Detail Information

Basic Information:


  VIRBase ID:  

HHID00099147

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-762:           RNF165:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-762 RNF165
miRBase
Accession/Entrez ID		 MIMAT0010313 494470
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - Ark2C//ARKL2//RNF111L2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-762
rs1379218716 chr16:30893951    G/A
rs1401867087 chr16:30893964    G/A
rs1406702631 chr16:30893966    G/A
rs1407433182 chr16:30893961    C/G
rs374396561 chr16:30893962    C/T
rs751832217 chr16:30893968    C/G
rs752364708 chr16:30893961    CCGGGGCCGAGCCCGCGG/C
rs755205907 chr16:30893971    G/T
rs758841312 chr16:30893963    G/A
rs758841312 chr16:30893963    G/C
rs1241251631 chr16:30893956    T/A
rs1288563923 chr16:30893956    T/TGGGGCC
rs1307177311 chr16:30893953    G/A
rs750763225 chr16:30893954    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RNF165
chr18:44033929(+) A-I      intronic
chr18:43945600(+) A-I      intronic
chr18:43946220(+) A-I      intronic
chr18:44024478(+) A-I      intronic
chr18:44031725(+) A-I      intronic
chr18:44033965(+) A-I      intronic
chr18:44031552(+) A-I      intronic
chr18:44033973(+) A-I      intronic
chr18:43945491(+) A-I      intronic
chr18:44032304(+) A-I      intronic
chr18:44032342(+) A-I      intronic
chr18:44032266(+) A-I      intronic
chr18:44021596(+) A-I      intronic
chr18:43956913(+) A-I      intronic
chr18:44033996(+) A-I      intronic
chr18:44021049(+) A-I      intronic
chr18:44035624(+) A-I      intronic
chr18:44035542(+) A-I      intronic
chr18:44033995(+) A-I      intronic
chr18:44033894(+) A-I      intronic
chr18:44035733(+) A-I      intronic
chr18:44026536(+) A-I      intronic
chr18:44020053(+) A-I      intronic
chr18:44031683(+) A-I      intronic
chr18:44031688(+) A-I      intronic
chr18:44024698(+) A-I      intronic
chr18:43945541(+) A-I      intronic
chr18:44035710(+) A-I      intronic
chr18:43982673(+) A-I      intronic
chr18:44033962(+) A-I      intronic
chr18:44033866(+) A-I      intronic
chr18:44021098(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RNF165
chr18:44036522-44036523(+) m6A 3'UTR//CDS       25456834
chr18:44036567-44036568(+) m6A 3'UTR//CDS       25456834//22608085
chr18:44036575-44036576(+) m6A 3'UTR//CDS       25456834//22608085
chr18:44036618-44036619(+) m6A 3'UTR       25456834//24981863//22608085
chr18:44036670-44036671(+) m6A 3'UTR       24209618//25456834//24981863//22608085
chr18:44036777-44036778(+) m6A 3'UTR       25456834
chr18:44036886-44036887(+) m6A 3'UTR       25456834
chr18:44036979-44036980(+) m6A 3'UTR       -
chr18:44039386-44039387(+) m6A 3'UTR       25456834
chr18:44039415-44039416(+) m6A 3'UTR       25456834
chr18:44039445-44039446(+) m6A 3'UTR       25456834
chr18:44040014-44040015(+) m6A 3'UTR       25456834
chr18:44040059-44040060(+) m6A 3'UTR       25456834
chr18:44040128-44040129(+) m6A 3'UTR       25456834
chr18:44041528-44041529(+) m6A 3'UTR       -
chr18:44041595-44041596(+) m6A 3'UTR       24981863
chr18:44041600-44041601(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-762
Exosome Pooled sera     27278097
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Hepatoma cells     23771658
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
RNF165
Exosome Blood     -
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-762
Gemcitabine 60750 Drug interaction    RC00007981
Imatinib 5291 Drug interaction    RC00007980
Bortezomib 387447 Drug interaction    RC00007983
5-Fluorouracil 3385 Drug interaction    RC00007979
Gefitinib 123631 Drug interaction    RC00007982
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-762
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-762
Interactor2: RNF165

Evidence Support:


Weak-Evidence Illumina sequencing
Prediction-Evidence miRanda
Support Database ViRBase

References:


PMID 32223537 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Calu-3 cells Interactor2 expression Downregulation
Description The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.

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