Detail Information

Basic Information:


  VIRBase ID:  

HHID00099360

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-619-5p:           VPS4A:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-619-5p VPS4A
miRBase
Accession/Entrez ID		 MIMAT0026622 27183
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - SKD1//SKD1A//SKD2//VPS4//VPS4-1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-619-5p
rs1173633685 chr12:108836970    C/A
rs1360600602 chr12:108836973    G/A
rs368283564 chr12:108836983    C/A
rs747519669 chr12:108836968    T/A
rs747519669 chr12:108836968    T/G
rs1395416108 chr12:108836979    C/G
rs1466244611 chr12:108836977    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR VPS4A
chr16:69348976(+) A-I      intronic
chr16:69357710(+) A-I      intronic
chr16:69357722(+) A-I      intronic
chr16:69357774(+) A-I      intronic
chr16:69349023(+) A-I      intronic
chr16:69349000(+) A-I      intronic
chr16:69348978(+) A-I      intronic
chr16:69346590(+) A-I      intronic
chr16:69346738(+) A-I      intronic
chr16:69348053(+) A-I      intronic
chr16:69346668(+) A-I      intronic
chr16:69351700(+) A-I      intronic
chr16:69357781(+) A-I      intronic
chr16:69357199(+) A-I      intronic
chr16:69346945(+) A-I      intronic
chr16:69351697(+) A-I      intronic
chr16:69349017(+) A-I      intronic
chr16:69357163(+) A-I      intronic
chr16:69348961(+) A-I      intronic
chr16:69357109(+) A-I      intronic
chr16:69347948(+) A-I      intronic
chr16:69352008(+) A-I      intronic
chr16:69349027(+) A-I      intronic
chr16:69351641(+) A-I      intronic
chr16:69357732(+) A-I      intronic
chr16:69357692(+) A-I      intronic
chr16:69352061(+) A-I      intronic
chr16:69357273(+) A-I      intronic
chr16:69357159(+) A-I      intronic
chr16:69357164(+) A-I      intronic
chr16:69348975(+) A-I      intronic
chr16:69357241(+) A-I      intronic
chr16:69357238(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED VPS4A
chr16:69357218(+) A-I intron -    22327324
chr16:69357228(+) A-I intron -    22327324
chr16:69356695(+) A-I intron -    21960545
chr16:69347948(+) A-G intron -    22484847
chr16:69356716(+) T-C intron -    22484847
chr16:69356729(+) T-C intron -    22484847
chr16:69356786(+) T-C intron -    22484847
chr16:69356888(+) T-C intron -    22484847
chr16:69356889(+) T-C intron -    22484847
chr16:69356924(+) T-C intron -    22484847
chr16:69357218(+) T-C intron -    22484847
chr16:69357228(+) T-C intron -    22484847
chr16:69357229(+) T-C intron -    22484847
chr16:69357326(+) T-C intron -    22484847
chr16:69357353(+) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase VPS4A
chr16:69345260-69345261(+) m6A 5'UTR       24209618
chr16:69345335-69345336(+) m6A 5'UTR       24209618
chr16:69345363-69345364(+) m6A 5'UTR       24209618
chr16:69345400-69345401(+) m6A 5'UTR       24209618
chr16:69349947-69349948(+) m6A CDS       24209618//22575960
chr16:69349959-69349960(+) m6A CDS       24209618//22575960
chr16:69350187-69350188(+) m6A CDS       24209618//24981863//27773535//22575960
chr16:69350230-69350231(+) m6A CDS       24209618//24981863//27773535//27371828//22575960
chr16:69350256-69350257(+) m6A CDS       24209618//24981863//27773535//27371828//22575960
chr16:69352594-69352595(+) m6A CDS       24209618//24981863//27773535//22575960
chr16:69352603-69352604(+) m6A CDS       24209618//24981863//27773535//22575960
chr16:69354054-69354055(+) m6A CDS//exon       -
chr16:69354613-69354614(+) m6A CDS//exon       27371828//27773536
chr16:69354635-69354636(+) m6A CDS//exon       27371828//27773536
chr16:69355054-69355055(+) m6A CDS//exon       27773535
chr16:69355615-69355616(+) m6A exon//intron       27773535
chr16:69355628-69355629(+) m6A exon//intron       27773535
chr16:69355650-69355651(+) m6A exon//intron       24981863//27773535
chr16:69355760-69355761(+) m6A exon//intron       27773535
chr16:69355796-69355797(+) m6A exon//intron       27773535
chr16:69356191-69356192(+) m6A exon//intron       24284625
chr16:69356253-69356254(+) m6A exon//intron       24284625
chr16:69356312-69356313(+) m6A exon//intron       24284625
chr16:69356361-69356362(+) m6A exon//intron       24284625
chr16:69356384-69356385(+) m6A exon//intron       24284625
chr16:69356396-69356397(+) m6A exon//intron       24284625
chr16:69356532-69356533(+) m6A CDS//exon       24284625
chr16:69356574-69356575(+) m6A CDS//exon       24284625
chr16:69356578-69356579(+) m6A CDS//exon       -
chr16:69358114-69358115(+) m6A CDS//exon       24284625//24981863
chr16:69358192-69358193(+) m6A CDS//exon       24284625//25456834//24981863
chr16:69358290-69358291(+) m6A 3'UTR//exon       24284625//25456834//24981863
chr16:69358386-69358387(+) m6A 3'UTR//exon       24284625//24981863
chr16:69358415-69358416(+) m6A 3'UTR//exon       24284625//24981863
chr16:69358622-69358623(+) m6A 3'UTR//exon       27773535
chr16:69358727-69358728(+) m6A 3'UTR//exon       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-619-5p
Exosome Pooled sera     27278097
Exosome Serum     24683445
Exosome Kidney tissue     -
Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     -
VPS4A
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-619-5p
Interactor2: VPS4A

Evidence Support:


Weak-Evidence Illumina sequencing
Prediction-Evidence miRanda
Support Database ViRBase

References:


PMID 32223537 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Calu-3 cells Interactor2 expression Downregulation
Description The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.

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