Detail Information

Basic Information:


  VIRBase ID:  

HHID00105038

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9526

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-125 VEGFA
miRBase
Accession/Entrez ID		 hsa-miR-125 7422
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - MVCD1//VEGF//VPF

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase VEGFA
chr6:43738036-43738037(+) m6A 5'UTR//exon       24981863
chr6:43738048-43738049(+) m6A 5'UTR//exon       24981863
chr6:43738124-43738125(+) m6A 5'UTR//exon       24981863
chr6:43738139-43738140(+) m6A 5'UTR//exon       24284625
chr6:43738249-43738250(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr6:43738450-43738451(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr6:43738458-43738459(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr6:43738509-43738510(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr6:43738601-43738602(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr6:43738738-43738739(+) m1A 5'UTR//CDS//exon       26863196//26863410
chr6:43738825-43738826(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr6:43738980-43738981(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960
chr6:43738987-43738988(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960
chr6:43741786-43741787(+) m6A exon//intron       -
chr6:43745461-43745462(+) m6A exon//intron       27773535
chr6:43745833-43745834(+) m6A exon//intron       -
chr6:43745926-43745927(+) m6A exon//intron       -
chr6:43746210-43746211(+) m6A CDS//exon//intron       24284625//24209618
chr6:43746477-43746478(+) m6A exon//intron       24981863
chr6:43746646-43746647(+) m6A CDS//exon//intron       24981863
chr6:43746762-43746763(+) m6A exon//intron       24981863
chr6:43747745-43747746(+) m6A exon//intron       -
chr6:43748323-43748324(+) m6A exon//intron       -
chr6:43749769-43749770(+) m6A CDS//exon//intron       24284625
chr6:43749775-43749776(+) m6A CDS//exon//intron       24284625
chr6:43752338-43752339(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr6:43752360-43752361(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr6:43752386-43752387(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr6:43752423-43752424(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr6:43752441-43752442(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr6:43752463-43752464(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr6:43752498-43752499(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr6:43752632-43752633(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085
chr6:43752790-43752791(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr6:43752852-43752853(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr6:43752961-43752962(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr6:43752971-43752972(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr6:43753013-43753014(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr6:43753021-43753022(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr6:43753022-43753023(+) Cm 3'UTR//exon       -
chr6:43753046-43753047(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr6:43753082-43753083(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr6:43753211-43753212(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr6:43753243-43753244(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr6:43753288-43753289(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr6:43753339-43753340(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085
chr6:43753362-43753363(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085
chr6:43753387-43753388(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085
chr6:43753464-43753465(+) m6A 3'UTR//exon       24284625//24209618//22575960
chr6:43753562-43753563(+) m6A 3'UTR//exon       24284625

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-125
Exosome Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Lung epithelial carcinoma cell line (A549)     20615901
VEGFA
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Endoplasmic reticulum Human fibrosarcoma cells (HT1080)     25753659
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HeLa cells     25063809

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-125
Interactor2: VEGFA

Evidence Support:


Strong-Evidence Luciferase assay//RT-PCR//Western blot
Support Database ViRBase

References:


PMID 33675361 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line RKO cells Interactor2 expression None
Description In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.

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