Basic Information:

  VIRBase ID:  

HHID00099233

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:  MIMAT0019058          WNT2B:  NM_001291880     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4521	WNT2B
miRBase Accession/Entrez ID	MIMAT0019058	7482
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	WNT13

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4521	rs1011991709 chr17:8186962    G/A rs1011991709 chr17:8186962    G/C rs1041768648 chr17:8186965    C/T rs1056190393 chr17:8186959    C/A rs1231036635 chr17:8186958    T/A rs1231036635 chr17:8186958    T/G rs1316923680 chr17:8186964    G/A rs1316923680 chr17:8186964    G/C rs1316923680 chr17:8186964    G/T rs1365122718 chr17:8186957    G/C rs559116584 chr17:8186963    T/C rs559116584 chr17:8186963    T/G rs561824123 chr17:8186969    G/A rs768576971 chr17:8186966    T/A rs768576971 chr17:8186966    T/C rs776348878 chr17:8186967    C/A rs893173803 chr17:8186960    C/G rs893173803 chr17:8186960    C/T rs999343007 chr17:8186968    A/G rs1310598293 chr17:8186951    A/G rs928871091 chr17:8186953    G/A rs928871091 chr17:8186953    G/C rs937623219 chr17:8186954    G/A rs953552065 chr17:8186949    C/A rs953552065 chr17:8186949    C/G rs953552065 chr17:8186949    C/T rs962385560 chr17:8186955    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	WNT2B	chr1:113039474(+) A-I      intronic chr1:113039279(+) A-I      intronic chr1:113038784(+) A-I      intronic chr1:113037145(+) A-I      intronic chr1:113038789(+) A-I      intronic chr1:113038799(+) A-I      intronic chr1:113038810(+) A-I      intronic chr1:113037230(+) A-I      intronic chr1:113025175(+) A-I      intronic chr1:113026141(+) A-I      intronic chr1:113026140(+) A-I      intronic chr1:113026133(+) A-I      intronic chr1:113026131(+) A-I      intronic chr1:113013024(+) A-I      intronic chr1:113013060(+) A-I      intronic chr1:113025189(+) A-I      intronic chr1:113064714(+) A-I      3'UTR chr1:113025190(+) A-I      intronic chr1:113064752(+) A-I      3'UTR chr1:113064756(+) A-I      3'UTR chr1:113026159(+) A-I      intronic chr1:113026150(+) A-I      intronic chr1:113025193(+) A-I      intronic chr1:113025207(+) A-I      intronic chr1:113025217(+) A-I      intronic chr1:113025229(+) A-I      intronic chr1:113025235(+) A-I      intronic chr1:113041575(+) A-I      intronic chr1:113037129(+) A-I      intronic chr1:113037137(+) A-I      intronic chr1:113041783(+) A-I      intronic chr1:113041815(+) A-I      intronic chr1:113064732(+) A-I      3'UTR chr1:113041816(+) A-I      intronic chr1:113043134(+) A-I      intronic chr1:113016612(+) A-I      intronic chr1:113012470(+) A-I      intronic chr1:113022076(+) A-I      intronic chr1:113043137(+) A-I      intronic chr1:113022117(+) A-I      intronic chr1:113017044(+) A-I      intronic chr1:113022904(+) A-I      intronic chr1:113012456(+) A-I      intronic chr1:113015505(+) A-I      intronic chr1:113022065(+) A-I      intronic chr1:113012441(+) A-I      intronic chr1:113022976(+) A-I      intronic chr1:113022049(+) A-I      intronic chr1:113043319(+) A-I      intronic chr1:113012433(+) A-I      intronic chr1:113025075(+) A-I      intronic chr1:113043348(+) A-I      intronic chr1:113025144(+) A-I      intronic chr1:113025169(+) A-I      intronic chr1:113028004(+) A-I      intronic chr1:113028008(+) A-I      intronic chr1:113016584(+) A-I      intronic chr1:113016572(+) A-I      intronic chr1:113021279(+) A-I      intronic chr1:113043351(+) A-I      intronic chr1:113043358(+) A-I      intronic chr1:113064861(+) A-I      3'UTR chr1:113028809(+) A-I      intronic chr1:113064904(+) A-I      3'UTR chr1:113030761(+) A-I      intronic chr1:113012419(+) A-I      intronic chr1:113016607(+) A-I      intronic chr1:113012329(+) A-I      intronic chr1:113033318(+) A-I      intronic chr1:113036873(+) A-I      intronic chr1:113016423(+) A-I      intronic chr1:113037071(+) A-I      intronic chr1:113037108(+) A-I      intronic chr1:113012313(+) A-I      intronic chr1:113037125(+) A-I      intronic chr1:113037135(+) A-I      intronic chr1:113039322(+) A-I      intronic chr1:113039323(+) A-I      intronic chr1:113016907(+) A-I      intronic chr1:113039352(+) A-I      intronic chr1:113041708(+) A-I      intronic chr1:113041721(+) A-I      intronic chr1:113041734(+) A-I      intronic chr1:113041753(+) A-I      intronic chr1:113041777(+) A-I      intronic chr1:113021281(+) A-I      intronic chr1:113037139(+) A-I      intronic chr1:113016992(+) A-I      intronic chr1:113016977(+) A-I      intronic chr1:113037943(+) A-I      intronic chr1:113024604(+) A-I      intronic chr1:113025062(+) A-I      intronic chr1:113026641(+) A-I      intronic chr1:113021656(+) A-I      intronic chr1:113013113(+) A-I      intronic chr1:113036223(+) A-I      intronic chr1:113016424(+) A-I      intronic chr1:113012353(+) A-I      intronic chr1:113038837(+) A-I      intronic