Detail Information

Basic Information:


  VIRBase ID:  

HHID00099596

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-6836-5p:           POLR3H:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-6836-5p POLR3H
miRBase
Accession/Entrez ID		 MIMAT0027574 171568
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - C25//RPC22.9//RPC8

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-6836-5p
rs1175923434 chr7:2257551    A/T
rs1397797431 chr7:2257557    G/T
rs1402374487 chr7:2257560    C/T
rs373301992 chr7:2257555    C/T
rs751019973 chr7:2257572    G/A
rs751019973 chr7:2257572    G/T
rs752401585 chr7:2257559    G/A
rs752401585 chr7:2257559    G/C
rs762697510 chr7:2257562    A/T
rs765066033 chr7:2257558    C/A
rs765066033 chr7:2257558    C/T
rs767238780 chr7:2257563    G/A
rs767238780 chr7:2257563    G/T
rs776617786 chr7:2257553    G/A
rs776617786 chr7:2257553    G/T
rs1378787511 chr7:2257565    G/A
rs747250755 chr7:2257571    C/CT
rs756757197 chr7:2257570    G/A
rs768462924 chr7:2257568    C/G
rs780841384 chr7:2257571    C/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR POLR3H
chr22:41938895(-) A-I      intronic
chr22:41939387(-) A-I      intronic
chr22:41939388(-) A-I      intronic
chr22:41939568(-) A-I      intronic
chr22:41938859(-) A-I      intronic
chr22:41938844(-) A-I      intronic
chr22:41935128(-) A-I      intronic
chr22:41934421(-) A-I      intronic
chr22:41934418(-) A-I      intronic
chr22:41934359(-) A-I      intronic
chr22:41933887(-) A-I      intronic
chr22:41933879(-) A-I      intronic
chr22:41939623(-) A-I      intronic
chr22:41930701(-) A-I      intronic
chr22:41933939(-) A-I      intronic
chr22:41934402(-) A-I      intronic
chr22:41935022(-) A-I      intronic
chr22:41934491(-) A-I      intronic
chr22:41938931(-) A-I      intronic
chr22:41932028(-) A-I      intronic
chr22:41934467(-) A-I      intronic
chr22:41933945(-) A-I      intronic
chr22:41932023(-) A-I      intronic
chr22:41935010(-) A-I      intronic
chr22:41935151(-) A-I      intronic
chr22:41935097(-) A-I      intronic
chr22:41938320(-) A-I      intronic
chr22:41931761(-) A-I      intronic
chr22:41933903(-) A-I      intronic
chr22:41938315(-) A-I      intronic
chr22:41932788(-) A-I      intronic
chr22:41938360(-) A-I      intronic
chr22:41932398(-) A-I      intronic
chr22:41931665(-) A-I      intronic
chr22:41938304(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase POLR3H
chr22:41921866-41921867(-) m6A 3'UTR       24981863//27773535
chr22:41921925-41921926(-) m6A 3'UTR       24284625//24981863//27773535
chr22:41921940-41921941(-) m6A 3'UTR       24284625//27773535
chr22:41921952-41921953(-) m6A 3'UTR       24284625//27773535
chr22:41922004-41922005(-) m6A 3'UTR       24284625
chr22:41922129-41922130(-) m6A 3'UTR       24284625
chr22:41922243-41922244(-) m6A 3'UTR       24284625
chr22:41922319-41922320(-) m6A 3'UTR       24284625
chr22:41922421-41922422(-) m6A 3'UTR       24284625//27773535
chr22:41922642-41922643(-) m6A 3'UTR       24284625
chr22:41922660-41922661(-) m6A 3'UTR       24284625
chr22:41922994-41922995(-) m6A 3'UTR       24284625//24209618//25456834//27773535//22608085
chr22:41923054-41923055(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr22:41923089-41923090(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr22:41923111-41923112(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr22:41923435-41923436(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr22:41923511-41923512(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr22:41923523-41923524(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr22:41923671-41923672(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr22:41923795-41923796(-) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr22:41923840-41923841(-) m6A 3'UTR       24284625//24209618//25456834
chr22:41924040-41924041(-) m6A 3'UTR       24284625
chr22:41924077-41924078(-) m6A 3'UTR       24284625
chr22:41924147-41924148(-) m6A 3'UTR       24284625
chr22:41924327-41924328(-) m6A 3'UTR       24284625//24209618//27773536
chr22:41924368-41924369(-) m6A 3'UTR       24284625//24209618//27371828//27773536
chr22:41924389-41924390(-) m6A 3'UTR       24284625//24209618//27371828//27773536
chr22:41924407-41924408(-) m6A 3'UTR       24284625//24209618
chr22:41924569-41924570(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773536//22608085
chr22:41924652-41924653(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27773536//22575960//22608085
chr22:41924782-41924783(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr22:41924823-41924824(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr22:41924828-41924829(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr22:41924891-41924892(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr22:41924947-41924948(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr22:41924985-41924986(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr22:41925003-41925004(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr22:41925024-41925025(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr22:41925031-41925032(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr22:41925042-41925043(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr22:41925177-41925178(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr22:41925224-41925225(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr22:41925266-41925267(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr22:41925273-41925274(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr22:41925297-41925298(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr22:41926823-41926824(-) m6A 3'UTR//CDS       24284625//27773535//27773536//22575960
chr22:41928624-41928625(-) m6A CDS//intron       24284625//27773535//27773536//22575960
chr22:41928632-41928633(-) m6A CDS//exon//intron       24284625//27773535//27773536//22575960
chr22:41928637-41928638(-) m6A CDS//exon//intron       24284625//27773535//22575960
chr22:41928676-41928677(-) Cm 3'UTR//CDS//exon//intron       -
chr22:41940013-41940014(-) m6A CDS//exon       25456834//27371828
chr22:41940079-41940080(-) m6A CDS//exon       25456834//27371828//27773536
chr22:41940189-41940190(-) m6A 5'UTR//exon//intron       24284625//24209618//24981863//27371828//27773536
chr22:41940242-41940243(-) m6A 5'UTR//exon//intron       24284625//24209618//27773536
chr22:41940256-41940257(-) m6A 5'UTR//exon//intron       24284625//24209618//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-6836-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
POLR3H
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-6836-5p
Interactor2: POLR3H

Evidence Support:


Weak-Evidence Illumina sequencing
Prediction-Evidence miRanda
Support Database ViRBase

References:


PMID 32223537 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Calu-3 cells Interactor2 expression Downregulation
Description The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.

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