Basic Information:

  VIRBase ID:  

HHID00099580

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-6836-5p:  MIMAT0027574          TMEM222:  NM_032125     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-6836-5p	TMEM222
miRBase Accession/Entrez ID	MIMAT0027574	84065
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C1orf160

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-6836-5p	rs1175923434 chr7:2257551    A/T rs1397797431 chr7:2257557    G/T rs1402374487 chr7:2257560    C/T rs373301992 chr7:2257555    C/T rs751019973 chr7:2257572    G/A rs751019973 chr7:2257572    G/T rs752401585 chr7:2257559    G/A rs752401585 chr7:2257559    G/C rs762697510 chr7:2257562    A/T rs765066033 chr7:2257558    C/A rs765066033 chr7:2257558    C/T rs767238780 chr7:2257563    G/A rs767238780 chr7:2257563    G/T rs776617786 chr7:2257553    G/A rs776617786 chr7:2257553    G/T rs1378787511 chr7:2257565    G/A rs747250755 chr7:2257571    C/CT rs756757197 chr7:2257570    G/A rs768462924 chr7:2257568    C/G rs780841384 chr7:2257571    C/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TMEM222	chr1:27654067(+) A-I      intronic chr1:27654046(+) A-I      intronic chr1:27654027(+) A-I      intronic chr1:27654041(+) A-I      intronic chr1:27654045(+) A-I      intronic chr1:27654307(+) A-I      intronic chr1:27654333(+) A-I      intronic chr1:27654089(+) A-I      intronic chr1:27654319(+) A-I      intronic chr1:27654332(+) A-I      intronic chr1:27654069(+) A-I      intronic chr1:27650070(+) A-I      intronic chr1:27650087(+) A-I      intronic chr1:27653949(+) A-I      intronic chr1:27653997(+) A-I      intronic chr1:27654009(+) A-I      intronic chr1:27656378(+) A-I      intronic chr1:27656572(+) A-I      intronic chr1:27654372(+) A-I      intronic chr1:27656808(+) A-I      intronic chr1:27656432(+) A-I      intronic chr1:27654318(+) A-I      intronic chr1:27656809(+) A-I      intronic chr1:27656428(+) A-I      intronic chr1:27654359(+) A-I      intronic chr1:27656679(+) A-I      intronic chr1:27656837(+) A-I      intronic chr1:27650127(+) A-I      intronic chr1:27656472(+) A-I      intronic chr1:27654154(+) A-I      intronic chr1:27654060(+) A-I      intronic chr1:27654226(+) A-I      intronic chr1:27654102(+) A-I      intronic chr1:27654271(+) A-I      intronic chr1:27650054(+) A-I      intronic chr1:27654366(+) A-I      intronic chr1:27656433(+) A-I      intronic chr1:27654234(+) A-I      intronic chr1:27654142(+) A-I      intronic chr1:27656435(+) A-I      intronic chr1:27650133(+) A-I      intronic chr1:27653979(+) A-I      intronic chr1:27656512(+) A-I      intronic chr1:27650104(+) A-I      intronic chr1:27653980(+) A-I      intronic chr1:27650193(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TMEM222	chr1:27653979(+) A-G intron -    22484847 chr1:27653980(+) A-G intron -    22484847 chr1:27656472(+) A-G intron -    22484847 chr1:27656679(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMEM222	chr1:27648785-27648786(+) m6A 5'UTR//CDS       25456834//24981863 chr1:27651739-27651740(+) Y intron       16381836 chr1:27651748-27651749(+) Y intron       16381836 chr1:27651755-27651756(+) Am intron       16381836 chr1:27651761-27651762(+) Am intron       16381836 chr1:27651762-27651763(+) Gm intron       16381836 chr1:27657269-27657270(+) m6A CDS       24981863 chr1:27661998-27661999(+) m6A 3'UTR//exon       24284625//25456834//24981863//22608085 chr1:27662072-27662073(+) m6A 3'UTR//exon       24284625//25456834//24981863//22575960//22608085 chr1:27662102-27662103(+) m6A 3'UTR//exon       24284625//25456834//24981863//22575960//22608085 chr1:27662109-27662110(+) m6A 3'UTR//exon       24284625//25456834//24981863//22575960//22608085 chr1:27662238-27662239(+) Y 3'UTR//exon       26075521 chr1:27662306-27662307(+) m6A 3'UTR//exon       - chr1:27662339-27662340(+) m6A 3'UTR//exon       - chr1:27662576-27662577(+) m6A 3'UTR//exon       - chr1:27662617-27662618(+) m6A 3'UTR//exon       - chr1:27662646-27662647(+) m6A 3'UTR//exon       - chr1:27662660-27662661(+) m6A 3'UTR//exon       - chr1:27662689-27662690(+) m6A 3'UTR//exon       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-6836-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	TMEM222	Exosome Blood     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-6836-5p
Interactor2: TMEM222

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Downregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.