Basic Information:

  VIRBase ID:  

HHID00099556

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-6836-5p:  MIMAT0027574          PSD4:  NM_012455     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-6836-5p	PSD4
miRBase Accession/Entrez ID	MIMAT0027574	23550
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	EFA6B//TIC

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-6836-5p	rs1175923434 chr7:2257551    A/T rs1397797431 chr7:2257557    G/T rs1402374487 chr7:2257560    C/T rs373301992 chr7:2257555    C/T rs751019973 chr7:2257572    G/A rs751019973 chr7:2257572    G/T rs752401585 chr7:2257559    G/A rs752401585 chr7:2257559    G/C rs762697510 chr7:2257562    A/T rs765066033 chr7:2257558    C/A rs765066033 chr7:2257558    C/T rs767238780 chr7:2257563    G/A rs767238780 chr7:2257563    G/T rs776617786 chr7:2257553    G/A rs776617786 chr7:2257553    G/T rs1378787511 chr7:2257565    G/A rs747250755 chr7:2257571    C/CT rs756757197 chr7:2257570    G/A rs768462924 chr7:2257568    C/G rs780841384 chr7:2257571    C/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PSD4	chr2:113945262(+) A-I      intronic chr2:113949216(+) A-I      intronic chr2:113945267(+) A-I      intronic chr2:113948831(+) A-I      intronic chr2:113945300(+) A-I      intronic chr2:113945307(+) A-I      intronic chr2:113949877(+) A-I      intronic chr2:113945299(+) A-I      intronic chr2:113945163(+) A-I      intronic chr2:113945024(+) A-I      intronic chr2:113945021(+) A-I      intronic chr2:113949515(+) A-I      intronic chr2:113944980(+) A-I      intronic chr2:113919644(+) A-I      intronic chr2:113919001(+) A-I      intronic chr2:113935699(+) A-I      intronic chr2:113918998(+) A-I      intronic chr2:113918997(+) A-I      intronic chr2:113918924(+) A-I      intronic chr2:113918894(+) A-I      intronic chr2:113918258(+) A-I      intronic chr2:113935715(+) A-I      intronic chr2:113917494(+) A-I      intronic chr2:113917426(+) A-I      intronic chr2:113917405(+) A-I      intronic chr2:113935716(+) A-I      intronic chr2:113917489(+) A-I      intronic chr2:113935706(+) A-I      intronic chr2:113949083(+) A-I      intronic chr2:113921568(+) A-I      intronic chr2:113920060(+) A-I      intronic chr2:113949084(+) A-I      intronic chr2:113949092(+) A-I      intronic chr2:113949117(+) A-I      intronic chr2:113920052(+) A-I      intronic chr2:113919967(+) A-I      intronic chr2:113919960(+) A-I      intronic chr2:113924090(+) A-I      intronic chr2:113917427(+) A-I      intronic chr2:113917349(+) A-I      intronic chr2:113917378(+) A-I      intronic chr2:113918934(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PSD4	chr2:113945266(+) A-I intron -    22327324 chr2:113945303(+) A-I intron -    22327324 chr2:113945361(+) A-I intron -    22327324 chr2:113945372(+) A-I intron -    22327324 chr2:113948797(+) A-I intron -    22327324 chr2:113948801(+) A-I intron -    22327324 chr2:113945361(+) A-G intron -    22484847 chr2:113945372(+) A-G intron -    22484847 chr2:113948797(+) A-G intron -    22484847 chr2:113948801(+) A-G intron -    22484847 chr2:113949257(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PSD4	chr2:113939982-113939983(+) m6A 5'UTR//exon//intron       24209618 chr2:113940050-113940051(+) m6A CDS//exon//intron       24209618 chr2:113940100-113940101(+) m6A CDS//exon//intron       24209618//25456834 chr2:113940180-113940181(+) m6A CDS//exon//intron       24209618//25456834 chr2:113940203-113940204(+) m6A CDS//exon//intron       24209618//25456834 chr2:113940212-113940213(+) m6A CDS//exon//intron       24209618//25456834 chr2:113940303-113940304(+) m6A CDS//exon//intron       - chr2:113940335-113940336(+) m6A CDS//exon//intron       - chr2:113940415-113940416(+) m6A CDS//exon//intron       - chr2:113940442-113940443(+) m6A CDS//exon//intron       - chr2:113940472-113940473(+) m6A CDS//exon//intron       - chr2:113940538-113940539(+) m6A CDS//exon//intron       - chr2:113940613-113940614(+) m6A CDS//exon//intron       25456834 chr2:113940625-113940626(+) m6A CDS//exon//intron       24209618//25456834 chr2:113940661-113940662(+) m6A CDS//exon//intron       24209618//25456834 chr2:113940673-113940674(+) m6A CDS//exon//intron       24209618//25456834 chr2:113940720-113940721(+) m6A CDS//exon//intron       24209618//25456834//22608085 chr2:113940727-113940728(+) m6A