Basic Information:

  VIRBase ID:  

HHID00099165

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4448:  MIMAT0018967          KIAA1614:  NM_020950     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4448	KIAA1614
miRBase Accession/Entrez ID	MIMAT0018967	57710
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4448	rs1028016211 chr3:183886877    G/A rs1211909571 chr3:183886875    G/T rs1222929313 chr3:183886872    TA/T rs1485452454 chr3:183886871    C/G rs992162972 chr3:183886876    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	KIAA1614	chr1:180903743(+) A-I      intronic chr1:180909526(+) A-I      intronic chr1:180909928(+) A-I      intronic chr1:180902116(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	KIAA1614	chr1:180909574(+) T-C intron -    22484847 chr1:180912169(+) T-G intron -    22484847 chr1:180912173(+) T-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KIAA1614	chr1:180882321-180882322(+) m6A exon       - chr1:180882388-180882389(+) m6A CDS//exon       - chr1:180882408-180882409(+) m6A CDS//exon       - chr1:180883179-180883180(+) m6A exon//intron       - chr1:180885299-180885300(+) m6A CDS       - chr1:180885311-180885312(+) m6A CDS       - chr1:180885332-180885333(+) m6A CDS       - chr1:180885379-180885380(+) m6A CDS       - chr1:180885391-180885392(+) m6A CDS       - chr1:180885414-180885415(+) m6A CDS       - chr1:180885419-180885420(+) m6A CDS       - chr1:180885532-180885533(+) m6A CDS       25456834 chr1:180885583-180885584(+) m6A CDS       - chr1:180885620-180885621(+) m6A CDS       25456834 chr1:180885675-180885676(+) m6A CDS       25456834 chr1:180885815-180885816(+) m6A CDS       25456834 chr1:180885950-180885951(+) m6A CDS       - chr1:180886196-180886197(+) m6A CDS       - chr1:180886208-180886209(+) m6A CDS       - chr1:180886221-180886222(+) m6A CDS       - chr1:180887007-180887008(+) m6A CDS       - chr1:180887034-180887035(+) m6A CDS       - chr1:180887046-180887047(+) m6A CDS       - chr1:180897566-180897567(+) m6A 5'UTR//CDS       - chr1:180897653-180897654(+) m6A CDS//exon       - chr1:180904276-180904277(+) m6A CDS//intron       - chr1:180904303-180904304(+) m6A CDS//intron       - chr1:180904495-180904496(+) m6A CDS//intron       25456834 chr1:180904575-180904576(+) m6A CDS//intron       25456834//24981863//22608085 chr1:180904603-180904604(+) m6A CDS//intron       25456834//24981863//22608085 chr1:180904613-180904614(+) m6A CDS//intron       25456834//22608085 chr1:180904719-180904720(+) m6A CDS//intron       25456834//22608085 chr1:180904833-180904834(+) m6A CDS//intron       25456834//24981863//22608085 chr1:180904846-180904847(+) m6A CDS//intron       25456834//24981863//22608085 chr1:180904870-180904871(+) m6A CDS//intron       25456834//24981863//22608085 chr1:180904882-180904883(+) m6A CDS//intron       25456834//24981863//22608085 chr1:180904891-180904892(+) m6A CDS//intron       25456834//24981863//22608085 chr1:180904911-180904912(+) m6A CDS//intron       25456834//24981863//22608085 chr1:180904932-180904933(+) m6A CDS//intron       25456834//24981863//22608085 chr1:180904962-180904963(+) m6A CDS//intron       25456834//22608085 chr1:180905126-180905127(+) m6A CDS//intron       25456834 chr1:180905142-180905143(+) m6A CDS//intron       25456834 chr1:180905204-180905205(+) m6A CDS//intron       25456834 chr1:180905222-180905223(+) m6A CDS//intron       25456834 chr1:180905265-180905266(+) m6A CDS//intron       25456834 chr1:180905277-180905278(+) m6A CDS//intron       25456834 chr1:180905490-180905491(+) m6A CDS//intron       25456834 chr1:180905531-180905532(+) m6A CDS//intron       25456834 chr1:180905553-180905554(+) m6A CDS//intron       25456834 chr1:180905604-180905605(+) m6A CDS//intron       25456834 chr1:180905628-180905629(+) m6A CDS//intron       25456834 chr1:180905774-180905775(+) m6A CDS//intron       25456834 chr1:180905794-180905795(+) m6A CDS//intron       - chr1:180907694-180907695(+) m6A CDS//exon       - chr1:180907812-180907813(+) m6A CDS//exon       - chr1:180907832-180907833(+) m6A CDS//exon       - chr1:180915551-180915552(+) m6A 3'UTR//intron       24284625//25456834//27371828 chr1:180915677-180915678(+) m6A 3'UTR//intron       25456834 chr1:180919235-180919236(+) m6A 3'UTR//intron       27773535 chr1:180919253-180919254(+) m6A 3'UTR//intron       27773535 chr1:180919387-180919388(+) m6A 3'UTR//intron       27773535 chr1:180919653-180919654(+) m6A 3'UTR//exon       24284625//24209618//25456834//27371828//22608085 chr1:180919769-180919770(+) m6A 3'UTR//exon       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4448	Exosome Plasma     23663360 Exosome Breast milk     - Microvesicle Cerebrospinal fluid     24797360 Microvesicle Colon cancer cell line (LIM1863)     -
	KIAA1614	Exosome Blood     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4448
Interactor2: KIAA1614

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Upregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.