Basic Information:

  VIRBase ID:  

HHID00099577

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-6836-5p:  MIMAT0027574          TTYH3:  NM_025250     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-6836-5p	TTYH3
miRBase Accession/Entrez ID	MIMAT0027574	80727
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-6836-5p	rs1175923434 chr7:2257551    A/T rs1397797431 chr7:2257557    G/T rs1402374487 chr7:2257560    C/T rs373301992 chr7:2257555    C/T rs751019973 chr7:2257572    G/A rs751019973 chr7:2257572    G/T rs752401585 chr7:2257559    G/A rs752401585 chr7:2257559    G/C rs762697510 chr7:2257562    A/T rs765066033 chr7:2257558    C/A rs765066033 chr7:2257558    C/T rs767238780 chr7:2257563    G/A rs767238780 chr7:2257563    G/T rs776617786 chr7:2257553    G/A rs776617786 chr7:2257553    G/T rs1378787511 chr7:2257565    G/A rs747250755 chr7:2257571    C/CT rs756757197 chr7:2257570    G/A rs768462924 chr7:2257568    C/G rs780841384 chr7:2257571    C/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TTYH3	chr7:2694483(+) A-I      intronic chr7:2693492(+) A-I      intronic chr7:2694482(+) A-I      intronic chr7:2694884(+) A-I      intronic chr7:2693908(+) A-I      intronic chr7:2695041(+) A-I      intronic chr7:2694919(+) A-I      intronic chr7:2693962(+) A-I      intronic chr7:2694851(+) A-I      intronic chr7:2690092(+) A-I      intronic chr7:2694013(+) A-I      intronic chr7:2694946(+) A-I      intronic chr7:2693830(+) A-I      intronic chr7:2694969(+) A-I      intronic chr7:2694977(+) A-I      intronic chr7:2693858(+) A-I      intronic chr7:2694897(+) A-I      intronic chr7:2693828(+) A-I      intronic chr7:2693377(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TTYH3	chr7:2682535(+) G-A intron -    22484847 chr7:2682601(+) G-A intron -    22484847 chr7:2693847(+) A-G intron -    22484847 chr7:2693909(+) A-G intron -    22484847 chr7:2694897(+) A-G intron -    22484847 chr7:2694919(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TTYH3	chr7:2671590-2671591(+) m6A 5'UTR       24209618 chr7:2671895-2671896(+) m6A CDS       24284625//24209618 chr7:2685180-2685181(+) m6A 5'UTR//intron       24284625 chr7:2685221-2685222(+) m6A 5'UTR//intron       24284625 chr7:2685514-2685515(+) m6A CDS//intron       - chr7:2686532-2686533(+) m6A CDS       - chr7:2686582-2686583(+) Am CDS       - chr7:2686812-2686813(+) m6A CDS       - chr7:2686882-2686883(+) m6A CDS       - chr7:2687058-2687059(+) m6A CDS       - chr7:2687076-2687077(+) m6A CDS       - chr7:2687102-2687103(+) m6A CDS       - chr7:2687214-2687215(+) m6A CDS       24284625 chr7:2690758-2690759(+) Gm intron       - chr7:2698037-2698038(+) m6A CDS//exon       24284625 chr7:2698596-2698597(+) m6A CDS       24284625//24209618//22575960 chr7:2698611-2698612(+) m6A CDS       24284625//24209618//22575960 chr7:2699592-2699593(+) m6A CDS//intron       24284625//24209618 chr7:2699631-2699632(+) m6A CDS//intron       24284625//24209618//24981863 chr7:2701373-2701374(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr7:2701457-2701458(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr7:2701756-2701757(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr7:2701821-2701822(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr7:2701827-2701828(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr7:2702046-2702047(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960 chr7:2702115-2702116(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960 chr7:2702136-2702137(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960 chr7:2702219-2702220(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960 chr7:2702307-2702308(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr7:2702324-2702325(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr7:2702356-2702357(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr7:2702380-2702381(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr7:2702517-2702518(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960 chr7:2702542-2702543(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960 chr7:2702576-2702577(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960 chr7:2702593-2702594(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960 chr7:2702611-2702612(+) m6A 3'UTR       24284625//24209618//24981863//22575960 chr7:2702952-2702953(+) m6A 3'UTR       24284625//24209618//22575960 chr7:2703011-2703012(+) m6A 3'UTR       24284625//24209618//22575960 chr7:2703041-2703042(+) m6A 3'UTR       24284625//24209618//22575960 chr7:2703137-2703138(+) m6A 3'UTR       24284625 chr7:2703267-2703268(+) Y 3'UTR       26075521 chr7:2703381-2703382(+) m6A 3'UTR       24284625//25456834//24981863//26404942//22575960//22608085 chr7:2703434-2703435(+) m6A 3'UTR       24284625//25456834//24981863//26404942//22575960//22608085 chr7:2703522-2703523(+) Y 3'UTR       26075521 chr7:2703526-2703527(+) m6A 3'UTR       24284625//24981863//26404942//22575960//22608085 chr7:2703732-2703733(+) m6A 3'UTR       24284625 chr7:2703749-2703750(+) m6A 3'UTR       24284625 chr7:2704084-2704085(+) m6A 3'UTR       24284625 chr7:2704134-2704135(+) m6A 3'UTR       24284625 chr7:2704208-2704209(+) m6A 3'UTR       24284625//24981863//27773535 chr7:2704220-2704221(+) m6A 3'UTR       24284625//24981863//27773535 chr7:2704302-2704303(+) m6A 3'UTR       24284625//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-6836-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	TTYH3	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-6836-5p
Interactor2: TTYH3

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Downregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.