Basic Information:

  VIRBase ID:  

HHID00099570

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-6836-5p:  MIMAT0027574          SEMA4G:  NR_172054     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-6836-5p	SEMA4G
miRBase Accession/Entrez ID	MIMAT0027574	57715
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-6836-5p	rs1175923434 chr7:2257551    A/T rs1397797431 chr7:2257557    G/T rs1402374487 chr7:2257560    C/T rs373301992 chr7:2257555    C/T rs751019973 chr7:2257572    G/A rs751019973 chr7:2257572    G/T rs752401585 chr7:2257559    G/A rs752401585 chr7:2257559    G/C rs762697510 chr7:2257562    A/T rs765066033 chr7:2257558    C/A rs765066033 chr7:2257558    C/T rs767238780 chr7:2257563    G/A rs767238780 chr7:2257563    G/T rs776617786 chr7:2257553    G/A rs776617786 chr7:2257553    G/T rs1378787511 chr7:2257565    G/A rs747250755 chr7:2257571    C/CT rs756757197 chr7:2257570    G/A rs768462924 chr7:2257568    C/G rs780841384 chr7:2257571    C/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SEMA4G	chr10:102736343(+) A-I      intronic chr10:102736333(+) A-I      intronic chr10:102734119(+) A-I      intronic chr10:102733555(+) A-I      intronic chr10:102733733(+) A-I      intronic chr10:102734021(+) A-I      intronic chr10:102733997(+) A-I      intronic chr10:102734003(+) A-I      intronic chr10:102735643(+) A-I      intronic chr10:102735578(+) A-I      intronic chr10:102735563(+) A-I      intronic chr10:102734022(+) A-I      intronic chr10:102736147(+) A-I      intronic chr10:102734171(+) A-I      intronic chr10:102734101(+) A-I      intronic chr10:102733603(+) A-I      intronic chr10:102733994(+) A-I      intronic chr10:102733605(+) A-I      intronic chr10:102736283(+) A-I      intronic chr10:102733669(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SEMA4G	chr10:102729540-102729541(+) m6A 5'UTR//exon//intron       25456834//27371828 chr10:102729562-102729563(+) m6A 5'UTR//exon//intron       25456834//27371828 chr10:102729591-102729592(+) m6A 5'UTR//exon//intron       27371828 chr10:102732499-102732500(+) m6A 5'UTR//exon//intron       24209618//24981863 chr10:102732571-102732572(+) m6A 5'UTR//exon//intron       24981863 chr10:102738862-102738863(+) m6A CDS//exon       27371828//22608085 chr10:102741146-102741147(+) m6A exon//intron       27773535 chr10:102741172-102741173(+) m6A exon//intron       27773535 chr10:102743081-102743082(+) m6A CDS//intron       27773535 chr10:102743392-102743393(+) m6A CDS//intron       24981863 chr10:102743555-102743556(+) m6A CDS//intron       25456834//24981863 chr10:102743818-102743819(+) m6A CDS//intron       24981863 chr10:102743903-102743904(+) m6A 3'UTR//intron       24981863 chr10:102744072-102744073(+) m6A 3'UTR//5'UTR//exon//intron       24209618 chr10:102744457-102744458(+) m6A 3'UTR//CDS//exon       24981863 chr10:102744565-102744566(+) m6A 3'UTR//CDS//intron       24209618//24981863 chr10:102744653-102744654(+) m6A 3'UTR//intron       24209618//24981863 chr10:102744766-102744767(+) m6A 3'UTR//intron       24981863 chr10:102744792-102744793(+) m6A 3'UTR//intron       24981863 chr10:102744919-102744920(+) m6A 3'UTR//intron       25456834//24981863 chr10:102744983-102744984(+) m6A 3'UTR//intron       25456834//24981863 chr10:102745096-102745097(+) m6A 3'UTR//intron       25456834//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-6836-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	SEMA4G	Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-6836-5p
Interactor2: SEMA4G

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Downregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.