Detail Information

Basic Information:


  VIRBase ID:  

HHID00105000

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      SNHG1:           IL10:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol SNHG1 IL10
miRBase
Accession/Entrez ID		 23642 3586
Organism Homo sapiens Homo sapiens
Category lncRNA mRNA
Alias LINC00057//lncRNA16//NCRNA00057//U22HG//UHG CSIF//GVHDS//IL-10//IL10A//TGIF

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IL10
chr1:206941331(-) A-I      3'UTR

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SNHG1
chr11:62619719-62619720(-) m6A exon       27773535
chr11:62619752-62619753(-) m6A exon//intron       27773535
chr11:62619758-62619759(-) m6A exon//intron       27773535
chr11:62619793-62619794(-) m6A exon//intron       27773535
chr11:62620007-62620008(-) m6A exon//intron       26404942
chr11:62620025-62620026(-) m6A exon//intron       26404942
chr11:62620037-62620038(-) m6A exon//intron       26404942
chr11:62620394-62620395(-) m6A exon//intron       24981863
chr11:62620408-62620409(-) Tm exon//intron       -
chr11:62620422-62620423(-) Gm exon//intron       -
chr11:62620433-62620434(-) m6A exon//intron       24981863
chr11:62620443-62620444(-) m6A exon//intron       24981863
chr11:62620493-62620494(-) m6A exon//intron       24981863
chr11:62620808-62620809(-) Tm exon//intron       -
chr11:62621138-62621139(-) Tm exon//intron       -
chr11:62621150-62621151(-) Tm exon//intron       -
chr11:62621376-62621377(-) m6A exon//intron       26404942
chr11:62621387-62621388(-) m6A exon//intron       26404942
chr11:62621422-62621423(-) m6A exon//intron       26404942
chr11:62622516-62622517(-) m6A exon//intron       26404942
chr11:62622542-62622543(-) m6A exon//intron       26404942
chr11:62622569-62622570(-) m6A exon//intron       26404942
chr11:62622772-62622773(-) Tm exon//intron       -
chr11:62623253-62623254(-) m6A exon//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate SNHG1
Chromatin HCC cell line (HepG2)|K562 cells     -
Cytoplasm Cell line (HeLa)     27090285
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)|K562 cells     -
Nucleolus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Nucleoplasm HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Nucleus HCT-116 cells|HeLa cells     28264987
Nucleus Cell line (A549)|Human colon carcinoma-derived cell line (HCT-116)     28825722
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Periphery of the nucleus Cell line (HeLa)     27090285
IL10
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug SNHG1
6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide       9956222
6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile       9956119
Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-       9952773
5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride       9938202
1,2-Ethanediamine, N-(1,8-dimethylimidazo(1,2-a)quinoxalin-4-yl)-, monohydrochloride       9926054
Tivozanib       9911830
Zibotentan       9910224
5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide       9903786
PI-103       9884685
2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide       9874913
Osi-930       9868037
2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine       9858940
4-[4-(2,3-Dihydro-1,4-benzodioxin-6-YL)-3-methyl-1H-pyrazol-5-YL]-6-ethylbenzene-1,3-diol       984170
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528
Tiotixene       941651
8-Hydroxy-7-(6-sulfo-naphthalen-2-ylazo)-quinoline-5-sulfonic acid       92577
Phenformin       8249
(E)-1-(2-Hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one       78243717
2-Methoxy-N-(3-Methyl-2-Oxo-1,2,3,4-Tetrahydroquinazolin-6-Yl)benzenesulfonamide       71271629
N-(3-Methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine       704473
(S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide       6918848
Panobinostat       6918837
Belinostat       6918638
Daporinad       6914657
N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide       6852167
AICA ribonucleotide       65110
Tanespimycin       6505803
9-(Acetyloxy)-7-hydroxy-10-(hydroxymethyl)-6-methyl-3-methylene-2-oxo-2,3,3a,4,7,8,9,11a-octahydrocyclodeca(b)furan-4-yl 2-methylbutanoate       6451077
Ispinesib mesylate       6450816
Axitinib       6450551
Pelitinib       6445562
Dacinostat       6445533
Cytarabine       6253
Irinotecan       60838
Gemcitabine       60750
Topotecan       60700
Mitomycin       5746
(2-(Phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone)       57339144
1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea       56962337
