Basic Information:

  VIRBase ID:  

HHID00105083

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9751

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-21-5p:  MIMAT0000076          IL1B:  NM_000576     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-21-5p	IL1B
miRBase Accession/Entrez ID	MIMAT0000076	3553
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	IL-1//IL1-BETA//IL1beta//IL1F2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-21-5p	rs1182837899 chr17:59841288    A/T rs1253814784 chr17:59841290    G/A rs779350466 chr17:59841283    G/A

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IL1B	chr2:113590257-113590258(-) m6A CDS//exon       - chr2:113590281-113590282(-) m6A CDS//exon       - chr2:113593136-113593137(-) m6A exon//intron       27371828 chr2:113593151-113593152(-) m6A CDS//exon       27371828 chr2:113594350-113594351(-) m6A 5'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-21-5p	Apoptotic body Human umbilical vein endothelial cells     19996457 Cytoplasm Breast cancer cells (MCF-7)     27482754 Cytoplasm Neural progenitor cells     21363885 Cytoplasm Cell line (HeLa)     21695135 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Lung cancer cell lines (A549|SK-MES)     22753494 Exosome Serum     23224754 Exosome Cell lines (MCF10A|MCF-7|MDA-MB-231)     25446899 Exosome Human cervical carcinoma cell line (HeLa|SiHa)     25760330 Exosome NBL cell lines (CHLA-255|IMR-32|SK-N-BE(2))     25972604 Exosome Urine     26417675 Exosome Human bronchial epithelial cells     26525579 Exosome Urine     26576778 Exosome Esophageal cancer cell line (EC9706)     27035745 Exosome EBV- and KSHV-negative Burkitt lymphoma cell line (Bjab)|EBV-infected lymphoblastoid cell line (LCL)|KSHV-infected lymphoma cell lines (BCBL-1|TY-1)     27611973 Exosome Plasma     29143228 Exosome Human cervical cancer cell line (HeLa)     29492481 Exosome HNSCC cell line (FaDu)     29981499 Exosome Peripheral blood|Portal vein blood     30561106 Exosome BC cell lines (HCC70|MCF-7|MDA-MB-231)     30728048 Exosome Extracellular vesicles from the medium of HCC cells (SMMC-7721)     31037150 Exosome Glioblastoma cells     19011622 Exosome Plasma     19289371 Exosome Placenta     19494253 Exosome Human embryonic kidney cell line (HEK-293)     20353945 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Ascites fluid|Pleural effusion     21601258 Exosome Breast milk     22211110 Exosome Colorectal cancer cell lines (HCT-15|SW480|WiDr)     22895844 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Plasma     24130905 Exosome Human esophageal cancer cell line (EC9706)     25184951 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Saliva|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Glioblastoma cells     19011622 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Hepatoma cells     23771658 Microvesicle Serum     24797360 Microvesicle Blood|Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Polysome Human cervical cancer cell line (HeLa)     25609084 Ribosome Human glioblastoma cell line (U-87)     27725160
	IL1B	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-21-5p	S-Hexadecyl methanethiosulfonate 97458 Drug resistant [(1R,2Z,4R,8R,9R,11R,12S)-1,12-Dihydroxy-2-(hydroxymethyl)-11-methyl-7-methylidene-6-oxo-5,14-dioxatricyclo[9.2.1.04,8]tetradec-2-en-9-yl] (Z)-2-methylbut-2-enoate 90475906 Drug resistant [(1R,2S,6R,7R,9S,12S,13S)-13-(Acetyloxymethyl)-12-hydroxy-9-methyl-5-methylidene-4-oxo-3,14-dioxatricyclo[7.4.1.02,6]tetradecan-7-yl] (Z)-2-(acetyloxymethyl)but-2-enoate 90473692 Drug resistant 2,5-Dimethyl-1,4-benzoquinone 8718 Drug resistant Benzethonium chloride 8478 Drug resistant 2,4,6-Tris(2-pyridyl)-s-triazine 77258 Drug resistant 2-Butenoic acid, 2-methyl-, 2,3,3a,4,5,8,9,11a-octahydro-8-hydroxy-6-(hydroxymethyl)-10-methyl-3-methylene-2-oxocyclodeca(b)furan-4-yl ester, (3aR-(3aR*,4R*(Z),6Z,8S*,10E,11aR*))- 71586750 Drug resistant Acnistin F 6712173 Drug resistant Chalcone analog 6296717 Drug resistant [(2Z)-12-Hydroxy-2,11-dimethyl-7-methylidene-6-oxo-5,14-dioxatricyclo[9.2.1.04,8]tetradec-2-en-9-yl] (E)-2-methylbut-2-enoate 5477565 Drug resistant (Z)-4-Bromo-4-iodo-3-phenylbut-3-en-2-one 5467656 Drug resistant Acetylrolandrolide 5384465 Drug resistant Ovatifolin acetate 5358419 Drug resistant Crassin, acetate 