Basic Information:

  VIRBase ID:  

HHID00099561

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-6836-5p:  MIMAT0027574          SAC3D1:  NR_160029     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-6836-5p	SAC3D1
miRBase Accession/Entrez ID	MIMAT0027574	29901
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HSU79266//SHD1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-6836-5p	rs1175923434 chr7:2257551    A/T rs1397797431 chr7:2257557    G/T rs1402374487 chr7:2257560    C/T rs373301992 chr7:2257555    C/T rs751019973 chr7:2257572    G/A rs751019973 chr7:2257572    G/T rs752401585 chr7:2257559    G/A rs752401585 chr7:2257559    G/C rs762697510 chr7:2257562    A/T rs765066033 chr7:2257558    C/A rs765066033 chr7:2257558    C/T rs767238780 chr7:2257563    G/A rs767238780 chr7:2257563    G/T rs776617786 chr7:2257553    G/A rs776617786 chr7:2257553    G/T rs1378787511 chr7:2257565    G/A rs747250755 chr7:2257571    C/CT rs756757197 chr7:2257570    G/A rs768462924 chr7:2257568    C/G rs780841384 chr7:2257571    C/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SAC3D1	chr11:64810087(+) A-I      intronic chr11:64811073(+) A-I      intronic chr11:64810929(+) A-I      intronic chr11:64809670(+) A-I      intronic chr11:64810433(+) A-I      intronic chr11:64811012(+) A-I      intronic chr11:64810875(+) A-I      intronic chr11:64810179(+) A-I      intronic chr11:64810926(+) A-I      intronic chr11:64810980(+) A-I      intronic chr11:64811006(+) A-I      intronic chr11:64810970(+) A-I      intronic chr11:64811003(+) A-I      intronic chr11:64810408(+) A-I      intronic chr11:64809509(+) A-I      intronic chr11:64810118(+) A-I      intronic chr11:64810964(+) A-I      intronic chr11:64811053(+) A-I      intronic chr11:64810155(+) A-I      intronic chr11:64810044(+) A-I      intronic chr11:64810088(+) A-I      intronic chr11:64810113(+) A-I      intronic chr11:64810873(+) A-I      intronic chr11:64810971(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SAC3D1	chr11:64808399-64808400(+) m6A 5'UTR       24284625//24981863//22608085 chr11:64808444-64808445(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr11:64808470-64808471(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr11:64808534-64808535(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr11:64808573-64808574(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr11:64808586-64808587(+) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr11:64808646-64808647(+) m6A 5'UTR//CDS//exon//intron       24209618//25456834//24981863//22575960//22608085 chr11:64808801-64808802(+) m6A CDS//exon//intron       24284625//24209618//24981863//22575960 chr11:64808885-64808886(+) m6A CDS//exon//intron       24209618//22575960 chr11:64809071-64809072(+) m6A CDS//exon//intron       24209618//24981863 chr11:64809095-64809096(+) m6A CDS//exon//intron       24209618//24981863 chr11:64809204-64809205(+) m6A CDS//exon//intron       24209618 chr11:64809212-64809213(+) m6A CDS//exon//intron       24209618 chr11:64810628-64810629(+) m1A 3'UTR//exon//intron       26863410 chr11:64811830-64811831(+) m6A 3'UTR//CDS//exon       24284625//24209618//22575960//22608085 chr11:64811935-64811936(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr11:64811979-64811980(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:64811996-64811997(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:64812117-64812118(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:64812176-64812177(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:64812230-64812231(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr11:64812284-64812285(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-6836-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	SAC3D1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-6836-5p
Interactor2: SAC3D1

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Downregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.