l-685,458       5479543
2-Butenoic acid, 2-methyl-, 2,3,3a,4,5,6,7,8,9,11a-decahydro-7,9-dihydroxy-10-(hydroxymethyl)-6-methyl-3-methylene-2-oxo-6,9-epoxycyclodeca[b]furan-4-yl ester, [3aR-[3aR*,4R*(Z),6R*,7S*,9R*,10Z,11aR*]]-       5477575
Caracemide       54747
Fumagillin dicyclohexylamine salt       5474187
2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid       54685215
Mito-tempol       54613387
Thiram       5455
Temozolomide       5394
Acetylrolandrolide       5384465
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide       53340664
Palbociclib       5330286
Bosutinib       5328940
Vinorelbine       5311497
Vorinostat       5311
5-Quinoxalin-6-ylmethylene-thiazolidine-2,4-dione       5289247
2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one       5278396
Bis(2-hydroxy-1-naphthyl) disulfide       521106
2-{[4-(5-Ethylpyrimidin-4-Yl)piperazin-1-Yl]methyl}-5-(Trifluoromethyl)-1h-Benzimidazole       51371303
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide       5113032
Dichloroplatinum; 2-(4-methoxyphenyl)ethanamine       498558
Tubastatin A       49850262
Alectinib       49806720
Shikonin       479503
2-[(4s)-6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-4h-[1,2,4]triazolo[4,3-A][1,4]benzodiazepin-4-Yl]-N-Ethylacetamide       46943432
(S)-(+)-Tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate       46907787
3-(4-(4-(2-(3-((Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea       46885626
Avagacestat       46883536
2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine       46224516
N-(6,6-Dimethyl-5-(1-methylpiperidine-4-carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-3-methylbutanamide       46191454
Epothilone B       448013
N-(2,2,2-Trifluoroethyl)-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}benzenesulfonamide       447912
Thapsigargin       446378
1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine       44551660
Tretinoin       444795
Refametinib       44182295
Foretinib       42642645
Benzofurazan, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide       42640
(2S)-2-[[2-(2,3-Dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]-6-purinyl]amino]-3-phenyl-1-propanol       42623900
Spirogermanium       39075
4-(Benzo[d]thiazol-2-yl)-2-bromoaniline       387948
4-N-(3-Bromophenyl)pyrido[4,3-d]pyrimidine-4,7-diamine;methanesulfonic acid       382058
2,6-Dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol       3796
N-(8-Hydroxy-6-methyl-1,4-dioxo-1,4-dihydro-2-naphthalenyl)acetamide       377214
2-Amino-5,8-dihydroxy-1,4-naphthoquinone       377209
Etoposide       36462
Nilacrone       364456
4-(1-Benzofuran-2-yl)-7-methoxychromen-2-one       364364
Paclitaxel       36314
5-Fluorouracil       3385
Doxorubicin       31703
Tamoxifen       2733526
[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol       25262965
2-(4-Methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide       25257557
4-[3-Fluoro-5-(4-morpholinyl)phenyl]-N-[4-[3-(4-morpholinyl)-1,2,4-triazol-1-yl]phenyl]-2-pyrimidinamine       25222038
Omipalisib       25167777
Ruxolitinib       25126798
N-(2,6-Difluorophenyl)-5-[3-[2-[5-ethyl-2-methoxy-4-[4-(4-methylsulfonyl-1-piperazinyl)-1-piperidinyl]anilino]-4-pyrimidinyl]-2-imidazo[1,2-a]pyridinyl]-2-methoxybenzamide       25124816
Cabozantinib       25102847
2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid       25022668
Navitoclax       24978538
Tert-Butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate       24951314
Quizartinib       24889392
Ponatinib       24826799
Vismodegib       24776445
4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide       24772860
Cudc-101       24756910
Ethoxytris(2-methyl-8-chinolineolato)titanium(IV)       24202327
Vincaleukoblastine       241903
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide       24180719
Bicalutamide       2375
Olaparib       23725625
Salinomycin, sodium       23682228
(2E,5E)-2,5-Bis(thiophen-2-ylmethylene)cyclopentanone       2314623
Nutlin-3       216345
Lenalidomide       216326
Sorafenib       216239
Erlotinib       176870
Enzastaurin       176167
4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide       16747388
Gsk-690693       16725726
Fedratinib       16722836
Obatoclax mesylate       16681698
N-(3-{[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-[2-(morpholin-4-yl)ethoxy]benzamide       16095342
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Butyltriphenylphosphonium bromide       159628
Tipifarnib       159324
