Basic Information:

  VIRBase ID:  

HHID00105069

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2494

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-15a-5p:  MIMAT0000068          TLR3:  NM_003265     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-15a-5p	TLR3
miRBase Accession/Entrez ID	MIMAT0000068	7098
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD283//IIAE2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-15a-5p	rs1359939022 chr13:50049168    A/G rs753467375 chr13:50049178    A/G rs766120172 chr13:50049169    C/T rs923737993 chr13:50049177    T/C rs1355089203 chr13:50049181    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TLR3	chr4:187001863(+) A-I      intronic chr4:187003336(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TLR3	chr4:186990367-186990368(+) m6A 5'UTR       24981863 chr4:186997778-186997779(+) m6A CDS       24981863 chr4:187003525-187003526(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003579-187003580(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003649-187003650(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003659-187003660(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003978-187003979(+) m6A CDS//exon       24981863 chr4:187004022-187004023(+) m6A CDS//exon       24284625//24981863 chr4:187004037-187004038(+) m6A CDS//exon       24284625//24981863 chr4:187004177-187004178(+) m6A CDS//exon       24209618//24981863 chr4:187004260-187004261(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004635-187004636(+) m6A CDS//exon       24981863 chr4:187004686-187004687(+) m6A CDS//exon       24981863 chr4:187004746-187004747(+) m6A CDS//exon       24981863 chr4:187004829-187004830(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004906-187004907(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004932-187004933(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004948-187004949(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187005082-187005083(+) m6A CDS//exon       24284625//24981863 chr4:187005090-187005091(+) m6A CDS//exon       24284625//24981863 chr4:187005095-187005096(+) m6A CDS//exon       24284625//24981863 chr4:187005155-187005156(+) m6A CDS//exon       24284625//24981863 chr4:187005181-187005182(+) m6A CDS//exon       24284625//25456834//24981863 chr4:187005214-187005215(+) m6A CDS//exon       25456834//24981863 chr4:187005236-187005237(+) m6A CDS//exon       25456834//24981863 chr4:187005310-187005311(+) m6A CDS//exon       24981863 chr4:187005888-187005889(+) m6A CDS//exon       24981863 chr4:187005893-187005894(+) m6A CDS//exon       24981863 chr4:187005944-187005945(+) m6A CDS//exon       24981863 chr4:187006013-187006014(+) m6A CDS//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-15a-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Serum     18589210 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Renal cancer cells     21670082 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Plasma     24130905 Exosome Serum     25349172 Exosome Peripheral blood     32785072 Exosome Blood|B lymphoblastoid cells|Endothelial cells|Lymphoma tissue|Mast cells     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Hepatoma cells     23771658 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Colon adenocarcinoma cells     20864815
	TLR3	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-15a-5p	Iodine Green 9956454 Drug sensitive 8-Aminoadenosine 96851 Drug resistant (3Z,8S,11Z,16S)-8,16-Bis(2-oxopropyl)-1,9-dioxacyclohexadeca-3,11-diene-2,5,10,13-tetrone 92973777 Drug sensitive 4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive 1,5-Methano-11H-furo(3,2-g)pyrano(3,2-b)xanthene-3a(4H)-crotonaldehyde, 1,2,5,7-tetrahydro-8-hydroxy-alpha,2,2,11,11-pentamethyl-13-(3-methyl-2-butenyl)-4,7-dioxo-, trans- 78358492 Drug sensitive Sulbentine 67686 Drug sensitive 2-Debenzoyl-2-(3',5'-difluorobenzoyl)-A-nortaxol 6712230 Drug sensitive Reactive Blue 2 656725 Drug sensitive Crotonoside 65085 Drug sensitive (2R,3R,4S,5R)-2-(6-Benzylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol 6477178 Drug sensitive Verrucarin A 6326658 Drug sensitive Tributyrin 6050 Drug sensitive trans-1,2-Bis(propylsulfonyl)ethylene 5904452 Drug sensitive 2,3-Diphenyl-1,4-naphthoquinone 555037 Drug sensitive Caracemide 54747 Drug sensitive Artelasticin 5471311 Drug sensitive Trimethyl 2-phosphono-3-(2-furan)acrylate 5467926 Drug resistant [3-Keto-Bmt(sup 1)]-[Val(sup 2)]-Cyclosporin 5467197 Drug sensitive 3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive 5,10-Dimethoxybenzo[g]quinolin-2(1H)-one 54612875 Drug resistant Tetracarboxyphthalocyanine-Gadolinium 54608636 Drug sensitive Selendale 54601159 Drug resistant Aspiculamycin hcl 54600418 Drug resistant Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive Methyl (1R,4R,7E,9S,10R,11S)-9-acetyloxy-10-(2,3-dimethyloxirane-2-carbonyl)oxy-4-methyl-12-methylidene-13-oxo-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-ene-8-carboxylate 5458601 Drug sensitive Thiram 5455 Drug sensitive Simvastatin 54454 Drug resistant (E)-1-(2,5-Dihydroxyphenyl)ethene-2-isonitrile 5388136 Drug sensitive (1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive Melampodin B acetate 5359212 Drug sensitive Hemiasterlin 5352092 Drug sensitive Indanthren Corinth RK 5351878 Drug sensitive 3-[1-(2-Chlorophenyl)ethoxy]-5-(6-methoxybenzimidazol-1-yl)thiophene-2-carboxamide 53338698 Drug sensitive Vorinostat 5311 Drug sensitive Pyrethrosin 5281496 Drug sensitive Erioflorin acetate 5281443 Drug sensitive 8-Hydroxymanzamine A 5270765 Drug sensitive Kekule 499328 Drug sensitive Lychnopholide 49767028 Drug sensitive 6-Methoxy-7-(2lambda(5)-1,2-triazadienyl)-5,8-quinolinedione 494043 Drug sensitive Tiazofurin 457954 Drug sensitive Ditercalinium dimethanesulfonate dimethanesulfonate 435243 Drug sensitive 2,6-Epoxy-2H-1-benzoxocin-5(6H)-one, 6,8-dimethyl- 434882 Drug sensitive Di-n-octyl-secalonsaure A 430141 Drug sensitive S-(Dimethylarsino)-3-mercapto-1,2-propyl dibenzoate 406481 Drug sensitive S-(Dimethylarsino)-3-mercapto-1,2-propyl diacetate 406479 Drug sensitive Aminopyrimidine-CH3 406278 Drug sensitive 3-Acetoxymethyl-1-methyl-5-methoxyindole-4,7-dione 404937 Drug resistant Rogiolol 402519 Drug sensitive 2-Amino-4-(2-hydroxy-4-methylphenyl)-5-phenylpyrimidine 392744 Drug sensitive 3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one 387973 Drug resistant Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive 4-Phenacyloxychromen-2-one 386272 Drug resistant 2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive Stereoisomer of NSC 674066-O 384359 Drug sensitive (-)7,8-Dihydrocalanolide A 383107 Drug sensitive (3R,5S)-Fluvastatin(1-) 37888681 Drug resistant 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant 3,8-Dimethyl-1,2-naphthoquinone 373912 Drug sensitive 11H-Benzo[a]carbazole-1,4-dione, 7,11-dimethyl- 371271 Drug sensitive Thiosangivamycin 3580213 Drug sensitive 2-Benzoylaminobenzamide, N-thiazol-2-yl- 355710 Drug sensitive 1-Chloro-3-(3-chloropropylsulfonylsulfanyl)propane 355643 Drug sensitive Bis(helenalinyl)glutarate 336831 Drug sensitive 4-Selenazolecarboxamide, 2-beta-D-ribofuranosyl- 334706 Drug sensitive Helenin 327378 Drug sensitive Rustaiyan A 324967 Drug sensitive 2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug sensitive 1,4-Naphthalenedione, 5,8-dihydroxy-2,3-bis(hydroxymethyl)- 313371 Drug sensitive 2,3-Bis(iodomethyl)-6-methoxyquinoxaline 286257 Drug sensitive 6-Bromotoyocamycin 270861 Drug sensitive 1H-Benzo[a]carbazole-1,4(11H)-dione, 11-methyl- 261066 Drug sensitive 3-[(2-Chlorophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide 25263092 Drug sensitive [(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug sensitive Antibiotic U 29135 24196291 Drug sensitive 7-Fluoro-2-benzoyl-3-trifluoromethylquioxaline 1,4-dioxide 23635154 Drug sensitive Pirarubicin hydrochloride 20846247 Drug sensitive Sudan II 18386 Drug sensitive 4-Chloro-5-phenoxy-3H-1,2-dithiole-3-thione 16766044 Drug sensitive (3As,3bR)-3b-hydroxy-3a,5,5-trimethyl-3-methylidene-4H-cyclopenta[a]pentalene-2,6-dione 15699597 Drug sensitive (6R)-1,6,11-Trihydroxy-8-[(2S,4R,5R,6R)-4-hydroxy-5-[(2S,4R,5R,6R)-5-hydroxy-4-[(2S,5S,6S)-5-[(2S,4R,5R,6R)-4-hydroxy-5-[(2S,4R,5R,6R)-5-hydroxy-4-[(2S,5S,6S)-5-hydroxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-3-methyl-5,6-dihydrobenzo[a]anthracene-7,12-dione 15507920 Drug sensitive 1H-2,10a-Ethanophenanthrene, kaur-16-en-15-one deriv. 