Basic Information:

  VIRBase ID:  

HHID00099567

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-6836-5p:  MIMAT0027574          PCDHB2:  NM_018936     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-6836-5p	PCDHB2
miRBase Accession/Entrez ID	MIMAT0027574	56133
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PCDH-BETA2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-6836-5p	rs1175923434 chr7:2257551    A/T rs1397797431 chr7:2257557    G/T rs1402374487 chr7:2257560    C/T rs373301992 chr7:2257555    C/T rs751019973 chr7:2257572    G/A rs751019973 chr7:2257572    G/T rs752401585 chr7:2257559    G/A rs752401585 chr7:2257559    G/C rs762697510 chr7:2257562    A/T rs765066033 chr7:2257558    C/A rs765066033 chr7:2257558    C/T rs767238780 chr7:2257563    G/A rs767238780 chr7:2257563    G/T rs776617786 chr7:2257553    G/A rs776617786 chr7:2257553    G/T rs1378787511 chr7:2257565    G/A rs747250755 chr7:2257571    C/CT rs756757197 chr7:2257570    G/A rs768462924 chr7:2257568    C/G rs780841384 chr7:2257571    C/A

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PCDHB2	chr5:140474363-140474364(+) m6A 5'UTR       24209618//25456834//24981863 chr5:140474409-140474410(+) m6A CDS       25456834//24981863 chr5:140474531-140474532(+) m6A CDS//intron       25456834//24981863 chr5:140474553-140474554(+) m6A CDS//intron       25456834//24981863 chr5:140474620-140474621(+) m6A CDS//intron       25456834//24981863 chr5:140474651-140474652(+) m6A CDS//intron       25456834//24981863 chr5:140474783-140474784(+) m6A CDS//intron       24981863 chr5:140474827-140474828(+) m6A CDS//intron       24981863 chr5:140474855-140474856(+) m6A CDS//intron       24981863//26404942 chr5:140474869-140474870(+) m6A CDS//intron       24981863//26404942 chr5:140474930-140474931(+) m6A 3'UTR//CDS       24981863//26404942 chr5:140474969-140474970(+) m6A 3'UTR//CDS       25456834//24981863 chr5:140475080-140475081(+) m6A 3'UTR//CDS       24209618//25456834//24981863//22575960 chr5:140475140-140475141(+) m6A 3'UTR//CDS       24209618//25456834//24981863//22608085 chr5:140475188-140475189(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr5:140475196-140475197(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr5:140475239-140475240(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960 chr5:140475279-140475280(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960 chr5:140475291-140475292(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960 chr5:140475297-140475298(+) m6A 3'UTR//CDS       24209618//25456834//24981863//22575960 chr5:140475319-140475320(+) m6A 3'UTR//CDS       24209618//25456834//24981863//22575960 chr5:140475367-140475368(+) m6A 3'UTR//CDS       24209618//25456834//24981863//27773535//22575960 chr5:140475417-140475418(+) m6A 3'UTR//CDS       24209618//25456834//24981863//22575960 chr5:140475455-140475456(+) m6A 3'UTR//CDS       24209618//25456834//24981863 chr5:140475464-140475465(+) m6A 3'UTR//CDS       24209618//25456834//24981863 chr5:140475509-140475510(+) m6A 3'UTR//CDS       24209618//24981863 chr5:140475561-140475562(+) m6A 3'UTR//CDS       24284625//24209618//24981863 chr5:140475575-140475576(+) m6A 3'UTR//CDS       24284625//24209618//24981863 chr5:140475608-140475609(+) m6A 3'UTR//CDS       24284625//24209618//24981863 chr5:140475616-140475617(+) m6A 3'UTR//CDS       24284625//24209618//24981863 chr5:140475661-140475662(+) m6A 3'UTR//CDS       24209618//24981863 chr5:140475676-140475677(+) m6A 3'UTR//CDS       24209618//24981863 chr5:140475739-140475740(+) m6A 3'UTR//CDS       24981863 chr5:140475767-140475768(+) m6A 3'UTR//CDS       24981863 chr5:140475809-140475810(+) m6A 3'UTR//CDS       25456834//24981863 chr5:140475815-140475816(+) m6A 3'UTR//CDS       25456834//24981863 chr5:140475863-140475864(+) m6A 3'UTR//CDS       25456834 chr5:140475905-140475906(+) m6A 3'UTR//CDS       25456834 chr5:140475938-140475939(+) m6A 3'UTR//CDS       25456834 chr5:140476316-140476317(+) m6A 3'UTR//CDS       25456834//24981863 chr5:140476609-140476610(+) m6A 3'UTR//CDS       25456834 chr5:140476660-140476661(+) m6A 3'UTR//CDS       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-6836-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	PCDHB2	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-6836-5p
Interactor2: PCDHB2

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Downregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.