Detail Information

Basic Information:


  VIRBase ID:  

HHID00099560

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-6836-5p:           ZDHHC8:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-6836-5p ZDHHC8
miRBase
Accession/Entrez ID		 MIMAT0027574 29801
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DHHC8//ZDHHCL1//ZNF378

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-6836-5p
rs1175923434 chr7:2257551    A/T
rs1397797431 chr7:2257557    G/T
rs1402374487 chr7:2257560    C/T
rs373301992 chr7:2257555    C/T
rs751019973 chr7:2257572    G/A
rs751019973 chr7:2257572    G/T
rs752401585 chr7:2257559    G/A
rs752401585 chr7:2257559    G/C
rs762697510 chr7:2257562    A/T
rs765066033 chr7:2257558    C/A
rs765066033 chr7:2257558    C/T
rs767238780 chr7:2257563    G/A
rs767238780 chr7:2257563    G/T
rs776617786 chr7:2257553    G/A
rs776617786 chr7:2257553    G/T
rs1378787511 chr7:2257565    G/A
rs747250755 chr7:2257571    C/CT
rs756757197 chr7:2257570    G/A
rs768462924 chr7:2257568    C/G
rs780841384 chr7:2257571    C/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZDHHC8
chr22:20121143(+) A-I      intronic
chr22:20120996(+) A-I      intronic
chr22:20121075(+) A-I      intronic
chr22:20121141(+) A-I      intronic
chr22:20121137(+) A-I      intronic
chr22:20121197(+) A-I      intronic
chr22:20121018(+) A-I      intronic
chr22:20121019(+) A-I      intronic
chr22:20121109(+) A-I      intronic
chr22:20121148(+) A-I      intronic
chr22:20122572(+) A-I      intronic
chr22:20122596(+) A-I      intronic
chr22:20122584(+) A-I      intronic
chr22:20122478(+) A-I      intronic
chr22:20122657(+) A-I      intronic
chr22:20122654(+) A-I      intronic
chr22:20121132(+) A-I      intronic
chr22:20122486(+) A-I      intronic
chr22:20122555(+) A-I      intronic
chr22:20121158(+) A-I      intronic
chr22:20121155(+) A-I      intronic
chr22:20122594(+) A-I      intronic
chr22:20122567(+) A-I      intronic
chr22:20122742(+) A-I      intronic
chr22:20121145(+) A-I      intronic
chr22:20122702(+) A-I      intronic
chr22:20122581(+) A-I      intronic
chr22:20122720(+) A-I      intronic
chr22:20121215(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ZDHHC8
chr22:20122594(+) A-G intron -    22484847
chr22:20122654(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZDHHC8
chr22:20130330-20130331(+) m6A CDS//exon       24284625
chr22:20130354-20130355(+) m6A CDS//exon       -
chr22:20130791-20130792(+) m6A CDS       24284625//24209618//25456834//24981863//22575960
chr22:20130822-20130823(+) m6A CDS       24284625//24209618//25456834//24981863//22575960
chr22:20131242-20131243(+) m6A CDS       24284625//24209618
chr22:20132753-20132754(+) m6A CDS//intron       24284625//24209618//25456834
chr22:20132770-20132771(+) m6A CDS//intron       24284625//24209618//25456834
chr22:20132820-20132821(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960
chr22:20132899-20132900(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr22:20132925-20132926(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr22:20132960-20132961(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr22:20132966-20132967(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr22:20133012-20133013(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr22:20133039-20133040(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr22:20133137-20133138(+) m6A 3'UTR//intron       24284625//24209618//25456834//22575960
chr22:20133303-20133304(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr22:20133320-20133321(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr22:20133374-20133375(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr22:20133425-20133426(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085
chr22:20133501-20133502(+) m6A 3'UTR//intron       24284625//25456834
chr22:20133758-20133759(+) m6A 3'UTR//intron       24284625
chr22:20133766-20133767(+) m6A 3'UTR//intron       -
chr22:20134242-20134243(+) m6A 3'UTR//intron       24209618
chr22:20134269-20134270(+) m6A 3'UTR//intron       24209618
chr22:20134638-20134639(+) m6A 3'UTR//CDS       -
chr22:20134787-20134788(+) m6A 3'UTR       -
chr22:20134802-20134803(+) m6A 3'UTR       -
chr22:20134910-20134911(+) m6A 3'UTR       24209618
chr22:20134997-20134998(+) m6A 3'UTR       -
chr22:20135044-20135045(+) m6A 3'UTR       -
chr22:20135162-20135163(+) m6A 3'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-6836-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
ZDHHC8
Chromatin K562 cells     -
Cytosol K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-6836-5p
Interactor2: ZDHHC8

Evidence Support:


Weak-Evidence Illumina sequencing
Prediction-Evidence miRanda
Support Database ViRBase

References:


PMID 32223537 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Calu-3 cells Interactor2 expression Downregulation
Description The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.

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