146156727 Drug sensitive Methyl 3-bromo-2-(bromomethyl)propionate 140895 Drug sensitive (S)-2-Amino-3-(hydroxy(nitroso)amino)propanoic acid 136096147 Drug resistant 12-Iminodaunorubicin hcl 135539784 Drug sensitive 5-[(E)-[Amino(methyl)amino]azo]-1H-imidazole-4-carboxamide 135493930 Drug sensitive 2-Chloro-3-(2-butoxyethoxy)naphthazarin 135406263 Drug sensitive Inosine dialdehyde 135400916 Drug sensitive Melampodinin 11953936 Drug sensitive Unii-C616DV5Y11 117587576 Drug sensitive 2,2'-Bioxirane 11254 Drug sensitive Uridine, 2'-deoxy-2'-methylene- 11075548 Drug resistant Acetylenedicarboxamide 10971 Drug sensitive Perillyl alcohol 10819 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive Fusariotoxin T-2 102515111 Drug sensitive Chimaphilin 101211 Drug sensitive 6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione - Drug resistant .alpha.-sarcin - Drug resistant antineoplastic-d655481 - Drug resistant geldanamycin dimethylglycinate - Drug resistant tp4ek - Drug resistant (3-(4-bromophenyl)-5-(1,3-diphenyl-1H-pyrazol-4-yl)-4,5-dihydropyrazol-1-yl)(4-methoxyphenyl)methanone - Drug sensitive (Z)-5-methoxy-3-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive 1,2-naphthoquinone, 3,7-dimethyl- - Drug sensitive 1,4-anthracenedione, 5-hydroxy- - Drug sensitive 1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug sensitive 1h-benzimidazole, 5,5'-dithiobis[2-(trifluoromethyl)- (9ci) - Drug sensitive 1h-benzo[a]carbazole-1,4(11h)-dione, 11-phenyl- - Drug sensitive 2-(n,n-diethyl)acetyl-1,2-dihydroellipticine - Drug sensitive 2,2',5,5'-tetrahydroxy-4,4'-dimethylbiphenyl - Drug sensitive 2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive 2h-naphtho[1,2-b]pyran-2-one, 9-hydroxy-4-phenyl- - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive 9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive anthracen-9-one, 10-[(2-methoxyphenyl)methylene]- - Drug sensitive benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive geldanamycin, n,n'-dimethyl - Drug sensitive isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive [bis(aminomethyl)diethylsilane]dichloroplatinum (ii) - Drug sensitive 1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive 2-amino-5-chloro-6-(2-thiazolyloxy)-benzimidazole - Drug sensitive 4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug sensitive ambrosin piperidine diadduct di-n-oxide - Drug sensitive antibiotic a54556 - Drug sensitive antineoplastic-641296 - Drug sensitive antineoplastic-641297 - Drug sensitive arylmethylene-f - Drug sensitive bisarylpurine - Drug sensitive cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive from cephalodiscus gilchristi - Drug sensitive geldanamycin analog - Drug sensitive isatin dr - Drug sensitive leucinostatine d - Drug sensitive n-acetyl-4-s-cystaminyl phenol - Drug sensitive phosphocitrate penta sodium salt - Drug sensitive secafascaplysin - Drug sensitive streptorubrin - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-15a-5p	Curcumin 969516 Drug interaction    RC00000341 Formaldehyde 712 Drug interaction    RC00000321 Oxaliplatine 6857599 Drug interaction    RC00000345 Gemcitabine 60750 Drug interaction    RC00000334 Vincristine 5978 Drug interaction    RC00000330 Mitomycin 5746 Drug interaction    RC00000329 Dexamethasone 5743 Drug interaction    RC00000328 Eloxatine 5310940 Drug interaction    RC00000344 Imatinib 5291 Drug interaction    RC00000327 Calcitriol 5280453 Drug interaction    RC00000343 Melphalan 460612 Drug interaction    RC00000340 Decitabine 451668 Drug interaction    RC00000339 Diethylstilbestrol 448537 Drug interaction    RC00000338 Tretinoin 444795 Drug interaction    RC00000337 Metformin 4091 Drug interaction    RC00000326 Carboplatinum 38904 Drug interaction    RC00000333 Bortezomib 387447 Drug interaction    RC00000336 Paclitaxel 36314 Drug interaction    RC00000332 5-Fluorouracil 3385 Drug interaction    RC00000325 Doxorubicin 31703 Drug interaction    RC00000331 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000324 Tamoxifen 2733526 Drug interaction    RC00000342 Verapamil 2520 Drug interaction    RC00000323 Benzo[a]pyrene 2336 Drug interaction    RC00000322 Docetaxel 148124 Drug interaction    RC00000335 Leucovorin 135403648 Drug interaction    RC00000346

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-15a-5p
Interactor2: TLR3

Evidence Support:

Prediction-Evidence	microT//miRanda//miRMap//PicTar//PITA//Targetscan
Support Database	ViRBase

References:

PMID	33428154	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	To explore the regulatory relationship between the 5 key genes, 3 coronavirus-related genes (ACE2, TMPRSS2, BSG), and their target miRNA, we used 6 miRNA target prediction databases to predict the target miRNA of these genes.