Docetaxel       148124
1-(Tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea       1401
Astrazon Orange R       135747272
(Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide       135659062
Luminespib       135539077
Streptovaricin complex, fraction a       135474562
(E)-5-(2-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime       135421339
Pac-1       135421197
Osi-027       135398516
Dovitinib       135398510
Akt inhibitor VIII       135398501
[(1R,2R,4R,8S,9R,10S,12S,13S,16R)-2,8,16-Trihydroxy-5,5,9-trimethyl-14-methylidene-15-oxo-12-tetracyclo[11.2.1.01,10.04,9]hexadecanyl] acetate       13193213
Methotrexate       126941
Lestaurtinib       126565
Gefitinib       123631
(1S,2S,4R,12S,13R,15R,18R)-2-Bromo-8-[(2R,3S)-1,1-dichloro-3-hydroxy-3-[(2R,4R)-4-methyl-5-oxooxolan-2-yl]propan-2-yl]-18-hydroxy-9,13-dimethyl-17,19-dioxapentacyclo[13.3.1.01,13.04,12.05,10]nonadeca-5(10),6,8-trien-11-one       11966550
Veliparib       11960529
(Z)-But-2-enedioic acid;3-[4-[(3Z)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]-N-methylpropanamide       11954261
BAY 61-3606 dihydrochloride       11784504
N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-YL)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide       11754511
PF-00562271 free base       11713159
Trametinib       11707110
4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine       11647372
Linsitinib       11640390
4-[2-(2-Chloro-4-fluoroanilino)-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide       11634725
Crizotinib       11626560
Idelalisib       11625818
JNK Inhibitor VIII       11624601
5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine       11617559
Benzamide, 4-((1R)-1-aminoethyl)-N-1H-pyrrolo(2,3-b)pyridin-4-yl-, hydrochloride (1:1)       11507964
(S)-N-((S)-1-Cyclohexyl-2-oxo-2-((3aR,7aS)-6-phenethyloctahydro-1H-pyrrolo[2,3-c]pyridin-1-yl)ethyl)-2-(methylamino)propanamide       11503417
5-(2-Phenylpyrazolo[1,5-A]pyridin-3-YL)-1H-pyrazolo[3,4-C]pyridazin-3-amine       11493598
Linifanib       11485656
Bafetinib       11387605
N-(6-Fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide       11373846
4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide       11338033
8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one       11327430
Amuvatinib       11282283
Sepantronium bromide       11178236
(S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide       11152667
[(4-Methylphenyl)methyl](triphenyl)arsanium bromide       10672721
7-Ethyl-10-hydroxycamptothecin       104842
5,7-Dihydroxy-2-(4-Hydroxyphenyl)-4-Oxo-4h-Chromen-3-Yl 3,4-Di-O-Acetyl-6-Deoxy-alpha-L-Mannopyranoside       10459196
VX-702       10341154
Selumetinib       10127622
1,3-Benzothiazol-2-yl(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile       10109823
N-(3-{[5-Iodo-4-({3-[(Thiophen-2-Ylcarbonyl)amino]propyl}amino)pyrimidin-2-Yl]amino}phenyl)pyrrolidine-1-Carboxamide       10077147
Masitinib       10074640
Saframycin A       100594
PDK1 inhibitor AR-12       10027278
Cyanocycline A       100158
1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion       -
4-morpholinecarbodithioic acid, antimony complex       -
4-thiomorpholinecarbodithioic acid, antimony complex       -
5,6-ethylenediquino[3,2-b       -
6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione       -
Cisplatin       -
[co(me2dtc)2(dee)]clo4       -
Genentech Cpd 10       -
ICL1100013       -
JQ12       -
JW-7-24-1       -
KIN001-236       -
KIN001-244       -
KIN001-260       -
KIN001-266       -
KIN001-270       -
MPS-1-IN-1       -
NPK76-II-72-1       -
Nutlin-3a (-)       -
piperidinium, 1,1-didodecyl-3-methyl-, bromide       -
QL-X-138       -
QL-XI-92       -
QL-XII-47       -
rhodium dimer       -
rTRAIL       -
SB52334       -
sodium[(tetratropolonato)bismuthate(iii)]       -
THZ-2-102-1       -
THZ-2-49       -
TL-1-85       -
TL-2-105       -
Vinorelbine       -
VNLG/124       -
WZ3105       -
XMD13-2       -
XMD14-99       -
XMD15-27       -

Interaction Network (The top 100 interactions):


Interactor1: SNHG1
Interactor2: IL10

Evidence Support:


Prediction-Evidence LncRNA2Target
Support Database ViRBase

References:


PMID 33520952 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description We identified a total of 24 cytokine-lncRNA relationships using LncRNA2Target (Table 2). The most significant lncRNAs associated with COVID-19 cytokine storm cytokines, accompanied by lncRNA target prediction analysis using average ndG values.

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