Detail Information

Basic Information:


  VIRBase ID:  

HHID00099143

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-762:           JMJD8:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-762 JMJD8
miRBase
Accession/Entrez ID		 MIMAT0010313 339123
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - C16orf20//PP14397

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-762
rs1379218716 chr16:30893951    G/A
rs1401867087 chr16:30893964    G/A
rs1406702631 chr16:30893966    G/A
rs1407433182 chr16:30893961    C/G
rs374396561 chr16:30893962    C/T
rs751832217 chr16:30893968    C/G
rs752364708 chr16:30893961    CCGGGGCCGAGCCCGCGG/C
rs755205907 chr16:30893971    G/T
rs758841312 chr16:30893963    G/A
rs758841312 chr16:30893963    G/C
rs1241251631 chr16:30893956    T/A
rs1288563923 chr16:30893956    T/TGGGGCC
rs1307177311 chr16:30893953    G/A
rs750763225 chr16:30893954    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR JMJD8
chr16:732586(-) A-I      3'UTR
chr16:732597(-) A-I      3'UTR
chr16:732599(-) A-I      3'UTR
chr16:732602(-) A-I      3'UTR
chr16:732612(-) A-I      3'UTR
chr16:732628(-) A-I      3'UTR
chr16:732638(-) A-I      3'UTR
chr16:732620(-) A-I      3'UTR
chr16:732639(-) A-I      3'UTR
chr16:732640(-) A-I      3'UTR

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase JMJD8
chr16:731759-731760(-) m6A 3'UTR//exon       24284625//24981863//27773535
chr16:731908-731909(-) m6A 3'UTR//exon       24284625//27773535//27371828//27773536//22575960
chr16:731955-731956(-) m6A 3'UTR//exon       24284625//26404942//27773535//27773536//22575960
chr16:731986-731987(-) m6A 3'UTR//exon       24284625//26404942//27773535//27773536//22575960
chr16:732320-732321(-) m6A 3'UTR//exon       24284625//27773535//27773536//22575960
chr16:732491-732492(-) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr16:732516-732517(-) m6A 3'UTR//exon       24284625//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr16:732559-732560(-) m6A 3'UTR//exon       24284625//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr16:732565-732566(-) m6A 3'UTR//exon       24284625//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr16:732595-732596(-) m6A 3'UTR//exon       24284625//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr16:732618-732619(-) m6A 3'UTR//exon       24284625//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr16:732775-732776(-) m6A 3'UTR//exon       24284625//24981863//27773535//22575960//22608085
chr16:732787-732788(-) m6A 3'UTR//exon       24284625//24981863//27773535//22575960//22608085
chr16:733013-733014(-) m6A 3'UTR//CDS//exon//intron       24284625//27773535
chr16:733035-733036(-) m6A 3'UTR//CDS//exon//intron       24284625//27773535
chr16:733199-733200(-) m6A CDS//exon       24284625//27773535
chr16:733351-733352(-) m6A CDS//exon       24284625//27773535
chr16:733419-733420(-) m6A CDS//exon       24284625//27773535
chr16:733440-733441(-) m6A CDS//exon       24284625//27773535
chr16:733549-733550(-) m6A CDS//exon       24284625
chr16:733594-733595(-) m6A CDS//exon       24284625//27773536
chr16:733731-733732(-) m6A CDS//exon       24284625//27773536
chr16:733867-733868(-) m6A CDS//exon//intron       24284625//27773536
chr16:733875-733876(-) m6A CDS//exon//intron       27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-762
Exosome Pooled sera     27278097
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Hepatoma cells     23771658
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
JMJD8
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-762
Gemcitabine 60750 Drug interaction    RC00007981
Imatinib 5291 Drug interaction    RC00007980
Bortezomib 387447 Drug interaction    RC00007983
5-Fluorouracil 3385 Drug interaction    RC00007979
Gefitinib 123631 Drug interaction    RC00007982
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-762
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-762
Interactor2: JMJD8

Evidence Support:


Weak-Evidence Illumina sequencing
Prediction-Evidence miRanda
Support Database ViRBase

References:


PMID 32223537 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Calu-3 cells Interactor2 expression Downregulation
Description The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.

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