Basic Information:

  VIRBase ID:  

HHID00099176

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4455:  MIMAT0018977          RGMA:  NM_001166286     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4455	RGMA
miRBase Accession/Entrez ID	MIMAT0018977	56963
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	RGM

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4455	rs1200605939 chr4:184938433    A/C rs1369705881 chr4:184938430    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RGMA	chr15:93621179(-) A-I      intronic chr15:93621183(-) A-I      intronic chr15:93621155(-) A-I      intronic chr15:93621174(-) A-I      intronic chr15:93621110(-) A-I      intronic chr15:93621034(-) A-I      intronic chr15:93621026(-) A-I      intronic chr15:93621033(-) A-I      intronic chr15:93623045(-) A-I      intronic chr15:93623525(-) A-I      intronic chr15:93624616(-) A-I      intronic chr15:93621009(-) A-I      intronic chr15:93623524(-) A-I      intronic chr15:93622967(-) A-I      intronic chr15:93621101(-) A-I      intronic chr15:93623463(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RGMA	chr15:93587904-93587905(-) m6A 3'UTR       24284625//24209618//25456834//24981863 chr15:93587915-93587916(-) m6A 3'UTR       24284625//24209618//25456834//24981863 chr15:93587953-93587954(-) m6A 3'UTR       24284625//24209618//25456834//24981863 chr15:93588076-93588077(-) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr15:93588105-93588106(-) m6A 3'UTR       24284625//24209618//25456834//27773536//22608085 chr15:93588164-93588165(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773536 chr15:93588324-93588325(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr15:93588331-93588332(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr15:93588354-93588355(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr15:93588414-93588415(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr15:93588465-93588466(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27371828//27773536//22608085 chr15:93588505-93588506(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27371828//27773536//22608085 chr15:93588520-93588521(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27371828//27773536//22608085 chr15:93588657-93588658(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773536//22608085 chr15:93588663-93588664(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773536//22608085 chr15:93588825-93588826(-) m6A 3'UTR//CDS       24209618//25456834//24981863//27773536//22608085 chr15:93588897-93588898(-) m6A 3'UTR//CDS       24209618//25456834//24981863//27773536//22608085 chr15:93588915-93588916(-) m6A 3'UTR//CDS       24209618//25456834//24981863//27773536//22608085 chr15:93595100-93595101(-) m6A intron       25456834//27773536 chr15:93595162-93595163(-) m6A intron       25456834//27773536 chr15:93595329-93595330(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//22608085 chr15:93595350-93595351(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//22608085 chr15:93595364-93595365(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//22608085 chr15:93595448-93595449(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//22608085 chr15:93595466-93595467(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//22608085 chr15:93595544-93595545(-) m6A 3'UTR//5'UTR//CDS//exon//intron       25456834 chr15:93609217-93609218(-) m6A 5'UTR//intron       25456834 chr15:93609246-93609247(-) m6A 5'UTR//exon//intron       25456834 chr15:93609251-93609252(-) m6A 5'UTR//exon//intron       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4455	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	RGMA	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4455
Interactor2: RGMA

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Upregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.