CDS//exon//intron       24209618//25456834//22608085 chr2:113940808-113940809(+) m6A CDS//exon//intron       24209618//25456834 chr2:113940847-113940848(+) m6A CDS//exon//intron       24209618//25456834 chr2:113940867-113940868(+) m6A CDS//exon//intron       24209618//25456834 chr2:113940872-113940873(+) m6A CDS//exon//intron       24209618//25456834 chr2:113940913-113940914(+) m6A CDS//exon//intron       25456834 chr2:113941010-113941011(+) m6A CDS//exon//intron       - chr2:113943653-113943654(+) m6A 3'UTR//CDS//exon       - chr2:113943697-113943698(+) m6A 3'UTR//CDS//exon       - chr2:113943742-113943743(+) m6A 3'UTR//CDS//exon       - chr2:113943770-113943771(+) m6A 3'UTR//CDS//exon       - chr2:113943788-113943789(+) m6A 3'UTR//CDS//exon       - chr2:113943829-113943830(+) m6A 3'UTR//CDS//exon       - chr2:113949969-113949970(+) m6A 3'UTR//CDS//exon       - chr2:113949979-113949980(+) m6A 3'UTR//CDS//exon       - chr2:113950040-113950041(+) m6A 3'UTR//CDS//exon       - chr2:113950054-113950055(+) m6A 3'UTR//CDS//exon       - chr2:113950078-113950079(+) m6A 3'UTR//CDS//exon       - chr2:113950096-113950097(+) m6A 3'UTR//CDS//exon       - chr2:113956276-113956277(+) m6A exon//intron       - chr2:113956293-113956294(+) m6A exon//intron       - chr2:113956495-113956496(+) m6A exon//intron       24981863 chr2:113956523-113956524(+) m6A exon//intron       24981863 chr2:113956568-113956569(+) m6A exon//intron       24981863 chr2:113956629-113956630(+) m6A exon//intron       24209618 chr2:113956684-113956685(+) m6A 3'UTR//CDS//exon       - chr2:113956729-113956730(+) m6A 3'UTR//CDS//exon       - chr2:113958737-113958738(+) m6A 3'UTR//CDS//exon       24981863 chr2:113958749-113958750(+) m6A 3'UTR//CDS//exon       24981863 chr2:113958801-113958802(+) m6A 3'UTR//CDS//exon       24209618//24981863 chr2:113958947-113958948(+) m6A 3'UTR//CDS//exon       24209618//25456834//24981863//22575960 chr2:113958975-113958976(+) m6A 3'UTR//CDS//exon       24209618//25456834//24981863//22575960 chr2:113959011-113959012(+) m6A 3'UTR//exon       24209618//25456834//24981863//22608085 chr2:113959035-113959036(+) m6A 3'UTR//exon       24209618//25456834//24981863//22608085 chr2:113959046-113959047(+) m6A 3'UTR//exon       24209618//25456834//24981863//22575960//22608085 chr2:113959061-113959062(+) m6A 3'UTR//exon       24209618//25456834//24981863//22575960//22608085 chr2:113959117-113959118(+) m6A 3'UTR//exon       24209618//24981863//22575960 chr2:113959255-113959256(+) m6A 3'UTR//exon       24209618//25456834//24981863//22575960 chr2:113959329-113959330(+) m6A 3'UTR//exon       24209618//25456834//24981863//22575960 chr2:113959340-113959341(+) m6A 3'UTR//exon       24209618//25456834//24981863//22575960 chr2:113959359-113959360(+) m6A 3'UTR//exon       24209618//25456834//24981863//22575960 chr2:113959516-113959517(+) m6A 3'UTR//exon       24209618//24981863//22575960 chr2:113959589-113959590(+) m6A 3'UTR//exon       24981863 chr2:113959607-113959608(+) m6A 3'UTR//exon       24981863 chr2:113959786-113959787(+) m6A 3'UTR//exon       - chr2:113959794-113959795(+) m6A 3'UTR//exon       - chr2:113959803-113959804(+) m6A 3'UTR//exon       - chr2:113959854-113959855(+) m6A 3'UTR//exon       - chr2:113960169-113960170(+) m6A 3'UTR//exon       - chr2:113960177-113960178(+) m6A 3'UTR//exon       - chr2:113960218-113960219(+) m6A 3'UTR//exon       24981863 chr2:113961783-113961784(+) m6A 3'UTR       24981863 chr2:113961789-113961790(+) m6A 3'UTR       24981863 chr2:113961806-113961807(+) m6A 3'UTR       24981863 chr2:113961828-113961829(+) m6A 3'UTR       24981863 chr2:113961865-113961866(+) m6A 3'UTR       24981863 chr2:113961907-113961908(+) m6A 3'UTR       24981863 chr2:113961928-113961929(+) m6A 3'UTR       24981863 chr2:113962345-113962346(+) m6A 3'UTR       - chr2:113962392-113962393(+) m6A 3'UTR       - chr2:113962426-113962427(+) m6A 3'UTR       - chr2:113962459-113962460(+) m6A 3'UTR       - chr2:113963731-113963732(+) m6A 3'UTR       24981863 chr2:113963766-113963767(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-6836-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	PSD4	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-6836-5p
Interactor2: PSD4

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Downregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.