5355441 Drug resistant Herbimycin 5311102 Drug resistant Plumericin 5281545 Drug resistant Erioflorin acetate 5281443 Drug resistant Ammonia; dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498559 Drug resistant Dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498558 Drug resistant Patulin 4696 Drug resistant Elephantopin 442206 Drug resistant Butyric acid, rhodium salt (4:2) 432833 Drug resistant S-(Diethylarsino)-3-mercapto-1,2-propanediol 406476 Drug resistant Sampangine 387195 Drug resistant N-(8-Hydroxy-6-methyl-1,4-dioxo-1,4-dihydro-2-naphthalenyl)acetamide 377214 Drug resistant 2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant 1,6-Dimethyl-phenothiazone 369388 Drug resistant Tetrakis(8-chinolineolato)titanium(IV)-tetrahydrochloride 368279 Drug resistant 4-Nitro-6-(trifluoromethyl)-2,1,3-benzoselenadiazole 362897 Drug resistant Discorhabdin C-nitrodienone . TFA 362394 Drug resistant 3'-Chloro-2-hydroxy-2'-methyl-3-nitrobenzanilide 332278 Drug resistant Dmask 32465 Drug resistant 2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug resistant 6-(Dimethylarsanylsulfanylmethyl)oxane-2,3,4,5-tetrol 311912 Drug resistant Antibiotic U 29135 24196291 Drug resistant (1S,2R,5Z,10R,11S,12R,16S)-2-Hydroxy-2,6,10-trimethyl-15-methylidene-13,18-dioxatricyclo[9.6.1.012,16]octadec-5-en-14-one 23425613 Drug resistant Methyl 1,6,8,14a-tetrahydroxy-11-[(4-hydroxy-3,5-dimethoxy-6-methyloxan-2-yl)amino]-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-5,6-dihydrobenzo[a]tetracene-2-carboxylate 197261 Drug resistant 8-Hydroxyquinoline 1923 Drug resistant Cyanonaphthyridinomycin 16072298 Drug resistant 1H-2,10a-Ethanophenanthrene, kaur-16-en-15-one deriv. 146156727 Drug resistant Inosine dialdehyde 135400916 Drug resistant (1R,2S,5S,8S,9S,17R,18R,21S,24R,26S,27S)-14-Chloro-5,15-dihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacos-11-ene-4,10,22,29-tetrone 134715214 Drug resistant Triphenyltin chloride 12540 Drug resistant (1S,3R,7Z,9R,12S,13R,15S)-13-Butan-2-yl-13-hydroxy-3,7,12-trimethyl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 11972510 Drug resistant Melampodinin 11953936 Drug resistant 15,16-Dihydrocuracin A 101683509 Drug resistant [(1S,2S,4Z,8Z,12R,13S)-12-Hydroxy-4,8,12-trimethyl-16-methylidene-15-oxo-14-oxabicyclo[11.3.1]heptadeca-4,8-dien-2-yl] acetate 100921072 Drug resistant 1,3-butadiene, 1,1,2,4,4-pentachloro-3-nitro- - Drug resistant 1,6,7,8-tetra-o-phenylcarbamoylcastnospermine - Drug resistant 2,4,16-tribromoestra-1,3,5(10)-trien-3-ol-17-one - Drug resistant 9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 2-phenyl- - Drug resistant benzene, 1,1'-[(1,3-butadiene-1,4-diyl)sulfonyl]bis - Drug resistant geldanamycin, n,n'-dimethyl - Drug resistant gold(1+), bis(trimethylphosphine)-, chloride - Drug resistant n,n'-bis(oxydiethylene)thiocarbamoylsulfenamide - Drug resistant dichlorobisoxinatotitanium(iv) - Drug resistant methyl 3-farnesylthioacetate - Drug resistant somatostatin analog in diacetic form mw=1067.2 - Drug resistant 1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion - Drug sensitive 1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug sensitive pyrazino[1,2-a]benzimidazole, 1,3-diphenyl- - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-21-5p	Curcumin 969516 Drug interaction    RC00000617 N-Methyl-N-nitro-N'-nitrosoguanidine 9576410 Drug interaction    RC00000627 Hyaluronidase 91820602 Drug interaction    RC00000631 Matrine 91466 Drug interaction    RC00000599 Nicotine 89594 Drug interaction    RC00000598 Hydrogen peroxide 784 Drug interaction    RC00000556 Formaldehyde 712 Drug interaction    RC00000555 Ethanol 702 Drug interaction    RC00000554 Oxaliplatine 6857599 Drug interaction    RC00000626 Bisphenol A 6623 Drug interaction    RC00000581 Fludarabine 657237 Drug interaction    RC00000616 Betulinic acid 64971 Drug interaction    RC00000596 Cytarabine 6253 Drug interaction    RC00000580 Gemcitabine 60750 Drug interaction    RC00000595 Topotecan 60700 Drug interaction    RC00000594 CID 6037 6037 Drug interaction    RC00000579 Cholesterol 5997 Drug interaction    RC00000578 Progesterone 5994 Drug interaction    RC00000577 Vincristine 5978 Drug interaction    RC00000576 Prednisone 5865 Drug interaction    RC00000575 Thymidine 5789 Drug interaction    RC00000574 Estradiol 