Detail Information

Basic Information:


  VIRBase ID:  

HHID00099119

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-762:           SLC46A1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-762 SLC46A1
miRBase
Accession/Entrez ID		 MIMAT0010313 113235
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - G21//HCP1//PCFT

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-762
rs1379218716 chr16:30893951    G/A
rs1401867087 chr16:30893964    G/A
rs1406702631 chr16:30893966    G/A
rs1407433182 chr16:30893961    C/G
rs374396561 chr16:30893962    C/T
rs751832217 chr16:30893968    C/G
rs752364708 chr16:30893961    CCGGGGCCGAGCCCGCGG/C
rs755205907 chr16:30893971    G/T
rs758841312 chr16:30893963    G/A
rs758841312 chr16:30893963    G/C
rs1241251631 chr16:30893956    T/A
rs1288563923 chr16:30893956    T/TGGGGCC
rs1307177311 chr16:30893953    G/A
rs750763225 chr16:30893954    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SLC46A1
chr17:26730818(-) A-I      intronic
chr17:26731000(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SLC46A1
chr17:26723295-26723296(-) m6A 3'UTR       24981863
chr17:26723309-26723310(-) m6A 3'UTR       24981863
chr17:26723316-26723317(-) m6A 3'UTR       24981863
chr17:26723381-26723382(-) m6A 3'UTR       24981863
chr17:26723438-26723439(-) m6A 3'UTR       -
chr17:26723875-26723876(-) m6A 3'UTR       27773535
chr17:26724016-26724017(-) m6A 3'UTR       27773536
chr17:26724028-26724029(-) m6A 3'UTR       27773536
chr17:26724920-26724921(-) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr17:26724950-26724951(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:26724962-26724963(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:26725004-26725005(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:26725034-26725035(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:26725166-26725167(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr17:26725202-26725203(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:26725213-26725214(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:26725231-26725232(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:26725256-26725257(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:26725298-26725299(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27773536//22575960//22608085
chr17:26725345-26725346(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27773536//22575960//22608085
chr17:26725365-26725366(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27773536
chr17:26725430-26725431(-) m6A 3'UTR       24981863//27773535
chr17:26725577-26725578(-) m6A 3'UTR       27773535
chr17:26725691-26725692(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr17:26725791-26725792(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:26725803-26725804(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:26725977-26725978(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:26726048-26726049(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:26726054-26726055(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr17:26726290-26726291(-) m6A 3'UTR       24284625//24981863//27773535
chr17:26726333-26726334(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr17:26726420-26726421(-) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//22575960//22608085
chr17:26726445-26726446(-) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//22575960//22608085
chr17:26726525-26726526(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085
chr17:26726580-26726581(-) m6A 3'UTR//CDS       24284625//25456834//24981863//27773535//22608085
chr17:26726628-26726629(-) m6A 3'UTR//CDS       24284625//24981863//27773535//27773536//22608085
chr17:26726653-26726654(-) m6A 3'UTR//CDS       24284625//24981863//27773535//27773536//22608085
chr17:26726661-26726662(-) m6A 3'UTR//CDS       24284625//24981863//27773535//27773536//22608085
chr17:26727888-26727889(-) m6A exon//intron       24981863
chr17:26731370-26731371(-) m6A exon//intron       27773535
chr17:26731440-26731441(-) m6A exon//intron       27773535
chr17:26731495-26731496(-) m6A exon//intron       27773535
chr17:26731526-26731527(-) m6A exon//intron       27773535
chr17:26731582-26731583(-) m6A exon//intron       27773535
chr17:26731808-26731809(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr17:26731815-26731816(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr17:26731838-26731839(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr17:26731857-26731858(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr17:26731919-26731920(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:26732017-26732018(-) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr17:26733514-26733515(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-762
Exosome Pooled sera     27278097
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Hepatoma cells     23771658
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
SLC46A1
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-762
Gemcitabine 60750 Drug interaction    RC00007981
Imatinib 5291 Drug interaction    RC00007980
Bortezomib 387447 Drug interaction    RC00007983
5-Fluorouracil 3385 Drug interaction    RC00007979
Gefitinib 123631 Drug interaction    RC00007982
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-762
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-762
Interactor2: SLC46A1

Evidence Support:


Weak-Evidence Illumina sequencing
Prediction-Evidence miRanda
Support Database ViRBase

References:


PMID 32223537 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Calu-3 cells Interactor2 expression Downregulation
Description The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.

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