chr1:113015500(+) A-I      intronic chr1:113041657(+) A-I      intronic chr1:113036811(+) A-I      intronic chr1:113038161(+) A-I      intronic chr1:113038805(+) A-I      intronic chr1:113022866(+) A-I      intronic chr1:113039407(+) A-I      intronic chr1:113025086(+) A-I      intronic chr1:113021327(+) A-I      intronic chr1:113037123(+) A-I      intronic chr1:113041707(+) A-I      intronic chr1:113064836(+) A-I      3'UTR chr1:113037058(+) A-I      intronic chr1:113030647(+) A-I      intronic chr1:113016407(+) A-I      intronic chr1:113025087(+) A-I      intronic chr1:113064753(+) A-I      3'UTR chr1:113013090(+) A-I      intronic chr1:113031254(+) A-I      intronic chr1:113025044(+) A-I      intronic chr1:113038131(+) A-I      intronic chr1:113037039(+) A-I      intronic chr1:113020762(+) A-I      intronic chr1:113033192(+) A-I      intronic chr1:113025027(+) A-I      intronic chr1:113037119(+) A-I      intronic chr1:113039495(+) A-I      intronic chr1:113028810(+) A-I      intronic chr1:113030799(+) A-I      intronic chr1:113024862(+) A-I      intronic chr1:113038088(+) A-I      intronic chr1:113037009(+) A-I      intronic chr1:113018584(+) A-I      intronic chr1:113024904(+) A-I      intronic chr1:113038854(+) A-I      intronic chr1:113030870(+) A-I      intronic chr1:113064929(+) A-I      3'UTR chr1:113031495(+) A-I      intronic chr1:113039484(+) A-I      intronic chr1:113037027(+) A-I      intronic chr1:113036821(+) A-I      intronic chr1:113041574(+) A-I      intronic chr1:113064757(+) A-I      3'UTR chr1:113024861(+) A-I      intronic chr1:113037944(+) A-I      intronic chr1:113013135(+) A-I      intronic chr1:113037044(+) A-I      intronic chr1:113033821(+) A-I      intronic chr1:113037054(+) A-I      intronic chr1:113036817(+) A-I      intronic chr1:113064792(+) A-I      3'UTR chr1:113017031(+) A-I      intronic chr1:113016566(+) A-I      intronic chr1:113036844(+) A-I      intronic chr1:113025058(+) A-I      intronic chr1:113013130(+) A-I      intronic chr1:113064746(+) A-I      3'UTR chr1:113041652(+) A-I      intronic chr1:113035983(+) A-I      intronic chr1:113022830(+) A-I      intronic chr1:113021424(+) A-I      intronic chr1:113038753(+) A-I      intronic chr1:113022802(+) A-I      intronic chr1:113024664(+) A-I      intronic chr1:113033814(+) A-I      intronic chr1:113043304(+) A-I      intronic chr1:113024386(+) A-I      intronic chr1:113013052(+) A-I      intronic chr1:113038876(+) A-I      intronic chr1:113031278(+) A-I      intronic chr1:113012947(+) A-I      intronic chr1:113030907(+) A-I      intronic chr1:113064770(+) A-I      3'UTR chr1:113021938(+) A-I      intronic chr1:113043267(+) A-I      intronic chr1:113021657(+) A-I      intronic chr1:113064708(+) A-I      3'UTR chr1:113025176(+) A-I      intronic chr1:113038870(+) A-I      intronic chr1:113022474(+) A-I      intronic chr1:113039253(+) A-I      intronic chr1:113064765(+) A-I      3'UTR chr1:113024648(+) A-I      intronic chr1:113038132(+) A-I      intronic chr1:113030800(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	WNT2B	chr1:113012346(+) C-T intron -    22484847 chr1:113012353(+) A-G intron -    22484847 chr1:113013090(+) A-G intron -    22484847 chr1:113016977(+) A-G intron -    22484847 chr1:113016992(+) A-G intron -    22484847 chr1:113017031(+) A-G intron -    22484847 chr1:113021656(+) A-G intron -    22484847 chr1:113021657(+) A-G intron -    22484847 chr1:113022802(+) A-G intron -    22484847 chr1:113022830(+) A-G intron -    22484847 chr1:113022866(+) A-G intron -    22484847 chr1:113024904(+) A-G intron -    22484847 chr1:113033814(+) A-G intron -    22484847 chr1:113033821(+) A-G intron -    22484847 chr1:113036811(+) A-G intron -    22484847 chr1:113037044(+) A-G intron -    22484847 chr1:113037123(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	WNT2B	chr1:113058843-113058844(+) m6A CDS//exon       - chr1:113058902-113058903(+) m6A CDS//exon       - chr1:113063120-113063121(+) m6A CDS       24284625//25456834//24981863//22608085 chr1:113063125-113063126(+) m6A CDS       24284625//25456834//24981863//22608085 chr1:113063131-113063132(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr1:113063271-113063272(+) m6A 3'UTR       - chr1:113065366-113065367(+) m6A 3'UTR       27773535 chr1:113066145-113066146(+) m6A 3'UTR       27773535 chr1:113066163-113066164(+) m6A 3'UTR       27773535 chr1:113066338-113066339(+) m6A 3'UTR       27773535 chr1:113066382-113066383(+) m6A 3'UTR       27773535 chr1:113066389-113066390(+) m6A 3'UTR       27773535 chr1:113068091-113068092(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4521	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	WNT2B	Chromatin K562 cells     - Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4521
Interactor2: WNT2B

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Upregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.