Detail Information

Basic Information:


  VIRBase ID:  

HHID00105004

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      GAS5:           IL10:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol GAS5 IL10
miRBase
Accession/Entrez ID		 60674 3586
Organism Homo sapiens Homo sapiens
Category lncRNA mRNA
Alias NCRNA00030//SNHG2 CSIF//GVHDS//IL-10//IL10A//TGIF

RNA Editing:


Resource Symbol Editing Position
Lncediting GAS5
    chr1: 173833193
    chr1: 173833166
    chr1: 173836568
    chr1: 173836554
    chr1: 173836545
    chr1: 173836542
    chr1: 173835216
    chr1: 173836541
    chr1: 173836478
    chr1: 173834175
    chr1: 173836532
    chr1: 173836501
    chr1: 173833215
    chr1: 173836503
    chr1: 173834320
    chr1: 173834251
    chr1: 173836441
    chr1: 173836464
    chr1: 173836492
    chr1: 173836628
Resource Symbol Editing Position Change Genetic Region
RADAR GAS5
chr1:173836501(-) A-I      intronic
chr1:173836541(-) A-I      intronic
chr1:173836492(-) A-I      intronic
chr1:173836554(-) A-I      intronic
chr1:173836628(-) A-I      intronic
chr1:173836545(-) A-I      intronic
chr1:173836464(-) A-I      intronic
chr1:173836478(-) A-I      intronic
chr1:173836568(-) A-I      intronic
chr1:173836441(-) A-I      intronic
chr1:173833166(-) A-I      ncRNA
chr1:173833193(-) A-I      ncRNA
chr1:173836532(-) A-I      intronic
chr1:173833215(-) A-I      intronic
chr1:173836542(-) A-I      intronic
chr1:173836503(-) A-I      intronic
chr1:173835216(-) A-I      intronic
IL10
chr1:206941331(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED GAS5
chr1:173836441(-) A-I intron -    22028664
chr1:173836464(-) A-I intron -    22028664
chr1:173836478(-) A-I intron -    22028664
chr1:173836492(-) A-I intron -    22028664
chr1:173836501(-) A-I intron -    22028664
chr1:173836503(-) A-I intron -    22028664
chr1:173836541(-) A-I intron -    22028664
chr1:173836542(-) A-I intron -    22028664
chr1:173836545(-) A-I intron -    22028664
chr1:173836546(-) A-I intron -    22028664
chr1:173836554(-) A-I intron -    22028664
chr1:173836568(-) A-I intron -    22028664
chr1:173836628(-) A-I intron -    22028664
chr1:173834644(-) A-T exon 3'UTR    21725310
chr1:173833166(-) A-G exon 3'UTR    22484847
chr1:173833193(-) A-G exon 3'UTR    22484847
chr1:173833215(-) A-G intron -    22484847
chr1:173834231(-) T-C intron -    22484847
chr1:173834320(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase GAS5
chr1:173833328-173833329(-) m6A exon//intron       24981863//26404942
chr1:173833372-173833373(-) m6A exon//intron       24981863//26404942
chr1:173833514-173833515(-) Tm exon//intron       -
chr1:173833530-173833531(-) m6A exon//intron       26404942
chr1:173833625-173833626(-) m6A exon//intron       26404942
chr1:173833639-173833640(-) m6A exon//intron       26404942
chr1:173833647-173833648(-) m6A exon//intron       26404942
chr1:173834490-173834491(-) m6A exon//intron       26404942
chr1:173834496-173834497(-) m6A exon//intron       26404942
chr1:173834518-173834519(-) Am exon//intron       -
chr1:173835113-173835114(-) Tm exon//intron       -
chr1:173835659-173835660(-) m6A exon//intron       -
chr1:173835749-173835750(-) m6A exon//intron       -
chr1:173835786-173835787(-) Tm exon//intron       -
chr1:173835826-173835827(-) Y exon//intron       26075521
chr1:173836823-173836824(-) Gm exon//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate GAS5
Chromatin K562 cells     -
Cytoplasm HeLa cells     20124551
Cytoplasm Foreskin fibroblasts     25630241
Cytoplasm Hepatic stellate cells     26446789
Exosome Serum     -
Membrane HCC cell line (HepG2)|K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa cells     20124551
Nucleus Cell lines (GM12878|HeLaS3|HepG2|K562)|Human umbilical vein endothelial cells     22955988
Nucleus Colon cancer cells     24393600
Nucleus Foreskin fibroblasts|HeLa cells|Lung fibroblasts     25630241
Nucleus Hepatic stellate cells     26446789
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
IL10
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug GAS5
6-(Bromomethyl)anthracene-1,4-dione       9995010
Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-       9952773
Tivozanib       9911830
5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide       9903786
2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine       9858940
Tiotixene       941651
Pentamidine isethionate       8813
Acridine Yellow G       8672
Benzethonium chloride       8478
2-Methoxy-N-(3-Methyl-2-Oxo-1,2,3,4-Tetrahydroquinazolin-6-Yl)benzenesulfonamide       71271629
Decafluorobenzophenone       70068
Panobinostat       6918837
2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide       6918454
Temsirolimus       6918289
3',4'-Ethylendithio-avarone       6712611
2-Chloro-3-(N-(L)-tyrosinamido)naphthazarin       6712245
AICA ribonucleotide       65110
Mevastatin       64715
Ispinesib mesylate       6450816
Axitinib       6450551
Rifamycin       6324616
Cytarabine       6253
Acridine orange       62344
Primaquine phosphate       6135
Irinotecan       60838
Gemcitabine       60750
Topotecan       60700
3-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)phenol;hydrochloride       57399804
l-685,458       5479543
5-Bromo-3-(2-oxo-2-phenylethylidene)-1,3-dihydroindol-2-one       5477132
Fumagillin dicyclohexylamine salt       5474187
2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid       54685215
(2R,4S,6S,7E,9Z,11R)-2-Hydroxy-4,9-dimethyl-14-methylidene-5,12-dioxatricyclo[9.3.0.04,6]tetradeca-7,9-dien-13-one       5459288
Stereoisomer of 672120 (MW=262)       5459262
Austrocortirubin       5459130
Trunculin A       5459125
Zimeldine       5365247
Bleomycin a2       5360373
Crassin       5357909
Buddledin C       5352042
[(1R,2R,4R,8R,11Z,13R)-4,6,6,11-Tetramethyl-16-methylidene-10,15-dioxo-5,7,14-trioxatricyclo[11.3.0.04,8]hexadec-11-en-2-yl] (Z)-2-methylbut-2-enoate       5351315
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide       53340664
Palbociclib       5330286
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[(E)-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)ethenyl]-4-methylbenzamide       53302361
Bosutinib       5328940
Chlorprothixene hydrochloride       5282478
2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one       5278396
Bis(2-hydroxy-1-naphthyl) disulfide       521106
Dichloroplatinum; 2-(4-methoxyphenyl)ethanamine       498558
Pentamidine       4735
3-(4-(4-(2-(3-((Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea       46885626
5-Fluoro-2'-deoxyuridyly-(3'->5')-3'-C-ethynylcytosine       45028394
N-(2,2,2-Trifluoroethyl)-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}benzenesulfonamide       447912
Tretinoin       444795
Dabrafenib       44462760
Ditercalinium dimethanesulfonate dimethanesulfonate       435243
Withaferin-A diacetate       433361
Foretinib       42642645
Benzofurazan, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide       42640
Vemurafenib       42611257
Antineoplastic-690271       391308
Spirogermanium       39075
Withafastuosin D diacetate       388300
4-(Benzo[d]thiazol-2-yl)-2-bromoaniline       387948
2,6-Dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol       3796
7-Chloro-6-(2-fluoroethylamino)quinoline-5,8-dione       379079
N-(8-Hydroxy-6-methyl-1,4-dioxo-1,4-dihydro-2-naphthalenyl)acetamide       377214
2-[Bromo(iodo)methylidene]cyclohexan-1-one       376548
Dermocanarin-4       373887
9-[(4-Nitrophenyl)methylsulfanyl]acridin-3-amine       371147
Diisopropoxybis(1,4-naphthochinone-2-olato)titanium(IV)       368058
Paclitaxel       36314
3,4-Dihydroxynaphthalene-2-carboxylic acid       356138
2,3-Dimethylbenzo[g]quinoxaline-5,10-dione       353644
Predorine       333830
Tamoxifen       2733526
4-Amino-6-bromo-7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxamide       270853
[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol       25262965
2-(4-Methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide       25257557
Cabozantinib       25102847
2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid       25022668
Navitoclax       24978538
Ponatinib       24826799
Vismodegib       24776445
4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide       24772860
