00000802
Interferon-alpha - Drug interaction    RC00000801
Chemotherapy - Drug interaction    RC00008822

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-26b-5p
Interactor2: PLOD2

Evidence Support:


Strong-Evidence Dual luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 33675361 Target region 3'UTR
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line Bladder cancer tissues Interactor2 expression Downregulation
Description In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.

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