5757 Drug interaction    RC00000573 Dexamethasone 5743 Drug interaction    RC00000572 RETINOIC ACID, 13-cis- 5538 Drug interaction    RC00000571 Arsorite 544 Drug interaction    RC00000553 Temozolomide 5394 Drug interaction    RC00000570 Bleomycin a2 5360373 Drug interaction    RC00000625 Sulindac sulfide 5352624 Drug interaction    RC00000624 Sunitinib 5329102 Drug interaction    RC00000623 Lovastatin 53232 Drug interaction    RC00000593 Eloxatine 5310940 Drug interaction    RC00000622 Imatinib 5291 Drug interaction    RC00000569 Morphine 5288826 Drug interaction    RC00000621 Sirolimus 5284616 Drug interaction    RC00000620 Dinoprostone 5280360 Drug interaction    RC00000619 Propofol 4943 Drug interaction    RC00000568 Teniposide 452548 Drug interaction    RC00000615 Decitabine 451668 Drug interaction    RC00000614 Microcystin-LR 445434 Drug interaction    RC00000613 Resveratrol 445154 Drug interaction    RC00000612 Tretinoin 444795 Drug interaction    RC00000611 Trichostatin A 444732 Drug interaction    RC00000610 Staurosporine 44259 Drug interaction    RC00000592 Puromycin 439530 Drug interaction    RC00000609 Paroxetine 43815 Drug interaction    RC00000591 Bortezomib 387447 Drug interaction    RC00000608 Isoflurane 3763 Drug interaction    RC00000567 Hydroxychloroquine 3652 Drug interaction    RC00000566 Etoposide 36462 Drug interaction    RC00000590 Paclitaxel 36314 Drug interaction    RC00000589 5-Fluorouracil 3385 Drug interaction    RC00000565 Enoxacin 3229 Drug interaction    RC00000564 Doxorubicin 31703 Drug interaction    RC00000588 Valproic acid 3121 Drug interaction    RC00000563 Diphenyleneiodonium 3101 Drug interaction    RC00000562 3,3'-Diindolylmethane 3071 Drug interaction    RC00000561 Daunorubicin 30323 Drug interaction    RC00000587 Cyclophosphamide 2907 Drug interaction    RC00000560 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000559 Tamoxifen 2733526 Drug interaction    RC00000618 Arsenic(III)oxide,arsenic trioxide,arsenous acid anhydride,arsenous acid,arsenic sesquioxide,white arsenic 261004 Drug interaction    RC00000607 Verapamil 2520 Drug interaction    RC00000558 Hyaluronan 24759 Drug interaction    RC00000586 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00000629 Berberine 2353 Drug interaction    RC00000557 Caudatin 21633059 Drug interaction    RC00000628 Sorafenib 216239 Drug interaction    RC00000606 Trimetazidine 21109 Drug interaction    RC00000585 Erlotinib 176870 Drug interaction    RC00000605 Polylysine 162282 Drug interaction    RC00000604 Arsenic trioxide 14888 Drug interaction    RC00000584 Docetaxel 148124 Drug interaction    RC00000603 Leucovorin 135403648 Drug interaction    RC00000632 O,P'-Ddt 13089 Drug interaction    RC00000583 Gefitinib 123631 Drug interaction    RC00000602 Ginsenoside Rh2 119307 Drug interaction    RC00000601 Triptolide 107985 Drug interaction    RC00000600 Androstanolone 10635 Drug interaction    RC00000582 Interferon - Drug interaction    RC00000633 Interferon-alpha - Drug interaction    RC00000634 Rituximab - Drug interaction    RC00000635 Sargramostim - Drug interaction    RC00000636 TRAIL therapy - Drug interaction    RC00000637 Trastuzumab - Drug interaction    RC00000638 CDF(analogues of curcumin) - Drug interaction    RC00000639 CDF(analogues of curcumin) + gemcitabine - Drug interaction    RC00000640 Diazobenzene and its derivatives - Drug interaction    RC00000641 Glossy ganoderma spore oil - Drug interaction    RC00000642 Glucocorticoid - Drug interaction    RC00000643 Chemotherapy - Drug interaction    RC00008818 Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00000644 Marine fungal metabolite 1386A - Drug interaction    RC00000645 Trypaflavine - Drug interaction    RC00000646

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-21-5p	Oxaliplatin 9887053       31089750 Cisplatin 5702198       26676926 5-Fluorouracil 3385       31089750 Doxorubicin 31703       29393355 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-21-5p
Interactor2: IL1B

Evidence Support:

Strong-Evidence	ELISA//RT-PCR//Western blot
Weak-Evidence	Microarray
Support Database	ViRBase

References:

PMID	33675361	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	None	Interactor2 expression	Downregulation
Description	In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.