2,3-Dichloro-1,3-bis(4-methylphenyl)propan-1-one       244246
Vincaleukoblastine       241903
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide       24180719
Salinomycin, sodium       23682228
Tenulin       227830
Propiophenone, 3-phenyl-3-piperidino-       219163
Nutlin-3       216345
Lenalidomide       216326
Sorafenib       216239
Elegin       182337
Erlotinib       176870
Coriolin B, diketo-       169644
Adiantifoline       167937
4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide       16747388
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Neferine       159654
Butyltriphenylphosphonium bromide       159628
5,12-Naphthacenedione, 8-acetyl-10-((3-(bis(phenylmethyl)amino)-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-       153204
N-[5-[5-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-pyridin-4-ylfuran-3-yl]-2,3-dihydroinden-1-ylidene]hydroxylamine;hydrochloride       136207967
Astrazon Orange R       135747272
(Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide       135659062
Streptovaricin complex, fraction a       135474562
Dovitinib       135398510
Methotrexate       126941
Lestaurtinib       126565
Dactolisib       11977753
Veliparib       11960529
(Z)-But-2-enedioic acid;3-[4-[(3Z)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]-N-methylpropanamide       11954261
BAY 61-3606 dihydrochloride       11784504
N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-YL)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide       11754511
4-[2-(2-Chloro-4-fluoroanilino)-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide       11634725
Crizotinib       11626560
Benzamide, 4-((1R)-1-aminoethyl)-N-1H-pyrrolo(2,3-b)pyridin-4-yl-, hydrochloride (1:1)       11507964
(S)-N-((S)-1-Cyclohexyl-2-oxo-2-((3aR,7aS)-6-phenethyloctahydro-1H-pyrrolo[2,3-c]pyridin-1-yl)ethyl)-2-(methylamino)propanamide       11503417
Linifanib       11485656
Bafetinib       11387605
N-(6-Fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide       11373846
8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one       11327430
(S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide       11152667
[(4-Methylphenyl)methyl](triphenyl)arsanium bromide       10672721
7-Ethyl-10-hydroxycamptothecin       104842
VX-702       10341154
N-(3-{[5-Iodo-4-({3-[(Thiophen-2-Ylcarbonyl)amino]propyl}amino)pyrimidin-2-Yl]amino}phenyl)pyrrolidine-1-Carboxamide       10077147
Saframycin A       100594
PDK1 inhibitor AR-12       10027278
25-Dihydrosaframycin A       100180
Thymidine, 5'-((bromoacetyl)amino)-5'-deoxy-       100092
2,6-bis(4-morpholinylmethyl)cyclohexanone,dihydrochloride       -
3h-1,2-dithiole, tetrachloro-       -
;4-fluoro-N-(3-(4-(6-(4-hydroxyphenyl)imidazo[2,1-b]thia...       -
5,6-ethylenediquino[3,2-b       -
acridine, 9-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-       -
benzo[b]naphtho[2,3-d]furan-6,11-dione, 4-chloro-3-hydroxy       -
Bleomycin (50 uM)       -
Carboxyphthalatoplatinum       -
chlorotris(chinoline-8-olato)titanium(iv)-trihydrochloride       -
crotoxin cd       -
g-tpp       -
Hypothemycin       -
ICL1100013       -
indole-2,3-dione, 3-[(pentafluorophenyl)hydrazone]       -
KIN001-236       -
KIN001-260       -
naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)-       -
NPK76-II-72-1       -
Nutlin-3a (-)       -
protein toxin c 10 - mw approx. 6700       -
protein toxin d 5 - mw approx 6700       -
rhodium dimer       -
TL-1-85       -
VNLG/124       -
XMD14-99       -
XMD15-27       -

Interaction Network (The top 100 interactions):


Interactor1: GAS5
Interactor2: IL10

Evidence Support:


Prediction-Evidence LncRNA2Target
Support Database ViRBase

References:


PMID 33520952 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description We identified a total of 24 cytokine-lncRNA relationships using LncRNA2Target (Table 2). The most significant lncRNAs associated with COVID-19 cytokine storm cytokines, accompanied by lncRNA target prediction analysis using average ndG values.

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